Focus on AD/ADRD

Focus on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD)

Dementia conveys substantial health and financial costs, affecting more than 47 million people worldwide. Alzheimer’s disease alone, as one dementia disorder, affects more than 5 million people in the U.S. The toll on individuals, caregivers and society is enormous and is expected to increase as the population ages. The National Plan to Address Alzheimer’s Disease, launched by the National Alzheimer’s Project Act (NAPA) that was signed into law in 2011, plans, coordinates, and integrates federal and non-federal (private and state-level) activities to overcome AD and ADRD including through research, clinical care, and long-term services and support. The National Plan’s Goal 1 aims to prevent and effectively treat AD/ADRD (delay onset, slow progression) by 2025. To help achieve Goal 1, and as a federal action specified in the National Plan, periodic summits are held that set and refine ADRD research priorities in the National Plan.

NINDS research areas of focus cover:

  • Alzheimer’s disease
  • Frontotemporal degeneration (FTD)
  • Lewy body dementia (LBD)
  • Vascular contributions to cognitive impairment and dementia (VCID)
  • Mixed etiology dementias (MED)

Summits and Planning

To help inform the research agenda toward achieving this goal, the National Institutes of Health hosts periodic Summits that set and refine relevant research priorities for the subsequent 5- to 10-years. In 2016 the NINDS held the Alzheimer’s Disease-Related Dementias Summit, including discussion of scientific progress, challenges and opportunities in major areas of dementia research, including: mixed-etiology dementias, Lewy body dementia, frontotemporal degeneration, vascular contributions to cognitive impairment and dementia, dementia disparities, and dementia nomenclature.

ADRD Summit 2016

NIH AD/ADRD Research Planning and Relationship to Funding chart showing investments into AD/ADRD research from 2012 to 2017, with the goal of reaching Goal 1 of the National Plan: Prevent and Effectively Treat Alzheimer's Disease and Related Dementias by 2025.

AD Summit 2015

AD Summit 2013

ADRD Conference 2013

AD Summit 2012

Current FOAs

RFA-NS-17-016: Leveraging Existing Resources for Research on Lewy Body Dementia (R03)

RFA-NS-17-017: Frontotemporal Degeneration (FTD) Sequencing Consortium: Discovery, Replication and Validation (UG3/UH3)

RFA-NS-17-012: Detecting Cognitive Impairment, Including Dementia, in Primary Care and Other Everyday Clinical Settings for the General Public and in Health Disparities Populations (UG3/UH3)

Upcoming Events

Alzheimer's Association International Conference

NAPA Council


NIH consortium takes aim at vascular disease-linked cognitive impairment and dementia

Tools & Resources

International Alzheimer’s Disease Research Portfolio (IADRP) - database brings together funded research supported by public and private organizations both in the US and abroad.

Alzheimer’s Disease and AD-Related Research Implementation Milestone Database - database is a web-based tool for tracking funding initiatives and activities developed by the NIH and other funding organizations supporting Alzheimer's disease (AD) and AD-Related Dementias (ADRD) aimed at achieving the research milestones associated with the first goal of the National Plan to Address Alzheimer's: to treat and prevent Alzheimer's by 2025

National Plan to Address Alzheimer's Disease: 2016 Update - The National Plan was designed to address the major challenges presented by AD/ADRD

Alzheimer's Disease-Related Dementias (ADRD) Summit 2016 -- Prioritized Research Milestones

NAPA Research Milestones for Goal #1 -- To Treat or Prevent Alzheimer's Disease By 2025