Dr. Reoma has expertise in conducting clinical studies in HIV-infected patients and was elected as a member of the AIDS Clinical Trials Group (ACTG) End-organ Disease, the Inflammation Transformative Science Group and the ACTG Neurology Collaborative Science Group. She is the lead investigator on an FDA approved clinical study. NCT03239899: PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection; IND 13390. She is an Associate Investigator on several other studies. This includes, NCT03367754: A single dose of Pembrolizumab in HIV-infected people: NCT02437/ IO: HERV-K Suppression Using Antiretroviral Therapy in Volunteers with Amyotrophic Lateral Sclerosis (Al,S); NCT02435810: Inflammatory and Infectious Diseases of the Nervous System and NCTO J 86210 7: Cerebrospinal Fluid Collection and Repository Storage. She also has experience as a member of the Safety Monitoring Committee on a Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency and as an Independent Monitor on a Phase l Cytokine microdialysis for real time immune monitoring in glioblastoma patients undergoing checkpoint blockade.
Dr. Lauren Bowen Reoma is a Staff Clinician and Director of the NINDS Clinical Trials Unit in the Office of the Clinical Director where she oversees the centralized support for NINDS sponsored IND and IDE clinical trials and Data and Safety Monitoring procedures, as well as serves as the Medical Monitor for selected NINDS sponsored trials. She is a board-certified neurologist who received her medical degree from the University of Florida in May 2011. She completed her Internal Medicine Internship at the University of Florida College of Medicine in 2012 and completed her neurology residency at the University of Florida College of Medicine in 2015. From 2015-2019, she trained as a Clinical Fellow in the NINDS Neuroimmunology and Neurovirology Program where she completed additional training in Clinical Trials Methodology and the FDA Clinical Investigator Training.
All publications: https://www.ncbi.nlm.nih.gov/myncbi/lauren.bowen.1/bibliography/public/
Selected publications:
Henderson L*, Reoma LB*, Kovacs L, Nath A. Advances towards curing HIV-1 infection from tissue reservoirs. JVI. J Virol. 2019 Nov 6. pii: JVI.00375-19. doi: 10.1128/JVI.00375-19. [Epub ahead of print] Review.
Reoma LB, Trindade C, Monaco-Kushner M, Solis J, Montojo MG, Vu P, Beck E, Khan O, Quezado M, Reich DS, Childs R, Nath A. Fatal Encephalopathy within the context of Wild-type JC Virus and Ruxolitinib Therapy. Ann Neurol. 2019 Dec;86(6):878-884. doi: 10.1002/ana.25608. Epub 2019 Oct 16.
Henderson LJ, Johnson TP, Smith B, Reoma LB, Santamaria UA, Bachani M, Demarino C, Barclay RA, Snow J, Sacktor N, Mcarthur J, Letendre S, Steiner J, Kashanchi F, Nath A. Presence of Tat and Trans-activation response (TAR) element in spinal fluid despite antiretroviral therapy. AIDS. 2019 Dec 1;33 Suppl 2:S145-S157. doi: 10.1097/QAD.0000000000002268.
Cortese I, Muranski P, Akahata Y, Ha SK, Smith B, Monaco MC, Ryschewitsch C, Major EO, Ohayon J, Schindler M, Beck E, Reoma LB, Jacobson S, Reich DS, Nath A. Treatment of progressive multifocal leukoencephalopathy with a checkpoint-inhibitor. NEJM. 2019 Apr 10; doi: 10.1056/NEJMoa1815039.
Bowen LN, Smith B, Reich D, Quezado M, Nath A. Opportunistic CNS Infections in HIV-infected individuals. Nat Rev Neurol. 2016 Oct 27;12(11):662-674.
Margaret Gatti-Mays MD MPH, Maura Manion MD, Lauren Bowen MD, G. Thomas Brown, MD PhD, Robert Danner MD, Omar Khan MD, Avindra Nath MD, Minoo Battiwalla MD, Austin John Barrett MD, Sawa Ito MD. Toxoplasmosis Encephalitis with Immune-Reconstitution Inflammatory Syndrome in an allogeneic stem cell transplant patient. Bone Marrow Transplant. 2016 Dec;51(12):1622-1624.
Bowen LN, Tyagi R, Li W, Alfahad T, Smith B, Wright M, Singer E, Nath A. HIV-associated Motor Neuron Disease: HERV-K Activation and response to anti-retroviral therapy. Neurology. 2016;87:1–7.
Bowen LN, S.H. Subramony MD, Kenneth M. Heilman MD. Apraxia in Anti-GAD Associated Stiff Person Syndrome: Link to Corticobasal Degeneration? Ann Neurol. 2015 Jan;77(1):173-6