Various neuroscience reagents and resources can be obtained by researchers, including human DNA, brain bank tissue and stem cell lines.
AIDS Tissue Resource
The National NeuroAIDS Tissue Consortium (NNTC) collects, stores, and distributes samples of nervous tissue, cerebrospinal fluid, blood, and other tissue from HIV-infected individuals. The NNTC has been supported by NIMH and NINDS since 1998 and operates through a National Coordinating Office and four regional centers: the Texas NeuroAIDS Research Center; the California NeuroAIDS Tissue Network; the National Neurological AIDS Bank; and the Manhattan HIV Brain Bank. The mission of the NNTC is to provide high quality and well-characterized tissue samples from patients who died with HIV, including neuromedical and neuropsychiatric data gathered antemortem, to scientists studying the effects of HIV on the human brain. Since NNTC inception 2,158 participants have been enlisted for clinical evaluation and tissue donation. As of February 14, 2008, 723 central nervous system specimens from both HIV-infected and control subjects have been collected with an additional 1,450 blood samples available, 710 participates have at least three serial samples and 917 CSF samples available obtained from the NNTC patient cohort. NNTC encourages researchers to request tissues and/or clinical data for ancillary studies.
The Human Brain and Spinal Fluid Resource Center was created to help provide specimens related to neuropsychiatric and neurological diseases and disorders. The Center is associated with the Veterans Administration of Greater Los Angeles and is supported jointly with NINDS, NIMH and the National Multiple Sclerosis Society. The Center collects, stores, and distributes the highest quality and quantity of pre- and post-mortem tissues and fluids: brains, spinal cords, cerebrospinal fluid, serum, blood cells and urine. In addition the Center can provide neurological tissue from subjects with neurological disorders as well as control tissues from family members or other donors for use in research toward identifying treatments and cures for neurological diseases.
Dr. May Wong, Program Director, NINDS
The Harvard Brain Tissue Resource Center is a centralized resource for the collection and distribution of human brain specimens for brain research. Utilizing postmortem brain tissue from the center scientists have been able to develop genetic tests for Huntington's and Parkinson's disease. In addition, neurochemical and anatomical studies are being performed focusing on the biological nature of severe mental illnesses with the hope to eventually understand the underlying brain mechanisms associated with psychosis and other brain disorders. The Brain Bank also provides normal control tissue for neuroscience research.
Harvard Brain Tissue Resource Center
NIH Neuroscience Blueprint
Dr. Beth-Anne Sieber, Program Director, NINDS
NINDS Human Genetics Resource Center
The aim of the NINDS Human Genetics Resource Center (also known as the NINDS Repository) is to store and distribute genetics samples, cell lines, and clinical data to aid in the discovery of genes involved in neurological disorders. The Repository is an NINDS-funded contract to the Coriell Institute for Medical Research that banks and distributes cell lines and DNA for neurological disease. The available high quality DNA is accompanied by excellent clinical data. The NINDS Repository aims to bank a large number of samples to generate the statistical power necessary to detect the moderate effects of a single susceptibility gene in complex genetic disorders. Currently the repository has samples with the following diagnoses: Parkinson's disease (~2500 available), cerebrovascular disease and stroke (~4200 available), epilepsy (~680 available), motor neuron disease (~2100 available), and Tourette syndrome (~ 124 available). The Repository also banks and distributes neurologically normal control samples (~ 4100 available) as well as family-based control samples (~ 1000 available). Finally, samples with known Mendelian mutations are also available. To date, more than 4000 NINDS Repository samples have SNP genotype and phenotype data publically available in dbGaP. We encourage both academic and industry-sponsored investigators to deposit or withdraw samples from the NINDS Repository. Current plans include the addition of Dystonia samples to the disease collection and fibroblast cultures from patients with known Mendelian mutations in Parkinson's disease and other neurological disorders.
Last updated February 28, 2013