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Viral Immunology Section - Division of Intramural Research



2000

Kubota R, Soldan S, Martin R, and Jacobson S.
An altered peptide ligand antagonizes antigen-specific CD8+ CTL in peripheral blood of HAM/TSP patients., J Immunology, 2000

2005

Yamano Y, Takenouchi N, Chris Grant, Li H-C, Tomaru U, Yao K, Maric D, and Jacobson S
Human T-cell lymphotropic virus type I (HTLV-I) induced dysfunction of CD4+CD25+ T cells breaks immunological self-tolerance in patients with HTLV-I associated neurological disease, J Clin Invest, 2005, vol. 115, pp. 1361-1368.

Oh U, Yamano Y, Mora CA, Ohayon J, Bagnato F, Buttman J, Dambrosia J, Leist T, McFarland HF and Jacobson S
Interferon-ƒÒ1a therapy for HTLV-I-associated Myelopathy / Tropical Spastic Paraparesis (HAM/TSP) Reduces HTLV-I-specific CD8+ T cells: Analysis of HAM/TSP biomarkers, Annals of Neurology, 2005, vol. 57, pp. 526-534.

R Cassiani-Ingoni, H Greenstone, D Donati, A Fogdell-Hahn, E Martinelli, D Refai, R Martin, EA Berger and S Jacobson
Viral infection induces cell-cell fusion of human lymphocytes with oligodendrocytes through CD46, Glia, 2005

Semmes OJ, Cazares L, Ward M, Moody M, Bray S, Maloney E, Kisada M, Wright GL, Gygi S and Jacobson S
Discrete Protein Signatures Discriminate between Adult T-cell Leukemia and HTLV-1-Associated Myelopathy, Leukemia, 2005, vol. 19 (7), pp. 1229-1238.

2004

Maloney EM, Nagai M, Hisada M, Soldan SS, Goebel PB, Carrington M, Sawada T, Brennan M, Quinan G, Cranston B, Hanchard B, and Jacobson S
Pre-diagnostic Levels of HTLV-I Proviral Load are Highest in Children who Developed Seborrheic Dermatitis and Severe Anemia in Jamaican, J Inf Disease, 2004, vol. 189, pp. 41- 45.

Monsurro V, Wang E, Yamano Y, Migueles SA, Panelli MC, Smith K, Nagorsen D, Connors M, Jacobson S, and Marincola FM
Quiescent phenotype of tumor-specific CD8+ T cells following immunization, Blood, 2004, vol. 104, pp. 1970-1978. Full Text/Abstract

Yoshihisa Y, Cohen CJ, Tomaru U, Li HC, Takenouchi N, Biddison WE, Reiter Y, and Jacobson S
Increased expression of HTLV-I Tax11-19 peptide/HLA-A*201 complexes on CD4+CD25+ T cells detected by TCR-like antibody in HAM/TSP patients, J. Exp., 2004, vol. 199, pp. 1367-1377.

Sundaram R, Rawale SV, Dakappagari NK, Young D, Walker CM, Jacobson S, and Kaumaya PTP
Protective Efficacy of Multiepitope HLA*0201 Restricted CTL Peptide Construct Against Challenge with HTLV-1 Tax Recombinant Vaccinia Virus, Acquir Immune Defic Syndr, 2004, vol. 37, pp. 1329–1339.

Yoshihisa Y, Cohen CJ, Tomaru U, Li HC, Takenouchi N, Biddison WE, Reiter Y, and Jacobson S
Increased expression of HTLV-I Tax11-19 peptide/HLA-A*201 complexes on CD4+CD25+ T cells detected by TCR-like antibody in HAM/TSP patients, J. Exp. Med., 2004, vol. 199, pp. 1367-1377.

Monsurro V, Wang E, Yamano Y, Migueles SA, Panelli MC, Smith K, Nagorsen D, Connors M, Jacobson S, and Marincola FM
Quiescent phenotype of tumor-specific CD8+ T cells following immunization, Blood, 2004, vol. 104, pp. 1970-1978. Full Text/Abstract

2003

Puccioni-Sohler M, Chimelli L, Marcon M, Goncalves RR, Pimenta G, Bianco C, Rios M, and Jacobson S
Acute HAM/TSP Complicated With Encephalopathy And Systemic Inflammation, Journal of Neurological Sciences, 2003, vol. 207, pp. 87-93. Full Text/Abstract

Cermelli C, Berti R, Soldan S, Ludwin SK, and Jacobson S
High Frequency of HHV-6 DNA in Multiple Sclerosis Plaques Isolated by Laser Microdissection, J Infectious Disease, 2003, vol. 187, pp. 1377-1387. Full Text/Abstract

Tomaru U, Yamano Y, Nagai M, Maric D, Kaumaya PTP, Biddison WE, and Jacobson S
Detection of virus specific T cells and novel CD8+ T cell epitopes by acquisition of peptide/HLA/GFP complexes, Nature Medicine, 2003, vol. 9, pp. 469-475.

Sundaram R, Sun Y, Walker CM, Lemonnier FA, Jacobson S, and Kaumaya PTP
A Novel HTLV-1 Multi-Epitope CTL Peptide Construct Elicits Robust Cellular Immune Responses in HLA-A*0201 Transgenic ƒÒ2M, Db Double Knockout Mice, Vaccine, 2003, vol. 3808, pp. 1-15.

Cohen CJ, Sarig O, Yamano Y, Tomaru U, Jacobson S, and Reiter Y
Direct Phenotypic Analysis of human MHC Class I Antigen Presentation: Visualization, Quantitation, and In Situ Detection of Human Viral Epitopes Using Peptide-Specific, MHC-restricted TCR-like Human Recombinant Antibodies, Journal of Immunology, 2003, vol. 170 (8), pp. 4349-4361. Full Text/Abstract

Donati D, Ahkyani N, Fogdell-Hahn A, Cermelli C, Vortmeyer A, Heiss JD, P. Cogen P, Gaillard WD, Sato S, Theodore WH, and Jacobson S
Detection of Human Herpesvirus 6 (HHV-6) in Mesial Temporal Lobe Epilepsy Surgical Brain Resections, Neurology, 2003, vol. 61, pp. 1405-1411. Full Text/Abstract

2002

Berti R, Brennan MB, Soldan SS, Ohayon JM, Casareto L, McFarland HF, Jacobson S
Increased detection of serum HHV-6 DNA sequences during MS exacerbations and correlation with parameters of multiple sclerosis disease progression, J Neurovirol, 2002, vol. 8, pp. 252-259. Full Text/Abstract

Jacobson S
Immunopathogenesis of HTLV-I Associated Neurological Disease, Journal of Infectious Disease, 2002, vol. 186, pp. S187–192. Full Text/Abstract

Kubota R, Soldan SS, Martin R, and Jacobson S
Selected cytotoxic T lymphocytes with High Specificity for HTLV-I in Cerebrospinal Fluid from a HAM/TSP Patient, J NeuroVirol, 2002, vol. 8, pp. 53-57.

Yamano Y, Nagai M, Brennan B, Mora CA, Soldan SS, Tomaru U, Takenouchi N, Syuji Izumo S, Osame M, and Jacobson S
Real-time quantitative RT-PCR analysis of Human T-cell lymphotropic virus type-I (HTLV-I) tax mRNA: correlation with HTLV-I proviral DNA load, Tax protein expression, Tax specific CD8+ T cell frequency and disease severity in patients with HTLV-I-associat, Blood, 2002, vol. 99, pp. 88-94.

Grant C, Barmak K, Alefantis T, Yao J, Jacobson S, Wigdahl B
Human T Cell Leukemia Virus Type I and Neurologic Disease: Events in Bone Marrow, Peripheral Blood, and Central Nervous System During Normal Immune Surveillance and Neuroinflammation, Journal of Cellular Physiology, 2002, vol. 190, pp. 133-159. Full Text/Abstract

2001

Nagai M, Brennan MB, Sakai JA, Mora CA, and Jacobson S
CD8+ T cells An in vivo Reservoir for HTLV-I, Blood, 2001, vol. 98, pp. 1858-1861.

Mayne M, Cheadle C, Soldan SS, Cermelli C, Yamano Y, Akhyani N, Nagel JE, Taub DD, Becker KG, and Jacobson S
Gene Expression Profile of Herpesvirus Infected T cells using Immuno-Microarrays: Upregulation of Pro-Inflammatory Genes, J Virol, 2001, vol. 75, pp. 11641-11650.

Jacobson S and Cross A
Association of Chlamydia pneumoniae and Multiple Sclerosis. Stage Two, Neurology, 2001, vol. 56, pp. 1128-1129. Full Text/Abstract

Soldan SS, Fogdell-Hahn A, Brennan MB, Mittleman BB, Massacesi L, Seya T, McFarland HF, and Jacobson S
Elevated Serum and CSF Levels of Soluble HHV-6 Cellular Receptor, Membrane Cofactor Protein (MCP; CD46), In Patients with Multiple Sclerosis, Annals of Neurology, 2001, vol. 50, pp. 486-493.

Nagai M, Yamano Y, Brennan MB, Mora CA, and Jacobson S
Increased HTLV-I Proviral Load And Preferential Expansion Of HTLV-I Tax-Specific CD8+ T Cells In Cerebrospinal Fluid From Patients With HAM/TSP, Annals of Neurology, 2001, vol. 50, pp. 807-812. Full Text/Abstract

Nagai M, Kubota R, Greten TF, Schneck JP, Leist TP, and Jacobson S
Increased Differentiated and Activated HTLV-I Tax11-19-Specific CD8+ Cells in Patients with HTLV-I-Associated Myelopathy / Tropical Spastic Paraparesis: Correlation with HTLV-I Proviral Load, J Inf Dis, 2001, vol. 183, pp. 197-205.

Sakai JA, Nagai M, and Jacobson S
In Vitro Spontaneous Lymphoproliferation in Patients with HTLV-I-Associated Neurological Disease: Predominant Expansion of CD8+ T-cells, Blood, 2001, vol. 98, pp. 1506-1511. Full Text/Abstract

Azimi N, Nagai M, Jacobson S, Waldmann TA
Interleukin 15 is an Essential Factor for The Persistence of the Tax-Specific CD8 Cells in HAM/TSP Patients, Patients. Proc Natl Acad Sci, 2001, vol. 1073, pp. 14559-14564.

Levin MC, Rosenblum MC, Fox CH, and Jacobson S
In Situ Localization of Retrovirus in The Central Nervous System of A Patient Co-infected with HTLV-I and HIV with HAM/TSP and AIDS Dementia Complex, J Neurovirol, 2001, vol. 7, pp. 6-65. Full Text/Abstract

2000

Soldan SS, Leist TP, Juhng KN, McFarland HF, and Jacobson S.
Increased lymphoproliferative response to HHV-6 A variant in multiple sclerosis patients., Annals of Neurology, 2000, vol. 47, pp. 306-313.

Akhyani N, Berti R, Brennan M, Soldan SS, Eaton JM, McFarland HF and Jacobson S
. Tissue Distribution and Variant Characterization of HHV-6: Increased Prevalence of HHV-6A in Patients with Multiple Sclerosis, J Inf Dis, 2000, vol. 182 (5), pp. 1321-1325. Full Text/Abstract

Kubota R, Soldan S, Martin R, and Jacobson S
An Altered Peptide Ligand Antagonizes Antigen-Specific CD8+ CTL in Peripheral Blood of HAM/TSP Patients, J. Immunol, 2000, vol. 164, pp. 5192-5198. Full Text/Abstract

Berti R, Soldan S, Akyani N, Leist T, McFarland H, and Jacobson S
Extended Observations on the Association of HHV-6 and MS, J. Neurovirol, 2000, vol. 6: Suppl 2, pp. S85-S87. Full Text/Abstract

Kubota R, Nagai M, Kawanishi T, Osame M, and Jacobson S
Increased HTLV-I Tax Specific CD8+ Cells in HAM/TSP: Correlation with HTLV-I Proviral Load, AIDS Res Hum Retro, 2000, vol. 16, pp. 1705-1710. Full Text/Abstract

Cermelli C and Jacobson S
Viruses and Multiple Sclerosis, Viral Immunology, 2000, vol. 13, pp. 255-267. Full Text/Abstract

1998

Jacobson S, Soldan SS, Berti R
HHV-6 and Multiple Sclerosis, Nature Medicine, 1998, pp. (letter)4:538. Full Text/Abstract

Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi P, Brennan MB, Maloni HM, McFarland HF, Lin H, Patnaik M, and Jacobson S.
Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA., Nature Medicine, 1998, vol. 3, pp. 1394-1397. Full Text/Abstract

1997

Levin MC, Lehky TJ, Flerlage N, Katz D, Kingma DW, Jaffe ES, Heiss JD, Corbet JJ, Patronas N, McFarland HF, and Jacobson S.
Immunopathogenesis of HTLV-I associated chronic progressive neurologic disease: in vivo evidence based on a spinal cord biopsy from a patient with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), New Eng J Med, 1997, vol. 336, pp. 839-845.

1993

Elovaara I, Koenig, Breweh A, and Jacobson S.
High HTLV-I specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-I associated neurological disease, J Exp Med, 1993, vol. 177, pp. 1567-1573.

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