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Clinical Neurocardiology Section - Division of Intramural Research


David S. Goldstein Image

David S. Goldstein, M.D., Ph.D., Senior Investigator

Dr. Goldstein graduated from Yale College and received an M.D.-Ph.D. in Behavioral Sciences from Johns Hopkins. After medical internship and residency at the University of Washington, he came to the NIH as a Clinical Associate in the NHLBI, obtaining tenure as a Senior Investigator in 1984. He joined the NINDS in 1990 to head the Clinical Neurochemistry Section and founded and directs the Clinical Neurocardiology Section, an Independent Section. He has received Yale's Angier Prize for Research in Psychology, the Laufberger Medal of the Czech Academy of Sciences, 2 NIH Merit Awards, the Founders Award of the Bakken Heart-Brain Institute, the Distinguished Investigator Award of the Society for Clinical and Translational Science, and the NIH Distinguished Clinical Teacher Award. He is author of more than 500 research articles and several books, including "Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine," ”Dysautonomias: A Handbook for Patients,” "Stress, Catecholamines, and Cardiovascular Disease," and "The Autonomic Nervous System in Health and Disease.”

Laboratory Staff

Glen A. Cook, M.D., Clinical Fellow
Courtney Holmes, C.M.T., Biologist
Yunden Jinsmaa, Ph.D., Contractor
Irwin J. Kopin, M.D., Scientist Emeritus
Sandra Pechnik, R.N., Research Nurse

Research Interests

Dr. Goldstein's research interests are in catecholamine systems, clinical autonomic disorders, and scientific integrative medicine. The Clinical Neurocardiology Section, which he founded and directs, carries out mainly patient-oriented research. The Section operates a renowned Clinical Neurochemistry Laboratory for assays of levels of catecholamines and their metabolites. Current research of the Section focuses on biomarkers and mechanisms of catecholamine depletion in Parkinson disease and related disorders.

A major new study by the Clinical Neurocardiology Section is on biomarkers of risk of Parkinson disease (PD). We call this the PDRisk study (NIH Protocol 09-N-0010). There are two main purposes of this study. The first purpose is to determine whether people who have characteristics that may be risk factors for PD have objective evidence—“biomarkers”—that the disease process is actually going on. The evidence we are looking for is loss of nerves and nerve cells that use particular chemicals, called catecholamines. PD patients typically have a loss of nerves and nerve cells that use the catecholamines dopamine and norepinephrine as chemical messengers. The second purpose is to determine whether people who have abnormal “biomarkers” actually develop PD during several years of follow-up.

For more information about our PDRisk study please visit our Protocol-specific website, https://pdrisk.ninds.nih.gov.


Clinical Protocols

  • Clinical Laboratory Evaluation of Primary Chronic Autonomic Failure  03-N-0004
  • Biomarkers of Risk of Parkinson Disease  09-N-0010

Selected Recent Publications

  • Goldstein DS.
    Dysautonomias: A Handbook for Patients, (available from the Author), 2013
  • Goldstein DS.
    Concepts of scientific integrative medicine applied to the physiology and pathophysiology of catecholamine systems, Compr Physiol, 2013, vol. 3, pp. 1569-1610. (PMID 24265239).
  • Goldstein DS, Sullivan P, Holmes C, Miller GW, Alter S, Strong G, Mash DC, Kopin IJ, Sharabi Y.
    Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson disease., J Neurochem, 2013, vol. 126, pp. 591-603. (PMID: 23786406).
  • Goldstein DS.
    Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine, Johns Hopkins University Press, 2006
  • Goldstein DS, Smith LJ
    The NDRF Handbook for Patients with Dysautonomias, Futura, 2002
  • Goldstein DS
    The Autonomic Nervous System in Health and Disease, Taylor & Francis, 2001
  • Goldstein DS, Holmes C, Cannon RO III, Eisenhofer G, Kopin IJ
    Sympathetic cardioneuropathy in dysautonomias, N Engl J Med, 1997, vol. 336, pp. 696-702.
  • Goldstein DS
    Stress, Catecholamines, and Cardiovascular Disease, Oxford Univ. Press, 1995

Selected Earlier Publications


Contact Information

Clinical Neurocardiology Section, CNP, DIR, NINDS, NIH
Building 10, Room 5N220
10 Center Drive, MSC 1620
9000 Rockville Pike
Bethesda, MD 20892-1620

Telephone: 301-496-2103 (office), 301-496-1115 (laboratory), 301-496-7832 (fax)
Email: goldsteind@ninds.nih.gov