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Biochemistry Section - Division of Intramural Research



2014

Yamano K, Fogel AI, Wang C, van der Bliek AM, Youle RJ
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy, Elife, 2014, vol. 3, pp. e01612.. Full Text/Abstract

2013

Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ
High –content genome-wide RNAi screens identify regulators of Parkin upstream of mitophagy, Nature, 2013, vol. 504, pp. 291-5. Full Text/Abstract

Lazarou M, Narendra DP, Jin SM, Tekle E, Banerjee S, Youle RJ
Pink1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding, J Cell Biol, 2013, vol. 200, pp. 163-72.. Full Text/Abstract

2012

Youle RJ, van der Bliek AM
Mitochondrial fission, fusion, and stress, Science, 2012, vol. 337, pp. 1062-5.

Lazarou M, Jin SM, Kane LA, Youle RJ
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin, Dev Cell, 2012, vol. 22, pp. 320-33.

2011

Youle RJ, Narendra DP
Mechanisms of mitophagy, Nat Rev Mol Cell Biol 12: 9-14, 2011

Edlich F, Banerjee S, Suzuki M, Cleland MM, Arnoult D, Wang C, Neutzner A, Tjandra N, and Youle, RJ
Bclxl Retrotranslates Bax from the Mitochondria into the Cytosol, Cell 145: 104-116, 2011

2010

Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ
Proteosome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin, J Cell Biol 191:1367-80, 2010

Narendra DP, Jin SM, Tanaka A, Suen D-F, Gautier CA, Shen J, Cookson MR, Youle RJ
Pink is selectively stabilized on impaired mitochondria to activate Parkin, PLoBiol 8, e1000298, 2010

Suen D-F, Narandra DP, Tanaka A, Manfredi G, Youle RJ
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells, PNAS 107: 11835-11840, 2010

2008

Suen D-F, Norris KL, Youle RJ
Mitochondrial dynamics and apoptosis, Genes Dev., 2008, vol. 22:1577-90

2007

Karbowski M, Neutzner A, Youle RJ
The mitochondrial E3 ubiquitin ligase MARCH5 is required for DrpI dependent mitochondrial division, J Cell Biol, 2007, vol. 178, pp. 71-84.

2006

Karbowski M, Norris KL, Cleland MM, Jeong SY, Youle RJ.
Role of Bax and Bak in Mitochodrial Morphogenesis, Nature, 2006, vol. 443: 658-62

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