Circuit Dynamics and Connectivity Unit - Division of Intramural Research
Kevin L Briggman, Ph.D., Investigator
Dr. Briggman received his B.S. from Case Western Reserve University in 2000 and his Ph.D. from the University of California, San Diego in 2005, where he studied behavioral choice using voltage-sensitive dye population imaging in the leech nervous system with Bill Kristan. During a postdoctoral fellowship with Winfried Denk at the Max Planck Institute for Medical Research, he worked on the development of serial block-face scanning electron microscopy and used it in combination with two-photon population calcium imaging to investigate the circuit mechanisms underlying direction-selectivity in the mammalian retina. Dr. Briggman joined NINDS as an investigator in 2011. His laboratory combines techniques to measure the function and connectivity of neuronal circuits, focusing on the comparative study of sensory and motor systems across species.
Selected Recent Publications
Briggman KL, Bock DD.
Volume electron microscopy for neuronal circuit reconstruction., Curr Opin Neurobiol., 2012, vol. 22(1), pp. 154-61.. Full Text/Abstract
Briggman KL, Helmstaedter M, Denk W
Wiring specificity in the direction-selectivity circuit of the retina, Nature, 2011, vol. 471(7337), pp. 183-8. Full Text/Abstract
Helmstaedter M, Briggman KL, Denk W
High-accuracy neurite reconstruction for high-throughput neuroanatomy, Nat Neurosci., 2011, vol. 14(8), pp. 1081-8. Full Text/Abstract
Briggman KL, Kristan WB Jr.
Imaging dedicated and multifunctional neural circuits generating distinct behaviors., J Neurosci., 2006, vol. 26(42), pp. 10925-33. Full Text/Abstract
Briggman KL, Abarbanel HD, Kristan WB Jr.
Optical imaging of neuronal populations during decision-making., Science, 2005, vol. 307(5711), pp. 896-901. Full Text/Abstract