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Circuit Dynamics and Connectivity Unit - Division of Intramural Research


Kevin L Briggman Image

Kevin L Briggman, Ph.D., Investigator

Dr. Briggman received his B.S. in Electrical Engineering from Case Western Reserve University in 2000 and his Ph.D. in Computational Neurobiology from the University of California, San Diego in 2005, where he studied behavioral choice using voltage-sensitive dye population imaging in the leech nervous system with Bill Kristan. During a postdoctoral fellowship with Winfried Denk at the Max Planck Institute for Medical Research, he worked on the development of serial block-face scanning electron microscopy and used it in combination with two-photon population calcium imaging to investigate the circuit mechanisms underlying direction-selectivity in the mammalian retina. Dr. Briggman joined NINDS as an investigator in 2011. His laboratory develops large scale optical and electron microscopy-based methods to functionally and structurally map neuronal circuits in the central nervous systems of mice and fish.

Laboratory Staff

Christina Burghard, B.S., Post baccalaureate IRTA Fellow
Amauche Emenari, B.S., M.S, Technical IRTA
Boma Fubara, B.S., Laboratory Manager
Christopher Harris, Ph.D., Postdoctoral Fellow
Christian Hicks, B.S., Visiting Fellow
Marta Pallotto, Ph.D., Postdoctoral Fellow
Paul Watkins, Ph.D., Software Engineer

Selected Recent Publications

  • Helmstaedter M, Briggman KL, Turaga SC, Jain V, Seung HS, Denk W
    Connectomic reconstruction of the inner plexiform layer in the mouse retina, Nature, 2013, vol. 500, pp. 168-74.. Full Text/Abstract
  • Briggman KL, Bock DD.
    Volume electron microscopy for neuronal circuit reconstruction., Curr Opin Neurobiol., 2012, vol. 22(1), pp. 154-61.. Full Text/Abstract
  • Briggman KL, Helmstaedter M, Denk W
    Wiring specificity in the direction-selectivity circuit of the retina, Nature, 2011, vol. 471(7337), pp. 183-8. Full Text/Abstract
  • Helmstaedter M, Briggman KL, Denk W
    High-accuracy neurite reconstruction for high-throughput neuroanatomy, Nat Neurosci., 2011, vol. 14(8), pp. 1081-8. Full Text/Abstract
  • Briggman KL, Kristan WB Jr.
    Imaging dedicated and multifunctional neural circuits generating distinct behaviors., J Neurosci., 2006, vol. 26(42), pp. 10925-33. Full Text/Abstract
  • Briggman KL, Abarbanel HD, Kristan WB Jr.
    Optical imaging of neuronal populations during decision-making., Science, 2005, vol. 307(5711), pp. 896-901. Full Text/Abstract


Contact Information

Circuit Dynamics and Connectivity Unit
Building 37, Room 1016
37 Convent Dr
Bethesda, MD 20892

Telephone: 301-402-7155 (office)
Email: briggmankl@mail.nih.gov