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Synaptic Function Section - Division of Intramural Research


Tao Sun, Haifa Qiao, Ping-Yue Pan, Yanming Chen, and Zu-Hang Sheng
Mobile axonal mitochondria contribute to the variability of presynaptic strength, Cell Reports, 2013, pp. (see Video Summary: Full Text/Abstract

Yanmin Chen and Zu-Hang Sheng
Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport, Journal of Cell Biology, 2013, vol. 202, pp. 351-364 (Also see "In Focus" article by Ben Short). Full Text/Abstract


Qian Cai, Hesham Mostafa Zakaria, Anthony Simone, and Zu-Hang Sheng
Spatial Parkin Translocation and Degradation of Depolarized Mitochondria via Mitophagy in Live Cortical Neurons, Current Biology, 2012, vol. 22, pp. 545-552. Full Text/Abstract

Zu-Hang Sheng & Qian Cai
Mitochondrial Transport in Neurons: Impact on Synaptic Homeostasis and Neurodegeneration (Review article), Nature Reviews Neuroscience, 2012, vol. 13, pp. 77-93. Full Text/Abstract

Kim HJ, Zhong Q, Zu-Hang Sheng, Yoshimori T, Liang C, Jung JU
Beclin 1-interacting autophagy protein Atg14L targets SNARE-associated protein Snapin to coordinate endocytic trafficking, Journal of Cell Science, 2012, vol. 125, pp. 4740-4750.

Bing Zhou, Qian Cai, Yuxiang Xie, and Zu-Hang Sheng
Snapin recruits dynein to BDNF-TrkB signaling endosomes for retrograde axonal transport and is essential for dendrite growth of cortical neurons, Cell Reports, 2012, vol. 2, pp. 42-51. Full Text/Abstract

Qian Cai, Hesham M Zakaria, and Zu-Hang Sheng
Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons, Autophage, 2012, vol. 8, pp. 976-978.


Qian Cai, Matthew Davis, and Zu-Hang Sheng
Regulation of Axonal Mitochondrial Transport and Its Impact on Synaptic Transmission, Neuroscience Research, 2011, vol. 70, pp. 9-15 (invited review article).

Bing Zhou, Yi-Bing Zhu, Lin Lin, Qian Cai, and Zu-Hang Sheng
Snapin deficiency is associated with developmental defects of the central nervous system, Bioscience Reports, 2011, vol. 31, pp. 151-158. Full Text/Abstract

Qian Cai, Matthew Davis, and Zu-Hang Sheng
Regulation of Axonal Mitochondrial Transport and Its Impact on Synaptic Transmission, Neuroscience Research, 2011, vol. 70, pp. 9-15 (invited review article).

Qian Cai and Zu-Hang Sheng
Uncovering the role of Snapin in regulating autophagy-lysosomal function, Autophagy, 2011, vol. 7, pp. 445-447. Full Text/Abstract

Yi-Bing Zhu, Zu-Hang Sheng
Increased Axonal Mitochondrial Mobility Does Not Slow ALS-like Disease in Mutant SOD1 Mice, The Journal of Biological Chemistry, 2011, vol. 286, pp. 23432-23440. Full Text/Abstract


Qian Cai, Li Lu, Jin-Hua Tian, Yi-Bing Zhu, Haifa Qiao, and Zu-Hang Sheng
Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons, Neuron, 2010, vol. 68, pp. 73-86, (Also see Preview by M. Yuzaki). Full Text/Abstract


Qian Cai and Zu-Hang Sheng
Molecular Motors and Synaptic Assembly., The Neuroscientists, 2009, vol. 15, pp. 78-89. Full Text/Abstract

Yan-Min Chen, Claudia Gerwin, and Zu-Hang Sheng
Dynein Light Chain LC8 Regulates Syntaphilin-Mediated Mitochondrial Docking in Axons, Journal of Neuroscience, 2009, vol. 29, pp. 9429-9438. Full Text/Abstract

Huan Ma, Qian Cai, Wenbo Lu, Zu-Hang Sheng (co-corresponding author), Sumiko Mochida
KIF5B Motor Adaptor Syntabulin Maintains Synaptic Transmission in Sympathetic Neurons, Journal of Neuroscience, 2009, vol. 29, pp. 13019-13029. Full Text/Abstract

Qian Cai and Zu-Hang Sheng
Moving or Stopping Mitochondria: Miro as a Traffic Cop by Sensing Calcium (Previews), Neuron, 2009, vol. 61, pp. 493-496. Full Text/Abstract

Ping-Yue Pan, Jin-Hua Tian, Zu-Hang Sheng
Snapin facilitates the synchronization of synaptic vesicle fusion, Neuron, 2009, vol. 61, pp. 412-424. Full Text/Abstract

Qian Cai and Zu-Hang Sheng
Mitochondrial Transport and Docking in Axons, Experimental Neurology, 2009, vol. 218, pp. 257-267.


AG Miriam Leenders, Lin Lin, Li-Dong Huang, Claudia Gerwin, Pei-Hua Lu, and Zu-Hang Sheng
The Role of MAP1A Light Chain 2 in Synaptic Surface Retention of Cav2.2 Channels in Hippocampal Neurons, Journal of Neuroscience, 2008, vol. 28, pp. 11333-11346. Full Text/Abstract

Jian-Sheng Kang, Jin-Hua Tian*, Ping-Yue Pan*, Philip Zald, Cuiling Li, Chuxia Deng, and Zu-Hang Sheng
Docking of Axonal Mitochondria by Syntaphilin Controls their Mobility and Affects Short-term Facilitation (*equal contribution), Cell, 2008, vol. 132, pp. 137-248. Full Text/Abstract

Wenbo Lu, Huan Ma, Zu-Hang Sheng, and Sumiko Mochida.
Dynamin and activity regulate synaptic vesicle recycling in sympathetic neurons., The Journal of Biological Chemistry, 2008, vol. 284, pp. 1930-1937.


Qain Cai, Ping-Yue Pan, and Zu-Hang Sheng
Syntabulin-kinesin-1 family 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly, Journal of Neuroscience, 2007, vol. 27, pp. 7284-7296 (With Weekly Editorial News). Full Text/Abstract


Jin-Hua Tian, Zheng-Xing Wu, Michael Unzicker, Li Lu, Qian Cai, Cuiling Li, Claudia Schirra, Ulf Matti, David Stevens, Chuxia Deng, Jens Rettig, and Zu-Hang Sheng
The Role of Snapin in Neurosecretion: Snapin Knockout Mice Exhibit Impaired Calcium-dependent Exocytosis of Large Dense-core Vesicles in Chromaffin Cells, Journal of Neuroscience, 2005, vol. 25, pp. 10546-10555 (With Weekly Editorial News). Full Text/Abstract

Xiao-Ke Chen, Lie-Cheng Wang, Yang Zhou, Qian Cai, Murali Prakriya, Kai-Lai Duan, Zu-Hang Sheng, Christopher Lingle & Zhuan Zhou
Activation of GPCRs modulates quantal size in chromaffin cells through Gbg, Nature Neuroscience, 2005, vol. 8, pp. 1160-1168.

Ping-Yue Pan, Qian Cai, Lin Lin, Pei-Hua Lu, Shu-Min Duan, and Zu-Hang Sheng.
SNAP29-mediated modulation of synaptic transmission in cultured hippocampal neurons, The Journal of Biological Chemistry, 2005, vol. 280, pp. 25769-25779. Full Text/Abstract

Qian Cai, Claudia Gerwin, and Zu-Hang Sheng
Syntabulin-mediated anterograde transport of mitochondria along the neuronal processes, Journal of Cell Biology, 2005, vol. 170, pp. 959-969. Full Text/Abstract


Wu LJ, Leenders AG, Cooperman S, Meyron-Holtz E, Smith S, Land W, Tsai RY, Berger UV, Sheng ZH, Rouault TA
Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier, Brain Res., 2004, vol. 1001, pp. 108-17.

Pratima Thakur, David R. Stevens, Zu-Hang Sheng and Jens Rettig
Effects of PKA-mediated phosphorylation of Snapin on synaptic transmission in cultured hippocampal neurons, Journal of Neuroscience, 2004, vol. 24, pp. 6476-6481.

Judit Boczan, A. G. Miriam Leenders, and Zu-Hang Sheng
Phosphorylation of syntaphilin by PKA modulates its interaction with syntaxin-1 and annuls its inhibitory effect on vesicle exocytosis, The Journal of Biological Chemistry, 2004, vol. 279, pp. 18911-18919.

Brij B. Singh, Timothy P. Lockwich, Bidhan C. Bandyopadhyay, Xibao Liu, Sunitha Bollimuntha, So-ching Brazer, Christian Combs, Sunit Das, A.G. Miriam Leenders, Zu-Hang Sheng, Mark A. Knepper, Suresh V. Ambudkar, and Indu S. Ambudkar
VAMP2-Dependent Exocytosis Regulates Plasma Membrane Insertion of TRPC3 Channels and Contributes to Agonist-Stimulated Ca2+ Influx, Molecular Cell, 2004, vol. 15, pp. 635-646.

Qian Cai*, Qingning Su*, Claudia Gerwin, Carolyn L. Smith, Zu-Hang Sheng
Syntabulin: a microtubule-associated protein implicated in syntaxin trafficking in neurons, Nature Cell Biology, 2004, vol. 6, pp. 941-953 (with news & views)(*equal contributions). Full Text/Abstract


Haitao Song, Liping Nie, Adrian Rodriguez-Contreras, Zu-Hang Sheng, and Ebenexer Yamoah
Functional interaction of auxiliary subunits and synaptic proteins with Ca1.3 may impart hair cell Ca current properties, J Neurophysiol., 2003, vol. 89, pp. 1143.

Sunit Das, Judit Boczan, Claudia Gerwin, Philip B. Zald and Zu-Hang Sheng
Regional and developmental regulation of syntaphilin expression in the brain: a candidate molecular element of synaptic functional differentiation, Molecular Brain Research, 2003, vol. 116, pp. 38-49.

Sunit Das, Claudia Gerwin, and Zu-Hang Sheng
Syntaphilin binds to dynamin-1 and inhibits dynamin-dependent endocytosis, The Journal of Biological Chemistry, 2003, vol. 278, pp. 41221-41226.

Jin-Hua Tian, Sunit Das, and Zu-Hang Sheng
Ca-dependent phosphorylation of syntaxin-1A by DAP-kinase regulates its interaction with Munc-18, The Journal of Biological Chemistry, 2003, vol. 278, pp. 26265-26274.


Miriam Leenders, Arn M. J. M. van den Maagdenberg, Fernando H. Lopes da Silva, Zu-Hang Sheng, Peter C. Molenaar and Wim E.J.M. Ghijsen
Neurotransmitter release from tottering mice nerve terminals with reduced expression of mutated P-, Q-type Ca2+-channels, Eur. J. Neuroscience, 2002, vol. 15, pp. 13-18.


Milan G. Chheda, Uri Ashery, Pratima Thakur, Jens Rettig,and Zu-Hang Sheng
PKA phosphorylation of Snapin: modulating its interaction with the SNARE complex, Nature Cell Biology, 2001, vol. 3, pp. 331-338.

Qingning Su, Sumiko Mochida, Jin-Hua Tian, Rashi Mehta,and Zu-Hang Sheng
SNAP-29: A General SNARE Protein that Inhibits SNARE Disassembly and is Implicated in Synaptic Transmission, Proc. Natl. Acad. Sci. USA, 2001, vol. 98, pp. 1438-1443.


Guifang Lao, Volker Scheuss, Claudia M. Gerwin, Qingning Su, Sumiko Mochida, Jens Rettig, and Zu-Hang Sheng.
Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly, Neuron, 2000, vol. 25, pp. 191-201.


Lucas D. Pozzo-Miller, Wolfram Gottschalk, Li Zhang, Kathryn McDermott, Chikara Oho, Zu-Hang Sheng, and Bai Lu
The role of BDNF in Hippocampal synaptic plasticity: impairment in synaptic vesicle docking and synaptic protein distribution in BDNF knockout mice, J. Neuroscience, 1999, vol. 19, pp. 4972-4983.

Jeffrey M. Ilardi, Sumiko Mochida, and Zu-Hang Sheng
Snapin: a SNARE-associated protein implicated in synaptic transmission, Nature Neuroscience, 1999, vol. 2, pp. 119-124.


Zu-Hang Sheng, Ruth E. Westenbroek, and William A. Catterall
Physical link and functional coupling of presynaptic calcium channels and synaptic vesicle docking/fusion machinery, J. Bioenergetics & Biomembranes, 1998, vol. 30, pp. 335-345.


Zu-Hang Sheng, Charles Yokoyoma, and William A. Catterall
Interaction of the synprint site of N-type calcium channels with the C2B domain of synaptotagmin I, Proc. Natl. Acad. Sci. USA, 1997, vol. 94, pp. 5405-5410.

Jens Rettig, Christian Heinemann, Uri Ashery, Zu-Hang Sheng, Charles T. Yokoyama, William A. Catterall, and Erwin Neher
Alteration of Ca2+ dependence of neurotransmitter release by disruption of Ca2+ channel/SNARE protein interaction, J Neuroscience, 1997, vol. 17, pp. 6647-6656.

Charles Yokoyama, Zu-Hang Sheng, and William A. Catterall
Phosphorylation of the synprint site on N-type calcium channels inhibits interactions with SNARE protein, J Neuroscience, 1997, vol. 17, pp. 6929-6938.


Sumiko Mochida, Zu-Hang Sheng, Carl Baker, Haruo Kobayashi, and William A. Catterall
Inhibition of neurotransmission by peptides containing the synaptic protein interaction site of N-type calcium channels, Neuron, 1996, vol. 17, pp. 781-788.

Jens Rettig, Zu-Hang Sheng, D. Kyle Kim, Connie D. Hodson, Terry P. Snutch, and William A. Catterall
Isoform-specific interaction of the a1A subunits of brain calcium channels with the presynaptic proteins syntaxin and SNAP-25, Proc. Natl. Acad. Sci. USA, 1996, vol. 93, pp. 7363-7368.

Zu-Hang Sheng, Jens Rettig, Terry Cook, and William A. Catterall
Calcium dependent interaction of neuronal N-type calcium channels with presynaptic fusion proteins, Nature, 1996, vol. 379, pp. 451-454.


Zu-Hang Sheng, Jens Rettig, Masami Takahashi, and William A. Catterall
Identification of a syntaxin-binding site on N-type calcium channels, Neuron, 1994, vol. 13, pp. 1303-1313.

Zu-Hang Sheng, Hui Zhang, Robert L. Barchi, and Roland G. Kallen
Molecular cloning and functional analysis of the promoter of rat skeletal muscle voltage-sensitive sodium channel subtype 2 (rSkM2): evidence for muscle-specific nuclear protein binding to the core promoter, DNA and Cell Biology, 1994, vol. 13, pp. 9-23.


Roland G. Kallen, Zu-Hang Sheng, Liquiong Chen, Jan Yang, Rogart, R.B., and Robert L. Barchi
Primary structure and differential expression of a sodium channel characteristic of immature and denervated rat skeletal muscle, Neuron, 1990, vol. 4, pp. 233-242.


Trimmer, J.S., Cooperman, S.S., Tomiko, S.A., Zhou, J., Crean, S.M., Boyle, M.B., Kallen, R.G., Zu-Hang Sheng, Barchi, R.L., Sigworth, F.J., Goodman, R.G., Agnew, S.A., and Mandel, G
Primary structure and functional expression of a mammalian skeletal muscle sodium channel, Neuron, 1989, vol. 3, pp. 33-49.

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