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Molecular Physiology and Biophysics Section - Division of Intramural Research



2014

Toombes, E.S. and Swartz, K.J.
Divining the design principles of voltage sensors, J Gen Physiol, 2014, vol. 143, pp. 139-44. Full Text/Abstract

2013

Milescu, M., Lee, H.W., Bae, C., Kim, J.I. and Swartz, K.J.
Opening the Shaker Kv channel with hanatoxin, J Gen Physiol, 2013, vol. 141, pp. 203-16. Full Text/Abstract

Kalia, J. and Swartz, K.J.
The design principle of paddle motifs in voltage sensors, Nature Struct Mol Biol, 2013, vol. 20, pp. 534-5. Full Text/Abstract

Heymann, G., Dai, J., Li, M., Silberberg, S.D., Zhou, H-X. and Swartz, K.J.
Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels, Proc Nat'l Acad Sci, 2013, vol. 110, pp. E4045-54. Full Text/Abstract

Kalia, J and Swartz, KJ
Exploring structure-function relationships between TRP and Kv channels, Sci Reports, 2013, vol. 3:1523, pp. 1-9. Full Text/Abstract

Swartz KJ
The scorpion toxin and the potassium channel, eLife, 2013, vol. May 21;2:e00873 Full Text/Abstract

Kalia, J. and Swartz, K.J.
Common principles of voltage-dependent gating in Hv and Kv channels, Neuron, 2013, vol. 77, pp. 214-16. Full Text/Abstract

Li, M., Silberberg, S.D. and Swartz, K.J.
Subtype-specific control of P2X receptor channel signaling by ATP and magnesium, Proc Nat'l Acad Sci, 2013, vol. 110, pp. E3455-63. Full Text/Abstract

2012

Bae, C.H., Kalia, J., Song, I., Yu, J.H., Kim, H.H., Swartz, K.J. and Kim, J.I.
High yield production and refolding of the double-knot toxin, an activator of TRPV1 channels, Plos One, 2012, vol. 7, pp. 1-10. Full Text/Abstract

Krepkiy, D., Gawrisch, K. and Swartz K.J.
Structural interactions between lipids, water and S1-S4 voltage-sensing domains, J Mol Biol, 2012, vol. 423, pp. 632-647. Full Text/Abstract

Lee C.W., Bae C., Lee J., Ryu J.H., Kim H.H., Kohno T., Swartz K.J., Kim J.I.
Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated calcium channels, Biochemistry, 2012, vol. 51, pp. 1862-73. Full Text/Abstract

2011

Kalia, J. and Swartz K.J.
Elucidating the molecular basis of action of a classical drug: Guanidine compounds as inhibitors of voltage-gated potassium channels, Mol Pharmacol, 2011, vol. 80, pp. 1085-95. Full Text/Abstract

Lee C.W., Eu Y.J., Min H.J., Cho E.M., Lee J.H., Kim H.H., Nah S.Y., Swartz K.J., Kim J.I.
Expression and characterization of recombinant kurtoxin, an inhibitor of T-type voltage-gated calcium channels, Biochem Biophys Res Commun, 2011, vol. 416, pp. 277-82. Full Text/Abstract

Bosmans, F., Milescu, M. and Swartz, K.J.
Palmitoylation influences the function and pharmacology of sodium channels, Proc Nat'l Acad Sci, 2011, vol. 108, pp. 20213-18. Full Text/Abstract

Kawate, T., Robertson, J.L., Li, M., Silberberg, S.D. and Swartz, K.J.
Ion access pathway to the transmembrane pore in P2X receptor channels, J Gen Physiol, 2011, vol. 137, pp. 579-90. Full Text/Abstract

Bosmans, F., Puopolo, M., Martin-Eauclaire, M.F., Bean, B.P. and Swartz, K.J.
Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors, J Gen Physiol, 2011, vol. 138, pp. 59-72. Full Text/Abstract

2010

Jung, HH, Jung, HJ, Milescu, M, Lee, CW, Lee, S, Lee, JY, Eu, YJ, Kim, HH, Swartz, KJ and Kim, JI
Structure and orientation of a voltage-sensor toxin in lipid membranes, Biophysical J, 2010, vol. 99, pp. 638-46. Full Text/Abstract

Phillips, L.R. and Swartz, K.J.
Position and motions of the S4 helix during opening of the Shaker potassium channel, J Gen Physiol, 2010, vol. 136, pp. 629-44. Full Text/Abstract

Li, M., Kawate, T., Silberberg, S. and Swartz, K.J.
Pore-opening mechanism in trimeric P2X receptor channels, Nature Communications, 2010, vol. 1, pp. 44. Full Text/Abstract

Lee, S, Milescu, M, Jung, HH, Lee, JY, Bae, CH, Lee, CW, Kim, HH, Swartz, KJ and Kim, JI
Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage senors in Kv2.1 potassium channels, Biochemistry, 2010, vol. 49, pp. 5134-42. Full Text/Abstract

Bosmans, F. and Swartz, K.J.
Targeting voltage sensors in sodium channels with spider toxins, Trends in Pharmacol. Sci., 2010, vol. 31, pp. 175-182. Full Text/Abstract

2009

Krepkiy, D., Mihailescu, M., Freites, J.A., Schow, E., Worcester, D.L., Gawrisch, K., Tobias, D., White, S.H., and Swartz, K.J.
Structure and hydration of membranes embedded with voltage-sensing domains, Nature, 2009, vol. 462, pp. 473-479. Full Text/Abstract

Milescu, M., Bosmans, F., Lee, S., Alabi, A.A., Kim, J.I. and Swartz, K.J.
Interaction between lipids and voltage sensor paddles detected with tarantula toxins, Nature Structural and Molecular Biology, 2009, vol. 16, pp. 1080-1085. Full Text/Abstract

Silberberg, S.D. and Swartz, K.J.
Structural Biology - Trimeric ion channel design (News and Views), Nature, 2009, vol. 460, pp. 580-581. Full Text/Abstract

2008

Bosmans, F., Martin-Eauclaire, M.F. and Swartz, K.J.
Deconstructing voltage sensor function and pharmacology in sodium channels, Nature, 2008, vol. 456, pp. 202-208. Full Text/Abstract

Li, M., Chang, T-H., Silberberg, S.D. and Swartz, K.J.
Gating the pore of P2X receptor channels., Nature Neuroscience, 2008, vol. 11, pp. 883-887. Full Text/Abstract

Swartz, K.J.
Sensing voltage across lipid membranes, Nature, 2008, vol. 456, pp. 891-897. Full Text/Abstract

2007

Silberberg, S.D, Li, M. and Swartz, K.J.
Ivermectin interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channels, Neuron, 2007, vol. 54, pp. 263-274. Full Text/Abstract

Alabi, A.A., Bahamonde, M.I., Jung, H.J., Kim, J.I., and Swartz, K.J.
Portability of paddle motif function and pharmacology in voltage sensors, Nature, 2007, vol. 450, pp. 370-375. Full Text/Abstract

Milescu, M., Vobecky, J., Roh, S.H., Kim, S.H., Jung, H.J., Kim, J.I. and Swartz, K.J.
Tarantula toxins interact with voltage sensors within lipid membranes, J Gen Physiol, 2007, vol. 130, pp. 497-511. Full Text/Abstract

Swartz KJ
Tarantula toxins interacting with voltage sensors in potassium channels, Toxicon, 2007, vol. 49, pp. 213-230. Full Text/Abstract

2006

Soler-Llavina, G., Chang, T. and Swartz, K.J.
Functional interactions at the interface between voltage sensing and pore domains in the Shaker Kv channel, Neuron, 2006, vol. 52, pp. 623-634. Full Text/Abstract

Swartz, KJ
Greasing the gears of potassium channels (News and Views), Nature | Chemical Biology, 2006, vol. 2, pp. 401-2. Full Text/Abstract

2005

Kitaguchi, T. and Swartz, K.J.
An inhibitor of TRPV1 channels isolated from funnel web spider venom, Biochemistry, 2005, vol. 44, pp. 15544-15549. Full Text/Abstract

Phillips, L.R., Milescu, M., Li-Smerin, Y., Mindell, J., Kim, J.I. and Swartz, K.J.
Voltage-sensor activation with a tarantula toxin as cargo, Nature, 2005, vol. 436, pp. 857-860. Full Text/Abstract

Swartz, K.J.
Structure and anticipatory movements of the S6 Gate in Kv channels (Commentary), J. General Physiology, 2005, vol. 126, pp. 413-417. Full Text/Abstract

Silberberg, S.D., Chang, T.H. and Swartz, K.J.
Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels, J. General Physiology, 2005, vol. 125, pp. 347-359. Full Text/Abstract

Jung, H.J., Lee, J.Y., Kim, S.H., Eu, Y.-J., Shin, S.Y., Milescu, M., Swartz, K.J. and Kim, J.I.
Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the KvAP potassium channel, Biochemistry, 2005, vol. 44, pp. 6015-6023. Full Text/Abstract

2004

Lee, C.W., Kim, S., Roh, S.H., Endoh, H., Kodera, Y., Maeda, T., Kohno, T., Wang, J.M., Swartz, K.J. and Kim, J.I.
Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating, Biochemistry, 2004, vol. 43, pp. 890-897. Full Text/Abstract

Kitaguchi, T., Sukhareva, M. and Swartz, K.J.
Stabilizing the closed gate in the Shaker Kv channel through modification of a hydrophobic seal, J. General Physiology, 2004, vol. 124, pp. 319-332. Full Text/Abstract

Wang, J.M., Roh, S.H., Kim, S., Lee, C.W., Kim, J.I. and Swartz, K.J.
Molecular surface of tarantula toxins interacting with voltage-sensors in Kv channels, J. General Physiology, 2004, vol. 123, pp. 455-467. Full Text/Abstract

Swartz, KJ
Towards a structural view of gating in potassium channels, Nature Reviews | Neuroscience, 2004, vol. 5, pp. 905-916. Full Text/Abstract

Swartz, KJ
Opening the gate in potassium channels (News and Views), Nature Structural and Molecular Biology, 2004, vol. 11, pp. 499-501. Full Text/Abstract

2003

Lee, H.C., Wang, L.M. and Swartz, K.J.
Interaction between extracellular Hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels, Neuron, 2003, vol. 40, pp. 527-536. Full Text/Abstract

Soler-Llavina, G., Holmgren, M. and Swartz, K.J.
Defining the conductance of the closed state in a voltage-gated potassium channel, Neuron, 2003, vol. 38, pp. 61-67. Full Text/Abstract

Sukhareva, M., Hackos, D. and Swartz, K.J.
Constitutive activation of the Shaker Kv channel, J. General Physiology, 2003, vol. 122, pp. 541-556. Full Text/Abstract

2002

Hackos, D.H, Chang, T.H. and Swartz, K.J.
Scanning the intracellular S6 activation gate in the Shaker potassium channel, J. General Physiology, 2002, vol. 119, pp. 521-531. Full Text/Abstract

Takeuchi, K., Park, E., Lee, C., Kim, J., Takahashi, H., Swartz, K. & Shimada, I.
Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type calcium channel., J. Molecular Biology, 2002, vol. 321, pp. 517-526.

2001

Li-Smerin, Y. and Swartz, K.J.
Helical structure of the COOH-terminus of S3 and its contribution to the gating modifier toxin receptor in voltage-gated ion channels, J. General Physiology, 2001, vol. 117, pp. 205-217. Full Text/Abstract

2000

Winterfield, J.R. and Swartz, K.J.
A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels, J. General Physiology, 2000, vol. 116, pp. 637-644. Full Text/Abstract

Li-Smerin, Y., Hackos, D.H. and Swartz, K.J.
alpha-Helical structural elements within the voltage-sensing domains of a potassium channel, J. General Physiology, 2000, vol. 115, pp. 33-49. Full Text/Abstract

Li-Smerin, Y., Hackos, D.H. and Swartz, K.J.
A localized interaction surface for voltage-sensing domains on the pore domain of a potassium channel, Neuron, 2000, vol. 25, pp. 411-423. Full Text/Abstract

Takahashi, H., Kim, J.I., Min, H.J., Sato, K., Swartz, K.J. and Shimada, I.
Solution structure of hanatoxin1, a gating modifier of voltage-dependent potassium channels: common surface features of gating modifier toxins, J. Molecular Biology, 2000, vol. 297, pp. 771-780. Full Text/Abstract

Li-Smerin, Y. and Swartz, K.J.
Localization and molecular determinants of the hanatoxin receptors on the voltage-sensing domain of a potassium channel, J. General Physiology, 2000, vol. 115, pp. 673-684. Full Text/Abstract

1998

Chuang, R. S-I., Jaffe, H., Cribbs, L., Perez-Reyes, E., and K.J. Swartz
Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin, Nature Neuroscience, 1998, vol. 1, pp. 668-674. Full Text/Abstract

Li-Smerin, Y. and Swartz, K.J.
Gating modifier toxins reveal a conserved structural motif in voltage-gated calcium and potassium channels, Proc. Natl. Acad. Sci. (USA), 1998, vol. 95, pp. 8585-8589. Full Text/Abstract

1997

Swartz, K.J. and MacKinnon, R.
Hanatoxin modifies the gating of a voltage-gated potassium channel through multiple binding sites., Neuron, 1997, vol. 18, pp. 665-673. Full Text/Abstract

Swartz, K.J. and MacKinnon, R.
Mapping the receptor site for Hanatoxin, a gating modifier of voltage-dependent potassium channels, Neuron, 1997, vol. 18, pp. 675-682. Full Text/Abstract

1996

McDonough, S.I., Swartz, K.J., Mintz, I.M., Boland, L.M. and Bean, B.P.
Inhibition of calcium channels in rat central and peripheral neurons by w-conotoxin-MVIIC, J. Neuroscience, 1996, vol. 16, pp. 2612-2623. Full Text/Abstract

1995

Swartz, K.J. and MacKinnon, R.
An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula, Neuron, 1995, vol. 15, pp. 941-949. Full Text/Abstract

1993

Swartz, K.J.
Modulation of calcium channels by protein kinase C in rat central and peripheral neurons: disruption of G protein-mediated inhibition, Neuron, 1993, vol. 11, pp. 305-320. Full Text/Abstract

Swartz, K.J., Merritt, A., Bean, B.P. and Lovinger, D.M.
Protein kinase C modulates glutamate receptor inhibition of calcium channels and synaptic transmission, Nature, 1993, vol. 361, pp. 165-168.

1992

Swartz, K.J. and Bean, B.P.
Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor, J. Neuroscience, 1992, vol. 12, pp. 4358-4371. Full Text/Abstract

Swartz, K.J., Koroshetz, W.J., Rees, A.H. and Huettner, J.E.
Competitive antagonism of glutamate receptor channels by substituted benzazepines in cultured cortical neurons, Molecular Pharmacology, 1992, vol. 41, pp. 1130-1141.

1990

Swartz, K.J., During, M.J., Freese, A. and Beal, M.F
Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors, J. Neuroscience, 1990, vol. 10, pp. 2965-2973.

Swartz, K.J., Matson, W.R., MacGarvey, U.M., Ryan, E.A. and Beal, M.F.
Measurement of kynurenic acid in mammalian brain extracts and cerebralspinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode array detection, Analytical Biochemistry, 1990, vol. 185, pp. 363-376.

Barres, B.A., Koroshetz, W.J., Swartz, K.J., Chun, L.L.Y. and Corey, D.P.
Ion channel expression by white matter glia: the O-2A glial progenitor cell, Neuron, 1990, vol. 4, pp. 507-524.

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