Neurosurgical Biology and Therapeutics Unit - Division of Intramural Research

 Russell R.  Lonser  M.D., Investigator

Dr. Lonser received his M.D. from Loma Linda University Medical School in 1994 and completed his Neurological Surgery residency training at the University of Utah in 2001. During his residency training, he spent over 2 years performing research in the Surgical Neurology Branch (1995 to 1998). He returned to the Surgical Neurology Branch in 2001 as a Staff Clinician. He was awarded the Tumor Young Investigator Award in 2002 from the American Association of Neurological Surgeons and Congress of Neurological Surgeons. He is Chair of the Surgical Neurology Branch in NINDS. His laboratory studies drug delivery for treatment of neurologic disorders, as well as investigates tumor biology and treatment.

Laboratory Staff

Ashok  Asthagiri, M.D., Staff Clinician , 301-594- 8113
Barbara  Ikejiri, B.S., Research Assistant , 301-402- 4244
Jie  Lu, M.D., Ph.D., Research Fellow , 301-402- 4244
Stuart  Walbridge, B.S., Biologist , 301-496- 1155
Ping  Zhuang, M.D., Head, Molecular Pathology Unit , 301-435- 8445

Research Interests

Clinical Protocols

A Prospective Natural History Study of VHL Patients with CNS Hemangioblastomas   00-N-0140

Evaluation of the Mechanism of NO Formation and Pharmacokinetics of Long-term Intravenous Nitrite Infusion in Healthy Volunteers   05-N-0075

Evaluation and Treatment of Neurosurgical Disorders   03-N-0164

Assessment of cerebral circulation and perfusion in adults after neonatal carotid occlusion   08-N-0095

A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2)  08-N-0044

Selected Recent Publications

Park DM, Zhuang Z, Chen L, Maric I, Sohn T, Kim SH, Lubensky IA, Rodgers GP, Oldfield EH, Lonser RR
VHL-associated hemangioblastomas derive from embryologic multipotent cells - PLoS Medicine   4 333-341 2007

Butman JA, Kim HJ, Baggenstos M, Ammerman JM, Patsalides A, Patronas NJ, Oldfield EH, Lonser RR
Mechanisms of morbid hearing loss associated with tumors of the endolymphatic sac in von Hippel-Lindau disease - JAMA   298 41-48 2007

Lonser RR, Schiffmann R, Robison RA, Butman JA, Quezado Z, Walker ML, Morrison PF, Walbridge S, Murray G, Park DM, Brady RO, Oldfield EH
Image-guided direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease - Neurology   68 254-261 2007

Murad GJA, Walbridge S, Degen JW, Morrison PF, Brechbiel M, Garmestani K, Oldfield EH, Lonser RR
Real-time, image-guided, convection-enhanced delivery of interleukin 13 bound to Pseudomonas exotoxin - Clin Cancer Res   12 3145-3151 2006

Weil RJ, Lonser
Selective excision of metastatic brain tumors originating in the motor cortex with preservation of function - J Clin Oncol   23 1209-1217 2005

Lonser RR, Vortmeyer AO, Butman JA, Glasker S, Finn MA, Ammerman JM, Merrill MJ, Edwards NA, Zhuang Z, Oldfield EH
Edema is a precursor to central nervous system peritumoral cyst formation - Ann Neurol   58 392-399 2005

Selected Earlier Publications

Contact Information

National Institute of Neurological Disorders and Stroke National Institutes of Health  10 Center Drive  Building 10, Room 5D37 Bethesda MD  20892-1414

Telephone: 301-496- 5728 (office), 301- 496-5728 (laboratory), 301-402- 0380 (fax), Email: lonserr@ninds.nih.gov