Neurosurgical Biology and Therapeutics Section - Division of Intramural Research

Russell R. Lonser, M.D., Senior Investigator

Dr. Lonser received his M.D. from Loma Linda University Medical School and completed his Neurological Surgery residency training at the University of Utah. During his residency training, he spent over 2 years performing research in the Surgical Neurology Branch (1995 to 1998). He returned to the Surgical Neurology Branch in 2001 as a Staff Clinician. He was awarded the Tumor Young Investigator Award in 2002 from the American Association of Neurological Surgeons and Congress of Neurological Surgeons. He is Chief of the Surgical Neurology Branch in NINDS and Program Director for the NINDS Neurological Surgery Residency Training Program. His laboratory studies drug delivery for treatment of neurologic disorders and investigates tumor biology and treatment.

Laboratory Staff

Ashok Asthagiri, M.D., Assistant Clinical Investigator
Barbara Ikejiri, B.S., Research Assistant
Jie Lu, M.D., Ph.D., Research Fellow
Stuart Walbridge, B.S., Biologist
Ping Zhuang, M.D., Head, Molecular Pathology Unit

Clinical Protocols

A Prospective Natural History Study of VHL Patients with CNS Hemangioblastomas 00-N-0140
Evaluation of the Mechanism of NO Formation and Pharmacokinetics of Long-term Intravenous Nitrite Infusion in Healthy Volunteers 05-N-0075
Evaluation and Treatment of Neurosurgical Disorders 03-N-0164
Assessment of cerebral circulation and perfusion in adults after neonatal carotid occlusion 08-N-0095
A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2) 08-N-0044

Selected Recent Publications

Park DM, Zhuang Z, Chen L, Maric I, Sohn T, Kim SH, Lubensky IA, Rodgers GP, Oldfield EH, Lonser RR
VHL-associated hemangioblastomas derive from embryologic multipotent cells, PLoS Medicine, 2007, vol. 4, pp. 333-341.
Butman JA, Kim HJ, Baggenstos M, Ammerman JM, Patsalides A, Patronas NJ, Oldfield EH, Lonser RR
Mechanisms of morbid hearing loss associated with tumors of the endolymphatic sac in von Hippel-Lindau disease, JAMA, 2007, vol. 298, pp. 41-48.
Lonser RR, Schiffmann R, Robison RA, Butman JA, Quezado Z, Walker ML, Morrison PF, Walbridge S, Murray G, Park DM, Brady RO, Oldfield EH
Image-guided direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease, Neurology, 2007, vol. 68, pp. 254-261.
Murad GJA, Walbridge S, Degen JW, Morrison PF, Brechbiel M, Garmestani K, Oldfield EH, Lonser RR
Real-time, image-guided, convection-enhanced delivery of interleukin 13 bound to Pseudomonas exotoxin, Clin Cancer Res, 2006, vol. 12, pp. 3145-3151.
Lonser RR, Walbridge S, Murray GJ, Aizenberg MR, Vortmeyer AO, Aerts JMFG, Brady RO, Oldfield EH
Convection perfusion of glucocerebrosidase for neuronopathic Gaucher's disease, Ann Neurol, 2005, vol. 57, pp. 542-548.
Lonser RR, Vortmeyer AO, Butman JA, Glasker S, Finn MA, Ammerman JM, Merrill MJ, Edwards NA, Zhuang Z, Oldfield EH
Edema is a precursor to central nervous system peritumoral cyst formation, Ann Neurol, 2005, vol. 58, pp. 392-399.
Weil RJ, Lonser
Selective excision of metastatic brain tumors originating in the motor cortex with preservation of function, J Clin Oncol, 2005, vol. 23, pp. 1209-1217.
Lonser RR, Kim HJ, Butman JA, Vortmeyer AO, Choo DI, Oldfield EH
Tumors of the endolymphatic sac in von Hippel-Lindau disease, N Engl J Med, 2004, vol. 350, pp. 2481-2486.

Selected Earlier Publications

Contact Information

National Institute of Neurological Disorders and Stroke
National Institutes of Health
10 Center Drive
Building 10, Room 3D20
Bethesda, MD 20892-1414

Telephone: 301-496-5728 (office), 301-496-5728 (laboratory), 301-402-0380 (fax)
Email: lonserr@ninds.nih.gov