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Laboratory of Molecular Medicine and Neuroscience - Division of Intramural Research


Major, EO, Nath A.
Neurological infections: risks of globalisation and new drugs, Lancet Neurol, 2012, vol. 11 (1), pp. 14-5.

Monaco MC, Major EO
The link between VLA-4 and JC virus reactivation Expert Rev, Clin Immunol, 2012, vol. 8 (1), pp. 63-72.


Marshall LJ, Moore, LD, Mirsky MM, Major EO
JC virus promoter/enhancers contain TATA box associated with Spi-B binding sites that support early viral gene expression in primary astrocytes, J Gen Virol, 2011

W, Henderson LJ, Major EO, Al-Harthi L
IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathoway (DKK1) in a STAT 3-dependent manner, J Immunol, 2011, vol. 186 (12), pp. 6771-8.


Jiang, Z.G., Cohen, J., Marshall, L.J., and Major, E.O
Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures, Antimicrob Agents Chemother, 2010, vol. 54, pp. 4723-32.

Major, E.O
Progressive multifocal Leukoencephalopathy in patients on immunomodulatory therapies, Annual Review of Medicine, 2010, vol. 61, pp. 34-47.

Marshall, L J. , Dunham, L.D., Major, E.O
The transcription factor Spi-B binds unique sequence present in the tandem repeat promoter/enhancer of JC virus and support viral activity, J Gen Virol, 2010, vol. 91, pp. 3042-3052.

Ryschewitsch, C.F., Jensen, P.N., Monaco, M.C., Major, E.O
JC virus persistence following progressive multifocal Leukoencephalopathy in multiple sclerosis patients treated with Natalizumab, Annals of Neurology, 2010, vol. 68, pp. 384-391.

Gosert, R., Kardas, P., Major, E.O., Hirsch, H.H
Rearranged JC Virus Noncoding Control Regions Found in Progressive Multifocal Leukoencephalopathy Patient Samples Increase Virus Early Gene Expression and Replication Rate, J. of Virology, 2010, vol. 84, pp. 10448-10456.


Major, E.O
Reemergence of PML in Natalizumab-Treated Paients- New Cases, Same Concerns, N Eng J Med, 2009, vol. 361, pp. 1041-1043.


Messam CA, Hou J, Gronostajski RM, Major EO.
Lineage pathway of human brain progenitor cells identified by JC virus susceptability, Annals of Neurology, 2003 Full Text/Abstract


Monaco MC, Sabath BF, Durham LC, Major EO.
JC virus multiplication in human hematopoietic progenitor cells requires the NF-1 class D transcription, Journal of Virology, 2001, vol. 75(20), pp. 9687-95. Full Text/Abstract

Major E.O.
Human Polyomaviruses, Fields Virology, 2001, vol. Fourth Edition, pp. 2141.


Messam, C. A., J. Hou, and E. O. Major.
Coexpression of nestin in neural and glial cells in the developing human CNS defined by a human-specific anti-nestin antibody., Exp Neurol, 2000, vol. 161, pp. 585-596. Full Text/Abstract

Hamilton R.S., Gravell M, and Major E.O.
Comparison of antibody titers determined by hemagglutination inhibition and enzyme immunoassay for JC Virus and BK Virus, Journal of Clinical Microbiology, 2000, vol. 38(1), pp. 105-109. Full Text/Abstract


Yiannoutsas, C., E. O. Major, B. L. Curfman, P. Jensen, M. Gravell, J. Hou, D. Clifford, C. Hall, and the ACTG 243 Team.
Relation of JC Virus DNA in the CSF to survival in AIDS patients with biopsy proven Progressive Multifocal Leukoencephalopathy., Ann Neurol, 1999, vol. 45, pp. 816-821.

Jensen P.N. and Major E.O.
Viral variant nucleotide sequences help expose leukocytic positioning in the JC Virus pathway to the CNS, Journal of Leukocyte Biology, 1999, vol. 65, pp. 428-438. Full Text/Abstract


Major E.O., and Neel J.V.
The JC and BK human polyomaviruses appear to be recent introductions to some South American Indian tribes: there is no serological evidence of cross-reactivity with the polyomavirus SV40., PNAS, 1998, vol. 95, pp. 15525-15530. Full Text/Abstract

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