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Axon Guidance and Neural Connectivity Unit - Division of Intramural Research


Kuzina, I., Song, J.K. and Giniger, E.
How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS, Development, 2011, vol. 138, pp. 1839-49.

Trunova, S., Baek, B. and Giniger, E.
Cdk5 regulates the size of an AIS-like compartment in mushroom body neurons of the Drosophila central brain, J. Neurosci, 2011, vol. 31, pp. 10451-62.


Song, J.K., Kannan, R., Merdes, G., Singh, J., Mlodzik, M. and Giniger, E.
Disabled is a bona fide component of the Abl signaling network, Development, 2010, vol. 137, pp. 3719-3727.


Le Gall, M., DeMattei, C. and Giniger, E.
Molecular separation of two signaling pathways for the receptor, Notch, Dev. Biol, 2008, vol. 313, pp. 556-567.


Connell-Crowley, L., Vo, D., Luke, L. and Giniger, E.
Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan, Mech of Dev, 2007, vol. 124, pp. 341-9.


Le Gall, M. and Giniger, E.
Identification of two binding regions for the Suppressor of Hairless protein within the intracellular domain of Drosophila Notch, J. Biol. Chem, 2004, vol. 279, pp. 29418-29426.


Horiuchi, T. Giniger, E. and Aigaki, T.
Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola, Genes Dev, 2003, vol. 17, pp. 2496-2501.

Goeke, S., Greene, E.A., Gates, M.A., Grant, P.K., Crowner, D., Aigaki, T. and Giniger, E.
Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila, Nature Neuroscience, 2003, vol. 6, pp. 917-924.

Crowner, D., Le Gall, M., Gates, M.A., and Giniger, E.
Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway, Curr Biol, 2003, vol. 13, pp. 967-972.


Crowner, D., Madden, K., Goeke, S. and Giniger, E.
Lola regulates midline crossing of CNS axons in Drosophila, Development, 2002, vol. 129, pp. 1317-1325.

Giniger, E.
How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics, Differentiation, 2002, vol. 70, pp. 385-396.


Hiramoto, M., Hiromi, Y., Giniger, E. and Hotta, Y.
A Drosophila Netrin receptor, Frazzled, guides axons by controlling the distribution of Netrin, Nature, 2000, vol. 406, pp. 886-889.

Bothwell, M. and Giniger, E.
Alzheimer's Disease: Neurodevelopment Converges with Neurodegeneration, Cell, 2000, vol. 102, pp. 271-273.

Connell-Crowley, L., Le Gall, M., Vo, D. and Giniger, E.
Cdk5 controls multiple aspects of axon patterning in vivo., Curr Biol, 2000, vol. 10, pp. 599-602.


Madden, K., Crowner, D. and Giniger, E.
lola has the properties of a master regulator of axon-target interactions for SNb motor axons of Drosophila, Dev. Biol, 1999, vol. 301-313, pp. 213.

Ostrander, E. A. and Giniger, E.
Let sleeping dogs lie?, Nature Genetics, 1999, vol. 23, pp. 3-4.


Fuerstenberg, S. M. and Giniger, E.
Multiple roles for Notch in Drosophila myogenesis, Dev. Biol, 1998, vol. 201, pp. 66-77.


Ostrander, E. A. and Giniger, E.
What man's best friend can teach us about human biology and disease, Am. J. Hum. Genet, 1997, vol. 61, pp. 475-80.


Larkin, M. K., Holder, K., Yost, C., Giniger, E. and Ruohola-Baker, H.
Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte, Development, 1996, vol. 3639-3650, pp. 122.


Giniger, E., Tietje, K., Jan, L. Y. and Jan, Y. N.
lola encodes a putative transcription factor required for axon growth and guidance in Drosophila, Development, 1994, vol. 120, pp. 1385-98.

Clark, I., Giniger, E., Ruohola-Baker, H., Jan, L. Y. and Jan, Y. N.
Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte, Curr. Biol, 1994, vol. 4, pp. 289-300.


Giniger, E., Jan, L. Y. and Jan, Y. N.
Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch, Development, 1993, vol. 117, pp. 431-440.

Giniger, E., Wells, W., Jan, L. Y. and Jan, Y. N.
Tracing neurons with a kinesin-ƒÒ-galactosidase fusion protein., Roux's Arch Dev Biol, 1993, vol. 202, pp. 112-122.


Giniger, E.
A role for abl in Notch signaling, Neuron, 1988, vol. 20, pp. 667-681.

Giniger, E. and Ptashne, M.
Cooperative binding of the yeast transcriptional activator, GAL4, Proc Natl Acad Sci, USA, 1988, vol. 85, pp. 382-386.

Fischer, J. A., Giniger, E., Maniatis, T. and Ptashne, M.
GAL4 activates transcription in Drosophila., Nature, 1988, vol. 332, pp. 853-856.


Giniger, E. and Ptashne, M.
Transcription in yeast activated by a putative amphipathic Ą-helix linked to a DNA-binding unit, Nature, 1987, vol. 330, pp. 670-672.


Giniger, E., Varnum, S. M. and Ptashne, M.
Specific DNA binding of GAL4, a positive regulatory protein of yeast., Cell, 1985, vol. 40, pp. 767-774.


Wagner, P. D. and Giniger, E.
Calcium-sensitive binding of heavy meromyosin to regulated actin in the presence of ATP, J Biol Chem, 1981, vol. 256, pp. 12647-12650.

Wagner, P. D. and Giniger, E.
Hydrolysis of ATP and reversible binding to F-actin by myosin heavy chains free of all light chains, Nature, 1981, vol. 292, pp. 560-562.

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