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Cerebral Microcirculation Section - Division of Intramural Research


Lee J, Hirano Y, Fukunaga M, Silva AC, Duyn JH
On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field., Neuroimage, 2009, vol. July, pp. 17. Full Text/Abstract

Tucciarone J, Chuang KH, Dodd SJ, Silva A, Pelled G, Koretsky AP
Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI, Neuroimage, 2009, vol. 44(3), pp. 923-31. Full Text/Abstract

Chuang KH, Lee JH, Silva AC, Belluscio L, Koretsky AP
Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli, Neuroimage, 2009, vol. 44(2), pp. 363-72. Full Text/Abstract

Bock NA, Kocharyan A, Silva AC
Manganese-enhanced MRI visualizes V1 in the non-human primate visual cortex, NMR Biomed, 2009, vol. Mar, pp. 25. Full Text/Abstract

Silva AC, Paiva FF
Dynamic magnetic resonance imaging of cerebral blood flow using arterial spin labeling, Methods Mol Biol, 2009, vol. 489, pp. 277-95. Full Text/Abstract


Silva AC, Bock NA
Manganese-enhanced MRI: an exceptional tool in translational neuroimaging, Schizophr Bull, 2008, vol. 34(4), pp. 595-604. Full Text/Abstract

Bock NA, Paiva FF, Silva AC
Fractionated manganese-enhanced MRI, NMR Biomed, 2008, vol. 21(5), pp. 473-8. Full Text/Abstract

Paiva FF, Tannus A, Talagala SL, Silva AC
Arterial spin labeling of cerebral perfusion territories using a separate labeling coil, J Magn Reson Imaging, 2008, vol. 27(5), pp. 970-7. Full Text/Abstract

Stefanovic B, Hutchinson E, Yakovleva V, Schram V, Russell JT, Belluscio L, Koretsky AP, Silva AC
Functional reactivity of cerebral capillaries, J Cereb Blood Flow Metab, 2008, vol. 28(5), pp. 961-72. Full Text/Abstract

Goloshevsky AG, Silva AC, Dodd SJ, Koretsky AP
BOLD fMRI and somatosensory evoked potentials are well correlated over a broad range of frequency content of somatosensory stimulation of the rat forepaw, Brain Res, 2008, vol. 1195, pp. 67-76. Full Text/Abstract

Bock NA, Paiva FF, Nascimento GC, Newman JD, Silva AC
Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI, Brain Res, 2008, vol. 1198, pp. 160-70. Full Text/Abstract

Silva AC, Lee JH, Wu CW, Tucciarone J, Pelled G, Aoki I, Koretsky AP
Detection of cortical laminar architecture using manganese-enhanced MRI, J Neurosci Meth, 2008, vol. 167(2), pp. 246-57. Full Text/Abstract


Stefanovic B, Schwindt W, Hoehn M, Silva AC
Functional uncoupling of hemodynamic from neuronal response by inhibition of neuronal nitric oxide synthase, J Cereb Blood Flow Metab, 2007, vol. 27(4), pp. 741-54. Full Text/Abstract

Silva AC, Koretsky AP, Duyn JH
Functional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex, Magn Reson Med, 2007, vol. 57(6), pp. 1110-8. Full Text/Abstract

Paiva FF, Tannus A, Silva AC
Measurement of cerebral perfusion territories using arterial spin labelling, NMR Biomed, 2007, vol. 20(7), pp. 633-42. Full Text/Abstract

de Sousa PL, de Souza SL, Silva AC, de Souza RE, de Castro RM
Manganese-enhanced magnetic resonance imaging (MEMRI) of rat brain after systemic administration of MnCl2: changes in T1 relaxation times during postnatal development, J Magn Reson Imaging, 2007, vol. 25(1), pp. 32-8. Full Text/Abstract


Hutchinson EB, Stefanovic B, Koretsky AP, Silva AC
Spatial flow-volume dissociation of the cerebral microcirculatory response to mild hypercapnia, Neuroimage, 2006, vol. 32(2), pp. 520-30. Full Text/Abstract

Stefanovic B, Bosetti F, Silva AC
Modulatory role of cyclooxygenase-2 in cerebrovascular coupling, Neuroimage, 2006, vol. 32(1), pp. 23-32. Full Text/Abstract

Petridou N, Plenz D, Silva AC, Loew M, Bodurka J, Bandettini PA
Direct magnetic resonance detection of neuronal electrical activity, Proc Natl Acad Sci USA, 2006, vol. 103(43), pp. 16015-20. Full Text/Abstract

S. D. Keilholz, A. C. Silva, M. Raman, H. Merkle, A. P. Koretsky
BOLD and CBV-Weighted Functional Magnetic Resonance Imaging of the Rat Somatosensory System, Magnetic Resonance in Medicine, 2006, vol. 55(2), pp. 316–324. Full Text/Abstract

I. Aoki, Y. Takahashi, K.-H. Chuang, A. C. Silva, T. Igarashi, C. Tanaka, R. W. Childs, A. P. Koretsky
Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride, NMR in Biomedicine, 2006, vol. 19(1), pp. 50-59. Full Text/Abstract


J. H. Lee, A. C. Silva, H. Merkle, A. P. Koretsky
Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast, Magnetic Resonance in Medicine, 2005, vol. 53(3), pp. 640-648. Full Text/Abstract

J. A. de Zwart, A. C. Silva, P. van Gelderen, P. Kellman, M. Fukunaga, R. Chu, A. P. Koretsky, J. A. Frank, J. H. Duyn
Temporal dynamics of the BOLD fMRI impulse response, Neuroimage, 2005, vol. 24(3), pp. 667-677. Full Text/Abstract

Chen Z, Silva AC, Yang J, Shen J.
Elevated endogenous GABA level correlates with decreased fMRI signals in the rat brain during acute inhibition of GABA transaminase, J Neurosci Res., 2005, vol. 79(3), pp. 383-391. Full Text/Abstract

A. C. Silva
Perfusion-based fMRI: insights from animal models, Journal of Magnetic Resonance Imaging, 2005, vol. 22(6), pp. 745-750. Full Text/Abstract


Aoki I, Wu YJ, Silva AC, Lynch RM, Koretsky AP.
In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI., Neuroimage, 2004, vol. 22(3), pp. 1046-1059. Full Text/Abstract

A. C. Silva, J. H. Lee, I. Aoki, and A. P. Koretsky
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI): Methodological and Practical Considerations, NMR in Biomedicine, 2004, vol. 17(8), pp. 532-534. Full Text/Abstract

A. P. Koretsky and A. C. Silva
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI), NMR in Biomedicine, 2004, vol. 17(8), pp. 527-531. Full Text/Abstract

S. Keilholz, A. C. Silva, M. Raman, H. Merkle, and A. P. Koretsky
Functional MRI of the Rodent Somatosensory Pathway Using Multi-slice Echo Planar Imaging, Magn. Reson. Med, 2004, vol. 52(1), pp. 89-99. Full Text/Abstract


Hinds KA, Hill JM, Shapiro EM, Laukkanen MO, Silva AC, Combs CA, Varney TR, Balaban RS, Koretsky AP, Dunbar CE.
Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells., Blood, 2003, vol. 102(3), pp. 867-872. Full Text/Abstract

C. Grabill, A. C. Silva, S. S. Smith, A.P. Koretsky and T. A. Rouault
MRI detection of iron distribution and associated neuronal pathology in iron regulatory protein-2 knockout mice, Brain Res, 2003, vol. 971 (1), pp. 95-106. Full Text/Abstract


Lee SP, Silva AC, Kim SG.
Comparison of diffusion-weighted high-resolution CBF and spin-echo BOLD fMRI at 9.4 T., Magn Reson Med, 2002, vol. 47(4), pp. 736-741. Full Text/Abstract

A. C. Silva and A. P. Koretsky
Laminar specificity of fMRI onset times during somatosensory stimulation in rat, Proc. Natl. Acad. Sci., 2002, vol. 99 (23), pp. 15182-15187. Full Text/Abstract

Aoki I, Tanaka C, Takegami T, Ebisu T, Umeda M, Fukunaga M, Fukuda K, Silva AC, Koretsky AP, Naruse S.
Dynamic activity-induced manganese-dependent contrast magnetic resonance imaging (DAIM MRI)., Magn Reson Med., 2002, vol. 48(6), pp. 927-933. Full Text/Abstract


T. Duong, A. C. Silva, S.-P. Lee, and S.-G. Kim
Functional MRI of calcium-dependent synaptic activity: cross correlation with CBF and BOLD measurements, Magn. Reson. Med, 2000, vol. 43(3), pp. 383-392. Full Text/Abstract

A. C. Silva, S.-G. Kim and M. Garwood
Imaging Blood Flow in Brain Tumors Using Arterial Spin Labeling, Magn. Reson. Med, 2000, vol. 44(2), pp. 169-173. Full Text/Abstract

A. C. Silva, S.-P. Lee, C. Iadecola and S.-G. Kim
Early temporal characteristics of CBF and deoxyhemoglobin changes during somatosensory stimulation, J. Cereb. Blood Flow Metab, 2000, vol. 20(1), pp. 201-206. Full Text/Abstract


Barbier EL, Silva AC, Kim HJ, Williams DS, Koretsky AP.
Perfusion analysis using dynamic arterial spin labeling (DASL)., Magn Reson Med, 1999, vol. 41(2), pp. 299-308. Full Text/Abstract

E. L. Barbier, A. C. Silva, H. J. Kim, D. S. Williams and A. P. Koretsky
Perfusion analysis using dynamic arterial spin labeling (DASL), Magn. Reson. Med, 1999, vol. 41, pp. 299-308. Full Text/Abstract

Lee SP, Silva AC, Ugurbil K, Kim SG.
Diffusion-weighted spin-echo fMRI at 9.4 T: microvascular/tissue contribution to BOLD signal changes., Magn Reson Med., 1999, vol. 42(5), pp. 919-928. Full Text/Abstract

A. C. Silva, S.-P. Lee, G. Yang, C. Iadecola and S.-G. Kim
Simultaneous BOLD and CBF based functional MRI during forepaw stimulation in rat., J. Cereb. Blood Flow Metab, 1999, vol. 19(8), pp. 871-879. Full Text/Abstract

A. C. Silva and S.-G. Kim
Pseudo-continuous arterial spin labeling technique for measuring CBF dynamics with high temporal resolution, Magn. Reson. Med, 1999, vol. 43(2), pp. 425-429. Full Text/Abstract


A. C. Silva, E. L. Barbier, I. J. Lowe, and A. P. Koretsky
Radial Echo-Planar Imaging (rEPI), J. Magn. Reson. Med, 1998, vol. 135, pp. 242-247. Full Text/Abstract

R. G. Pautler, A. C. Silva and A. P. Koretsky
In vivo neuronal tract tracing using manganese enhanced magnetic resonance imaging, Magn. Reson. Med., 1998, vol. 40, pp. 740-748. Full Text/Abstract

Forman SD, Silva AC, Dedousis N, Barbier EL, Fernstrom JD, Koretsky AP.
Simultaneous glutamate and perfusion fMRI responses to regional brain stimulation., J Cereb Blood Flow Metab, 1998, vol. 18(10), pp. 1064-1070. Full Text/Abstract


Silva AC, Zhang W, Williams DS, Koretsky AP.
Estimation of water extraction fractions in rat brain using magnetic resonance measurement of perfusion with arterial spin labeling., Magn Reson Med, 1997, vol. 37(1), pp. 58-68. Full Text/Abstract

Silva AC, Williams DS, Koretsky AP.
Evidence for the exchange of arterial spin-labeled water with tissue water in rat brain from diffusion-sensitized, Magn Reson Med, 1997, vol. 38(2), pp. 232-237. Full Text/Abstract

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