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Synaptic Transmission Section - Division of Intramural Research



2012

Sheng J, He L, Zheng H, Xue L, Luo F, Shin W, Sun T, Kuner T, Yue DT, Wu LG.
Calcium-channel number critically influences synaptic strength and plasticity at the active zone., Nat Neurosci., 2012, vol. 15(7), pp. 998-1006. Full Text/Abstract

Xue L, McNeil BD, Wu XS, Luo F, He L, Wu LG.
A membrane pool retrieved via endocytosis overshoot at nerve terminals: a study of its retrieval mechanism and role., J Neurosci., 2012, vol. 32(10), pp. 3398-404. Full Text/Abstract

Xue L, Zhang Z, McNell B, Luo FJ, Wu XS, Sheng J, Shin W, Wu LG
Voltage-Dependent Calcium Channels at the Plasma Membrane, but Not Vesicular Channels, Couple Exocytosis to Endocytosis, Cell reports, 2012, vol. 1(6), pp. 632¨C638. Full Text/Abstract

2010

Yim YI, Sun T, Wu LG, Raimondi A, De Camilli P, Eisenberg E, Greene LE.
Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice., Proc Natl Acad Sci., 2010, vol. 107(9):, pp. 4412-7.. Full Text/Abstract

Xue L, Wu LG.
Post-tetanic potentiation is caused by two signalling mechanisms affecting quantal size and quantal content., Journal of Physiology, 2010, vol. 588(Pt 24):, pp. 4987-94.. Full Text/Abstract

Sun T, Wu XS, Xu J, McNeil BD, Pang ZP, Yang W, Bai L, Qadri S, Molkentin JD, Yue DT, Wu LG.
The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses., Journal of Neuroscience., 2010, vol. 30(35):, pp. 11838-47. Full Text/Abstract

2009

Paradiso K and Wu LG
Small voltage changes at nerve terminals travel up axons to affect action potential initiation, Nature Neuroscience, 2009, vol. 12, pp. 541 - 543. Full Text/Abstract

Wu XS, McNeil BD, Xu J, Fan J, Xue L, Melicoff E, Adachi R, Bai L, Wu LG
Ca(2+) and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal, Nat Neurosci., 2009, vol. 12(8), pp. 1003-10. Full Text/Abstract

McNeil BD, Wu LG
Location Matters: Synaptotagmin Helps Place Vesicles Near Calcium Channels, Neuron, 2009, vol. 63(4), pp. 419-421. Full Text/Abstract

He L, Xue L, Xu J, McNell B, Bai L, Melicoff E, Adachi R and Wu LG.
Compound vesicle fusion increases quantal size and potentiates synaptic transmission, Nature, 2009, vol. 459, pp. 93-98. Full Text/Abstract

Wu XS, Wu LG.
Rapid endocytosis does not recycle vesicles within the readily releasable pool., J Neurosci., 2009, vol. 29(35), pp. 11038-42. Full Text/Abstract

2008

Xu J, McNeil B, Wu W, Nees D, Bai L, Wu LG.
GTP-independent rapid and slow endocytosis at a central synapse, Nat Neurosci., 2008, vol. 11(1), pp. 45-53. Full Text/Abstract

2007

Wu LG, Ryan TA, Lagnado L.
Modes of vesicle retrieval at ribbon synapses, calyx-type synapses, and small central synapses, J Neurosci., 2007, vol. 27(44), pp. 11793-802. Full Text/Abstract

He L, Wu LG.
The debate on the kiss-and-run fusion at synapses., Trends in Neuroscience, 2007, vol. 30(9), pp. 447-55. Full Text/Abstract

Wu XS, Xue L, Mohan R, Paradiso K, Gillis KD, Wu LG.
The origin of quantal size variation: vesicular glutamate concentration plays a significant role., J Neurosci., 2007, vol. 27(11), pp. 3046-56. Full Text/Abstract

Xu J, He L, Wu LG.
Role of Ca(2+) channels in short-term synaptic plasticity., Curr Opin Neurobiol., 2007, vol. 17(3), pp. 352-9. Full Text/Abstract

Wu W, Wu LG.
Rapid bulk endocytosis and its kinetics of fission pore closure at a central synapse., Proc Natl Acad Sci U S A., 2007, vol. 104(24), pp. 10234-9. Full Text/Abstract

2006

He L, Wu XS, Mohan R, and Wu LG.
Two modes of fusion pore openings revealed by cell-attached recordings at a synapse, Nature, 2006, vol. 444, pp. 102-105. Full Text/Abstract

2005

Wu W, Xu J, Wu XS, Wu LG.
acceleration of endocytosis at a ceActivity-dependent ntral synapse., J Neurosci., 2005, vol. 25, pp. 11676-11683. Full Text/Abstract

Xu J and Wu LG
The decrease in the presynaptic calcium current is a major cause of short-term depression at a calyx-type synapse., Neuron, 2005, vol. 46, pp. 633-645. Full Text/Abstract

2004

Wu XS, Evers AS, Crowder M, Wu LG
Isoflurane inhibits transmitter release and the presynaptic action potential, Anesthesiology, 2004, vol. 100, pp. 663-700. Full Text/Abstract

Wu LG
Kinetic regulation of vesicle endocytosis at synapses, Trends Neurosci, 2004, vol. 27, pp. 548-554. Full Text/Abstract

Steinbach JH, Wu LG
Synaptic transmission at the neuromuscular junction. in Anesthetic Pharmacology: Physiologic Principles and Clinical Practice, Evers AS and Maze M. Harcourt Health Sciences, 2004, pp. 157-172.

Sun JY, Wu XS, Wu W, Jin SX, Dondzillo A, Wu LG
Capacitance measurements at the calyx of Held in the medial nucleus of the trapezoid body, J Neurosci Meth, 2004, vol. 134, pp. 121-131. Full Text/Abstract

2002

Sun JY, Wu XS, Wu LG
Single and multiple vesicle fusion induce different rates of endocytosis at a central synapse, Nature, 2002, vol. 417, pp. 555-559. Full Text/Abstract

2001

Wu X, Wu LG
Activation of protein kinase C enhances the release probability of the release machinery downstream of the binding between Ca2+ and its sensor, J Neurosci, 2001, vol. 21, pp. 7928-7936. Full Text/Abstract

Sun JY Wu LG
Fast kinetics of exocytosis revealed by simultaneous measurements of presynaptic capacitance and postsynaptic currents at a central synapse., Neuron, 2001, vol. 30, pp. 171-82. Full Text/Abstract

1999

Kay AR Alfonso A Alford S Cline HT Holgado AM Sakmann B Snitsarev VA Stricker TP Takahashi M Wu LG
Imaging synaptic activity in intact brain and slices with FM1-43 in C. elegans, lamprey, and rat., Neuron, 1999, vol. 24, pp. 809-17. Full Text/Abstract

Wu LG Borst JG
The reduced release probability of releasable vesicles during recovery from short-term synaptic depression., Neuron, 1999, vol. 23, pp. 821-832. Full Text/Abstract

Wu LG, Betz WJ
Spatial variability in release at the frog neuromuscular junction measured with FM1-43, Can J Physiol Pharmacol, 1999, vol. 77, pp. 672-678. Full Text/Abstract

Wu LG, Westenbroek RE, Borst JGG, Catterall WA, Sakmann B
Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses, J Neurosci, 1999, vol. 19, pp. 726-736. Full Text/Abstract

1998

Wu LG, Borst JGG, Sakmann B
R-type Ca2+ currents evoke transmitter release in a rat central synapse, Proc Natl Acad Sci USA, 1998, vol. 95, pp. 4720-4725. Full Text/Abstract

Wu LG, Betz WJ
Kinetics of synaptic depression and vesicle recycling after tetanic stimulation of frog motor nerve terminals, Biophys J, 1998, vol. 74, pp. 3003-3009. Full Text/Abstract

1997

Sinha SR, Wu LG, Saggau P
Presynaptic calcium dynamics and transmitter release evoked by single action potentials at mammalian central synapses, Biophys J, 1997, vol. 72, pp. 637-651. Full Text/Abstract

Wu LG, Saggau P
Presynaptic inhibition of elicited neurotransmitter release., Trends Neurosci, 1997, vol. 20, pp. 204-212. Full Text/Abstract

1996

Wu LG, Betz WJ
Nerve activity but not intracellular calcium determines the time course of endocytosis at the frog neuromuscular junction, Neuron, 1996, vol. 17, pp. 769-779. Full Text/Abstract

1995

Wu LG, Saggau P
Block of multiple presynaptic calcium channel types by w‑conotoxin ‑MVIIC at hippocampal CA3 to CA1 synapses, J Neurophysiol, 1995, vol. 73, pp. 1965-1972. Full Text/Abstract

Betz WJ, Wu LG
Kinetics of synaptic vesicle recycling, Curr Biol, 1995, vol. 5, pp. 1098-1101. Full Text/Abstract

Wu LG, Saggau P
GABAB receptor-mediated presynaptic inhibition in guinea pig hippocampus is caused by reduction of presynaptic Ca2+ influx, J Physiol (Lond), 1995, vol. 485, pp. 649-657. Full Text/Abstract

1994

Wu LG, Saggau P
Presynaptic calcium is increased during normal synaptic transmission and paired‑pulse facilitation, but not in long‑term potentiation in area CA1 of hippocampus, J Neurosci, 1994, vol. 14, pp. 645-654. Full Text/Abstract

Wu LG, Saggau P
Pharmacological identification of two types of presynaptic voltage‑ dependent calcium channels at CA3 to CA1 synapses of the hippocampus, J Neurosci, 1994, vol. 14, pp. 5613‑5622. Full Text/Abstract

Wu LG, Saggau P
Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus, Neuron, 1994, vol. 12, pp. 1139‑1148. Full Text/Abstract

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