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Neuronal Cytoskeletal Protein Regulation Section - Division of Intramural Research


Amin ND, Zheng YL, Kesavapany S, Kanungo J, Guszczynski T, Sihag RK, Rudrabhatla P, Albers W, Grant P, Pant HC.
Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis., J Neurosci., 2008, vol. 28(14), pp. 3631-43.


Kesavapany S, Patel V, Zheng YL, Pareek TK, Bjelogrlic M, Albers W, Amin N, Jaffe H, Gutkind JS, Strong MJ, Grant P, Pant HC.
Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons., Mol Biol Cell, 2007, vol. 18(9), pp. 3645-55.

Kino T, Ichijo T, Amin ND, Kesavapany S, Wang Y, Kim N, Rao S, Player A, Zheng YL, Garabedian MJ, Kawasaki E, Pant HC, Chrousos
Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress., Mol Endocrinol., 2007, vol. 21(7), pp. 1552-68.

Pareek TK, Keller J, Kesavapany S, Agarwal N, Kuner R, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB.
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1., Proc Natl Acad Sci U S A, 2007, vol. 104(2), pp. 660-5.

Sihag RK, Inagaki M, Yamaguchi T, Shea TB, Pant HC.
Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments., Exp Cell Res., 2007, vol. 313(10), pp. 2098-109.

Zheng YL, Li BS, Kanungo J, Kesavapany S, Amin N, Grant P, Pant HC.
Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival., Mol Biol Cell., 2007, vol. 18(2), pp. 404-13.

Kesavapany S, Pareek TK, Zheng YL, Amin N, Gutkind JS, Ma W, Kulkarni AB, Grant P, Pant HC.
Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1., Neurosignals, 2007, vol. 15(4), pp. 157-73.

Kanungo J, Li BS, Goswami M, Zheng YL, Ramchandran R, Pant HC.
Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5., Neurosci Lett., 2007, vol. 412(3), pp. 233-8.

Kesavapany S, Zheng YL, Amin N, Pant HC.
Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5., Biotechnol J., 2007, vol. 2(8), pp. 978-87.


Kanungo J, Li BS, Zheng Y, Pant HC.
Cyclin-dependent kinase 5 influences Rohon-Beard neuron survival in zebrafish., J Neurochem., 2006, vol. 99(1), pp. 251-9.


Zheng YL, Kesavapany S, Gravell M, Hamilton RS, Schubert M, Amin N, Albers A, Grant P and Pant HC.
A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons., The EMBO J., 2005, vol. 24(1), pp. 209-220.


Sharma, P., Veeranna, Sharma, M., Amin, N.D., Sihaf, R.K., Grant, P., Ahn, N., Kulkarni, A.B.and pant, H.C.
Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway, J. Biol. Chem., 2002


Li, B.S.,Wu, Ma, Zhang, Lei, Stenger David A. and Pant, H. C.
Activation of phosphatidylinositol 3-kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in progenitor cells., J. Neuroscience, 2001, vol. 21, pp. 1569-1579.

Tanaka, T., Veeranna, Sreenath, T., Pant, H.C., Brady, R> O., Kulkarni, A.B.
Neuronal cdk5 activity is crucial for survival., J. Neuroscience, 2001, vol. 21,, pp. 550-558..

Li, B.S., Sun,M.K.,Zhang,L., Takahashi, S., Ma. Wu, Vinade, L. Kulkarni, A.B., Brady, R.O. and Pant, H. C.
Regulation of NMDA receptors by cyclin- dependent kinase-5. Proc. Natl.Acad. Sci.USA, 98,12742-12747, 2001.Regulation of NMDA receptors by cyclin-dependent kinase 5(cdk5), Proc. Natl. Acad. Sci. USA, 2001, vol. 98, pp. 12742-12747.


Li, B.S., Zhang, L., GU, J., Amin, N.D and Pant, H.C.
Integrin a1b1-mediated activation of cyclin-dependent kinase5 (cd (cdk5 activation of cyclin-dependent kinase 5 activity is involved in neurite out growth and human neurofilament protein H lys-ser-pro tail domain phosphorylation, J. Neuroscience, 2000, vol. 20, pp. 6055-6062.


Sharma, P., Steinbach, P.J., Sharma, M., Amin, N.D., Barchi, J.J.and Pant, H.C.
Identification of substrate binding site of cyclin dependent kinase-5, J. Biol.Chem., 1999, vol. 274, pp. 9600-9606.

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