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Molecular Neuroscience Section - Division of Intramural Research


Lubelski, DL, Ponzio TA, and Gainer. H.
Effects of A-CREB, a dominant negative inhibitor of CREB, on the expression of c-fos and other immediate early genes in the rat SON during hyperosmotic stimulation in vivo, Brain Res., 2012, vol. 1429, pp. 18-28.

Fields, RL, Ponzio, TA, Kawasaki, M, and Gainer, H.
Cell-type specific oxytocin gene expression from adeno-associated virus delivered promoter deletion constructs into the rat supraoptic nucleus in vivo, PLoS ONE, 2012, vol. 7, pp. e32085.

Gainer, H.
Cell-type specific expression of oxytocin and vasopressin genes: An experimental odyssey, J. Neuroendocrinology, 2012, vol. 24, pp. 528-538.


Chen, X., Nelson, C., Li, X.,Winters, CA, Azzam, R., Sousa, A., Leapman, R., Gainer, H., Sheng, M., and , Reese, T.
PSD-95 is required to sustain the molecular organization of the postsynaptic density, J. Neuroscience, 2011, vol. 31, pp. 6329-6338.

Gainer, H., Ponzio, T.A., Yue, C., and Makoto Kawasaki, M.
Intron-specific Neuropeptide Probes. Chapter 5, In: "Neuropeptides: Methods & Protocols" Adalberto Merighi, Ed. (Methods in Molecular Biology series) Humana Press, NY, 2011, vol. 789, pp. 89-110.


Young, WS III and Gainer, H.
Vasopressin/Oxytocin and Receptors, In: Larry R. Squire, Editor(s)-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2009, pp. 51-59.

Kawasaki, M. Ponzio, T, Yue, C, Fields, RL, and Gainer, H.
Neurotransmitter regulation of c-fos and vasopressin gene expression in the rat supraoptic nucleus, Experimental Neurology, 2009, vol. 219, pp. 212-222.

House, S.B., Li, C., Yue, C., and Gainer, H.
Effects of ciliary neurotrophic factor and leukemia inhibiting factor on oxytocin and vasopressin magnocellular neuron survival in rat and mouse hypothalamic organotypic cultures, J. Neuroscience Methods, 2009, vol. 178, pp. 128-133.


Yue, C, Mutsuga, N, Sugimura, Y, Verbalis, J and Gainer, H.
Differential kinetics of oxytocin and vasopressin heteronuclear RNA expression in the rat supraoptic nucleus in response to chronic salt loading in vivo, J. Neuroendocrinol, 2008, vol. 20, pp. 227-232.

Yue, C, Ponzio TA, Fields, RL, and Gainer, H.
Oxytocin and vasopressin gene expression and RNA splicing patterns in the rat supraoptic nucleus, Physiological Genomics, 2008, vol. 35, pp. 231-242.

Scordalakes, E.M, Yue, C and Gainer, H.
Experimental Approaches for the Study of Oxytocin and Vasopressin Gene Expression in the Central Nervous System, Prog. In Brain Research, 2008, vol. 170, pp. 43-51.


Rusnak, M.,Tòth, Z.E., House, S.B., and Gainer, H
Depolarization and neurotransmitter regulation of vasopressin gene expression in the rat suprachiasmatic nucleus in vitro, J. Neuroscience, 2007, vol. 27, pp. 141-151. Full Text/Abstract

Ponzio, TA, Yue, C and Gainer, H.
An intron-based real-time PCR method for measuring vasopressin gene transcription, Journal of Neuroscience Methods, 2007, vol. 164, pp. 149-154.


Yue, C., Mutsuga, N., Scordalakes, E.M., and Gainer, H
Studies of oxytocin and vasopressin gene expression in the rat hypothalamus using exon- and intron-specific probes., American Journal of Physiology, 2006, vol. 290, pp. R1233-1241. Full Text/Abstract

Yue, C., Mutsuga, N., Verbalis, J., and Gainer, H
Microarray Analysis of Gene Expression in the Supraoptic Nucleus of Normoosmotic and Hypoosmotic Rats, Cellular and Molecular Neurobiology, 2006, vol. 26, pp. 957-76. Full Text/Abstract

Mutsuga, N and Gainer, H
Molecular Analysis of the Magnocellular Neuroendocrine Phenotype: From the Micropunch to Laser microdissection, Neurochem. Res, 2006, vol. 31, pp. 189-199. Full Text/Abstract

House, S.B., Rusnak, M., Liu, X-H, Youle, R.J., and Gainer, H
Bcl-xL and caspase inhibition increase the survival of rat oxytocin and vasopressin magnocellular neurons in organotypic culture, Experimental Neurology, 2006, vol. 200, pp. 267-71. Full Text/Abstract


Glasgow, E., Ryu, S-L, Yamashita, M, Zhang,, B-J, Mutsuga, N; and Gainer, H
APeg3, a novel Paternally Expressed Gene 3 antisense RNA transcript specifically expressed in vasopressinergic magnocellular neurons in the rat supraoptic nucleus, Molecular Brain Research, 2005, vol. 137, pp. 143-151. Full Text/Abstract

Mutsuga, N., Shahar, T, Verbalis, JG,. Brownstein, MJ, Xiang, CC, and Gainer,H.
Regulation of Gene Expression in Magnocellular Neurons in rat supraoptic nucleus during sustained Hypoosmolality, Endocrinology, 2005, vol. 146, pp. 1254-1267. Full Text/Abstract

Zhang, B-J, Yamashita, .M, Fields R, Kusano K, and Gainer ,H
EGFP-Tagged Vasopressin Precursor Protein Sorting Into Large Dense Core Vesicles and Secretion From PC12 Cells, Cell. Mol. Neurobiol, 2005, vol. 25, pp. 581-605. Full Text/Abstract

Rusnak, M., and Gainer ,H
Differential Effects of Forskolin on Tyrosine Hydroxylase Gene Transcription in Identified Brainstem Catecholaminergic Neuronal Subtypes in Organotypic Culture, European Journal of Neuroscience, 2005, vol. 21, pp. 889-898. Full Text/Abstract


Shahar, T, House, S.B., and Gainer, H
Neural activity protects hypothalamic magnocellular neurons against axotomy-induced programmed cell death., J. Neuroscience, 2004, vol. 24, pp. 6553-6562. Full Text/Abstract

Mutsuga,N., Shahar, T, Verbalis, JG,. Brownstein, MJ, Xiang, CC, Bonner, RF and Gainer,H
Selective gene expression in magnocellular neurons in rat supraoptic nucleus., J. Neuroscience, 2004, vol. 24, pp. 7174-7185. Full Text/Abstract


Fields, R.L., House, S. B., and Gainer, H
Regulatory domains in the intergenic region of the oxytocin and vasopressin genes that control their hypothalamus-specific expression in vitro., J. Neuroscience, 2003, vol. 23, pp. 7801-7809. Full Text/Abstract

Young, WS III & Gainer,H
Transgenesis and the study of expression, cellular targeting and function of oxytocin, vasopressin and their receptors., Neuroendocrinology, 2003, vol. 78(4), pp. 185-203. Full Text/Abstract


Burbach JPH, Luckman,SM, Murphy,D., and Gainer,H.
Gene regulation in the magnocellular hypothalamo-neurohypophysial system., Physiol. Rev, 2001, vol. 81, pp. 1197-1267. Full Text/Abstract


Xi, D, Chin H, Gainer H.
Analysis of synaptotagmin I-IV mRNA expression and developmental regulation in the rat hypothalamus and pituitary., Neuroscience, 1999, vol. 88, pp. 425-435. Full Text/Abstract

Xi, D., Kusano K, Gainer H.
Quantitative analysis of oxytocin and vasopressin mRNAs in single magnocellular neurons isolated from supraoptic nucleus of rat hypothalamus., Endocrinology, 1999, vol. 140, pp. 4677-4682. Full Text/Abstract


Thomas A, Kim DS, Fields RL,Chin H, Gainer H.
Quantitative Analysis of Gene Expression in Organotypic Slice-Explant Cultures using Particle-mediated Gene Transfer., J. Neuroscience Methods, 1998, vol. 84, pp. 181-191. Full Text/Abstract

House SB, Thomas A, Kusano K, Gainer H.
Stationary Organotypic Cultures of Oxytocin and Vasopressin Magnocellular Neurons from Rat and Mouse Hypothalamus., J. Neuroendocrinol., 1998, vol. 10, pp. 849-861. Full Text/Abstract


Wagner S, Castel M, Gainer H, Yarom,Y.
GABA in the mammalian suprachiasmatic nucleus and it's role in diurnal rhythmicity., Nature, 1997, vol. 387, pp. 598-603. Full Text/Abstract

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