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Molecular Neurophysiology Section - Division of Intramural Research


Oelstrom K, Goldschen-Ohm MP, Holmgren M, Chanda B
Evolutionarily conserved intracellular gate of voltage-dependent sodium channels, Nature Communications, 2014, vol. 5, pp. 3420. Full Text/Abstract


Miranda, P, Contreras, JE, Plested, AJR, Sigworth, FJ, Holmgren, M and Giraldez,T
State-dependent FRET reports calcium- and voltagedependent gating-ring motions in BK channels, Proc. Nat. Acad. Sci. USA, 2013, vol. 110, pp. 5217-5222. Full Text/Abstract


Lopez-Rodriguez A, Holmgren M
Restoration of proper trafficking to the cell surface for membrane proteins harboring cysteine mutations., PLoS One., 2012, vol. 2012;7(10), pp. e47693. Full Text/Abstract

Gadsby, D.C., Bezanilla, F., Rakowski, R.F., De Weer, P. and Holmgren
The dynamic relationships between the three events that release individual Na+ ions from the Na+/K+-ATPase, Nature Communications, 2012, vol. 3, pp. 669 doi:1038/ncomms1673. Full Text/Abstract


Galarza, G. Soto, S.I., Holmgren M. and Rosenthal, J.J.C
Physiological Adaptation of an Antarctic Na+/K+-ATPase to the cold., J. Exp. Biol., 2011, vol. 214, pp. 2164-2174. Full Text/Abstract

Castillo J.P., De Giorgis D., Basilio, D., Gadsby, D.C., Rosenthal, J.J., Latorre, R., Holmgren, M., Bezanilla,
Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the axon of the Humboldt squid., Proc. Nat. Acad. Sci. USA, 2011, vol. 108, pp. 20556-20561. Full Text/Abstract

Gonzalez, C., Lopez-Rodriguez, A., Srikumar, D., Rosenthal, J.J.C. and Holmgren, M.
Editing of human KV1.1 channel mRNAs disrupts binding of the N-terminus tip at the intracellular cavity., Nat. Commun., 2011, vol. 2, pp. 436 doi: 10.1038/ncomms1446. Full Text/Abstract

Sandtner, W., Egwolf, B., Khalili-Araghi, F., Sanchez-Rodriguez, J.E., Roux, B., Bezanilla, F. and Holmgren, M.
Ouabain binding site in a functioning Na+/K+-ATPase., J. Biol. Chem., 2011, vol. 286, pp. 38177-38183.. Full Text/Abstract


Colina, C., Palavicini, J.P., Srikumar, D., Holmgren, M. and Rosenthal, J.J.C
Regulation of Na+/K+ ATPase transport velocity by RNA editing., PLoS Biol., 2010, vol. 8, pp. e1000540. Full Text/Abstract

Contreras, J.E., Chen, J., Lau, A.Y., Jogini, V., Roux, B. and Holmgren, M
Voltage profile along the permeation pathway of an open channel., Biophys. J., 2010, vol. 99, pp. 2863-2869. Full Text/Abstract


Contreras, J.E. Srikumar, D. and Holmgren, M.
Gating at the selectivity filter in cyclic nucleotide-gated channels, PNAS, 2008, vol. 105, pp. 3310-3314. Full Text/Abstract


Colina, C., J.J.C. Rosenthal, J.A. DeGiorgis, D. Srikumar, N. Iruku& M. Holmgren
Structural basis of Na+/K+-ATPase adaptation to marine environments, Nature Structural Molecular Biology, 2007, vol. 14, pp. 427-431. Full Text/Abstract

Rakowski, R.F., P. Artigas, F. Palma, M. Holmgren, P. De Weer, & D.C. Gadsby
Sodium Flux Ratio in Na/K Pump-Channels Opened by Palytoxin, Journal of General Physiology, 2007, vol. 130, pp. 41-54. Full Text/Abstract


Holmgren, M. and Rakowski, RF.
Charge Translocation by the Na+/K+ Pump under Na+/Na+ Exchange Conditions: Intracellular Na+ Dependence, Biophys. J., 2006, vol. 90, pp. 1607-16. Full Text/Abstract

Contreras, JE and Holmgren, M.
Access of quaternary ammonium blockers to the internal pore of cyclic nucleotide-gated channels: implications for the location of the gate., J. Gen. Physiol., 2006, vol. 127, pp. 481-94. Full Text/Abstract


Bhalla, T., Rosenthal, JJC, Holmgren, M., and Reenan, R.
Control of Human Potassium Channel Inactivation by Editing of a Small mRNA Hairpin, Nature Structural & Molecular Biology, 2004, vol. 11, pp. 950-956. Full Text/Abstract


Holmgren, Miguel
Influence of Permeant Ions on Gating in Cyclic Nucleotide-gated Channels, J. Gen Physiol, 2003, vol. 121, pp. 61-72. Full Text/Abstract

Soler-Llavina GJ, Holmgren M, and Swartz KJ
Defining the Conductance of the Closed State in a Voltage-Gated K+ Channel, Neuron, 2003, vol. 38, pp. 61-67. Full Text/Abstract


Holmgren M, Wagg J, Bezanilla F, Rakowski RF, De Weer P and Gadsby DC
Three distinct and sequential steps in the release of sodium ions by the Na+/K+-ATPase, Nature, 2000, vol. 403(6772), pp. 898-901. Full Text/Abstract

del Camino D, Holmgren M, Liu Y, Yellen G.
Blocker protection in the pore of a voltage-gated K+ channel and its structural implications, Nature, 2000, vol. 403(6767), pp. 321-5. Full Text/Abstract


Holmgren M, Shin KS, Yellen G
The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge, Neuron, 1998, vol. 21(3), pp. 617-21. Full Text/Abstract


Liu Y, Holmgren M, Jurman ME, Yellen G.
Gated access to the pore of a voltage-dependent K+ channel, Neuron, 1997, vol. 19(1), pp. 175-84. Full Text/Abstract

Holmgren M, Smith PL, Yellen G.
Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating, J Gen Physiol, 1997, vol. 109(5), pp. 527-35. Full Text/Abstract


Holmgren M, Jurman ME, Yellen G.
N-type inactivation and the S4-S5 region of the Shaker K+ channel, :J Gen Physiol, 1996, vol. 108(3), pp. 195-206. Full Text/Abstract

Holmgren M, Liu Y, Xu Y, Yellen G.
On the use of thiol-modifying agents to determine channel topology, Neuropharmacology, 1996, vol. 35(7), pp. 797-804. Full Text/Abstract


Holmgren M, Rakowski RF.
Pre-steady-state transient currents mediated by the Na/K pump in internally perfused Xenopus oocytes, Biophys J, 1994, vol. 66(3 Pt 1), pp. 912-22. Full Text/Abstract

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