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Receptor Biology Section - Division of Intramural Research


Chen, B.S., Gray, J.A., Sanz-Clemente, A., Wei, Z., Thomas, E.V., Nicoll, R.A., and Roche, K.W.
SAP102 Mediates Synaptic Clearance of NMDA Receptors., Cell Reports, 2012, vol. 2(5), pp. 1120-8.

Sanz-Clemente, A., Nicoll, R.A., and Roche, K.W.
Diversity in NMDA Receptor Composition: Many Regulators, Many Consequences, Neuroscientist, 2012


Chen, B.S., Thomas, E.V., Sanz-Clemente, A., and Roche, K.W.
NMDA Receptor-Dependent Regulation of Dendritic Spine Morphology by SAP102 Splice Variants, J. Neurosci., 2011

Choi, K.Y., Chang, K., Pickel, J.M., Badger, J.D. 2nd, and Roche K.W.
Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice, PNAS, 2011, vol. 108 (37), pp. 15219-24.


Suh, Y.H., Terashima, A., Petralia, R.S., Wenthold, R.J., Isaac, J.T., Roche, K.W., and Roche, P.A.
A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking, Nat. Neurosci., 2010, vol. 13(3), pp. 338-43.

Nasu-Nishimura, Y., Jaffe, H., Isaac, J.T., and Roche, K.W.
Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6, J. Biol. Chem., 2010, vol. 285(4), pp. 2847-56.

Sanz-Clemente, A., Matta, J.A., Isaac, J.T.R., and Roche, K.W.
Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors, Neuron, 2010, vol. 67(6), pp. 984-96.


Chen, B.S. and Roche, K.W.
Growth Factor-Dependent Trafficking of Cerebellar NMDA Receptors Via Protein Kinase B/Akt Phosphorylation of NR2C, Neuron, 2009, vol. 62, pp. 471-8.


Suh, Y.H., Pelkey, K.A., Lavezzari, G., Roche, P.A., Huganir, R.L., McBain, C.J., and Roche, K.W.
Co-Requirement of PICK1 Binding and PKC Phosphorylation for Stable Surface Expression of the Metabotropic Glutamate Receptor mGluR7, Neuron, 2008, vol. 58, pp. 736-48.

Lee, J.H., Lee, J., Choi, K.Y., Hepp, R., Lee J.Y., Lim, M.K., Chatani-Hinze, M., Kim, D.G., Ahn, Y.S., Kim, C.H., and Roche, K.W.
Calmodulin Dynamically Regulates the Trafficking of the Metabotropic Glutamate Receptor mGluR5, PNAS, 2008, vol. 105, pp. 12575-80.


Nasu-Nishimura, Y., Hurtado, D., Braud, S., Tang, T.T., Isaac, J.T., and Roche, K.W.
Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2, J. Neurosci., 2006, vol. 26(26), pp. 7014-21.

Chen, B.S., Braud, S., Badger, J.D. 2nd, Isaac, J.T., and Roche, K.W.
Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation, J. Biol. Chem., 2006, vol. 281(24), pp. 16583-90.


Pelkey, K.A., Lavezzari, G., Racca, C., Roche, K.W., and McBain, C.J.
mGluR7 is a metaplastic switch controllling bi-directional plasticity of feedforward inhibition, Neuron, 2005, vol. 46, pp. 89-102.

Kim, C.H., Braud, S., Isaac, J.T.R., and Roche, K.W.
PKC phosphorylation of the metabotropic glutamate receptor mGluR5 on serine 839 regulates Ca2+ oscillations, J. Biol. Chem., 2005, vol. 280(27), pp. 25409-15.


Roche, K.W.
The Expanding Role of PSD-95: A New Link to Addiction, Trends Neurosci., 2004, vol. 27, pp. 699-700.

Lavezzari, G., McCallum, J., Dewey, C. M., and Roche, K.W.
Subunit-Specific Regulation of NMDA Receptor Endocytosis, Journal of Neuroscience, 2004, vol. 24(28), pp. 6383-91.


Lavezzari, G., McCallum, J., Lee, R., and Roche, K.W.
Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression, Neuropharmacology, 2003, vol. 45, pp. 729-737.

Hayes D.M., Braud S., Hurtado D.E., McCallum J., Standley S., Isaac J.T.R., and Roche K.W.
Trafficking and surface expression of the glutamate receptor subunit, KA2, Biochem. Biophys. Res. Commun., 2003, vol. 291, pp. 85-90.


Roche, K.W., Standley, S., McCallum, J., Ly, C.D., Ehlers, M.D., and Wenthold, R.J.
Molecular Determinants of NMDA Receptor Internalization, Nature Neuroscience, 2001, vol. 4, pp. 794-802.


Standley, S., Roche, K.W., McCallum, J., Sans, N., and Wenthold, R.J.
PDZ-Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants, Neuron, 2000, vol. 28, pp. 887-898.


Roche, K.W., Tu, J.C., Petralia, R.S., Xiao, B., Wenthold, R.J., and Worley, P.F.
Homer 1b Regulates the Trafficking of Group I Metabotropic Glutamate Receptors, J. Biol. Chem., 1999, vol. 274, pp. 25953-25957.

Roche, K.W., Ly, C.D., Petralia, R.S., Wang, Y.X., McGee, A.W., Bredt, D.S., and Wenthold, R.J.
PSD-93 Interacts with the Delta 2 Glutamate Receptor Subunit at Parallel Fiber Synapses, J. Neurosc., 1999, vol. 19, pp. 3926-3934.


Roche, K.W., O'Brien, R.J., Mammen, A.L., Bernhardt, J.P., and Huganir, R.L.
Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit, Neuron, 1996, vol. 16, pp. 1179-1188.

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