Receptor Biology Section - Division of Intramural Research

2012

Chen, B.S., Gray, J.A., Sanz-Clemente, A., Wei, Z., Thomas, E.V., Nicoll, R.A., and Roche, K.W.
SAP102 Mediates Synaptic Clearance of NMDA Receptors., Cell Reports, 2012, vol. 2(5), pp. 1120-8.

Sanz-Clemente, A., Nicoll, R.A., and Roche, K.W.
Diversity in NMDA Receptor Composition: Many Regulators, Many Consequences, Neuroscientist, 2012

2011

Chen, B.S., Thomas, E.V., Sanz-Clemente, A., and Roche, K.W.
NMDA Receptor-Dependent Regulation of Dendritic Spine Morphology by SAP102 Splice Variants, J. Neurosci., 2011

Choi, K.Y., Chang, K., Pickel, J.M., Badger, J.D. 2nd, and Roche K.W.
Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice, PNAS, 2011, vol. 108 (37), pp. 15219-24.

2010

Suh, Y.H., Terashima, A., Petralia, R.S., Wenthold, R.J., Isaac, J.T., Roche, K.W., and Roche, P.A.
A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking, Nat. Neurosci., 2010, vol. 13(3), pp. 338-43.

Nasu-Nishimura, Y., Jaffe, H., Isaac, J.T., and Roche, K.W.
Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6, J. Biol. Chem., 2010, vol. 285(4), pp. 2847-56.

Sanz-Clemente, A., Matta, J.A., Isaac, J.T.R., and Roche, K.W.
Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors, Neuron, 2010, vol. 67(6), pp. 984-96.

2009

Chen, B.S. and Roche, K.W.
Growth Factor-Dependent Trafficking of Cerebellar NMDA Receptors Via Protein Kinase B/Akt Phosphorylation of NR2C, Neuron, 2009, vol. 62, pp. 471-8.

2008

Suh, Y.H., Pelkey, K.A., Lavezzari, G., Roche, P.A., Huganir, R.L., McBain, C.J., and Roche, K.W.
Co-Requirement of PICK1 Binding and PKC Phosphorylation for Stable Surface Expression of the Metabotropic Glutamate Receptor mGluR7, Neuron, 2008, vol. 58, pp. 736-48.

Lee, J.H., Lee, J., Choi, K.Y., Hepp, R., Lee J.Y., Lim, M.K., Chatani-Hinze, M., Kim, D.G., Ahn, Y.S., Kim, C.H., and Roche, K.W.
Calmodulin Dynamically Regulates the Trafficking of the Metabotropic Glutamate Receptor mGluR5, PNAS, 2008, vol. 105, pp. 12575-80.

2006

Nasu-Nishimura, Y., Hurtado, D., Braud, S., Tang, T.T., Isaac, J.T., and Roche, K.W.
Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2, J. Neurosci., 2006, vol. 26(26), pp. 7014-21.

Chen, B.S., Braud, S., Badger, J.D. 2nd, Isaac, J.T., and Roche, K.W.
Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation, J. Biol. Chem., 2006, vol. 281(24), pp. 16583-90.

2005

Pelkey, K.A., Lavezzari, G., Racca, C., Roche, K.W., and McBain, C.J.
mGluR7 is a metaplastic switch controllling bi-directional plasticity of feedforward inhibition, Neuron, 2005, vol. 46, pp. 89-102.

Kim, C.H., Braud, S., Isaac, J.T.R., and Roche, K.W.
PKC phosphorylation of the metabotropic glutamate receptor mGluR5 on serine 839 regulates Ca2+ oscillations, J. Biol. Chem., 2005, vol. 280(27), pp. 25409-15.

2004

Roche, K.W.
The Expanding Role of PSD-95: A New Link to Addiction, Trends Neurosci., 2004, vol. 27, pp. 699-700.

Lavezzari, G., McCallum, J., Dewey, C. M., and Roche, K.W.
Subunit-Specific Regulation of NMDA Receptor Endocytosis, Journal of Neuroscience, 2004, vol. 24(28), pp. 6383-91.

2003

Lavezzari, G., McCallum, J., Lee, R., and Roche, K.W.
Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression, Neuropharmacology, 2003, vol. 45, pp. 729-737.

Hayes D.M., Braud S., Hurtado D.E., McCallum J., Standley S., Isaac J.T.R., and Roche K.W.
Trafficking and surface expression of the glutamate receptor subunit, KA2, Biochem. Biophys. Res. Commun., 2003, vol. 291, pp. 85-90.

2001

Roche, K.W., Standley, S., McCallum, J., Ly, C.D., Ehlers, M.D., and Wenthold, R.J.
Molecular Determinants of NMDA Receptor Internalization, Nature Neuroscience, 2001, vol. 4, pp. 794-802.

2000

Standley, S., Roche, K.W., McCallum, J., Sans, N., and Wenthold, R.J.
PDZ-Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants, Neuron, 2000, vol. 28, pp. 887-898.

1999

Roche, K.W., Tu, J.C., Petralia, R.S., Xiao, B., Wenthold, R.J., and Worley, P.F.
Homer 1b Regulates the Trafficking of Group I Metabotropic Glutamate Receptors, J. Biol. Chem., 1999, vol. 274, pp. 25953-25957.

Roche, K.W., Ly, C.D., Petralia, R.S., Wang, Y.X., McGee, A.W., Bredt, D.S., and Wenthold, R.J.
PSD-93 Interacts with the Delta 2 Glutamate Receptor Subunit at Parallel Fiber Synapses, J. Neurosc., 1999, vol. 19, pp. 3926-3934.

1996

Roche, K.W., O'Brien, R.J., Mammen, A.L., Bernhardt, J.P., and Huganir, R.L.
Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit, Neuron, 1996, vol. 16, pp. 1179-1188.

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