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Cellular and Systems Neurobiology Section - Division of Intramural Research



2010

Koizumi, H., S. Smerin, T. Yamanishi, B. Moorjani, R. Zhang, and J.C. Smith
TASK channels contribute to the K+-dominated leak current regulating respiratory rhythm generation in vitro, J. Neurosci., 2010, vol. 30, pp. 4273-4284.

2009

Ptak, K., T. Yamanishi, J. Aungst, L. Milescu, R. Zhang, G.B. Richerson, and J.C. Smith
Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P, J. Neurosci., 2009, vol. 29, pp. 370-3737.

Rubin, J.E., N.A, Shevtsova, G.B. Ermentrout, J.C. Smith, and I.A. Rybak.
Multiple rhythmic states in a model of the respiratory CPG, J. Neurophysiol., 2009, vol. 101, pp. 2146-2165.

Hodges, M., M. Wehner, J. Aungst, J.C. Smith, and G.B. Richerson
Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development, J. Neurosci., 2009, vol. 29, pp. 10341-10349.

Smith, J.C., A.P.L. Abdala, I. A. Rybak, and J.F.R. Paton
Structural and functional architecture of respiratory networks in the mammalian brainstem, Phil. Trans. Royal Soc. B, 2009, vol. 364, pp. 2577-2587.

2008

Ben-Tal. A. and J.C. Smith
A model for control of breathing in mammals: coupling neural dynamics to peripheral gas exchange and transport, J. Theor. Biol., 2008, vol. 251, pp. 480-497.

Koizumi, H., C.G. Wilson, S. Wong, T. Yamanishi, N. Koshiya, and J.C. Smith
Functional imaging, spatial reconstruction, and biophysical analysis of a respiratory motor circuit isolated in vitro, J. Neurosci., 2008, vol. 28, pp. 2353-2365.

Koizumi, H. and J.C. Smith
Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre-Botzinger complex in vitro, J. Neurosci., 2008, vol. 28, pp. 1773-1785.

Milescu, L. S., T. Yamanishi, K. Ptak, M.Z. Mogri, and J.C. Smith
Real-time kinetic modeling of voltage-gated ion channels using dynamic clamp, Biophys. J., 2008, vol. 95, pp. 66-87.

2007

Purvis, L., J.C. Smith, H. Koizumi, and R.J. Butera
Intrinsic bursters increase the robustness of rhythm generation in an excitatory network, J. Neurophysiol., 2007, vol. 97, pp. 1515-1526.

Smith, J.C., A.P.L. Abdala, H. Koizumi, I.A. Rybak, and F.F.R. Paton
Spatial and functional architecture of the mammalian brainstem respiratory network: a hierarchy of three oscillatory mechanisms, J. Neurophysiol., 2007, vol. 98, pp. 3370-3387.

Rybak, I.A., A.P.L. Abdula, S.N. Markin, J.F.R. Paton, and J.C. Smith
Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation, Progress in Brain Research, 2007, vol. 165, pp. 201-220.

2006

Paton, J.F.R., A.P.L. Abdala, H. Koizumi, J.C. Smith, and W. M. St-John
Paton, J.F.R., A.P.L. Abdala, H. Koizumi, J.C. Smith, and W. M. St-John. Respiratory rhythm generation during gasping depends on persistent sodium curren, Nature Neurosci., 2006, vol. 9, pp. 311-313.

2005

Yuste, R., J.N. McClean, J. Smith, and A. Lansner
The cortex as a central pattern generator, Nature Rev. Neurosci., 2005, vol. 6, pp. 477-483.

2002

Del Negro, C., N. Koshiya, R.J. Butera, and J.C. Smith
Persistent sodium current, membrane properties, and bursting behavior of pre-Bötzinger complex inspiratory neurons in vitro, J. Neurophysiology, 2002, vol. 88, pp. 2242-2250.

Del Negro, C., R.J. Butera, C.G. Wilson, and J.C. Smith
Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network, Biophysical Journal, 2002, vol. 82, pp. 206-214.

2001

Johnson, S.M., N. Koshiya, and J.C. Smith
Isolation of the kernel for respiratory rhythm generation in a novel in vitro preparation: the pre-Botzinger complex island, J. Neurophysiology, 2001, vol. 85, pp. 1772-1776.

Del Negro, C., S.M. Johnson, R.J. Butera, and J.C. Smith
Models of respiratory rhythm generation in the pre-Bötzinger complex. III. Experimental tests of model predictions, J. Neurophysiology, 2001, vol. 86, pp. 59-74.

Butera, R.J., C.G. Wilson, C. Del Negro, and J.C. Smith
A methodology for achieving high-speed rates for artificial conductance injection in electrically excitable biological cells, IEEE Transactions on Biomedical Engineering, 2001, vol. 48, pp. 1460-1470.

2000

Smith, J.C., R.J. Butera, N. Koshiya, C. Del Negro, G.G. Wilson, ans S.M. Johnson
Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model, Respiration Physiology, 2000, vol. 122, pp. 131-148.

1999

Butera, R.J., Jr., J. Rinzel, and J. C. Smith
Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons, J. Neurophysiology, 1999, vol. 81, pp. 382-397.

Butera, R.J., Jr., J. Rinzel, and J.C. Smith
Models of respiratory rhythm generation in the pre-Bötzinger complex. II. Populations of coupled pacemaker neurons, J. Neurophysiology, 1999, vol. 81, pp. 398-415.

Koshiya, N. and J.C. Smith
Neuronal pacemaker for breathing visualized in vitro, Nature, 1999, vol. 400, pp. 360-363.

1991

Smith, J.C., H.H. Ellenberger, K. Ballanyi, D.W. Richter, and J.L. Feldman
Pre-Botzinger Complex: A brainstem region that may generate respiratory rhythm in mammals, Science, 1991, vol. 254, pp. 726-729.

1990

Smith, J.C., J.J. Greer, G. Liu, and J.L. Feldman
Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity, J. Neurophysiology, 1990, vol. 64, pp. 1149-1169.

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