Laboratory of Functional and Molecular Imaging - Division of Intramural Research

 Alan P.  Koretsky  Ph.D., Senior Investigator

Dr. Koretsky received his S.B. degree from the Massachusetts Institute of Technology and Ph.D. from the University of California at Berkeley. He performed postdoctoral work in the NHLBI at NIH studying regulation of mitochondrial metabolism using optical and NMR techniques. Dr. Koretsky spent twelve years on the faculty in the Department of Biological Sciences at Carnegie Mellon University where he was the Eberly Professor of Structural Biology and Chemistry. In summer 1999, he moved to NINDS as Chief of the Laboratory of Functional and Molecular Imaging and Director of the NIH MRI Research Facility. Dr. Koretsky's laboratory is interested in two main areas. They are actively developing novel imaging techniques to visualize brain function and study the regulation of cellular energy metabolism combining molecular genetics with non-invasive imaging tools.

Laboratory Staff

Nadia Bouraoud, , Contractor , 301-451- 9938
Der-Yow Chen, Ph.D., Research Fellow , 301-594- 7314
Yun Chen, Ph.D., Guest Researcher , 301-402- 1329
Richard Conroy, Ph.D., Contractor , 301-594- 7310
Sam Day, , Pre-doctoral IRTA , 301-402- 9709
Steve Dodd, Ph.D., Staff Scientist , 301-402- 0389
Samuel Hou, , Contractor , 301-594- 7313
Kathy Ireland-Pardini, , Office Manager , 301-594- 2133
Mary Kiganda, M.S., Biologist , 301-435- 7945
Hellmut Merkle, Ph.D., Staff Scientist , 301-594- 7306
Joseph Murphy-Boesch, Ph.D., Staff Scientist , 301-594- 1305
Steven Newman, , Contractor , 301-402- 9456
Ana Paz, , Contractor , 301-451- 1863
Chunqi Qian, Ph.D., Contractor , 301-435- 2146
Galit Saar, Ph.D., Visiting Fellow , 301-451- 9913
Kathy  Sharer, , Research Assistant , 301-402- 9652
James Sumner, Ph.D., IRTA Fellow , 301-594- 0365
Shumin Wang, Ph.D., Staff Scientist , 301-402- 0286
Xin Yu, Ph.D., Research Fellow , 301-594- 7311

Research Interests

The Functional and Molecular Imaging Section has two major research interests. One is to develop novel functional and molecular imaging techniques to study brain structure and function. Emphasis is on MRI but some optical imaging is performed as well. Current areas of interest are to extend spatial resolution and understand the relation of functional MRI to neuronal architecture. New imaging tools are being developed to image calcium influx and gene expression non-invasively in the mouse brain.

Selected Recent Publications

S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. Koretsky
BOLD and CBV-Weighted Functional Magnetic Resonance Imaging of the Rat Somatosensory System - Magnetic Resonance in Medicine  55 316-324 2006

I. Aoki, Y. Takahashi, K. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R.W. Childs, A.P. Koretsky
Cell Labeling for Magnetic Resonance Imaging with the T1 Agent Manganese Chloride - NMR in Biomedicine  19 50-59 2006

O. Rodriguez, S. Fricke, C. Chien, L. Dettin, J. Vanmeter, E.M. Shapiro, H. Dai, M. Casimiro, L. Lleva, J. Dagata, M.D. Johnson, M.P. Lisanti, A.P. Koretsky, C. Albanese
Contrast-Enhanced in Vivo Imaging of Breast and Prostate Cancer Cells by MRI - Cell Cycle  5 113-119 2006

E.M. Shapiro, K. Sharer, Skrtic, A.P. Koretsky
In Vivo Detection of Single Cells By MRI - Magnetic Resonance in Medicine  55 242-249 2006

K. Chuang, A.P. Koretsky
Improved Neuronal Tract Tracing Using Manganese Enhanced Magnetic Resonance Imaging with Fast T1 Mapping - Magnetic Resonance in Medicine  55 604-611 2006

A.P. Koretsky, S.L. Talagala, S.D. Keilholz, A.C. Silva
MRI Detection of Regional Blood Flow Using Arterial Spin Labeling - Cambridge University Press   119-140 2005

Selected Earlier Publications

Contact Information

NIH/NINDS/LFMI 10 Center Drive, MSC 1065  Building 10, Room B1D728   Bethesda MD  20892-1065

Telephone: 301-402- 9659 (office), 301- 402-9659 (laboratory), 301-480- 2558 (fax), Email: koretskya@ninds.nih.gov