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Advanced MRI Section - Division of Intramural Research


Jeff H. Duyn Image

Jeff H. Duyn, Ph.D., Investigator

Dr. Duyn received his M.Sc. and Ph.D. degrees in physics at the University of Delft, Holland where he was involved with the development of X-ray diffraction techniques, as well as the early development of magnetic resonance imaging (MRI). During his postdoctoral assignments at the University of California, San Francisco, and at NIH, his research focused on the study of human brain physiology, as measured by spectroscopic and functional MRI techniques. Dr. Duyn moved to NINDS in 2000.

Laboratory Staff

Catherine Chang, Ph.D., IRTA Fellow
Jacco A de Zwart, Ph.D., Staff Scientist
Xiao Liu, Ph.D., Visiting Fellow
Zhongming Liu, Ph.D., Research Fellow
Hendrik Mandelkow, Ph.D., Visiting Fellow
Peter van Gelderen, Ph.D., Staff Scientist
Bing (Brian) Yao, Ph.D., Research Fellow

Research Interests

In addition to providing structural information, MRI has the potential to non-invasively map physiologic parameters and function. Our research focuses on optimally exploiting this potential by investigating the mechanisms behind MRI contrast, exploring avenues to manipulate the contrast, and optimizing MRI data acquisition and analysis to achieve optimum sensitivity, resolution, reliability, and accuracy. Specific aims are the development of MRI techniques for the measurements of structural anatomy, tissue metabolism, tissue perfusion, and the spatial distribution of brain activity. Recent work has focused on high field MRI technology, the magnetic properties of brain tissue, and the study of spontaneous brain activity.

Website of the Advanced MRI section of LFMI: http://www.amri.ninds.nih.gov/
Website of the Laboratory of Functional and Molecular Imaging: http://www.lfmi.ninds.nih.gov/


Selected Recent Publications

  • Freed M, de Zwart JA, Loud JT, El Khouli RH, Myers KJ< Greene MH, Duyn JH, Badano A
    An Anthropomorphic phantom for quantitative evaluation of breast MRI, Medical Physics, 2011
  • Picchioni D, Horovitz SG, Fukunaga M, Carr WS, Meltzer JA, Balkin TJ, Duyn JH, Braun AR
    Infraslow EEG oscillations organize large-scale cortico-subcortical interactions during sleep: a combined EEG/fMRI study, Brain Research, 2011, vol. 1374, pp. 63-72.
  • Duyn JH
    High-Field MRI of Brain Iron, Methods in Molecular Biology, 2011, vol. 711, pp. 239-249.
  • Bianciardi M, Fukunaga M, van Gelderen P, de Zwart JA
    Negative BOLD-fMRI signals in large cerebral veins, J Cereb Blood Flow Metab, 2010, vol. Sep 22
  • Bright MG, Donahue MJ, Duyn JH, Jezzard P, Bulte DP
    The effect of basal vasodilation on hypercapnic and hypocapnic reactivity measured using MRI, J Cereb Blood Flow Metab, 2010, vol. Oct 20
  • Lee J, Fukunaga M, Duyn JH
    Improving contrast to noise ration of resonance frequency contrast images (phase images) using balanced steady state free precession, Neuroimage, 2010, vol. 54, pp. 2779-2788.
  • Lee J, Shmueli K, Fukunaga M, van Gelderen P, Merkle H, Silva AC, Duyn JH.
    Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure., Proc. Nat. Acad. Sci., 2010
  • Liu Z, Fukunaga M, de Zwart JA, Duyn JH.
    Large-scale spontaneous fluctuations and correlations in brain electrical activity observed with magnetoencephalography., Neuroimage, 2010

Selected Earlier Publications


Contact Information

NIH/NINDS/LFMI/AMS
10 Center Drive, MSC 1065
Building 10, Room B1D724
Bethesda, MD 20892-1065

Telephone: 301-594-7305 (office), 301-594-7305 (laboratory), 301-480-2558 (fax)
Email: jhd@helix.nih.gov