Advanced MRI Section - Division of Intramural Research

 Jeff H.  Duyn  Ph.D., Investigator

Dr. Duyn received his M.Sc. and Ph.D. degrees in physics at the University of Delft, Holland where he was involved with the development of X-ray diffraction techniques, as well as the early development of magnetic resonance imaging (MRI). During his postdoctoral assignments at the University of California, San Francisco, and at NIH, his research focused on the study of human brain physiology, as measured by spectroscopic and functional MRI techniques. Dr. Duyn moved to NINDS in 2000.

Laboratory Staff

Marta Bianciardi, Ph.D., Visiting Fellow , 301-594- 2626
Molly Bright, , Pre-doctoral IRTA , 301-594- 2133
Jacco de Zwart, Ph.D., Staff Scientist , 301-594- 7315
Masaki Fukunaga, Ph.D., Research Fellow , 301-594- 7312
Susan Guttman, , Medical Technologist , 301-451- 9912
Jongho Lee, Ph.D., Research Fellow , 301-451- 9919
Zhongming Liu, Ph.D., Contractor , 301-451- 9915
Karin Shmueli, Ph.D., Visiting Fellow , 301-451- 9916
Peter van Gelderen, Ph.D., Staff Scientist , 301-402- 1472
Brian (Bing) Yao, Ph.D., Research Fellow , 301-451- 9918

Research Interests

In addition to providing structural information, MRI has the potential to non-invasively map physiologic parameters and function. The current research focus is to optimally exploit this potential by investigating the mechanisms behind MRI contrast, exploring avenues to manipulate the contrast, and optimizing MRI data acquisition and analysis to achieve optimum sensitivity, resolution, reliability, and accuracy. Specific aims are the development of MRI techniques for the measurements of structural anatomy, tissue metabolism, tissue perfusion, and blood oxygenation level dependent contrast in both normal and diseased human brain.

Selected Recent Publications

F.J. Langheim, J.H. Callicott, V.S. Mattay, J.H. Duyn, D.R. Weinberger
Cortical Systems Associated with Covert Music Rehearsal - NeuroImage  16 (4) 901-8 2002

M.N. Yongbi, F. Fera, J.A. Frank, V.S. Mattay, J.H. Duyn
Comparison of Multi-Slice Baseline and fMRI Perfusion Signal at 1.5T and 3.0T Using Pulsed Arterial Spin Labeling: Initial Results in Six Subjects - Radiology  222 569-575 2002

E.L. Barbier, S. Marrett, A. Danek, A. Vortmeyer, P. van Gelderen, J. Duyn, P. Bandettini, J. Grafman, A.P. Koretsky
Imaging Cortical Anatomy by High Resolution MR at 3.0T: Detection of the Stripe of Gennari in Visual Area 17 - Magn. Resonance Med.  48 (4) 738-8 2002

G. Tedeschi, S. Bonavita, H.F. McFarland, N. Richert, J.H. Duyn, J.A. Frank
Proton MR Spectroscopic Imaging in Multiple Schlerosis - Neuroradiology  44 (1) 37-42 2002

J.A. de Zwart, P. van Gelderen, P. Kellman, J.H. Duyn
Application of Sensitivity-Encoded Echo-Planar Imaging for Blood Oxygen Level-Dependent Functional Brain Imaging - Magn. Resonance Med.  48 (6) 1011-20 2002

J.A. de Zwart, P. van Gelderen, P. Kellman, J.H. Duyn
Reduction of Gradient Acoustic Noise in MRI Using SENSE-EPI - NeuroImage  16 (4) 1151-5 2002

Selected Earlier Publications

Contact Information

NIH/NINDS/LFMI/AMS 10 Center Drive, MSC 1065  Building 10, Room B1D724   Bethesda MD  20892-1065

Telephone: 301-594- 7305 (office), 301- 594-7305 (laboratory), 301-480- 2558 (fax), Email: jhd@helix.nih.gov