Curing Epilepsy 2007 Conference Agenda

March 28-30, 2007
Natcher Conference Center
National Institutes of Health
Bethesda, Maryland

March 28, 2007 (Junior Investigators only)

SCIENTIFIC SESSION

• Welcome
  Story Landis, Ph.D., Director, National Institute of Neurological Disorders and Stroke
• Junior Investigator Session
  Chair: Manisha Patel, Ph.D. (University of Colorado)
• The experience of epilepsy
  Brendan Malone, Chicago Illinois
• Scientific Talks
  • Genetics
    
    • Gene Mapping in Complex Epilepsies*
      Jocelyn F. Bautista, M.D.(Cleveland Clinic)
  • Epileptogenesis
    • Electrophysiological Biomarkers of Epileptogenesis
      Susan Herman, M.D. (University of Pennsylvania)
    • Prevention of Posttraumatic Neocortical Epileptogenesis
      Kevin D. Graber, M.D. (Stanford University)
• Co-morbidities
  • Neurobehavioral aspects of epilepsy*
    W. Curt LaFrance, M.D. (Brown University)
• Imaging/technology
  • A hybrid cell silicon neural prosthesis for the treatment of epilepsy*
    Jenna L. Rickus, Ph.D. (Purdue University)

• Discussion (view session photo)

POSTER SESSION/RECEPTION

DINNER

• Career success talks
  Scott Baraban, Ph.D. (University of California, San Francisco)
  Anne Anderson, M.D. (Baylor College of Medicine)
  

March 29, 2007

• 7:30 CONTINENTAL BREAKFAST
• 8:30 Welcome: Story Landis, Ph.D., Director National Institute of Neurological Disorders and Stroke
• 8:45 Introduction and Keynote Address*: Gerald Fischbach, M.D. (Columbia University)

MORNING SESSION

• Session 1: Translating discoveries of epilepsy genes into cures*
  Chair: Jeffrey Noebels, M.D., Ph.D. (Baylor College of Medicine)
  • 9:15 The experience of epilepsy
    April Cooper, Irvine, California
  • 9:30 Approaches to complex inheritance*
    Richard A. Gibbs, Ph.D. (Baylor College of Medicine)
  • 9:50 Imaging endophenotypes
    Ellen Grant, M.D. (Massachusetts General Hospital)
  • 10:10 Monogenic epilepsies and epilepsy/malformation syndromes*
    Ingrid Scheffer, M.B.B.S., FRACP, Ph.D. (University of Melbourne)
  • 10:30 BREAK
  • 10:50 Developmental reversibility of cortical malformations*
    Joseph LoTurco, Ph.D. (University of Connecticut)
  • 11:10 Targeting common signaling pathways in cortical dysplasia*
    Gabriella D'Arcangelo, Ph.D. (Talk given by Cecilia Ljungberg, Ph.D.) (Baylor College of Medicine)
  • 11:25 Rapamycin as a treatment for tuberous sclerosis complex*
    David N. Franz, M.D. (Cincinnati Children's Hospital Medical Center)
• 11:40 Panel Discussion (view session photo)
  • Moderator:
    Jeffrey L. Noebels, M.D., Ph.D.
  • Discussants:
    Session 1 Speakers
• 12:15 BOX LUNCHES

AFTERNOON SESSION

• 1:30 Keynote Address
  Elias A. Zerhouni, M.D., Director, National Institutes of Health
• Session 2: Translating discoveries of epileptogenic mechanisms into cures*
  Chair: Frances E. Jensen, M.D. (Harvard Univeristy)
  • 1:45 The experience of epilepsy
    Denise Pease, Corona, New York
  • 2:00 What is the clinical evidence for epileptogenesis?*
    Shlomo Shinnar, M.D., Ph.D. (Albert Einstein College of Medicine)
  • 2:20 Epileptogenic phenotypes in experimental model systems*
    Asla Pitkänen, M.D., Ph.D. (University of Kuopio)
  • 2:40 BREAK
  • 3:10 Candidate cellular and molecular mechanisms for epileptogenesis: impact from basic neurobiology*
    Helen E. Scharfman, Ph.D. (Columbia University and Helen Hayes Hospital)
  • 3:30 Epileptogenic biomarkers: human studies and experimental systems*
    Jerome Engel, Jr., M.D., Ph.D. (University of California, Los Angeles) (Talk given by Solomon Moshé, Albert Einstein College of Medicine)
• 3:50 Panel discussion (view session photo)
  • Moderator:
    Frances E. Jensen, M.D. (Harvard University)
  • Discussants:
    Barry W. Connors, Ph.D. (Brown University) (Toward an understanding of seizures and epileptogenesis)
    Richard L. Huganir, Ph.D. (Johns Hopkins University)
    David C. Van Essen, Ph.D. (Washington University) (Neuroimaging advances relevant to epilepsy*)
    Session 2 Speakers
• 5:30-6:30 RECEPTION

March 30, 2007

• 7:30 CONTINENTAL BREAKFAST
• 8:30 Greeting: Peter Wolf, M.D., Ph.D. (International League Against Epilepsy)
  Introduction: John W. Swann, Ph.D. (Baylor College of Medicine)

MORNING SESSION

• Session 3: Beyond seizures: cognitive and psychological issues in epilepsy*
  Chair: Amy Brooks-Kayal, M.D. (University of Pennsylvania)
  • 8:45 The experience of epilepsy
    Sherry Healey, Naperville, Illinois
  • 9:00 Cognitive and psychological issues in epilepsy: the scope of the problem
    Anne T. Berg, Ph.D. (Northern Illinois University)
  • 9:20 Imaging cognitive and psychological issues in epilepsy*
    John D.E. Gabrieli, Ph.D. (Massachusetts Institute of Technology)
  • 9:40 Longitudinal imaging of brain plasticity in children* Judith L. Rapoport, M.D. (National Institute of Mental Health)
  • 10:00 BREAK
  • 10:30 Unraveling mechanisms and searching for cures for learning disabilities*
    Alcino J. Silva, Ph.D. (National Institute of Mental Health)
• 10:50 Panel discussion (view session photo)
  • Moderator:
    Amy Brooks-Kayal, M.D.
  • Discussants:
    John J. Barry, Ph.D. (Stanford University)
    Rochelle Caplan, M.D. (UCLA)
    Bruce P. Hermann, M.D. (University of Wisconsin)
    Gregory L. Holmes, M.D. (Dartmouth College)
    Session 3 Speakers
• 11:30 BOX LUNCHES and discussion of potential outcomes: Benchmarks (view session photo)
  Chair: Daniel H. Lowenstein, M.D. (University of California at San Francisco)

AFTERNOON SESSION

• Session 4: Emerging technologies of diagnostic materials and cellular and molecular therapeutics
  Chairs: Arnold R. Kriegstein, M.D., Ph.D. (University of California at San Francisco) and Dennis Spencer, M.D. (Yale University)
• 1:00 The experience of epilepsy
  Jeffrey Smith
• Part I Technology
  • 1:15 Next-generation implantable technologies: materials, power/telemetry and sensors*
    Bruce Lanning, Ph.D. (ITN Energy Systems)
  • 1:35 Nanotechnology for delivery and tracking therapy*
    W. Mark Saltzman, Ph.D. (Yale University)
  • 1:55 Brain mapping in the study of epilepsy
    Arthur Toga, Ph.D. (University of California at Los Angeles)
• Part II Therapeutics
  • 2:15 Neural interfaces for repair and therapy: potential for epilepsy*
    John Donoghue, Ph.D. (Brown University)
  • 2:35 Future of gene therapy*
    R. Jude Samulski, Ph.D. (University of North Carolina)
  • 2:55 Mechanisms that generate inhibitory interneurons—insights into cell-based therapies for epilepsy
    John L.R. Rubenstein, M.D., Ph.D. (University of California at San Francisco)
• 3:15 Panel discussion: (view session photo)
  • Moderator:
    Dennis Spencer, M.D.
  • Discussants:
    Session 4 Speakers
• 4:00 WRAP-UP AND CLOSING REMARKS*
  • Walter Koroshetz, M.D., Deputy Director, National Institute of Neurological Disorders and Stroke
    
    ADJOURNMENT