Active CounterACT Researchers & Projects

Abstracts, budgets, and contact information for all CounterACT-supported  projects are available via the NIH RePORTER database

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Research Centers of Excellence (U54)

Center for Catalytic Bioscavenger Medical Defense Research II: Discovery, Formulation, & Preclinical Evaluation 
Douglas M. Cerasoli, Ph.D.
U.S. Army Medical Research Institute of Chemical Defense

UMDNJ/Rutgers University CounterACT Research Center of Excellence 
Jeffrey D. Laskin, Ph.D.
UMDNJ - Robert Wood Johnson Medical School

Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication 
Pamela J. Lein, Ph.D.
University of California, Davis

A Discovery and Development Pipeline for Cyanide Countermeasures
Calum A. MaCrae, M.D., Ph.D.
Brigham and Women's Hospital

Novel Therapeutics for Vesicant and Toxic Inhaled Chemicals   
Carl W. White, M.D.
University of Colorado, Denver

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Individual Research Projects (U01)

Effective Therapies for Ocular Injuries by Vesicating Agents 
Rajesh Agarwal, Ph.D.
University of Colorado Health Sciences Center

Pharmacotherapy to CounterACT Parathion-induced NMJ Dysfunction 
Steven B. Bird, M.D.
University of Massachusetts Medical School 

Preclinical and Clinical Studies of Cobinamide, a New Cyanide Detoxifying Agent 
Gerry R. Boss, M.D.  
University of California, San Diego

Efficacy of GluR5 Antagonists Against Soman-Induced Seizures and Neuropathology 
Maria F.M. Braga, D.D.S., Ph.D.
Uniformed Services University of the Health Sciences

Parathion Exposure: Mechanisms of Toxicity and Treatment 
Robert J. DeLorenzo, M.D., Ph.D., M.P.H.  
Virginia Commonwealth University

Prostanoid Modulators that Reduce Brain Injury After Seizures 
Raymond J. Dingledine, Ph.D.  
Emory University School of Medicine

Intralipid: A Novel Frontline Countermeasure for Brodifacoum Poisoning
Douglas L. Feinstein, Ph.D.  
University of Illinois

Improved Standard of Care Reactivators and Facilitative Transport into the Central Nervous System
Gregory E. Garcia, Ph.D.  
U.S. Army Medical Research Institute of Chemical Defense

Development of Therapeutics for Chlorine-induced Airway and Lung Injury 
Michael D. Gunn, M.D.
Duke University Medical Center 

Novel Therapies for Chlorine-Induced Lung Injury 
Gary W. Hoyle, Ph.D.    
University of Louisville

Countermeasures for Chlorine-Induced Airway Fibrosis 
Gary W. Hoyle, Ph.D.    
University of Louisville

Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity 
Sven-Eric Jordt, Ph.D.
Yale University

Developing Drugs to Mitigate Parathion Intoxication
Jeffrey D. Laskin, Ph.D.
UMDNJ-Roberts W. Johnson Medical School

Functional Genomics of Chemical -Induced Acute Lung Injury 
George D. Leikauf, Ph.D.    
University of Pittsburgh

Amelioration of Vesicant-Induced Skin Injury by High Dose 25-Hydroxyvitamin D 
Kurt Lu, M.D.
Case Western Reserve University 

Neuroprotective Effects of AEOL 10150 Against Organophosphate Toxicity
Manisha N. Patel, Ph.D.
University of Colorado, Denver

Countermeasures Against Chemical Threats: Countermeasures Against Cyanide 
Steven Patterson, Ph.D.  
University of Minnesota Twin Cities Center for Drug Design

Neurosteroid Treatment for OP Intoxication
Doodipala S. Reddy, Ph.D.
Texas A&M University Health Science Center

Induced Therapeutic Overexpression of Acetylcholinesterase in vivo 
Richard L. Rotundo, Ph.D.   
University of Miami Miller School of Medicine

Multifunctional Therapeutics for Treatment of Acute Chlorine Inhalational Injury 
Garry J. Southan, Ph.D.
Radikal Therapeutics, Inc. 

Rational Polytherapy in the Treatment of Cholinergic Seizures 
Claude G. Wasterlain, M.D.
Brentwood Medical Research Institute

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Active Small Business Innovation Research (SBIR) 

Definitive Studies for Use of Galantamine as a Pre-treatment Countermeasure Against Nerve Agent Poisoning 
William Basinger, Jr., M.S.
CounterVail Corporation

Aerosol Delivery of a Recombinant Butyrylcholinesterase "Bioshield" to Protect Against OP Respiratory Toxicity 
Yvonne Rosenberg, Ph.D.
PlantVax, Inc.

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Exploratory/Developmental Projects (R21)

Therapeutic Intervention of Lewisite-Mediated Cutaneous Blistering-Inflammation 
Mohammad Athar, Ph.D.
University of Alabama at Birmingham

Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning 
Steven B. Bird, M.D.
University of Massachusetts Medical School 

Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats 
Gerry R. Boss, M.D.
University of California, San Diego

Hypothermia Protects Against Organophosphate Toxicity 
Robert J. DeLorenzo, M.D., Ph.D., M.P.H.  
Virginia Commonwealth University

Perinatal Methylmercury Targets Hippocampal Stem Cells, and Reduces Neurogenesis 
Emanuel M. Dicicco-Bloom, M.D.
UMDNJ-Robert Wood Johnson Medical School

Crystalline Hydroxocobalamin and Methemoglobin as a Treatment of H2S Intoxication 
Philippe A. Haouzi, M.D., Ph.D.
Pennsylvania State University, Hershey Medical Center

Accelerating Inflammation Resolution to CounterACT Chemical Injury 
Sven E. Jordt, Ph.D.
Yale University

Development of Amodiaquine and its Analogs as Reactivators of Organophosphate-inhibited Acetylcholinesterases
Donald Landry, M.D.
Columbia University Health Sciences

Development of Drugs to Mitigate Parathion Intoxication 
Jeffrey D. Laskin, Ph.D.
UMDNJ-Roberts W. Johnson Medical School

Identification of Novel Therapeutic Approaches for TETS and OP Intoxication 
Pamela J. Lein, Ph.D. & Michael A. Rogawski, M.D. Ph.D.
University of California, Davis 

Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
Stuart A. Lipton, M.D., Ph.D.
Sanford-Burnham Medical Research Institute

Intranasal CNS delivery of drugs against organophosphorous threat agents
Aryan M. Namboodiri, Ph.D.
Uniformed Services University of Health Sciences

Finding Effective Treatments for Inhaled Chlorine-Induced Injury Related Pain
Timothy J. Ness, M.D., Ph.D. & Sadis Matalon, Ph.D.
University of Alabama, Birmingham

Evaluation of Neuroprotective Effects of AEOL10150 Against Chemical Threat Agents 
Manisha N. Patel, Ph.D.
University of Colorado, Denver

Synthesis of Methylating Ligands that Reactivate Aged Acetylcholinesterase 
Daniel M. Quinn, Ph.D.
University of Iowa

A Neurosteroid-based Novel Treatment for OP-Intoxication 
Doodipala S. Reddy, Ph.D.
Texas A&M University Health Science Center

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Contracts, Inter-Agency Agreements, and Other Resources

CounterACT Preclinical Development Facility (CPDF) 
Carol Green, Ph.D., D.A.B.T.   
SRI International

Anticonvulsant Screening Program - New Countermeasures Screening Services
H. Steve White, Ph.D.
University of Utah

NIH Molecular Libraries Program: Pathways to Discovery 
NIH Contacts

Inter-Agency Agreement between the National Institutes of Health and the Department of Defense
Chemicals Affecting Skin, Eyes & Mucous Membranes - Toxic Vesicants and Industrial Chemicals
Chemicals Affecting the Nervous System - Anticonvulsants and Neuroprotectants
Cyanide Diagnostics and Efficacy Testing of Next Generation Cyanide Antidotes
Chemicals Affecting the Respiratory Tract - Pulmonary Toxicants
James F. Dillman, Ph.D.   
U.S. Army Medical Research Institute of Chemical Defense 
 

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