Active CounterACT Researchers & Projects

Abstracts, budgets, and contact information for all CounterACT-supported  projects are available via the NIH RePORTER database

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Research Centers of Excellence (U54)

Center for Catalytic Bioscavenger Medical Defense Research II: Discovery, Formulation, & Preclinical Evaluation
Douglas M. Cerasoli, Ph.D.
U.S. Army Medical Research Institute of Chemical Defense

UMDNJ/Rutgers University CounterACT Research Center of Excellence
Jeffrey D. Laskin, Ph.D.
UMDNJ - Robert Wood Johnson Medical School

Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication
Pamela J. Lein, Ph.D.
University of California, Davis

A Discovery and Development Pipeline for Cyanide Countermeasures
Calum A. MaCrae, M.D., Ph.D.
Brigham and Women's Hospital

Novel Therapeutics for Vesicant and Toxic Inhaled Chemicals  
Carl W. White, M.D.
National Jewish Medical and Research Center

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Individual Research Projects (U01)

Effective Therapies for Ocular Injuries by Vesicating Agents
Rajesh Agarwal, Ph.D.
University of Colorado Health Sciences Center

Preclinical and Clinical Studies of Cobinamide, a New Cyanide Detoxifying Agent
Gerry R. Boss, M.D.  
University of California, San Diego

Efficacy of GluR5 Antagonists Against Soman-Induced Seizures and Neuropathology
Maria F.M. Braga, D.D.S., Ph.D.
Uniformed Services University of the Health Sciences

Parathion Exposure: Mechanisms of Toxicity and Treatment
Robert J. DeLorenzo, M.D., Ph.D., M.P.H.  
Virginia Commonwealth University

Prostanoid Modulators that Reduce Brain Injury After Seizures
Raymond J. Dingledine, Ph.D.  
Emory University School of Medicine

Development of Therapeutics for Chlorine-induced Airway and Lung Injury
Michael D. Gunn, M.D.
Duke University Medical Center

Novel Therapies for Chlorine-Induced Lung Injury
Gary W. Hoyle, Ph.D.   
University of Louisville

Countermeasures for Chlorine-Induced Airway Fibrosis
Gary W. Hoyle, Ph.D.   
University of Louisville

Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity
Sven-Eric Jordt, Ph.D.
Yale University

Functional Genomics of Chemical -Induced Acute Lung Injury
George D. Leikauf, Ph.D.   
University of Pittsburgh

Amelioration of Vesicant-Induced Skin Injury by High Dose 25-Hydroxyvitamin D
Kurt Lu, M.D.
Case Western Reserve University

Countermeasures Against Chemical Threats: Countermeasures Against Cyanide
Steven Patterson, Ph.D.  
University of Minnesota Twin Cities Center for Drug Design

Induced Therapeutic Overexpression of Acetylcholinesterase in vivo
Richard L. Rotundo, Ph.D.   
University of Miami Miller School of Medicine

Multifunctional Therapeutics for Treatment of Acute Chlorine Inhalational Injury
Garry J. Southan, Ph.D.
Radikal Therapeutics, Inc.

Rational Polytherapy in the Treatment of Cholinergic Seizures
Claude G. Wasterlain, M.D.
Brentwood Medical Research Institute

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Active Small Business Innovation Research (SBIR) 

Definitive Studies for Use of Galantamine as a Pre-treatment Countermeasure Against Nerve Agent Poisoning
William Basinger, Jr., M.S.
CounterVail Corporation

Aerosol Delivery of a Recombinant Butyrylcholinesterase "Bioshield" to Protect Against OP Respiratory Toxicity
Yvonne Rosenberg, Ph.D.
PlantVax, Inc.

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Exploratory/Developmental Projects (R21)

Developmental Neurotoxicity of Sarin and Soman in Guinea Pigs
Edson Albuquerque, M.D., Ph.D.
University of Maryland, Baltimore

Therapeutic Intervention of Lewisite-Mediated Cutaneous Blistering-Inflammation
Mohammad Athar, Ph.D.
University of Alabama at Birmingham

Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning
Steven B. Bird, M.D.
University of Massachusetts Medical School 

Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
Gerry R. Boss, M.D.
University of California, San Diego

Protection Against Sarin-induced Neurotoxicity via an in vivo Caspase Inhibitor
David R. Cool, Ph.D.
Wright State University 

Hypothermia Protects Against Organophosphate Toxicity
Robert J. DeLorenzo, M.D., Ph.D., M.P.H.  
Virginia Commonwealth University

Perinatal Methylmercury Targets Hippocampal Stem Cells, and Reduces Neurogenesis
Emanuel M. Dicicco-Bloom, M.D.
UMDNJ-Robert Wood Johnson Medical School

Crystalline Hydroxocobalamin and Methemoglobin as a Treatment of H2S Intoxication
Philippe A. Haouzi, M.D., Ph.D.
Pennsylvania State University, Hershey Medical Center

Repair of Airway Epithelium Following Chlorine Lung Injury
Gary W. Hoyle, Ph.D.
University of Louisville 

Accelerating Inflammation Resolution to CounterACT Chemical Injury
Sven E. Jordt, Ph.D.
Yale University

Development of Amodiaquine and its Analogs as Reactivators of Organophosphate-inhibited Acetylcholinesterases
Donald Landry, M.D.
Columbia University Health Sciences

Development of Drugs to Mitigate Parathion Intoxication
Jeffrey D. Laskin, Ph.D.
UMDNJ-Roberts W. Johnson Medical School

Identification of Novel Therapeutic Approaches for TETS and OP Intoxication
Pamela J. Lein, Ph.D. & Michael A. Rogawski, M.D. Ph.D.
University of California, Davis 

Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
Stuart A. Lipton, M.D., Ph.D.
Sanford-Burnham Medical Research Institute

Intranasal CNS delivery of drugs against organophosphorous threat agents
Aryan M. Namboodiri, Ph.D.
Uniformed Services University of Health Sciences

Finding Effective Treatments for Inhaled Chlorine-Induced Injury Related Pain
Timothy J. Ness, M.D., Ph.D. & Sadis Matalon, Ph.D.
University of Alabama, Birmingham

Evaluation of Neuroprotective Effects of AEOL10150 Against Chemical Threat Agents
Manisha N. Patel, Ph.D.
University of Colorado, Denver

Counteracting Acute and Persistent Effects of OP Intoxication by Endocannabinoids
Cary N. Pope, Ph.D.
Oklahoma State University, Stillwater 

Synthesis of Methylating Ligands that Reactivate Aged Acetylcholinesterase
Daniel M. Quinn, Ph.D.
University of Iowa

A Neurosteroid-based Novel Treatment for OP-Intoxication
Doodipala S. Reddy, Ph.D.
Texas A&M University Health Science Center

Optimization of Nonpyridinium Oximes for BChE Hydrolysis of OPs in Plasma
Palmer W. Taylor, Ph.D. & Zoran Radic, Ph.D.
University of California, San Diego 

In vivo Pharmacokinetic and Pharmacodynamic Dispositions of Positron Radiolabeled Organophosphate Chemical Threats
Charles M. Thompson, Ph.D. & John M. Gerdes, Ph.D.
University of Montana, Missoula 

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Contracts, Inter-Agency Agreements, and Other Resources

CounterACT Preclinical Development Facility (CPDF)
Carol Green, Ph.D., D.A.B.T.  
SRI International

Anticonvulsant Screening Program - New Countermeasures Screening Services
H. Steve White, Ph.D.
University of Utah

NIH Molecular Libraries Program: Pathways to Discovery
NIH Contacts

Inter-Agency Agreement between the National Institutes of Health and the Department of Defense
Chemicals Affecting Skin, Eyes & Mucous Membranes - Toxic Vesicants and Industrial Chemicals
Chemicals Affecting the Nervous System - Anticonvulsants and Neuroprotectants
Cyanide Diagnostics and Efficacy Testing of Next Generation Cyanide Antidotes
Chemicals Affecting the Respiratory Tract - Pulmonary Toxicants
James F. Dillman, Ph.D.  
U.S. Army Medical Research Institute of Chemical Defense
 

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* Supplemental research supported by the CounterACT Administrative Supplement Program  
(Please contact PI directly for additional information about these research efforts).