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Active CounterACT Researchers & Projects

CounterACT: Countermeasures Against Chemical Threats - banner graphic

Research @ NIH
Scientific Contacts
David A. Jett, Ph.D.
Program Director
Phone: 301-496-6035

D. Yeung, Ph.D.
Project Manager
Tel: 301-443-7534

Sarah Norring, Ph.D.
Program Specialist
Phone: 301-443-8189

CounterACT network map

Abstracts, budgets, and contact information for all CounterACT-supported  projects are available via the NIH RePORTER database

Research Centers of Excellence (U54)

UMDNJ/Rutgers University CounterACT Research Center of Excellence 
Jeffrey D. Laskin, Ph.D.
RBHS - Robert Wood Johnson Medical School

Novel Therapeutics for Vesicant and Toxic Inhaled Chemicals   
Carl W. White, M.D.
University of Colorado, Denver

Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication 
Pamela J. Lein, Ph.D.
University of California, Davis

A Discovery and Development Pipeline for Cyanide Countermeasures
Calum A. MaCrae, M.D., Ph.D.
Brigham and Women's Hospital

Individual Research Projects (U01)

Preclinical and Clinical Studies of Cobinamide, a New Cyanide Detoxifying Agent 
Gerry R. Boss, M.D.  
University of California, San Diego

Efficacy of GluR5 Antagonists Against Soman-Induced Seizures and Neuropathology 
Maria F.M. Braga, D.D.S., Ph.D.
Uniformed Services University of the Health Sciences

Parathion Exposure: Mechanisms of Toxicity and Treatment 
Robert J. DeLorenzo, M.D., Ph.D., M.P.H.  
Virginia Commonwealth University

Prostanoid Modulators that Reduce Brain Injury After Seizures 
Raymond J. Dingledine, Ph.D.
Emory University School of Medicine

Novel Therapies for Chlorine-Induced Lung Injury 
Gary W. Hoyle, Ph.D.    
University of Louisville

Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity 
Sven-Eric Jordt, Ph.D.
Yale University

Functional Genomics of Chemical -Induced Acute Lung Injury 
George D. Leikauf, Ph.D.    
University of Pittsburgh

Countermeasures Against Chemical Threats: Countermeasures Against Cyanide 
Steven Patterson, Ph.D.  
University of Minnesota Twin Cities Center for Drug Design

Induced Therapeutic Overexpression of Acetylcholinesterase in vivo 
Richard L. Rotundo, Ph.D.   
University of Miami Miller School of Medicine

Multifunctional Therapeutics for Treatment of Acute Chlorine Inhalational Injury 
Garry J. Southan, Ph.D.
Radikal Therapeutics, Inc.

Rational Polytherapy in the Treatment of Cholinergic Seizures 
Claude G. Wasterlain, M.D.
Brentwood Medical Research Institute

Effective Therapies for Ocular Injuries by Vesicating Agents 
Rajesh Agarwal, Ph.D.
University of Colorado Health Sciences Center

Development of Therapeutics for Chlorine-induced Airway and Lung Injury 
Michael D. Gunn, M.D.
Duke University Medical Center 

Countermeasures for Chlorine-Induced Airway Fibrosis 
Gary W. Hoyle, Ph.D.    
University of Louisville

Amelioration of Vesicant-Induced Skin Injury by High Dose 25-Hydroxyvitamin D 
Kurt Lu, M.D.
Case Western Reserve University 

Pharmacotherapy to CounterACT Parathion-induced NMJ Dysfunction 
Steven B. Bird, M.D.
University of Massachusetts Medical School 

Intralipid: A Novel Frontline Countermeasure for Brodifacoum Poisoning
Douglas L. Feinstein, Ph.D.  
University of Illinois

Improved Standard of Care Reactivators and Facilitative Transport into the Central Nervous System
Gregory E. Garcia, Ph.D.  
U.S. Army Medical Research Institute of Chemical Defense

Developing Drugs to Mitigate Parathion Intoxication
Jeffrey D. Laskin, Ph.D.
RBHS-Roberts W. Johnson Medical School

Neuroprotective Effects of AEOL 10150 Against Organophosphate Toxicity
Manisha N. Patel, Ph.D.
University of Colorado, Denver

Nitrite Dependent Protection Against Cl2 Gas Toxicity Role of Chlorinated Lipids
Rakesh Patel, Ph.D.
University of Alabama, Birmingham

Neurosteroid Treatment for OP Intoxication
Doodipala S. Reddy, Ph.D.
Texas A&M University Health Science Center

Extracellular RNA as Therapeutic Target After Toxic Chemical Inhalation
Aftab Ahmad, Ph.D.
University of Colorado Denver

Brain-Penetrating Acetylcholinesterase Reactivators for Several Organophophates
Janice E. Chambers, Ph.D.
Mississippi State University

Reactivation of Aged Acetylcholinesterase: Design and Development of Novel Therapeutics against Exposure to Organophosphorus Chemical Nerve Agents
Christopher Hadad, Ph.D.
Ohio State University

Accelerate AChE Reactivator Design by Mechanistic Neutron Scattering Studies
Zoran Radic, Ph.D.
University of California San Diego

Thioredoxin Mimicry: Novel Treatment of Toxicant-mediated Inhalational Lung Injury
Andrew Salzman, M.D.

Radikal Therapeutics, Inc.

Active Small Business Innovation Research (SBIR) 

Definitive Studies for Use of Galantamine as a Pre-treatment Countermeasure Against Nerve Agent Poisoning 
William Basinger, Jr., M.S.
CounterVail Corporation

Enhanced Bioscavenger for Medical Countermeasures Against Organophosphorus Agents
Zhiguo Zhou, Ph.D.
Luna Innovations, Inc.

Development of a Field-Deployable Device to Rapidly Measure Blood Cyanide Levels
Hans Boehringer, Ph.D.
Diagnostic Consulting Network, Inc.

Multi-targeted Countermeasures Against Acute and Delayed Effects of OP Exposure
John Butera, Ph.D.
Hager Biosciences, Inc.

Exploratory/Developmental Projects (R21)

Novel Treatments of Acrolein-Induced Cardiotoxicity
Daniel Conklin, Ph.D.
University of Louisville

TIE2 Activation for the Treatment of Chemical-Induced Acute Lung Injury
Christopher Kontos, M.D.
Duke University

Formulation and Encapsulation of Enzyme Countermeasures Against Organophosphorus Compounds
Thomas J. Magliery, Ph.D.
Ohio State University

Mitochondrial Bioenergetic Dysfunction and Chlorine Toxicity
Sadis Matalon, Ph.D.
University of Alabama, Birmingham

Intracellular Targeting HSP70 for Pulmonary Cytoprotection after Toxin Inhalation
Missag Parseghian, Ph.D.
Rubion Biotechnology, Inc

Nitrites as Antidotes for Hydrogen Sulfide Poisoning
James Peterson, Ph.D.
University of Pittsburgh 

BChE Reactivators for Nerve Agent and Pesticide OP Detoxification in Human Tissue
Zoran Radic, Ph.D.
University of California, San Diego

Screening Therapies to Counteract Developmental Chlorpyrifos Intoxication
Jared Goldstone, Ph.D.
Woods Hole Oceanographic Institution

Methylene Blue, A Novel Treatment of H2S Poisoning-induced Brain Injury
Philippe Haouzi, M.D.
Pennsylvania State University Hershey Medical Center

Central Role of Heme Oxygenase in Reversing Bromine Morbidity and Mortality
Sadis Matalon, Ph.D.
University of Alabama at Birmingham

Cyanide Decorporation by Co(III) Schiff-base Macrocycles
Linda Pearce, Ph.D.
University of Pittsburgh

Efficacy of Cobinamide for Treatment of Hydrogen Sulfide-induced Neurotoxicity
Wilson Rumbeiha, Ph.D.
Iowa State University of Science and Technology

Developing and Evaluating Countermeasures Against Tetramethylenedisulfotetramine
Michael Shakarjian, Ph.D.
New York Medical College


Contracts, Inter-Agency Agreements, and Other Resources

CounterACT Preclinical Development Facility (CPDF) 
Carol Green, Ph.D., D.A.B.T.
SRI International

NIH Molecular Libraries Program: Pathways to Discovery
NIH Contacts

Inter-Agency Agreement between the National Institutes of Health and the Department of Defense
Chemicals Affecting Skin, Eyes & Mucous Membranes - Toxic Vesicants and Industrial Chemicals
Chemicals Affecting the Nervous System - Anticonvulsants and Neuroprotectants
Cyanide Diagnostics and Efficacy Testing of Next Generation Cyanide Antidotes
Chemicals Affecting the Respiratory Tract - Pulmonary Toxicants
James F. Dillman, Ph.D.
U.S. Army Medical Research Institute of Chemical Defense 

Last updated October 27, 2014