CounterACT Researchers & Projects

Abstracts, budgets, and contact information for all CounterACT-supported  projects are available via the NIH RePORTER database

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Active Research Centers of Excellence (U54)

Center for Catalytic Bioscavenger Medical Defense Research II: Discovery, Formulation, & Preclinical Evaluation
Douglas M. Cerasoli, Ph.D.
U.S. Army Medical Research Institute of Chemical Defense

UMDNJ/Rutgers University CounterACT Research Center of Excellence
Jeffrey D. Laskin, Ph.D.
UMDNJ - Robert Wood Johnson Medical School

Novel Therapeutics for Vesicant and Toxic Inhaled Chemicals 
Carl W. White, M.D.
National Jewish Medical and Research Center

 

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Active Individual Research Projects (U01)

Preclinical and Clinical Studies of Cobinamide, a New Cyanide Detoxifying Agent
Gerry R. Boss, M.D.  
University of California, San Diego

Efficacy of GluR5 Antagonists Against Soman-Induced Seizures and Neuropathology
Maria F.M. Braga, D.D.S., Ph.D.
Uniformed Services University of the Health Sciences

Parathion Exposure: Mechanisms of Toxicity and Treatment
Robert J. DeLorenzo, M.D., Ph.D., M.P.H.  
Virginia Commonwealth University

Prostanoid Modulators that Reduce Brain Injury After Seizures
Raymond J. Dingledine, Ph.D.  
Emory University School of Medicine

Novel Therapies for Chlorine-Induced Lung Injury
Gary W. Hoyle, Ph.D.   
University of Louisville

Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity
Sven-Eric Jordt, Ph.D.
Yale University

Functional Genomics of Chemical -Induced Acute Lung Injury
George D. Leikauf, Ph.D.   
University of Pittsburgh

Countermeasures Against Chemical Threats: Countermeasures Against Cyanide
Steven Patterson, Ph.D.  
University of Minnesota Twin Cities Center for Drug Design

Induced Therapeutic Overexpression of Acetylcholinesterase in vivo
Richard L. Rotundo, Ph.D.   
University of Miami Miller School of Medicine

Multifunctional Therapeutics for Treatment of Acute Chlorine Inhalational Injury
Garry J. Southan, Ph.D.
Radikal Therapeutics, Inc.

Rational Polytherapy in the Treatment of Cholinergic Seizures
Claude G. Wasterlain, M.D.
Brentwood Medical Research Institute

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Active Small Business Innovation Research (SBIR) 

Definitive Studies for Use of Galantamine as a Pre-treatment Countermeasure Against Nerve Agent Poisoning
William Basinger, Jr., M.S.
CounterVail Corporation

Development of a Field-Deployable Device to Rapidly Measure Blood Cyanide Levels
Hans Boehringer, Ph.D.
Diagnostic Consulting Network, Inc.

Aerosol Delivery of a Recombinant Butyrylcholinesterase "Bioshield" to Protect Against OP Respiratory Toxicity
Yvonne Rosenberg, Ph.D.
PlantVax, Inc.

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Active Exploratory/Developmental Projects (R21)

Developmental Neurotoxicity of Sarin and Soman in Guinea Pigs
Edson Albuquerque, M.D., Ph.D.
University of Maryland, Baltimore

Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning
Steven B. Bird, M.D.
University of Massachusetts Medical School 

Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
Gerry R. Boss, M.D.
University of California, San Diego

Protection Against Sarin-induced Neurotoxicity via an in vivo Caspase Inhibitor
David R. Cool, Ph.D.
Wright State University 

Hypothermia Protects Against Organophosphate Toxicity
Robert J. DeLorenzo, M.D., Ph.D., M.P.H.  
Virginia Commonwealth University

Perinatal Methylmercury Targets Hippocampal Stem Cells, and Reduces Neurogenesis
Emanuel M. Dicicco-Bloom, M.D.
UMDNJ-Robert Wood Johnson Medical School

Repair of Airway Epithelium Following Chlorine Lung Injury
Gary W. Hoyle, Ph.D.
University of Louisville 

High Affinity Capturing Agents for Strychnine
Kit S. Lam, Ph.D.
University of California, Davis 

Development of Drugs to Mitigate Parathion Intoxication
Jeffrey D. Laskin, Ph.D.
UMDNJ-Roberts W. Johnson Medical School

Identification of Novel Therapeutic Approaches for TETS and OP Intoxication
Pamela J. Lein, Ph.D. & Michael A. Rogawski, M.D. Ph.D.
University of California, Davis 

Evaluation of Neuroprotective Effects of AEOL10150 Against Chemical Threat Agents
Manisha N. Patel, Ph.D.
University of Colorado, Denver

Counteracting Acute and Persistent Effects of OP Intoxication by Endocannabinoids
Cary N. Pope, Ph.D.
Oklahoma State University, Stillwater 

Synthesis of Methylating Ligands that Reactivate Aged Acetylcholinesterase
Daniel M. Quinn, Ph.D.
University of Iowa

A Neurosteroid-based Novel Treatment for OP-Intoxication
Doodipala S. Reddy, Ph.D.
Texas A&M University Health Science Center

Countermeasure for Chlorine Inhalation
Sigridur G. Suman, Ph.D. & Theodore Mill, Ph.D.
SRI International 

Optimization of Nonpyridinium Oximes for BChE Hydrolysis of OPs in Plasma
Palmer W. Taylor, Ph.D. & Zoran Radic, Ph.D.
University of California, San Diego 

In vivo Pharmacokinetic and Pharmacodynamic Dispositions of Positron Radiolabeled Organophosphate Chemical Threats
Charles M. Thompson, Ph.D. & John M. Gerdes, Ph.D.
University of Montana, Missoula 

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Active Contracts, Clinical Trials, Inter-Agency Agreements, and Other Resources

CounterACT Preclinical Development Facility (CPDF)
Carol Green, Ph.D., D.A.B.T. 
SRI International

Intramuscular Midazolam versus Intravenous Lorazepam in the Pre-hospital Treatment of status epilepticus (the RAMPART trial)
Clinical Trial through NINDS Network
William Barsan, M.D. & Robert Silbergleit, M.D.
University of Michigan

Anticonvulsant Screening Program - New Countermeasures Screening Services
H. Steve White, Ph.D.
University of Utah

NIH Molecular Libraries Program: Pathways to Discovery
NIH Contacts

Inter-Agency Agreement between the National Institutes of Health and the Department of Defense
Chemicals Affecting Skin, Eyes & Mucous Membranes - Toxic Vesicants and Industrial Chemicals
Chemicals Affecting the Nervous System - Anticonvulsants and Neuroprotectants
Cyanide Diagnostics and Efficacy Testing of Next Generation Cyanide Antidotes
Chemicals Affecting the Respiratory Tract - Pulmonary Toxicants
James F. Dillman, Ph.D. 
U.S. Army Medical Research Institute of Chemical Defense
 

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* Supplemental research supported by the CounterACT Administrative Supplement Program 
(Please contact PI directly for additional information about these research efforts).