CounterACT Program

| Scientific Contacts |
|---|
| David A. Jett, Ph.D. Program Director National Institutes of Health, NINDS 6001 Executive Blvd. NSC, Room 2177, MSC 9535 Bethesda, MD 20892-9535 Phone: 301-496-6035 jettd@ninds.nih.gov D. Yeung, Ph.D. Margaret Ochocinska, Ph.D. Wendy Vasquez, M.B.A. |

Abstracts, budgets, and contact information for all CounterACT-supported projects are available via the NIH RePORTER database
Research Centers of Excellence (U54)
Center for Catalytic Bioscavenger Medical Defense Research II: Discovery, Formulation, & Preclinical Evaluation
Douglas M. Cerasoli, Ph.D.
U.S. Army Medical Research Institute of Chemical Defense
UMDNJ/Rutgers University CounterACT Research Center of Excellence
Jeffrey D. Laskin, Ph.D.
UMDNJ - Robert Wood Johnson Medical School
Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication
Pamela J. Lein, Ph.D.
University of California, Davis
A Discovery and Development Pipeline for Cyanide Countermeasures
Calum A. MaCrae, M.D., Ph.D.
Brigham and Women's Hospital
Novel Therapeutics for Vesicant and Toxic Inhaled Chemicals
Carl W. White, M.D.
National Jewish Medical and Research Center
Individual Research Projects (U01)
Effective Therapies for Ocular Injuries by Vesicating Agents
Rajesh Agarwal, Ph.D.
University of Colorado Health Sciences Center
Preclinical and Clinical Studies of Cobinamide, a New Cyanide Detoxifying Agent
Gerry R. Boss, M.D.
University of California, San Diego
Efficacy of GluR5 Antagonists Against Soman-Induced Seizures and Neuropathology
Maria F.M. Braga, D.D.S., Ph.D.
Uniformed Services University of the Health Sciences
Parathion Exposure: Mechanisms of Toxicity and Treatment
Robert J. DeLorenzo, M.D., Ph.D., M.P.H.
Virginia Commonwealth University
Prostanoid Modulators that Reduce Brain Injury After Seizures
Raymond J. Dingledine, Ph.D.
Emory University School of Medicine
Development of Therapeutics for Chlorine-induced Airway and Lung Injury
Michael D. Gunn, M.D.
Duke University Medical Center
Novel Therapies for Chlorine-Induced Lung Injury
Gary W. Hoyle, Ph.D.
University of Louisville
Countermeasures for Chlorine-Induced Airway Fibrosis
Gary W. Hoyle, Ph.D.
University of Louisville
Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity
Sven-Eric Jordt, Ph.D.
Yale University
Functional Genomics of Chemical -Induced Acute Lung Injury
George D. Leikauf, Ph.D.
University of Pittsburgh
Amelioration of Vesicant-Induced Skin Injury by High Dose 25-Hydroxyvitamin D
Kurt Lu, M.D.
Case Western Reserve University
Countermeasures Against Chemical Threats: Countermeasures Against Cyanide
Steven Patterson, Ph.D.
University of Minnesota Twin Cities Center for Drug Design
Induced Therapeutic Overexpression of Acetylcholinesterase in vivo
Richard L. Rotundo, Ph.D.
University of Miami Miller School of Medicine
Multifunctional Therapeutics for Treatment of Acute Chlorine Inhalational Injury
Garry J. Southan, Ph.D.
Radikal Therapeutics, Inc.
Rational Polytherapy in the Treatment of Cholinergic Seizures
Claude G. Wasterlain, M.D.
Brentwood Medical Research Institute
Active Small Business Innovation Research (SBIR)
Definitive Studies for Use of Galantamine as a Pre-treatment Countermeasure Against Nerve Agent Poisoning
William Basinger, Jr., M.S.
CounterVail Corporation
Aerosol Delivery of a Recombinant Butyrylcholinesterase "Bioshield" to Protect Against OP Respiratory Toxicity
Yvonne Rosenberg, Ph.D.
PlantVax, Inc.
Exploratory/Developmental Projects (R21)
Developmental Neurotoxicity of Sarin and Soman in Guinea Pigs
Edson Albuquerque, M.D., Ph.D.
University of Maryland, Baltimore
Therapeutic Intervention of Lewisite-Mediated Cutaneous Blistering-Inflammation
Mohammad Athar, Ph.D.
University of Alabama at Birmingham
Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning
Steven B. Bird, M.D.
University of Massachusetts Medical School
Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical Threats
Gerry R. Boss, M.D.
University of California, San Diego
Protection Against Sarin-induced Neurotoxicity via an in vivo Caspase Inhibitor
David R. Cool, Ph.D.
Wright State University
Hypothermia Protects Against Organophosphate Toxicity
Robert J. DeLorenzo, M.D., Ph.D., M.P.H.
Virginia Commonwealth University
Perinatal Methylmercury Targets Hippocampal Stem Cells, and Reduces Neurogenesis
Emanuel M. Dicicco-Bloom, M.D.
UMDNJ-Robert Wood Johnson Medical School
Crystalline Hydroxocobalamin and Methemoglobin as a Treatment of H2S Intoxication
Philippe A. Haouzi, M.D., Ph.D.
Pennsylvania State University, Hershey Medical Center
Repair of Airway Epithelium Following Chlorine Lung Injury
Gary W. Hoyle, Ph.D.
University of Louisville
Accelerating Inflammation Resolution to CounterACT Chemical Injury
Sven E. Jordt, Ph.D.
Yale University
Development of Amodiaquine and its Analogs as Reactivators of Organophosphate-inhibited Acetylcholinesterases
Donald Landry, M.D.
Columbia University Health Sciences
Development of Drugs to Mitigate Parathion Intoxication
Jeffrey D. Laskin, Ph.D.
UMDNJ-Roberts W. Johnson Medical School
Identification of Novel Therapeutic Approaches for TETS and OP Intoxication
Pamela J. Lein, Ph.D. & Michael A. Rogawski, M.D. Ph.D.
University of California, Davis
Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
Stuart A. Lipton, M.D., Ph.D.
Sanford-Burnham Medical Research Institute
Intranasal CNS delivery of drugs against organophosphorous threat agents
Aryan M. Namboodiri, Ph.D.
Uniformed Services University of Health Sciences
Finding Effective Treatments for Inhaled Chlorine-Induced Injury Related Pain
Timothy J. Ness, M.D., Ph.D. & Sadis Matalon, Ph.D.
University of Alabama, Birmingham
Evaluation of Neuroprotective Effects of AEOL10150 Against Chemical Threat Agents
Manisha N. Patel, Ph.D.
University of Colorado, Denver
Counteracting Acute and Persistent Effects of OP Intoxication by Endocannabinoids
Cary N. Pope, Ph.D.
Oklahoma State University, Stillwater
Synthesis of Methylating Ligands that Reactivate Aged Acetylcholinesterase
Daniel M. Quinn, Ph.D.
University of Iowa
A Neurosteroid-based Novel Treatment for OP-Intoxication
Doodipala S. Reddy, Ph.D.
Texas A&M University Health Science Center
Optimization of Nonpyridinium Oximes for BChE Hydrolysis of OPs in Plasma
Palmer W. Taylor, Ph.D. & Zoran Radic, Ph.D.
University of California, San Diego
In vivo Pharmacokinetic and Pharmacodynamic Dispositions of Positron Radiolabeled Organophosphate Chemical Threats
Charles M. Thompson, Ph.D. & John M. Gerdes, Ph.D.
University of Montana, Missoula
Contracts, Inter-Agency Agreements, and Other Resources
CounterACT Preclinical Development Facility (CPDF)
Carol Green, Ph.D., D.A.B.T.
SRI International
Anticonvulsant Screening Program - New Countermeasures Screening Services
H. Steve White, Ph.D.
University of Utah
NIH Molecular Libraries Program: Pathways to Discovery
NIH Contacts
Inter-Agency Agreement between the National Institutes of Health and the Department of Defense
Chemicals Affecting Skin, Eyes & Mucous Membranes - Toxic Vesicants and Industrial Chemicals
Chemicals Affecting the Nervous System - Anticonvulsants and Neuroprotectants
Cyanide Diagnostics and Efficacy Testing of Next Generation Cyanide Antidotes
Chemicals Affecting the Respiratory Tract - Pulmonary Toxicants
James F. Dillman, Ph.D.
U.S. Army Medical Research Institute of Chemical Defense
* Supplemental research supported by the CounterACT Administrative Supplement Program
(Please contact PI directly for additional information about these research efforts).
Last updated March 20, 2013