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CounterACT Publications (2007)

Neurotoxic Organophosphorus Poisons (e.g. anti-convulsants, anti-seizures, neuroprotectants, nerve agent bioscavengers)

Deshpande LS, Limbrick DD Jr, Sombati S, and DeLorenzo, RJ. (2007) Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury. J Pharmacol Exp Ther 322: 443-452. Abstract

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, and DeLorenzo RJ. (2007) In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons. Epilepsy Research 75(2-3): 171-179. Abstract

Evron T, Geyer BC, Cherni I, Muralidharan M, Kilbourne J, Fletcher SP, Soreq H, and Mor TS. (2007) Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath. FASEB J. 21:2961-9. Abstract

Fleming CD, Edwards CC, Kirby SD, Maxwell DM, Potter PM, Cerasoli DM, andRedinbo MR.(2007) Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry, 46, 5063-5071. Abstract

Geyer BC, Fletcher SP, Griffin TA, Lopker MJ, Soreq H, Mor TS. (2007) Translational control of recombinant human acetylcholinesterase accumulation in plants. BMC Biotechnol. 7:27. Abstract

Harel M, Brumshtein B, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, and Sussman JL. (2007) 3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability. Arh Hig Rada Toksikol. 58(3):347-53. Abstract

Li B, Nachon F, Froment MT, Verdier L, Debouzy JC, Brasme B, Gillon E, Schopfer LM, Lockridge O, and Masson P. (2007) Binding and hydrolysis of soman by human serum albumin. Chem Res Toxicol. 21(2):421-31. Abstract

Li H, Schopfer LM, Masson P, and Lockridge O. (2007) Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers. Biochem J.411(2): 425-32.  Abstract

Martin BS and Kapur J. (2007) A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation. Epilepsia 49(2): 248-55. Abstract

Raza M, Deshpande LS, Blair RE, Carter DS, Sombati S, and DeLorenzo RJ. (2007) Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons. Neuroscience Letters 418 (1): 77-81. Abstract

Taylor P, Talley TT, Radic' Z, Hansen SB, Hibbs RE and Shi J. (2007) Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes, Biochemical Pharmacology 74 (8): 1164-1171. Abstract

Tomizawa M, Maltby D, Medzihradszky KF, Zhang N, Durkin KA, Presley J, Talley TT, Taylor P, Burlingame AL, and Casida JE. (2007) Defining nicotinic agonist binding surfaces through photoaffinity labeling. Biochemistry46: 8798-8806. Abstract

Tomizawa M, Talley TT, Maltby D, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. (2007) Mapping the elusive neonicotinoid binding site. Proc Natl Acad Sci USA 104(21): 9075-80. Abstract

 

Vesicating Agents (e.g. sulfur mustard)

Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, and Laskin JD. (2007) Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes. Carcinogenesis 29(1): 219-25. Abstract

Chen LC, Gordon RE, Laskin JD, and Laskin DL. (2007) Role of TLR04 in liver macrophage and endothelial cell responsiveness during acute endotoxemia. Exp Mol Pathol. 83(3): 311-26. Abstract

Chen LC, Laskin JD, Gordon MK, and Laskin DL. (2007) Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Exp Mol Pathol. 84(2): 145-55. Abstract

Gray JP, Heck DE, Mishin V, Smith PJ, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, and Laskin JD. (2007) Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem. 282(11):7939-49. Abstract

Fakhrzadeh L, Laskin JD, and Laskin DL. (2007) Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation. Toxicol Appl Pharmacol 227(3): 380-9. Abstract  

Sunil VR, Laumbach RJ, Patel KJ, Turpin BJ, Lim HJ, Kipen HM, Laskin JD, and Laskin DL. (2007) Pulmonary effects of inhaled limonene ozone reaction products in elderly rats. Toxicol Appl Pharmacol. 222(2):211-20. Abstract

Sunil VR, Patel KJ, Nilsen-Hamilton M, Heck DE, Laskin JD, and Laskin DL. (2007) Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp Mol Pathol. 83(2):177-87. Abstract

 

Pulmonary Agents (e.g. chlorine)

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, and Leikauf GD. (2007) Acrolein activated matrix metalloproteinase 9 contributes to persistent mucin production.  Am J Respir Cell Mol Biol. 38:446-454. Abstract

Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, Ikegami M, Wesselkamper SC, Davidson C, Dietsch M, Nichols W, Whitsett JA, and Leikauf GD. (2007) Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.  Am. J. Respir.Cell Mol. Biol. 37: 309-321. Abstract 

Song W, and Matalon S. (2007) Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates. Am J Physiol Lung Cell Mol Physiol 293: L855-L858. Abstract

Tichelaar JW, Wesselkamper SC, Chowdhury S, Yin H, Berclaz PY, Sartor MA, Leikauf GD, and Whitsett JA. (2007) Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression. Exp Lung Res. 33(8):385-417. Abstract

 

Metabolic/Cellular Toxins (e.g. cyanide)

Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL Jr, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, and Boss GR. (2007) Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp. Biol. Med. (Maywood). 232(11): 1432-40. Abstract

Crankshaw DL, Goon DJ, Briggs JE, Delong D, Kuskowski M, Patterson SE, and Nagasawa HT. (2007) A novel paradigm for accessing efficacies of potential antidotes against neurotoxins in mice. Toxicol. Lett. 175(1-3): 111-7. Abstract

Nagasawa HT, Goon DJW, Crankshaw DL, Vince R, and Patterson SE. (2007) Novel, orally effective cyanide antidotes. J. Med. Chem. 50(26): 6462-4. Abstract

 

Paralytic Neurotoxins (e.g. scorpion toxins)

Cohen L, Troub Y, Turkov M, Gilles N, Ilan N, Benveniste M, Gordon D, and Gurevitz M. (2007) Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant "insect-selective" toxins when preconditioned. Mol Pharmacol. 72(5):1220-7. Abstract

Cohen L, Ilan N, Gur M, Stuhmer W, Gordon D, Guervitz M. (2007) Design of a specific activator for skeletal muscle sodium channels uncovers channel architecture. J Biol Chem. 282(40):29424-30. Abstract

 

Diagnostics (e.g. EEG devices, OP detectors/sensors)

Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O. (2007) Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411. Anal Biochem 361(2):263-72. Abstract

Li G and Lin Y. (2007) Nanomaterial labels in electrochemical immunosensors and immunoassays. Talanta 74(3):308-317. Abstract

Li H, Schopfer LM, Nachon F, Froment MT, Masson P, and Lockridge O. (2007) Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.  Toxicol. Sci. 100: 136-145. Abstract

Liu G, Lin Y, Wang J, Wu H, Wai CM, and Lin Y. (2007) Disposable electrochemical immunosensor diagnosis device based on nanoparticle probe and immunochromatographic strip. Anal. Chem. 79:7644-53 Abstract

Liu G, Wu H, Dohnalkova A, and Lin Y. (2007) Apoferrin-templated synthesis of encoded metallic phosphate nanoparticle tags. Anal. Chem. 79:5614-19. Abstract

Liu G, Wang J, Wu H, Lin Y, and Lin Y. (2007) Nanovehicles based bioassay labels. Electroanalysis 7-8:777-785. Abstract

Nagy JO, Zhang Y, Yi W, Liu X, Motari E, Song JC, Lejeune JT, Wang PG. (2007) Glycopolydiacetylene nanoparticles as a chromatic biosensor to detect Shiga-toxin producing Escherichia coli O157:H7. Bioorg. Med. Chem. Letters 18(2): 700-3. Abstract

Wang J, Liu G, Wu H, Lin Y. (2008) Quantum-dot-based electrochemical immunoassay for high-throughput screening of the prostate-specific antigen. Small 4(1): 82-6 Abstract

Wu H, Liu G, Wang J, and Lin Y (2007) Quantum-dots based electrochemical immunoassay of interleukin-1 alpha. Electrochemistry Communications 9:1573-77. Abstract

 

 

(38 Total 2007 Publications)

CounterACT Publications (2008)

Neurotoxic Organophosphorus Poisons (e.g. anti-convulsants, anti-seizures, neuroprotectants, cholinesterase reactivators, nerve agent bioscavengers)

Aroniadou-Anderjaska V, Fritsch B, Qashu F, and Braga MF. (2008) Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy. Epilepsy Res. 78(2-3): 102-16.  Abstract

Beck JM, Hadad CM. (2008) Hydrolysis of nerve agents by model nucleophiles: A computational study. Chem Biol Interact. 175(1-3): 200-3.  Abstract

Boado RJ, Zhang Y, Zhang Y, Wang Y, Pardridge WM. (2008) IgG-Paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier. Mol Pharm. 5(6): 1037-43.  Abstract

Carter DS, Harrison AJ, Falenski KW, Blair RE, DeLorenzo RJ. (2008) Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus. Epilepsy Res. 79(2-3): 213-23.  Abstract

Colletier JP, Bourgeois D, Sanson B, Fournier D, Sussman JL, Silman I, Weik M. (2008) Shoot-and-trap: use of specific x-ray damage to study structural protein dynamics by temperature controlled cryo-crytallography. Proc Natl Acad Sci USA 105(33): 11742-7.  Abstract

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E, Delorenzo RJ. (2008) Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry. Eur J Pharmacol. 583(1): 77-83. Abstract

Deshpande LS, Nagarkatti N, Sombati S, Delorenzo RJ. (2008) The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons. Epilepsy Res 79(2-3): 158-65.  Abstract

Deshpande LS, Sun DA, Sombati S, Baranova A, Wilson MS, Attkisson E, Hamm RJ, Delorenzo RJ. (2008) Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury. Neurosci Lett 441(1): 115-9.  Abstract

Ding SJ, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O. (2008) Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin. Chem Res Toxicol. 21(9): 1787-94.  Abstract 

Geyer BC, Woods RR, Mor TS. (2008) Increased organophosphate scavenging in a butyrylcholinesterase mutant. Chem Biol Interact 175(1-3): 376-9.  Abstract

Goodkin HP, Joshi S, Mtchedlishvili Z, Brar J, and Kapur J. (2008) Subunit-specific trafficking of GABAa receptors during status epilepticus. J Neurosci. 28(10): 2527-38.  Abstract  

Gupta RD, Tawfik DS (2008) Directed enzymeevolution via small and effective neutral drift libraries. Nature Methods 5(11): 939-42.  Abstract

Li H, Tong L, Schopfer LM, Masson P, Lockridge O. (2008) Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase. Chem Biol Interact 175(1-3): 68-72.  Abstract

Lockridge O, Xue W, Gaydess A, Grigoryan H, Ding SJ, Schopfer LM, Hinrichs SH, Masson P. (2008) Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including residue 59 lysines. J Biol Chem 283(33): 22582-90.  Abstract

Nagarkatti N, Deshpande LS, Delorenzo RJ. (2008) Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. Neurosci Lett. 436(3): 289-93.  Abstract

Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. (2008) Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chem Biol Interact. 175(1-3): 161-5.  Abstract

Reeves TE, Wales ME, Grimsley JK, Li P, Cerasoli DM, Wild JR. (2008) Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities. Protein Engineering, Design & Selection 21(6): 405-412. Abstract

Sun DA, Despande LS, Sombati S, Baranova A, Wilson MS, Hamm RJ, Delorenzo RJ. (2008) Traumatic brain injury causes a long-lasting calcium (Ca(2 ))-plateau of elevated intracellular Ca levels and altered Ca(2 ) homeostatic mechanisms in hippocamplal neurons surviving brain injury. Eur J Neurosci 27(7): 1659-72. Abstract

Talley TT, Harel M, Hibbs Re, Radic Z, Tomizawa M, Casida JE, Taylor P. (2008) Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci USA 105(21): 7606-11. Abstract

Tomizawa M, Maltby D, Talley TT, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. (2008) Atypical nicotinic agonist bound conformations conferring subtype selectivity. Proc Natl Acad Sci USA 105(5): 1728-32. Abstract

Wang H, Cheng X, Taylor P, McCammon JA, Sine SM. (2008) Control of cation permeation through the nicotinic receptor channel. PLoS Comput. Biol. 4(2): e41. Abstract

Wetherington J, Serrano G, Dingledine R. (2008) Astrocytes in the epileptic brain. Neuron 58(2): 168-78. Abstract

Woods RR, Geyer BC, Mor TS. (2008) Hairy-root organ cultures for the production of human acetylcholinesterase. BMC Biotechnol. 8(1): 95.  Abstract

Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, Weik M. (2008) Induced-fit or pre-existing equlibrium dyanmics? Lessons from protein crystallography and MDsimulations on acetycholinesterase and implications for structure-based drug design. Protein Sci. 17(4): 601-5.  Abstract

Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, Sussman JL. (2008) Flexibility of aromatic residues in the active site gorge of acetylcholinesterase: X-ray versus molecular dynamics. Biophys J. 95(5): 2500-11.  Abstract

Yeung DT, Smith JR, Sweeney, RE, Lenz DE, and Cerasoli DM. (2008). A gas chromatography-mass spectrometry approach to examine stereoselective interaction of human plasma proteins with soman. J. Anal. Toxicol. 32(1): 86-91. Abstract

 

Vesicating Agents (e.g. sulfur mustard)

Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, Laskin JD. (2008) Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat. Toxicol Appl Pharmacol 231(3): 384-92.  Abstract

Black AT, Gray JP, Shakarjian MP, Mishin V, Laskin DL, Heck DE, Laskin JD. (2008) UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicol Appl Pharmacol 232(1): 14-24.  Abstract

Conlon P, Yang CJ, Wu Y, Chen Y, Martinez K, Kim Y, Stevens N, Marti AA, Jockusch S, Turro NJ, Tan W. (2008) Pyrene excimer signaling molecular beacons for probing nucleic acids. J Am Chem Soc 130(1): 336-42.  Abstract

Day BJ. (2008) Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal. 10(2): 355-70.  Abstract

Kim Y, Cao Z, Tan W. (2008) Molecular assembly for high-performance bivalent nucleic acid inhibitor. Proc Natl Acad Sci USA 105(15): 5664-9.  Abstract

Mallikaratchy P, Tang Z, Tan W. (2008) Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy. ChemMedChem 3(3): 425-8.  Abstract

Price JA, Rogers JV, McDougal JN, Shaw MQ, Reid FM, Kiser RC, Graham JS. (2008) Gene expression analysis of bromine-induced burns in porcine skin. Toxicol Lett 182(1-3): 69-78.  Abstract

O'Neill HC, Rancourt RC, White CW. (2008) Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH. Antioxidants & Redox Signaling 10(2): 277-85. Abstract

Shangguan D, Meng L, Cao ZC, Xiao Z, Fang X, Li Y, Cardonna D, Witek RP, Liu C, Tan W. (2008) Identification of liver cancer-specific aptamers using whole live cells. Anal Chem. 80(3): 721-8. Abstract

Svoboda KK, Fischman DA, Gordon MK. (2008) Embryonic chick corneal epithelium: A model system for exploring cell-matrix interactions. Dev Dyn. 237(10): 2667-75.  Abstract

Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. (2008) Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med 44(6): 1169-79. Abstract

Weinberger B, Quizon C, Vetrano AM, Archer F, Laskin JD, Laskin DL. (2008) Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4. Pediatr Res. 64(4): 393-8.  Abstract

Xiao Z, Shangguan D, Cao Z, Fang X, Tan W. (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14(6): 1769-75.  Abstract

 

Pulmonary Agents (e.g. chlorine, bromine, etc.)

Bessac BF, Jordt SE. (2008) Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda).  23:360-70.  Abstract

Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. (2008) TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest. 118(5): 1899-910. Abstract

Che MM, Conti M, Boylan M, Sciuto AM, Gordon RK, Nambiar MP. (2008) Blood and bronchoalveolar lavage fluid acetylcholinesterase levels following microinstillation inhalation exposure to sarin in guinea pigs. Inhal Toxiocl. 20(9): 821-8.  Abstract

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. (2008) EGFR-tyrosine kinase inhibitors diminish transforming growth factor-alpha induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 294(6): L1217-25. Abstract

Janciauskiene S, Nita I, Subramaniyam D, Li Q, Lancaster JR, Matalon S. (2008) Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro. Am J Respir Cell Mol Biol. 39(6):631-7.  Abstract

Leustik M, Doran S, Bracher A, Williams S, Squadrito GL, Schoeb TR, Postlethwait EM, Matalon S. (2008) Mitigation of chlorine induced lung injury by low molecular weight antioxidants. Am J Physiol Lung Cell Mol Physiol. 295(5): L733-43.  Abstract

Mongan M, Tan Z, Chen L, Peng Z, Dietsch M, Su B, Leikauf G, Xia Y. (2008) Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. Toxicol Sci 104(2): 405-11. Abstract

Panayiotidis MI, Stabler SP, Allen RH, Papa A, White CW. (2008) Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutat Res 674(1-2): 23-30.  Abstract

Tian X, Tao H, Brisolara J, Chen J, Rando RJ, Hoyle GW. (2008) Acute lung injury induced by chlorine inhalation in C57BL/6 and FVB/N mice. Inhal Toxicol. 20(9): 783-93. Abstract

 

Metabolic/Cellular Toxins (e.g. cyanide)

Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. (2008) Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J. Infect. Dis. 197(3): 457-64. Abstract

 

Paralytic Neurotoxins (e.g. scorpion toxins)

Cohen L, Lipstein N, Karbat I, Ilan N, Gilles N, Kahn R, Gordon D, Gurevitz M. (2008) Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated Na-channels. J. Biol. Chem. 283(22): 15169-76. Abstract

Schnur E, Turkov M, Kahn R, Gordon D, Gurevitz M, Anglister J. (2008) NMR analysis of interaction of Lqh-alphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel. Biochemistry 47(3): 911-21.  Abstract

Sokolov S, Kraus RL, Scheuer T, Catterall WA. (2008) Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II. Mol Pharmacol. 73(3): 1020-8.  Abstract

 

Diagnostics (e.g. EEG devices, OP detectors/biosensors)

Lee A, Liu G, Heng C, Tan S, Lim T, Lin Y. (2008) Sensitive electrochemical detection of horseradish peroxidase at disposable screen-printed carbon electrode. Electroanalysis 20(18): 2040-6. Abstract

Lin YY, Liu G, Wai CM, Lin Y. (2008) Bioelectrochemical immunoassay of polychlorinated biphenyl. Anal Chim Acta 612(1): 23-8. Abstract

Liu G, Wang J, Barry R, Petersen C, Timchalk C, Gassman PL, Lin Y. (2008) Nanoparticle-based electrochemical immunosensor for detection of phosphorylated acetylcholinesterase: An exposure biomarker of organophosphate pesticides and nerve agents. Chemistry - A European Journal 14(32): 9951-9.  Abstract

Wang H, Wang J, Timchalk C, Lin Y. (2008) Magnetic electrochemical immunoassays with quantum dot labels for sensitive detection of phosphorylated acetylcholinesterase in plasma.  Anal. Chem. 80(22): 8477-84.  Abstract

Wang J, Lin Y. (2008) Functionalized carbon nanotubes and nanofibers for biosensing applications. Trends Anal.Chem. 27(7): 619-26. Abstract  

Wang J, Liu G, Wu H, Lin Y. (2008) Quantum-dot-based electrochemical immunoassay for high-throughput screening of the prostate-specific antigen. Small 4(1): 82-6 Abstract

Wang J, Liu G, Timchalk C, Lin Y. (2008) Carbon nanotube-based electrochemical sensor for assay of salivary cholinesterase enzyme activity: an exposure biomarker of organophosphate pesticides and nerve agents. Environ. Sci. Technol. 42(7): 2688-2693. Abstract

Wu H, Huo Q, Varnum S, Wang J, Liu G, Nie Z, Liu J, Lin Y. (2008) Dye-doped silica nanoparticle labels/protein microarray for detection of protein biomarkers. Analyst 133: 1550-5. Abstract  

Wu H, Wang J, Wang Z, Fisher DR, Lin Y. (2008) Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapey of cancers. J Nanosci Nanotechnol. 8(5): 2316-22.  Abstract

 

(61 Total 2008 Publications)

 

CounterACT Publications (2009)

Neurotoxic Organophosphorus Poisons (e.g. anti-convulsants, anti-seizures, neuroprotectants, cholinesterase reactivators, nerve agent bioscavengers)

Albuquerque EX, Pereira, EF, Alkondon M, Rogers SW. (2009) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol. Rev. 89(1): 73-120.  Abstract

Alkondon M, Aracava Y, Pereira ER, Albuquerque EX. (2009) A single in vivo application of cholinesterase inhibitors has neuron type-specific effects on nicotinic receptor activity in guinea pig hippocampus. J Pharmacol Exp Ther. 328(1): 69-82.  Abstract 

Aroniadou-Anderjaska V, Figueiredo TH, Apland JP, Qashu F, Braga MF. (2009) Primary brain targets of nerve agents: the role of the amygdala in comparison to the hippocampus. Neurotoxicology [Epub ahead of print]  Abstract

Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J. (2009) Chemical synthesis of two series of nerve agent model compounds and their stereoselective interactions with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. [Epub ahead of Print]  Abstract

Blair RE, Deshpande LS, Holbert WH, Churn SB, Delorenzo RJ. (2009) Age-dependent mortality in the pilocarpine model of status epilepticus. Neurosci Lett 453(3): 233-4.  Abstract

Budai M, Chapela P, Grof P, Zimmer A, Wales ME, Wild JR, Klebovich I, Petrikovics I, Szilasi M. (2009) Physiochemical characterization of stealth liposomes encapsulating an organophosphate hydrolyzing enzyme. J Lipsome Res. 23:1-6.  Abstract

Che MM, Conti M, Chanda S, Boylan M, Sabnekar P, Rezk P, Amari E, Sciuto AM, Gordon RK, Doctor BP, Nambiar MP. (2009) Post-exposure treatment with nasal atropine methyl bromide protects against micoinstillation inhalation exposure to sarin in guinea pigs. Toxicol Appl Pharmacol. 239(3): 251-7.  Abstract

Falenski KW, Carter DS, Harrison AJ, Martin BR, Blair RE, DeLorenzo RJ. (2009) Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. Brain Res. 1262:64-72.  Abstract 

Fawcett WP, Aracava Y, Adler M, Pereira EF, Albuquerque EX. (2009) Acute toxicity of organophosphorus compounds in guinea pigs is sex and age dependent and cannot be solely accounted by acetycholinesterase inhibition. J Pharmacol Exp Ther. 328(2): 516-24.  Abstract

Fritsch B, Qashu F, Figueriredo TH, Aroniadou-Anderjaska V, Rogawski MA, Braga MF. (2009) Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis. Neuroscience 163(1): 415-29.  Abstract

Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O. (2009) Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase. Chem Res Toxicol. [Epub ahead of print]  Abstract

Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM. (2009) Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 180(3): 492-8.  Abstract

Grigoryan H, Li B, Xue W, Grigoryan M, Schopfer LM, Lockridge O. (2009) Mass spectral characterization of organophosphate-labeled lysine in peptides. Anal Biochem 394(1): 92-100.  Abstract

Grigoryan H, Lockridge O. (2009) Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxons; implications for neurotoxicity. Toxiol Appl Pharmacol [Epub ahead of print]  Abstract

Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O. (2009) Mass spectrometry identifies multiple organophosphorylated sites on tublin. Toxicol Appl Pharmacol. 240(2): 149-58.  Abstract

Gullapalli R, Aracava Y, Zhuo J, Neto EH, Wang J, Makris G, Merchenthaler I, Pereira EF, Albuquerque EX. (2009) Magnetic resonance imaging reveals that galantamine prevents structural brain damage induced by an acute exposure of guinea pigs to soman. Neurotoxicology [Epub ahead of print]  Abstract

Joshi S, Kapur J. (2009) Slow intracellular accumulation of GABAA receptor delta subunit is modulated by BDNF. Neuroscience [Epub ahead of print]  Abstract

Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, Tawfik DS. (2009) Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization. Biochemistry 48(28): 6644-54.  Abstract

Li H, Ricordel I, Tong L, Schopfer LM, Baud F, Megarbane B, Maury E, Masson P, Lockridge O. (2009) Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum. J Appl Toxicol. 29(2): 149-55.  Abstract

Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O. (2009) Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine. Toxicol Sci 107(1): 144-55.  Abstract

Nagarkatti N, Deshpande LS, Delorenzo RJ. (2009) Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis. Expert Rev Neurother 9(6): 813-24.  Abstract

Otto TC, Harsch CK, Yeung DT, Magliery TJ, Cerasoli DM, Lenz DE. (2009) Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes. Biochemistry [Epub ahead of print]  Abstract

Pereira EF, Aracava Y, Alkondon M, Akkerman M, Merchenthaler I, Albuquerque EX. (2009) Molecular and cellular actions of galantamine: Clinical implications for treatment of organophosphorus poisoning. J Mol Neurosci [Epub ahead of print]  Abstract

Qashu F, Figueiredo TH, Aroniadou-Anderjaska V, Apland, JP, Braga MF. (2009) Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis. Amino Acids [Epub ahead of print]  Abstract

Reeves TE, Paliwal S, Wales ME, Wild JR, Simonian AL. (2009) Orientation specific positioning of organophosphorus hydrolase on on solid interfaces for biosensor applications. Langmuir 25(16): 9615-8.  Abstract

Ruiz CA, Rotundo RL. (2009) Dissociation of transcription, translation, and assembly of collagen tailed acetycholinesterase in skeletal muscle. J Biol Chem 284(32): 21488-95.  Abstract

Ruiz CA, Rotundo RL. (2009) Limiting role of protein disulfide isomerase in the expression of collagen-tailed acetylcholinesterase forms in muscle. J Biol Chem  [Epub ahead of print]  Abstract

Schopfer LM, Grigoryan H, Li B, Nachon F, Masson P, Lockridge O. (2009) Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: Characteristic mass fragments and a new binding motif for organophosphates. J Chromatogr B Analyt Technol Biomed Life Sci [Epub ahead of print]  Abstract

Tokuriki N, Tawfik DS. (2009) Chaperonin overexpression promotes genetic variation and enzyme evolution. Nature 459(7247): 668-73.  Abstract

Tomizawa M, Talley TT, Park JF, Maltby D, Medzihradszky KF, Durkin KA, Cornejo-Bravo JM, Burlingame AL, Casida JE, Taylor P. (2009) Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling. J Med Chem 52(12): 3735-41.  Abstract

Zaja-Milatovic S, Gupta RC, Aschner M, Milatovic D. (2009) Protection of DFP-Induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. Toxicol Appl Pharmacol. 240(2): 124-31.  Abstract

 

Vesicating Agents (e.g. sulfur mustard)

Day BJ. (2009) Catalase and glutathione peroxidase mimics. Biochem Pharmacol. 77(3): 285-96. Abstract

Chang YC, Sabourin CL, Lu SE, Sasaki T, Svoboda KK, Gordon MK, Riley DJ, Casillas RP, Gerecke DR. (2009) Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model. J Biochem Mol Toxicol. 23(3): 172-184.  Abstract

Gerecke DR, Chen M, Isukapalli SS, Gordon MK, Chang YC, Tong W, Androulakis IP, Georgopoulos PG. (2009) Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect. Toxicol Appl Pharmacol. 234(2): 156-65.  Abstract

Gordon MK, Hahn RA. (2009) Collagens. Cell Tissue Res. [Epub ahead of print]  Abstract

Gould N, White CW, Day BJ. (2009) A role for mitochondrial oxidative stress in sulfur mustard analog CEES-induced lung cell injury and antioxidant protection.  J Pharmacol Exp Ther  328(3): 732-9.  Abstract

Laskin DL. (2009) Macrophages and inflammatory mediators in chemical toxicity: A battle of forces. Chem Res Toxicol. [Epub ahead of print]  Abstract

Pal A, Tewari-Singh N, Gu M, Agarwal C, Huang J, Day BJ, White CW, Agarwal R. (2009) Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. Free Radic Biol Med. [Epub ahead of print]  Abstract

Roberts RA, Laskin DL, Smith CV, Robertson FM, Allen EM, Doorn JA, Slikker W. (2009) Nitrative and oxidative stress in toxicology and disease. Toxicol Sci. [Epub ahead of print]  Abstract

Stabler SP, Sekhar J, Allen RH, O'Neill HC, White CW. (2009) Alpha-lipoic acid induced eleveated s-adenosylhomocysteine and depleted s-adenosylmethionine. Free Radic Biol Med 47(8): 1147-53.  Abstract

Sunil VR, Patel KJ, Mainelis G, Turpin BJ, Ridgely S, Laumbach RJ, Kipen HM, Nazarenko Y, Veleeparambil M, Gow AJ, Laskin JD, Laskin DL. (2009) Pulmonary effects of inhaled diesel exhaust in aged mice. Toxicol Appl Pharmacol [Epub ahead of print]  Abstract

Tewari-Singh N, Rana S, Gu M, Pal A, Orlicky DJ, White CW, Agarwal R. (2009) Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES)-induced skin injury in SKH-1 hairless mice. Toxicol Sci. 108(1): 194-206.  Abstract

 

Pulmonary Agents (e.g. chlorine, bromine, etc.)

Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor M, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD. (2009) Surfactant associated protein B is critical to survival in nickel-induced injury in mice. Am J Respir Cell Mol Biol. 41(2): 226-36.  Abstract

Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE. (2009) Transient receptor potential ankyrin 1 antagonist block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 23(4):1102-14.  Abstract

Caceres AI, Brackmann M, Elie MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. (2009) A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Nat Acad Sci.106(22): 9099-104.  Abstract

Chang W, Chen J, Schlueter CF, Hoyle GW. (2009) Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung eputhelial and endothelial cells. Exp Lung Res 35(4):324-43.  Abstract

Chen L, Song W, Davis IC, Shrestha K, Schwiebert E, Sullender WM, Matalon S. (2009) Inhibition of Na transport in lung epithelial cells by respiratory syncytial virus infection. Am J Respir Cell Mol Biol. 40(5):588-600.  Abstract

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. (2009) Matrix metalloproteinase (MMP) 14 mediates a phenotypic shift in airways to increase mucin production. Am J Respir Crit Care Med. [Epub ahead of print]  Abstract

Ganguly K, Depner M, Fattman C, Bein K, Oury TD, Wesselkamper SC, Borchers MT, Schreiber M, Gao F, Mutius EV, Kabesch M, Leikauf GD, Schulz H. (2009) Superoxide dismutase 3, extracellular (SOD3) variants and lung function. Physiol Genomics. 37(3):260-7.  Abstract

Ji HL, Song W, Gao Z, Su XF, Nie HG, Jiang Y, Peng JB, He YX, Liao Y, Zhou YJ, Tousson A, Matalon S. (2009) SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms. Am J Physiol Lung Cell Mol Physiol. 296(3): L372-83.  Abstract

Jurkuvenaite A, Chen L, Bartoszewski R, Goldstein R, Bebok Z, Matalon S, Collawn JF. (2009) Functional stability of rescued delta-F808 cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. Am J Respir Cell Mol Biol. [Epub ahead of print]  Abstract

Lazrak A, Iles KE, Liu G, Noah DL, Noah JW, Matalon S. (2009) Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species. FASEB J. [Epub ahead of Print]  Abstract

Lazrak A, Nita I, Subramaniyam D, Wei S, Song W, Ji H, Janciauskiene S, Matalon S. (2009) Alpha1-antitrypsin inhibits epithelial Na transport in vitro and in vivo. Am J Respir Cell Mol Biol. 41(3): 261-70.  Abstract

Matalon S, Shrestha K, Kirk M, Waldheuser S, McDonald B, Smith K, Gao Z, Belaaouaj A, Crouch EC. (2009) Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo. FASEB J. 23(5):1415-30.  Abstract

Nemec AA, Leikauf GD, Pitt BR, Wasserloos KJ, Barchowsky A. (2009) Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. Am J Respir Cell Mol Biol. 41(1): 69-75.  Abstract

Sartor MA, Leikauf GD, Medvedovic M. (2009) LRpath: A logistic regression approach for identifying enriched biological groups in gene expression data. Bioinformatics 25(2):211-7.  Abstract

Song W, Liu G, Bosworth CA, Walker JR, Megaw GA, Lazrak A, Abraham E, Sullender WM, Matalon S. (2009) Respiratory syncytial virus inhibits lung ENaC by upregulating iNOS. J Biol Chem. 284(11): 7294-306.  Abstract

Vitturi DA, Teng X, Toledo JC, Matalon S, Lancaster Jr J, Patel, RP. (2009) Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation. Am J Physiol Heart Circ Physiol. 296(5):H1398-407.  Abstract

 

Metabolic/Cellular Toxins (e.g. cyanide)

Lee J, Keuter KA, Kim J, Tran A, Uppal A, Mukai D, Mahon SB, Cancio LC, Batchinsky A, Tromberg BJ, Brenner M. (2009) Noninvasive in vivo monitoring of cyanide toxicity and treatment using diffuse optical spectroscopy in a rabbit model. Mil Med. 174(6): 615-21.  Abstract

Logue BA, Maserek WK, Rockwood GA, Keebaugh MW, Baskin SI (2009) The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers. Toxicology Mechanisms and Methods 19(3): 202-208.  Abstract

Petrikovics I, Budai M, Baskin SI, Rockwood GA, Childress J, Budai L, Grof P, Klebovich I, Szilasi M. (2009) Characterization of a liposomal vesicles encapsulating rhodanese for cyanide antagonism. Drug Deliv 16(6): 312-9.  Abstract 

Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. (2009) The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J Biol Chem. 284(6): 3521-8.  Abstract

Zottola MA. (2009) A partial exploration of the potential energy surfaces of SCN and HSCN: Implications for the enzyme-mediated detoxification of cyanide. J Mol Graph Model [Epub ahead of print]  Abstract

 

Paralytic Neurotoxins (e.g. scorpion toxins)

Kahn R, Karbat I, Ilan N, Cohen L, Sokolov S, Catterall WA, Gordon D, Gurevitz M. (2009) Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins. J Biol Chem 284(31): 20684-91.  Abstract

 

Diagnostics (e.g. EEG devices, OP detectors/biosensors)

Barry RC, Lin Y, Wang J, Liu G, Timchalk CA. (2009) Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures. J Expo Sci Environ Epidemiol. 19(1):1-18.  Abstract

Wang H, Wang J, Choi D, Tang Z, Wu H, Lin Y. (2009) EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation.  Biosens Bioelectron  24(8):2377-89.  Abstract

 

(66 Total 2009 Publications)

 

Last updated November 10, 2009