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Research @ NINDS
Scientific Contacts
David A. Jett, Ph.D.
Program Director
National Institutes of Health, NINDS
6001 Executive Blvd.
NSC, Room 2177, MSC 9535
Bethesda, MD 20892-9535
Phone: 301-496-6035

D. Yeung, Ph.D.
Project Manager
National Institute of Health, NINDS
6001 Executive Blvd.
NSC, Room 2195A, MSC 9527
Bethesda, MD 20892-9527
Tel: 301-443-7534

Margaret Ochocinska, Ph.D.
Program Specialist
National Institutes of Health, NINDS
6001 Executive Blvd.
NSC, Room 2228
Bethesda, MD 20892
Phone: 301-451-8342

CounterACT Publications (2007)

Neurotoxic Agents 

Deshpande LS, Limbrick DD Jr, Sombati S, and DeLorenzo, RJ. (2007) Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury. J Pharmacol Exp Ther 322: 443-452. Abstract

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, and DeLorenzo RJ. (2007) In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons. Epilepsy Research 75(2-3): 171-179. Abstract

Evron T, Geyer BC, Cherni I, Muralidharan M, Kilbourne J, Fletcher SP, Soreq H, and Mor TS. (2007) Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath. FASEB J. 21:2961-9. Abstract

Fleming CD, Edwards CC, Kirby SD, Maxwell DM, Potter PM, Cerasoli DM, and Redinbo MR. (2007) Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry, 46, 5063-5071. Abstract

Geyer BC, Fletcher SP, Griffin TA, Lopker MJ, Soreq H, Mor TS. (2007) Translational control of recombinant human acetylcholinesterase accumulation in plants. BMC Biotechnol. 7:27. Abstract

Harel M, Brumshtein B, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, and Sussman JL. (2007) 3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability. Arh Hig Rada Toksikol. 58(3):347-53. Abstract

Li B, Nachon F, Froment MT, Verdier L, Debouzy JC, Brasme B, Gillon E, Schopfer LM, Lockridge O, and Masson P. (2007) Binding and hydrolysis of soman by human serum albumin. Chem Res Toxicol. 21(2):421-31. Abstract

Li H, Schopfer LM, Masson P, and Lockridge O. (2007) Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers. Biochem J.411(2): 425-32.   Abstract

Martin BS and Kapur J. (2007) A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation. Epilepsia 49(2): 248-55. Abstract

McCulla RD, Gohar GA, Hadad CM, Platz MS. (2007) Computational study of the Curtius-like rearrangements of phosphoryl, phosphinyl, and phosphinoyl azides and their corresponding nitrenes. J Org Chem 72(25): 9426-38.  Abstract

Raza M, Deshpande LS, Blair RE, Carter DS, Sombati S, and DeLorenzo RJ. (2007) Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons. Neuroscience Letters 418 (1): 77-81. Abstract

Taylor P, Talley TT, Radic' Z, Hansen SB, Hibbs RE and Shi J. (2007) Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes, Biochemical Pharmacology 74 (8): 1164-1171. Abstract

Tomizawa M, Maltby D, Medzihradszky KF, Zhang N, Durkin KA, Presley J, Talley TT, Taylor P, Burlingame AL, and Casida JE. (2007) Defining nicotinic agonist binding surfaces through photoaffinity labeling. Biochemistry 46: 8798-8806. Abstract

Tomizawa M, Talley TT, Maltby D, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. (2007) Mapping the elusive neonicotinoid binding site. Proc Natl Acad Sci USA 104(21): 9075-80. Abstract


Vesicating Agents

Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, and Laskin JD. (2007) Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes. Carcinogenesis 29(1): 219-25. Abstract

Chen LC, Gordon RE, Laskin JD, and Laskin DL. (2007) Role of TLR04 in liver macrophage and endothelial cell responsiveness during acute endotoxemia. Exp Mol Pathol. 83(3): 311-26. Abstract

Chen LC, Laskin JD, Gordon MK, and Laskin DL. (2007) Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Exp Mol Pathol. 84(2): 145-55. Abstract

Gray JP, Heck DE, Mishin V, Smith PJ, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, and Laskin JD. (2007) Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem. 282(11):7939-49. Abstract

Fakhrzadeh L, Laskin JD, and Laskin DL. (2007) Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation. Toxicol Appl Pharmacol 227(3): 380-9. Abstract  

Sunil VR, Laumbach RJ, Patel KJ, Turpin BJ, Lim HJ, Kipen HM, Laskin JD, and Laskin DL. (2007) Pulmonary effects of inhaled limonene ozone reaction products in elderly rats. Toxicol Appl Pharmacol. 222(2):211-20. Abstract

Sunil VR, Patel KJ, Nilsen-Hamilton M, Heck DE, Laskin JD, and Laskin DL. (2007) Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp Mol Pathol. 83(2):177-87. Abstract


Pulmonary Agents 

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, and Leikauf GD. (2007) Acrolein activated matrix metalloproteinase 9 contributes to persistent mucin production.  Am J Respir Cell Mol Biol. 38:446-454. Abstract

Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, Ikegami M, Wesselkamper SC, Davidson C, Dietsch M, Nichols W, Whitsett JA, and Leikauf GD. (2007) Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.  Am. J. Respir.Cell Mol. Biol. 37: 309-321. Abstract 

Song W, and Matalon S. (2007) Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates. Am J Physiol Lung Cell Mol Physiol 293: L855-L858. Abstract

Tichelaar JW, Wesselkamper SC, Chowdhury S, Yin H, Berclaz PY, Sartor MA, Leikauf GD, and Whitsett JA. (2007) Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression. Exp Lung Res. 33(8):385-417. Abstract


Metabolic/Cellular Poisons 

Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL Jr, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, and Boss GR. (2007) Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp. Biol. Med. (Maywood). 232(11): 1432-40. Abstract

Crankshaw DL, Goon DJ, Briggs JE, Delong D, Kuskowski M, Patterson SE, and Nagasawa HT. (2007) A novel paradigm for accessing efficacies of potential antidotes against neurotoxins in mice. Toxicol. Lett. 175(1-3): 111-7. Abstract

Nagasawa HT, Goon DJW, Crankshaw DL, Vince R, and Patterson SE. (2007) Novel, orally effective cyanide antidotes. J. Med. Chem. 50(26): 6462-4. Abstract


Paralytic Neurotoxins 

Cohen L, Troub Y, Turkov M, Gilles N, Ilan N, Benveniste M, Gordon D, and Gurevitz M. (2007) Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant "insect-selective" toxins when preconditioned. Mol Pharmacol. 72(5):1220-7. Abstract

Cohen L, Ilan N, Gur M, Stuhmer W, Gordon D, Guervitz M. (2007) Design of a specific activator for skeletal muscle sodium channels uncovers channel architecture. J Biol Chem. 282(40):29424-30. Abstract



Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O. (2007) Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411. Anal Biochem 361(2):263-72. Abstract

Li G and Lin Y. (2007) Nanomaterial labels in electrochemical immunosensors and immunoassays. Talanta 74(3):308-317. Abstract

Li H, Schopfer LM, Nachon F, Froment MT, Masson P, and Lockridge O. (2007) Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.  Toxicol. Sci. 100: 136-145. Abstract

Liu G, Lin Y, Wang J, Wu H, Wai CM, and Lin Y. (2007) Disposable electrochemical immunosensor diagnosis device based on nanoparticle probe and immunochromatographic strip. Anal. Chem. 79:7644-53 Abstract

Liu G, Wu H, Dohnalkova A, and Lin Y. (2007) Apoferrin-templated synthesis of encoded metallic phosphate nanoparticle tags. Anal. Chem. 79:5614-19. Abstract

Liu G, Wang J, Wu H, Lin Y, and Lin Y. (2007) Nanovehicles based bioassay labels. Electroanalysis 7-8:777-785. Abstract

Nagy JO, Zhang Y, Yi W, Liu X, Motari E, Song JC, Lejeune JT, Wang PG. (2007) Glycopolydiacetylene nanoparticles as a chromatic biosensor to detect Shiga-toxin producing Escherichia coli O157:H7. Bioorg. Med. Chem. Letters 18(2): 700-3. Abstract

Wang J, Liu G, Wu H, Lin Y. (2008) Quantum-dot-based electrochemical immunoassay for high-throughput screening of the prostate-specific antigen. Small 4(1): 82-6 Abstract

Wu H, Liu G, Wang J, and Lin Y (2007) Quantum-dots based electrochemical immunoassay of interleukin-1 alpha. Electrochemistry Communications 9:1573-77. Abstract



(39 Total 2007 Publications)

CounterACT Publications (2008)

Neurotoxic Agents 

Aroniadou-Anderjaska V, Fritsch B, Qashu F, and Braga MF. (2008) Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy. Epilepsy Res. 78(2-3): 102-16.  Abstract

Beck JM, Hadad CM. (2008) Hydrolysis of nerve agents by model nucleophiles: A computational study. Chem Biol Interact. 175(1-3): 200-3.  Abstract

Boado RJ, Zhang Y, Zhang Y, Wang Y, Pardridge WM. (2008) IgG-Paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier. Mol Pharm. 5(6): 1037-43.  Abstract

Carter DS, Harrison AJ, Falenski KW, Blair RE, DeLorenzo RJ. (2008) Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus. Epilepsy Res. 79(2-3): 213-23.  Abstract

Colletier JP, Bourgeois D, Sanson B, Fournier D, Sussman JL, Silman I, Weik M. (2008) Shoot-and-trap: use of specific x-ray damage to study structural protein dynamics by temperature controlled cryo-crytallography. Proc Natl Acad Sci USA 105(33): 11742-7.  Abstract

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E, Delorenzo RJ. (2008) Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry. Eur J Pharmacol. 583(1): 77-83.  Abstract

Deshpande LS, Nagarkatti N, Sombati S, Delorenzo RJ. (2008) The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons. Epilepsy Res 79(2-3): 158-65.  Abstract

Deshpande LS, Sun DA, Sombati S, Baranova A, Wilson MS, Attkisson E, Hamm RJ, Delorenzo RJ. (2008) Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury. Neurosci Lett 441(1): 115-9.  Abstract

Ding SJ, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O. (2008) Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin. Chem Res Toxicol. 21(9): 1787-94.  Abstract 

Geyer BC, Woods RR, Mor TS. (2008) Increased organophosphate scavenging in a butyrylcholinesterase mutant. Chem Biol Interact 175(1-3): 376-9.  Abstract

Goodkin HP, Joshi S, Mtchedlishvili Z, Brar J, and Kapur J. (2008) Subunit-specific trafficking of GABAa receptors during status epilepticus. J Neurosci. 28(10): 2527-38.  Abstract  

Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O. (2008) Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropylfluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanisms of long term toxicity by organophosphorus agents. Chem Biol Interact 175(1-3): 180-6.  Abstract

Gupta RD, Tawfik DS (2008) Directed enzymeevolution via small and effective neutral drift libraries. Nature Methods 5(11): 939-42.  Abstract

Li H, Tong L, Schopfer LM, Masson P, Lockridge O. (2008) Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase. Chem Biol Interact 175(1-3): 68-72.  Abstract

Lockridge O, Xue W, Gaydess A, Grigoryan H, Ding SJ, Schopfer LM, Hinrichs SH, Masson P. (2008) Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including residue 59 lysines. J Biol Chem 283(33): 22582-90.  Abstract

Nagarkatti N, Deshpande LS, Delorenzo RJ. (2008) Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. Neurosci Lett. 436(3): 289-93.  Abstract

Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. (2008) Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chem Biol Interact. 175(1-3): 161-5.  Abstract

Reeves TE, Wales ME, Grimsley JK, Li P, Cerasoli DM, Wild JR. (2008) Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities. Protein Engineering, Design & Selection 21(6): 405-412. Abstract

Sun DA, Despande LS, Sombati S, Baranova A, Wilson MS, Hamm RJ, Delorenzo RJ. (2008) Traumatic brain injury causes a long-lasting calcium (Ca(2+))-plateau of elevated intracellular Ca levels and altered Ca(2+) homeostatic mechanisms in hippocamplal neurons surviving brain injury. Eur J Neurosci 27(7): 1659-72. Abstract

Talley TT, Harel M, Hibbs Re, Radic Z, Tomizawa M, Casida JE, Taylor P. (2008) Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci USA 105(21): 7606-11. Abstract

Tomizawa M, Maltby D, Talley TT, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. (2008) Atypical nicotinic agonist bound conformations conferring subtype selectivity. Proc Natl Acad Sci USA 105(5): 1728-32. Abstract

Vyas S, Hadad CM. (2008) Reactivation of model cholinesterases by oximes and intermediate phosphyloximes: a computational study. Chem Biol Interact 175(1-3): 187-91.  Abstract

Wang H, Cheng X, Taylor P, McCammon JA, Sine SM. (2008) Control of cation permeation through the nicotinic receptor channel. PLoS Comput. Biol. 4(2): e41. Abstract

Wetherington J, Serrano G, Dingledine R. (2008) Astrocytes in the epileptic brain. Neuron 58(2): 168-78. Abstract

Woods RR, Geyer BC, Mor TS. (2008) Hairy-root organ cultures for the production of human acetylcholinesterase. BMC Biotechnol. 8(1): 95.  Abstract

Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, Weik M. (2008) Induced-fit or pre-existing equlibrium dyanmics? Lessons from protein crystallography and MDsimulations on acetycholinesterase and implications for structure-based drug design. Protein Sci. 17(4): 601-5.  Abstract

Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, Sussman JL. (2008) Flexibility of aromatic residues in the active site gorge of acetylcholinesterase: X-ray versus molecular dynamics. Biophys J. 95(5): 2500-11.  Abstract

Yeung DT, Smith JR, Sweeney, RE, Lenz DE, and Cerasoli DM. (2008). A gas chromatography-mass spectrometry approach to examine stereoselective interaction of human plasma proteins with soman. J. Anal. Toxicol. 32(1): 86-91. Abstract


Vesicating Agents 

Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, Laskin JD. (2008) Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat. Toxicol Appl Pharmacol 231(3): 384-92.  Abstract

Black AT, Gray JP, Shakarjian MP, Mishin V, Laskin DL, Heck DE, Laskin JD. (2008) UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicol Appl Pharmacol 232(1): 14-24.  Abstract

Conlon P, Yang CJ, Wu Y, Chen Y, Martinez K, Kim Y, Stevens N, Marti AA, Jockusch S, Turro NJ, Tan W. (2008) Pyrene excimer signaling molecular beacons for probing nucleic acids. J Am Chem Soc 130(1): 336-42.  Abstract

Day BJ. (2008) Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal. 10(2): 355-70.  Abstract

Kim Y, Cao Z, Tan W. (2008) Molecular assembly for high-performance bivalent nucleic acid inhibitor. Proc Natl Acad Sci USA 105(15): 5664-9.  Abstract

Mallikaratchy P, Tang Z, Tan W. (2008) Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy. ChemMedChem 3(3): 425-8.  Abstract

Price JA, Rogers JV, McDougal JN, Shaw MQ, Reid FM, Kiser RC, Graham JS. (2008) Gene expression analysis of bromine-induced burns in porcine skin. Toxicol Lett 182(1-3): 69-78.  Abstract

O'Neill HC, Rancourt RC, White CW. (2008) Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH. Antioxidants & Redox Signaling 10(2): 277-85. Abstract

Shangguan D, Meng L, Cao ZC, Xiao Z, Fang X, Li Y, Cardonna D, Witek RP, Liu C, Tan W. (2008) Identification of liver cancer-specific aptamers using whole live cells. Anal Chem. 80(3): 721-8. Abstract

Svoboda KK, Fischman DA, Gordon MK. (2008) Embryonic chick corneal epithelium: A model system for exploring cell-matrix interactions. Dev Dyn. 237(10): 2667-75.  Abstract

Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. (2008) Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med 44(6): 1169-79. Abstract

Weinberger B, Quizon C, Vetrano AM, Archer F, Laskin JD, Laskin DL. (2008) Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4. Pediatr Res. 64(4): 393-8.  Abstract

Xiao Z, Shangguan D, Cao Z, Fang X, Tan W. (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14(6): 1769-75.  Abstract


Pulmonary Agents 

Bessac BF, Jordt SE. (2008) Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda).  23:360-70.  Abstract

Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. (2008) TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest. 118(5): 1899-910. Abstract

Che MM, Conti M, Boylan M, Sciuto AM, Gordon RK, Nambiar MP. (2008) Blood and bronchoalveolar lavage fluid acetylcholinesterase levels following microinstillation inhalation exposure to sarin in guinea pigs. Inhal Toxiocl. 20(9): 821-8.  Abstract

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. (2008) EGFR-tyrosine kinase inhibitors diminish transforming growth factor-alpha induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 294(6): L1217-25. Abstract

Janciauskiene S, Nita I, Subramaniyam D, Li Q, Lancaster JR, Matalon S. (2008) Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro. Am J Respir Cell Mol Biol. 39(6):631-7.  Abstract

Leustik M, Doran S, Bracher A, Williams S, Squadrito GL, Schoeb TR, Postlethwait EM, Matalon S. (2008) Mitigation of chlorine induced lung injury by low molecular weight antioxidants. Am J Physiol Lung Cell Mol Physiol. 295(5): L733-43.  Abstract

Mongan M, Tan Z, Chen L, Peng Z, Dietsch M, Su B, Leikauf G, Xia Y. (2008) Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. Toxicol Sci 104(2): 405-11. Abstract

Panayiotidis MI, Stabler SP, Allen RH, Papa A, White CW. (2008) Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutat Res 674(1-2): 23-30.  Abstract

Tian X, Tao H, Brisolara J, Chen J, Rando RJ, Hoyle GW. (2008) Acute lung injury induced by chlorine inhalation in C57BL/6 and FVB/N mice. Inhal Toxicol. 20(9): 783-93. Abstract


Metabolic/Cellular Poisons 

Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. (2008) Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J. Infect. Dis. 197(3): 457-64. Abstract


Paralytic Neurotoxins 

Cohen L, Lipstein N, Karbat I, Ilan N, Gilles N, Kahn R, Gordon D, Gurevitz M. (2008) Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated Na-channels. J. Biol. Chem. 283(22): 15169-76. Abstract

Schnur E, Turkov M, Kahn R, Gordon D, Gurevitz M, Anglister J. (2008) NMR analysis of interaction of Lqh-alphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel. Biochemistry 47(3): 911-21.  Abstract

Sokolov S, Kraus RL, Scheuer T, Catterall WA. (2008) Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II. Mol Pharmacol. 73(3): 1020-8.  Abstract



Lee A, Liu G, Heng C, Tan S, Lim T, Lin Y . (2008) Sensitive electrochemical detection of horseradish peroxidase at disposable screen-printed carbon electrode. Electroanalysis 20(18): 2040-6.  Abstract

Lin YY, Liu G, Wai CM, Lin Y. (2008) Bioelectrochemical immunoassay of polychlorinated biphenyl. Anal Chim Acta 612(1): 23-8. Abstract

Liu G, Wang J, Barry R, Petersen C, Timchalk C, Gassman PL, Lin Y. (2008) Nanoparticle-based electrochemical immunosensor for detection of phosphorylated acetylcholinesterase: An exposure biomarker of organophosphate pesticides and nerve agents. Chemistry - A European Journal 14(32): 9951-9.  Abstract

Wang H, Wang J, Timchalk C, Lin Y. (2008) Magnetic electrochemical immunoassays with quantum dot labels for sensitive detection of phosphorylated acetylcholinesterase in plasma.  Anal. Chem. 80(22): 8477-84.  Abstract

Wang J, Lin Y. (2008) Functionalized carbon nanotubes and nanofibers for biosensing applications. Trends Anal.Chem. 27(7): 619-26. Abstract  

Wang J, Liu G, Wu H, Lin Y. (2008) Quantum-dot-based electrochemical immunoassay for high-throughput screening of the prostate-specific antigen. Small 4(1): 82-6 Abstract

Wang J, Liu G, Timchalk C, Lin Y. (2008) Carbon nanotube-based electrochemical sensor for assay of salivary cholinesterase enzyme activity: an exposure biomarker of organophosphate pesticides and nerve agents. Environ. Sci. Technol. 42(7): 2688-2693. Abstract

Wu H, Huo Q, Varnum S, Wang J, Liu G, Nie Z, Liu J, Lin Y. (2008) Dye-doped silica nanoparticle labels/protein microarray for detection of protein biomarkers. Analyst 133: 1550-5. Abstract  

Wu H, Wang J, Wang Z, Fisher DR, Lin Y. (2008) Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapey of cancers. J Nanosci Nanotechnol. 8(5): 2316-22.  Abstract


(63 Total 2008 Publications)

CounterACT Publications (2009)

Neurotoxic Agents 

Albuquerque EX, Pereira EF, Alkondon M, Rogers SW. (2009) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol. Rev. 89(1): 73-120.  Abstract

Alkondon M, Aracava Y, Pereira EF, Albuquerque EX. (2009) A single in vivo application of cholinesterase inhibitors has neuron type-specific effects on nicotinic receptor activity in guinea pig hippocampus. J Pharmacol Exp Ther. 328(1): 69-82.  Abstract 

Aracava Y, Pereira EF, Akkerman M, Adler M, Albuquerque EX. (2009) Effectiveness of donepezil, rivastigmine, and (+/-) huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine. J Pharmacol Exp Ther. 331(3): 1014-24.  Abstract

Aroniadou-Anderjaska V, Figueiredo TH, Apland JP, Qashu F, Braga MF. (2009) Primary brain targets of nerve agents: the role of the amygdala in comparison to the hippocampus. Neurotoxicology 30(5): 772-6.  Abstract

Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J. (2009) Chemical synthesis of two series of nerve agent model compounds and their stereoselective interactions with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 22(10): 1669-79.  Abstract

Blair RE, Deshpande LS, Holbert WH, Churn SB, Delorenzo RJ. (2009) Age-dependent mortality in the pilocarpine model of status epilepticus. Neurosci Lett 453(3): 233-4.  Abstract

Budai M, Chapela P, Grof P, Zimmer A, Wales ME, Wild JR, Klebovich I, Petrikovics I, Szilasi M. (2009) Physiochemical characterization of stealth liposomes encapsulating an organophosphate hydrolyzing enzyme. J Lipsome Res. 23:1-6.  Abstract

Che MM, Conti M, Chanda S, Boylan M, Sabnekar P, Rezk P, Amari E, Sciuto AM, Gordon RK, Doctor BP, Nambiar MP. (2009) Post-exposure treatment with nasal atropine methyl bromide protects against micoinstillation inhalation exposure to sarin in guinea pigs. Toxicol Appl Pharmacol. 239(3): 251-7.  Abstract

Conti ML, Che MM, Boylan M, Sciuto AM, Gordon RK, Nambiar MP. (2009) Acute microinstillation inhalation exposure to sarin induces changes in respiratory dynamics and functions in guinea pigs. Int J Toxicol. 28(5): 436-47.  Abstract 

Falenski KW, Carter DS, Harrison AJ, Martin BR, Blair RE, DeLorenzo RJ. (2009) Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. Brain Res. 1262:64-72.  Abstract 

Fawcett WP, Aracava Y, Adler M, Pereira EF, Albuquerque EX. (2009) Acute toxicity of organophosphorus compounds in guinea pigs is sex and age dependent and cannot be solely accounted by acetycholinesterase inhibition. J Pharmacol Exp Ther. 328(2): 516-24.  Abstract

Fritsch B, Qashu F, Figueriredo TH, Aroniadou-Anderjaska V, Rogawski MA, Braga MF. (2009) Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis. Neuroscience 163(1): 415-29.  Abstract

Gaidukov L, Bar D, Yacobson S, Naftali E, Kaufman O, Tabakman R, Tawfik DS, Levy-Nissenbaum E. (2009) In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes. BMC Clin Pharmacol. 9(1): 18.  Abstract

Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O. (2009) Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase. Chem Res Toxicol. 22(10): 1680-8.  Abstract

Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM. (2009) Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 180(3): 492-8.  Abstract

Grigoryan H, Li B, Xue W, Grigoryan M, Schopfer LM, Lockridge O. (2009) Mass spectral characterization of organophosphate-labeled lysine in peptides. Anal Biochem 394(1): 92-100.  Abstract

Grigoryan H, Lockridge O. (2009) Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxons; implications for neurotoxicity. Toxiol Appl Pharmacol 240(2): 143-8. Abstract

Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O. (2009) Mass spectrometry identifies multiple organophosphorylated sites on tublin. Toxicol Appl Pharmacol. 240(2): 149-58.  Abstract

Joshi S, Kapur J. (2009) Slow intracellular accumulation of GABAA receptor delta subunit is modulated by BDNF. Neuroscience 164(2):507-19.  Abstract

Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, Tawfik DS. (2009) Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization. Biochemistry 48(28): 6644-54.  Abstract

Lavinder JJ, Hari SB, Sullivan BJ, Magliery TJ. (2009) High-throughput thermal scanning: a general, rapid dye-binding thermal shift screen for protein engineering. J Am Chem Soc 131(11): 3794-5.  Abstract

Lehmukuhle MJ, Thomson KE, Scheerlinck P, Pouliot W, Greger B, Dudek FE. (2009) A simple quantitative method of analyzing electrographic status epilepticus in rats. J Neurophysiol 101: 1660-70.  Abstract

Li H, Ricordel I, Tong L, Schopfer LM, Baud F, Megarbane B, Maury E, Masson P, Lockridge O. (2009) Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum. J Appl Toxicol. 29(2): 149-55.  Abstract

Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O. (2009) Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine. Toxicol Sci 107(1): 144-55.  Abstract

Nagarkatti N, Deshpande LS, Delorenzo RJ. (2009) Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis. Expert Rev Neurother 9(6): 813-24.  Abstract

Otto TC, Harsch CK, Yeung DT, Magliery TJ, Cerasoli DM, Lenz DE. (2009) Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes. Biochemistry 48(43): 10416-22.  Abstract

Reeves TE, Paliwal S, Wales ME, Wild JR, Simonian AL. (2009) Orientation specific positioning of organophosphorus hydrolase on on solid interfaces for biosensor applications. Langmuir 25(16): 9615-8.  Abstract

Ruiz CA, Rotundo RL. (2009) Dissociation of transcription, translation, and assembly of collagen tailed acetycholinesterase in skeletal muscle. J Biol Chem 284(32): 21488-95.  Abstract

Ruiz CA, Rotundo RL. (2009) Limiting role of protein disulfide isomerase in the expression of collagen-tailed acetylcholinesterase forms in muscle. J Biol Chem  284(46): 31753-63.  Abstract

Tokuriki N, Tawfik DS. (2009) Chaperonin overexpression promotes genetic variation and enzyme evolution. Nature 459(7247): 668-73.  Abstract

Tomizawa M, Talley TT, Park JF, Maltby D, Medzihradszky KF, Durkin KA, Cornejo-Bravo JM, Burlingame AL, Casida JE, Taylor P. (2009) Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling. J Med Chem 52(12): 3735-41.  Abstract

Voskresenska V, Wilson RM, Panov M, Tarnovsky AN, Krause JA, Vyas S, Winter AH, Hadad CM. (2009) Photoaffinity labeling via nitrenium ion chemistry: protonation of the nitrene derived from 4-amino-3-nitrophenyl azide to afford reactive nitrenium ion pairs. J Am Chem Soc. 131(32): 11535-47.  Abstract

Weiner L, Shnyrov VL, Konstantinovskii L, Roth E, Ashani Y, Silman I. (2009) Stabilization of Torpedo californica acetycholinerase by reversible inhibitors. Biochemistry 48(3): 563-74.  Abstract

Zaja-Milatovic S, Gupta RC, Aschner M, Milatovic D. (2009) Protection of DFP-Induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. Toxicol Appl Pharmacol. 240(2): 124-31.  Abstract


Vesicating Agents 

Anumolu SS, Desantis AS, Menjoge AR, Hahn RA, Beloni JA, Gordon MK, Sinko PJ. (2009) Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-indcued ocular wounds. Biomaterials 31(5): 964-74.  Abstract

Day BJ. (2009) Catalase and glutathione peroxidase mimics. Biochem Pharmacol. 77(3): 285-96. Abstract

Chang YC, Sabourin CL, Lu SE, Sasaki T, Svoboda KK, Gordon MK, Riley DJ, Casillas RP, Gerecke DR. (2009) Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model. J Biochem Mol Toxicol. 23(3): 172-184.  Abstract

Gerecke DR, Chen M, Isukapalli SS, Gordon MK, Chang YC, Tong W, Androulakis IP, Georgopoulos PG. (2009) Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect. Toxicol Appl Pharmacol. 234(2): 156-65.  Abstract

Gordon MK, Hahn RA. (2009) Collagens. Cell Tissue Res. 339(1): 247-57.  Abstract

Gould N, White CW, Day BJ. (2009) A role for mitochondrial oxidative stress in sulfur mustard analog CEES-induced lung cell injury and antioxidant protection.  J Pharmacol Exp Ther  328(3): 732-9.  Abstract

Kang H, Liu H, Phillips JA, Cao Z, Kim Y, Chen Y, Yang Z, Li J, Tan W. (2009) Single DNA molecule nanomotor regulated by photons. Nano Lett 9(7): 2690-6.  Abstract

Laskin DL. (2009) Macrophages and inflammatory mediators in chemical toxicity: A battle of forces. Chem Res Toxicol. 22(8): 1376-85.  Abstract

Pal A, Tewari-Singh N, Gu M, Agarwal C, Huang J, Day BJ, White CW, Agarwal R. (2009) Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. Free Radic Biol Med. 47(11): 1640-51.  Abstract

Roberts RA, Laskin DL, Smith CV, Robertson FM, Allen EM, Doorn JA, Slikker W. (2009) Nitrative and oxidative stress in toxicology and disease. Toxicol Sci. 112(1): 4-16.  Abstract

Stabler SP, Sekhar J, Allen RH, O'Neill HC, White CW. (2009) Alpha-lipoic acid induced eleveated s-adenosylhomocysteine and depleted s-adenosylmethionine. Free Radic Biol Med 47(8): 1147-53.  Abstract

Sunil VR, Patel KJ, Mainelis G, Turpin BJ, Ridgely S, Laumbach RJ, Kipen HM, Nazarenko Y, Veleeparambil M, Gow AJ, Laskin JD, Laskin DL. (2009) Pulmonary effects of inhaled diesel exhaust in aged mice. Toxicol Appl Pharmacol 241(3): 283-93.  Abstract

Wang K, Tang Z, Yang CJ, Kim Y, Fang X, Li W, Medley CD, Cao Z, Li J, Conlon P, Lin H, Tan W. (2009) Molecular engineering of DNA: molecular beacons. Angew Chem Int Ed Engl. 48(5): 856-70.  Abstract

Tewari-Singh N, Rana S, Gu M, Pal A, Orlicky DJ, White CW, Agarwal R. (2009) Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES)-induced skin injury in SKH-1 hairless mice. Toxicol Sci. 108(1): 194-206.  Abstract


Pulmonary Agents 

Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor M, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD. (2009) Surfactant associated protein B is critical to survival in nickel-induced injury in mice. Am J Respir Cell Mol Biol. 41(2): 226-36.  Abstract

Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE. (2009) Transient receptor potential ankyrin 1 antagonist block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 23(4):1102-14.  Abstract

Caceres AI, Brackmann M, Elie MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. (2009) A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Nat Acad Sci.106(22): 9099-104.  Abstract

Chang W, Chen J, Schlueter CF, Hoyle GW. (2009) Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung eputhelial and endothelial cells. Exp Lung Res 35(4):324-43.  Abstract

Chen L, Song W, Davis IC, Shrestha K, Schwiebert E, Sullender WM, Matalon S. (2009) Inhibition of Na+ transport in lung epithelial cells by respiratory syncytial virus infection. Am J Respir Cell Mol Biol. 40(5):588-600.  Abstract

Conti ML, Che MM, Boylan M, Sciuto AM, Gordon RK, Nambiar MP. (2009) Acute microinstillation inhalation exposure to sarin induces changes in respiratory dynamics and functions in guinea pigs. Int J Toxicol. 28(5): 436-47.  Abstract

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. (2009) Matrix metalloproteinase (MMP) 14 mediates a phenotypic shift in airways to increase mucin production. Am J Respir Crit Care Med. 180(9): 834-45.  Abstract

Ganguly K, Depner M, Fattman C, Bein K, Oury TD, Wesselkamper SC, Borchers MT, Schreiber M, Gao F, Mutius EV, Kabesch M, Leikauf GD, Schulz H. (2009) Superoxide dismutase 3, extracellular (SOD3) variants and lung function. Physiol Genomics. 37(3):260-7.  Abstract

Garner AL, St Croix CM, Pitt BR, Leikauf GD, Ando S, Koide K. (2009)  Specific fluorogenic probes for ozone in biological an atmospheric samples. Nat Chem. 1(4): 316-21.  Abstract

Iles KE, Song W, Miller DW, Dickinson DA, Matalon S. (2009) Reactive species and pulmonary edema. Expert Rev Respir Med. 3(5): 487-496.  Abstract

Ji HL, Song W, Gao Z, Su XF, Nie HG, Jiang Y, Peng JB, He YX, Liao Y, Zhou YJ, Tousson A, Matalon S. (2009) SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms. Am J Physiol Lung Cell Mol Physiol. 296(3): L372-83.  Abstract

Lazrak A, Iles KE, Liu G, Noah DL, Noah JW, Matalon S. (2009) Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species. FASEB J. 23(11): 3829-42.  Abstract

Lazrak A, Nita I, Subramaniyam D, Wei S, Song W, Ji H, Janciauskiene S, Matalon S. (2009) Alpha1-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo. Am J Respir Cell Mol Biol. 41(3): 261-70.  Abstract

Matalon S, Shrestha K, Kirk M, Waldheuser S, McDonald B, Smith K, Gao Z, Belaaouaj A, Crouch EC. (2009) Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo. FASEB J. 23(5):1415-30.  Abstract

Nemec AA, Leikauf GD, Pitt BR, Wasserloos KJ, Barchowsky A. (2009) Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. Am J Respir Cell Mol Biol. 41(1): 69-75.  Abstract

Sartor MA, Leikauf GD, Medvedovic M. (2009) LRpath: A logistic regression approach for identifying enriched biological groups in gene expression data. Bioinformatics 25(2):211-7.  Abstract

Song W, Liu G, Bosworth CA, Walker JR, Megaw GA, Lazrak A, Abraham E, Sullender WM, Matalon S. (2009) Respiratory syncytial virus inhibits lung ENaC by upregulating iNOS. J Biol Chem. 284(11): 7294-306.  Abstract

Vitturi DA, Teng X, Toledo JC, Matalon S, Lancaster Jr J, Patel, RP. (2009) Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation. Am J Physiol Heart Circ Physiol. 296(5):H1398-407.  Abstract


Metabolic/Cellular Poisons 

Finn PW, Bigby TD. (2009) Innate immunity and asthma. Proc Am Thorac Soc. 6(3): 260-5.  Abstract

Lee J, Keuter KA, Kim J, Tran A, Uppal A, Mukai D, Mahon SB, Cancio LC, Batchinsky A, Tromberg BJ, Brenner M. (2009) Noninvasive in vivo monitoring of cyanide toxicity and treatment using diffuse optical spectroscopy in a rabbit model. Mil Med. 174(6): 615-21.  Abstract

Logue BA, Maserek WK, Rockwood GA, Keebaugh MW, Baskin SI (2009) The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers. Toxicology Mechanisms and Methods 19(3): 202-208.  Abstract

Petrikovics I, Budai M, Baskin SI, Rockwood GA, Childress J, Budai L, Grof P, Klebovich I, Szilasi M. (2009) Characterization of a liposomal vesicles encapsulating rhodanese for cyanide antagonism. Drug Deliv 16(6): 312-9.  Abstract 

Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. (2009) The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J Biol Chem. 284(6): 3521-8.  Abstract

Zottola MA. (2009) A partial exploration of the potential energy surfaces of SCN and HSCN: Implications for the enzyme-mediated detoxification of cyanide. J Mol Graph Model 28(2): 183-6.  Abstract


Paralytic Neurotoxins 

DeCaen PG, Yarov-Yarovoy V, Sharp EM, Scheuer T, Catterall WA. (2009) Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proc Natl Acad Sci USA 106(52): 22498-503.  Abstract

Kahn R, Karbat I, Ilan N, Cohen L, Sokolov S, Catterall WA, Gordon D, Gurevitz M. (2009) Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins. J Biol Chem 284(31): 20684-91.  Abstract

Moran Y, Gordon D, Gurevitz M. (2009) Sea anemone toxins affecting voltage-gated sodium channels-molecular and evolutionary features. Toxicon 54(8): 1089-101. Abstract



Barry RC, Lin Y, Wang J, Liu G, Timchalk CA. (2009) Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures. J Expo Sci Environ Epidemiol. 19(1):1-18.  Abstract

Bharate SB, Guo L, Reeves TE, Cerasoli DM, Thompson CM. (2010) New series of monoquaternary pyridinium oximes: synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. Bioorg Med Chem Lett. 19(17): 5101-4.  Abstract

Du D, Wang J, Smith JN, Timchalk C, Lin Y. (2009) Biomonitoring of organophosphorus agent exposure by reactivation of cholinesterase enzyme-based on carbon nanotube-enhanced flow-injection amperometric detection. Anal Chem 81(221): 9314-24.  Abstract

Wang H, Wang J, Choi D, Tang Z, Wu H, Lin Y. (2009) EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation.  Biosens Bioelectron  24(8):2377-89.  Abstract


(79 Total 2009 Publications)


CounterACT Publications (2010)

Neurotoxic Agents

Alexandrova EX, Aracava YX, Pereira EF, Albuquerque EX. (2010) Pre-treatment of guinea pigs with galantamine prevents immediate and delayed effects of soman on inhibitory synaptic transmission in the hippocampus. J Pharmacol Exp Ther 334(3): 1051-8.  Abstract

Angoa-Perez M, Kreopke CW, Thomas DM, Van Shura KE, Lyman M, McDonough JH, Kuhn DM. (2010) Soman increases neuronal COX-2 levels: Possible link between seizures and protracted neuronal damage. Neurotoxicology 31(6): 738-46.  Abstract

Apland JP, Figueriredo TH, Qashu F, Aroniadou-Anderjaska V, Souze AP, Braga MF. (2010) Higher susceptibility of the ventral versus the dorsal hippocampus and the posteroventral versus anterodorsal amygdala to soman-induced neuropathology. Neurotoxicology. 31(5): 485-92.  Abstract

Ashani Y, Gupta RD, Goldsmith M, Silman I, Sussman JL, Tawfik DS, Leader H. (2010) Stereospecific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers. Chem Biol Interact. 187(1-3): 362-9.  Abstract

Beck JM, Hadad CM. (2010) Reaction profiles of the interaction between sarin and acetylcholinesterase and the S203C mutant: model nucleophiles and QM/MM potential energy surfaces. Chem Biol Interact. 187(1-3): 220-4.  Abstract

Chandra S, Song J, Rezk P, Sabnekar P, Doctor BP, Sciuto AM, Nambiar MP. (2010) Gastrointestinal acetylcholinesterase activity following endo-tracheal microinstillation inhalation exposure to sarin in guinea pigs. Chem Biol Interact. 187(1-3): 309-11.  Abstract

Demar JC, Clarkson ED, Ratcliffe RH, Campbell AJ, Thangavelu SG, Herdman CA, Leader H, Schulz SM, Marek E, Medynets MA, Ku TC, Evans SA, Khan FA, Owens RR, Nambiar MP, Gordon RK. (2010) Pro-2-PAM therapy for central and peripheral cholinesterases. Chem Biol Interact. 187(1-3): 191-8.  Abstract

Despande LS, Carter DS, Blair RE, Delorenzo RJ. (2010) Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate. Toxicol Sci 116(2): 623-31.  Abstract

Dvir H, Silman I, Harel M, Rosenberry TL, Sussman JL. (2010) Acetylcholinesterase: from 3D structure to function. Chem Biol interact. 187(1-3): 10-22.  Abstract

Gaidukov L, Raveendran I V, Yacobson S, Rosenblat M, Aviram M, Tawfik DS. (2010) ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I. Biochemistry 49(3): 532-8.  Abstract

Geyer BC, Kannan L, Cherni I, Woods RR, Soreq H, Mor TS. (2010) Transgenic plants as a source for the bioscavenging enzyme, human butyrylcholinesterase. Plant Biotechnol J. 8(8): 873-86.  Abstract

Geyer BC, Kannan L, Garnaud PE, Broomfield CA, Cadieux CL, Cherni I, Hodgins SM, Kasten SA, Kelley K, Kilbourne J, Oliver ZP, Otto TC, Puffenberger I, Reeves TE, Robbins N 2nd, Woods RR, Soreq H, Lenz DE, Cerasoli DM, Mor TS. (2010) Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proc Natl Acad Sci USA.  107(47): 20251-6.  Abstract

Gullapalli R, Aracava Y, Zhuo J, Neto EH, Wang J, Makris G, Merchenthaler I, Pereira EF, Albuquerque EX. (2010) Magnetic resonance imaging reveals that galantamine prevents structural brain damage induced by an acute exposure of guinea pigs to soman. Neurotoxicology 31(1): 67-76.  Abstract

Hemmert AC, Otto TC, Weirdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo M. (2010) Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin. Mol Pharmacol 77(4): 508-16.  Abstract

Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R, Maltais J. (2010) Recommended nomenclature for five mammalian carboxylesterase gene familes: human, mouse, and rat genes and proteins. Mamm Genome. 21(9-10): 427-41.  Abstract 

Jiang W, Duysen EG, Hansen H, Shlyakhtenko L, Schopfer LM, Lockridge O. (2010) Mice treated with chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents. Toxicol Sci. 115(1): 183-93.  Abstract 

Kokel D, Bryan J, Laggner C, White R, Cheung CY, Mateus R, Healey D, Kim S, Werdich AA, Haggarty SJ, Macrae CA, Shoichet B, Peterson RT. (2010) Rapid behavior-based identification of neuroactive small molecules in zebrafish. Nat Chem Biol. 6(3): 231-7.  Abstract

Kozhemyakin M, Rajasekaran K, Kapur J. (2010) Central cholinesterase inhibition enhances glutamatergic synaptic transmission. J Neurophysiol. 103(4): 1748-57.  Abstract

Kucukkilinc T, Cochran R, Kalisiak J, Garcia E, Valle A, Amitai G, Radic Z, Taylor P. (2010) Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation. Chem Biol Interact. 187(1-3): 238-40.  Abstract 

Li B, Ricordel I, Schopfer LM, Baud F, Megarbane B, Nachon F, Masson P, Lockridge O. (2010) Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos. Toxicol Sci 116(1): 23-31.  Abstract

Li B, Ricordel I, Schopfer LM, Baud F, Megarbane B, Masson P, Lockridge O. (2010) Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose. J Appl Toxicol. 30(6): 559-65.  Abstract

Lockridge O, Schopfer LM. (2010) Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine. Chem Biol Interact.187(1-3): 344-8.  Abstract

Lu X, Roberts, E, Xia F, Sanchez-Alavez M, Liu T, Baldwin R, Wu S, Chang J, Wasterlain CG, Bartfai T. (2010) GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci USA. 107(34): 15229-34.  Abstract

Mamczarz J, Pereira EF, Aracava Y, Adler M, Albuquerque EX. (2010) An acute exposure to a sub-lethal dose of soman triggers anxiety-related behavior in guinea pigs: Interactions with acute restraint. Neurotoxicology 31(1): 77-84.  Abstract 

Masson P, Lockridge O. (2010) Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior. Arch Biochem Biophys 494(2): 107-20.  Abstract 

Nagarkatti N, Deshpande LS, Carter DS, Delorenzo RJ. (2010) Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. Eur J Neurosci 32(1): 80-8.  Abstract

Novikov BN, Grimsley JK, Kern RJ, Wild JR, Wales ME. (2010) Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol. J Control Release 146(3): 318-25.  Abstract

Pereira EF, Aracava Y, Alkondon M, Akkerman M, Merchenthaler I, Albuquerque EX. (2010) Molecular and cellular actions of galantamine: Clinical implications for treatment of organophosphorus poisoning. J Mol Neurosci 40(1-2): 196-203.  Abstract

Qashu F, Figueiredo TH, Aroniadou-Anderjaska V, Apland, JP, Braga MF. (2010) Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis. Amino Acids 38(1): 189-97.  Abstract

Radic Z, Kalisiak J, Fokin W, Sharpless KB, Taylor P. (2010) Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase. Chem Biol Interact.187(1-3): 163-6.  Abstract

Schopfer LM, Grigoryan H, Li B, Nachon F, Masson P, Lockridge O. (2010) Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: Characteristic mass fragments and a new binding motif for organophosphates. J Chromatogr B Analyt Technol Biomed Life Sci 878(17-18): 1297-311.  Abstract

Schopfer LM, Furlong CE, Lockridge O. (2010) Development of diagnostics in the search of an explanation of aerotoxic syndrome. Anal Biochem. 404(1): 64-74. Abstract

Tacal O, Lockridge O. (2010) Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry. J Appl Toxicol.30(5): 469-75.  Abstract 

Van Ham TJ, Mapes J, Kokel D, Peterson RT. (2010) Live imaging of apoptotic cells in zebrafish. FASEB J. 24(11): 4336-42. Abstract.

Vyas S, Beck JM, Xia S, Zhang J, Hadad CM. (2010) Butyrylcholinesterase and G116H, G117H, G117N, E197Q and G117H/E197Q mutants: A molecular dynamics study. Chem Biol Interact.187(1-3): 241-5.  Abstract

Vyas S, Muthukrishnan S, Kubicki J, McCulla RD, Burdzinski G, Sliwa M, Platz MS, Hadad CM. (2010) Ultrafast spectroscopy and computational study of the photochemistry of diphenylphosphoryl azide: direct spectroscopic observation of a singlet phosphorylnitrene. J Am Chem Soc. 132(47): 16796-804.  Abstract

Zheng X, Okolotowicz K, Wang B, Macdonald M, Cashman JR, Zhang J. (2010) Direct detection of the hydrolysis of nerve agent model compounds using a fluorescent probe. Chem Biol Interact. 187(1-3): 330-4.  Abstract


Vesicating Agents 

Black AT, Hayden PJ, Casillas RP, Heck DE, Gerecke DR, Sinko PJ, Laskin DL, Laskin JD. (2010) Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol. 249(2): 178-87.  Abstract

Black AT, Joseph LB, Casillas RP, Heck DE, Gerecke DR, Sinko PJ, Laskin DL, Laskin JD. (2010) Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol 245(3): 352-60.  Abstract

Chung P, Lin T, Schultz G, Batich C, Jiang P. (2010) Nanopyramid surface plasmon resonance sensors. Appl Phys Lett. 96: 261108-1.  Abstract

Gardner CR, Gray JP, Joseph LB, Cervelli J, Bremer N, Kim Y, Mishin V, Laskin JD, Laskin DL. (2010) Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity. Toxicol Appl Pharmacol. 245(1): 36-46.  Abstract

Gordon MK, Desantis A, Deshmukh M, Lacey CJ, Hahn RA, Beloni J, Anumolu SS, Schlager JJ, Gallo MA, Gerecke DR, Heindel ND, Svoboda KK, Babib MC, Sinko PJ. (2010) Doxcycline hydrogels as a potential therapy for ocular vesicant injury. J Ocul Pharmacol Ther. 26(5): 407-19.  Abstract

Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. (2010) Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species. Toxicol Appl Pharmacol.247(2): 76-82.  Abstract

Heck DE, Shakarjian M, Kim HD, Laskin JD, Vetrano AM. (2010) Mechanisms of oxidant generation by catalase. Ann NY Acad Sci. 1203: 120-5.  Abstract

Jan YH, Heck DE, Gray JP, Zheng H, Casillas RP, Laskin DL, Laskin JD. (2010) Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells. Chem Res Toxicol. 23(6): 1045-53.  Abstract 

Kutscher HL, Chao P, Deshmukh M, Singh Y, Hu P, Joseph LB, Reimer DC, Stein S, Laskin DL, Sinko PJ. (2010) Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats. J Control Release 143(1): 31-7.  Abstract

Kutscher HL, Chao P, Deshmukh M, Rajan SS, Singh Y, Hu P, Joseph LB, Stein S, Laskin DL, Sinko PJ. (2010) Enhanced passive pulmonary targeting and retention of PEGylated rigid microparticles in rats. Int J Pharm. 402(1-2): 64-71.  Abstract

Laskin DL, Chen L, Hankey PA, Laskin JD. (2010) Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia. J Leukoc Biol. 88(2): 373-82.  Abstract

Laskin DL, Sunil VR, Fakhrzadeh L, Groves A, Gow AJ, Laskin JD. (2010) Macrophages, reactive nitrogen species, and lung injury. Ann NY Acad Sci 1203: 60-5.  Abstract

Laskin JD, Black AT, Jan YH, Sinko PJ, Heindel ND, Sunil V, Heck DE, Laskin DL. (2010) Oxidants and antioxidants in sulfur-mustard-induced injury. Ann NY Acad Sci. 1203: 92-100. Abstract

Liu J, Powell KL, Thames HD, Macleod MC. (2010) Detoxification of sulfur mustards by nucleophilic scavengers: robust activity of thiopurines. Chem Res Toxicol 23(3): 488-96.  Abstract

Malaviya R, Laskin DL, Malaviya R. (2010) Janus kinase-3 dependent inflammatory responses in allergic asthma. Int Immunopharmacol.10(8): 829-36.  Abstract 

Malaviya R, Sunil VR, Cerevelli J, Anderson DR, Holmes WW, Conti ML, Gordon RE, Laskin JD, Laskin DL. (2010) Inflammatory effects of inhaled sulfur mustard in rat lung. Toxicol Appl Pharmacol. 248(2): 89-99.  Abstract

Mishin V, Gray JP, Heck DE, Laskin DL, Laskin JD. (2010) Application of the amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes. Free Radic Biol Med 48(11): 1485-91  Abstract

Mishra NC, Rir-Sima-Ah J, March T, Weber W, Benson J, Jaramillo R, Seagrave JC, Schultz G, Grotendorst G, Sopori M. (2010) Sulfur mustard induces immune sensitization in hairless guinea pigs. Int Immunopharmacol. 10(2): 193-9.  Abstract

O'Neill HC, White CW, Veress LA, Hendry-Hofer TB, Loader JE, Min E, Huang J, Rancourt RC, Day BJ. (2010) Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES). Free Radic Biol Med. 48(9): 1188-96.  Abstract

Powell KL, Boulware S, Thames H, Vasquez KM, Macleod MC. (2010) 2,6-Dithiopurine blocks toxicity and mutagenesis in human skin cells exposed to sulfur mustard analogues, 2-chloroethyl ethyl sulfide and 2-chloroethyl methyl sulfide. Chem Res Toxicol 23(3): 497-503.  Abstract

Seagrave J, Weber WM, Grotendorst GR. (2010) Sulfur mustard vapor effects on differentiated human lung cells. Inhal Toxicol. 22(11): 896-902.  Abstract

Shakarjian MP, Heck DE, Gray JP, Sinko PJ, Gordon MK, Casillas RP, Heindel ND, Gerecke DR, Laskin DL, Laskin JD. (2010) Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicol Sci 114(1): 5-19.  Abstract

Tewari-Singh N, Gu M, Agarwal C, White CW, Agarwal R. (2010) Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in JB6 and HaCaT cells: Possible role of ataxia telangiectasia-mutated/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway. Chem Res Toxicol. 23(6): 1034-44.  Abstract

Veress LA, O'Neill HC, Hendry-Hofer TB, Loader JE, Rancourt RC, White CW. (2010) Airway obstruction due to bronchial vascular injury after sulfur mustard analog inhalation. Am J Respir Crit Care Med. 182(11): 1352-61.  Abstract

Vetrano AM, Laskin DL, Archer F, Syed K, Gary JP, Laskin JD, Nwebube N, Weinberger B. (2010) Inflammatory effects of phthalates in neonatal neutrophils. Pediatr Res. 68(2): 134-9. Abstract

Vyas, Shubham; Muthukrishnan, Sivaramakrishnan; Kubicki, Jacek; McCulla, Ryan D; Burdzinski, Gotard; Sliwa, Michel; Platz, Matthew S; Hadad, Christopher M

Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. (2010) Distinct roles of cytochrome P450 reductase in mitomycin c redox cycling and cytotoxicity. Mol Cancer Ther 9(6): 1852-63.  Abstract

Weber WM, Kracko DA, Lehman MR, Irvin CM, Blair LF, White RK, Benson JM, Grotendorst GR, Cheng YS, McDonald JD. (2010) Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury. Toxicol Mech Methods. 20(1): 14-24.  Abstract

Young S, Fabio K, Guillon C, Mohanta P, Halton TA, Heck DE, Flowers RA 2nd, Laskin JD, Heindel ND. (2010) Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction. Bioorg Med Chem Lett. 20(9): 2987-90.  Abstract


Pulmonary Agents 

Bessac BF, Jordt SE. (2010) Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. Proc Am Thorac Soc. 7(4): 269-77.  Abstract

Chao P, Deshmukh M, Kutscher HL, Gao D, Rajan SS, Hu P, Laskin DL, Stein S, Sinko P. (2010) Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model. Anticancer Drugs 21(1): 65-76. Abstract

Cheng YS, Bowen L, Rando RJ, Postlethwait EM, Squadrito GL, Matalon S. (2010) Exposing animals to oxidant gases: nose only vs. whole body. Proc Am Thorac Soc. 7(4): 264-8.  Abstract

Crouch EC, Hirche TO, Shao B, Wartelle J, Benabid R, McDonald B, Heinecke J, Matalon S, Belaaouaj A. (2010) Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo. J Biol Chem 285(22): 16757-70.  Abstract

Hoyle GW. (2010) Mitigation of chlorine lung injury by increasing cyclic AMP levels. Proc Am Thorac Soc. 7(4): 284-9.  Abstract

Hoyle GW, Chang W, Chen J, Schlueter CF, Rando RJ. (2010) Deviations from Haber's Law for multiple measures of acute lung injury in chlorine-exposed mice. Toxicol Sci. 118(2): 696-703.  Abstract

Hoyle GW, Hoyle CL, Chen J, Chang W, Williams RW, Rando RJ. (2010) Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation. Am J Physiol Lung Cell Mol Physiol. 298(6): L830-6.  Abstract

Jang AS, Concel VJ, Bein K, Brant KA, Liu S, Pope-Varsalona H, Doprico Jr RA, Di YP, Knowll DL, Barchowsky A, Leikauf GD. (2010) Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury. Am J Respir Cell Mol Biol. 44(4): 483-90. Abstract

Jurkuvenaite A, Chen L, Bartoszewski R, Goldstein R, Bebok Z, Matalon S, Collawn JF. (2010) Functional stability of rescued delta-F808 cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. Am J Respir Cell Mol Biol. 42(3): 363-72.  Abstract

Kachadourian R, Brechbuhl HM, Ruiz-Azuara L, Gracia-Mora I, Day BJ. (2010) Casiopenia IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells. Toxicology 268(3): 176-183.  Abstract

Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Brant KA, Dopico RA, Di YP, Jang AS, Dietsch M, Medvedovic M, Li Q, Vuga L, Kaminiski N, You M, Prows DR. (2010) Functional genomics of chlorine-induced acute lung injury in mice. Proc Am Thorac Soc. 7(4): 294-6.  Abstract

Li H, Su X, Yan X, Wasserloos K, Chao W, Kaynar AM, Liu ZQ, Leikauf GD, Pitt BR, Zhang LM. (2010) Toll-like receptor 4-myleoid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice. Anesthesiology 113(3): 619-29.  Abstract

Liu Y, Wei L, Laskin DL, Fanburg BL. (2010) Role of protein transamidation in serotonin-induced proliferation and migration of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 44(4): 548-55.  Abstract

Matalon S, Maull EA. (2010) Understanding and treating chlorine-induced injury. Proc Am Thorac Soc. 7(4): 253.  Abstract

McGovern TK, Powell WS, Day BJ, White CW, Govindaraju K, Karmouty-Quintana H, Lavoie N, Tan JJ, Martin JG. (2010) Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma. Respir Res. 11(1): 138.  Abstract

Samal A, Honovar J, White CR, Patel RP. (2010) Potential for chlorine gas-induced injury in the extrapulmonary vasculature. Proc Am Thorac Soc. 7(4): 290-3.  Abstract

Song W, Wei S, Liu G, Yu Z, Estell K, Yadav AK, Schwiebert LM, Matalon S. (2010) Post exposure administrative of a {beta}2-agoinst decreases chlorine induced airway hyper-reactivity in mice. Am J Respir Cell Mol Biol. [Epub ahead of print]  Abstract

Song W, Wei S, Matalon S. (2010) Inhibition of epithelial sodium channels by respiratory syncytial virus in vitro and in vivo. Ann NY Acad Sci. 1203: 79-84.  Abstract

Song W, Wei S, Shou Y, Lazrak A, Liu G, Londino JD, Squadrito GL, Matalon S. (2010) Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorus acid and chloramines. J Biol Chem 285(13): 9716-28.  Abstract

Squadrito GL, Postlethwait EM, Matalon S. (2010) Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications. Am J Physiol Lung Cell Mol Phyisol.  299(3): L289-300.  Abstract

Stark JM, Barmada MM, Winterberg AV, Majumber N, Gibbons WJ Jr, Stark MA, Sartor MA, Medvedovic M, Kolls J, Bein K, Mailaparambil B, Krueger M, Heinzmann A, Leikauf GD, Prows DR. (2010) Genomewide association analysis of respiratory syncytial virus infection in mice. J Virol. 84(5): 2257-69. Abstract

Subramaniyam D, Steele C, Kohnlein T, Welte T, Grip O, Matalon S, Janciauskiene S. (2010) Effects of alpha 1-antitrypsin on endotoxin-induced lung inflammation in vivo. Inflamm Res. 59(7): 571-8.  Abstract

White CW, Martin JG. (2010) Chlorine gas inhalation: human clinical evidence of toxicity and experience in animal models. Proc Am Thorac Soc. 7(4): 257-63.  Abstract

Yadav AK, Bracher A, Doran SF, Leustik M, Squadrito GL, Postlethwait EM, Matalon S. (2010) Mechanisms and modification of chlorine-induced lung injury in animals. Proc Am Thorac Soc. 7(4): 278-83.  Abstract


Metabolic/Cellular Poisons 

Blackledge WC, Blackledge CW, Griesel A, Mahon SB, Brenner M, Pilz RB, Boss GR. (2010) New facile method to measure cyanide in blood. Anal Chem 82(10): 4216-21.  Abstract

Brenner M, Kim JG, Mahon SB, Lee J, Kreuter KA, Blackledge W, Mukai D, Patterson S, Mohammad O, Sharma VS, Boss GR. (2010) Intramuscular cobinamide sulfide in a rabbit model of sublethal cyanide toxicity. Ann Emerg Med. 55(4): 352-63.  Abstract

Brenner M, Kim JG, Lee J, Mahon SB, Lemor D, Ahdout R, Boss GR, Blackledge W, Jann L, Nagasawa HT, Patterson SE. (2010) Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity. Toxicol Appl Pharmacol. 248(3): 269-76.  Abstract

Brenner M, Mahon SB, Lee J, Kim J, Mukai D, Goodman S, Kreuter KA, Ahdout R, Mohammad O, Sharma VS, Blackledge W, Boss GR. (2010) Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring. J Biomed Opt. 15(1): 017001.  Abstract

Chan A, Balasubramanian M, Blackledge W, Mohammad OM, Alvarez L, Boss GR, Bigby TD. (2010) Cobinamide is superior to other treatments in a mouse model of cyanide poisoning. Clin Toxicol (Phila). 48(7): 709-17. Abstract

Logue BA, Hinkens DM, Baskin SI, Rockwood GA. (2010) The analysis of cyanide and its breakdown products in biological samples. Crit Rev Anal Chem. 40(2): 122-147.  Abstract

Ma J, Dasguta PK. (2010) Recent developments in cyanide detection: a review. Anal Chim Acta. 673(2): 117-25.  Abstract

Ma J, Dasgupta PK, Blackledge W, Boss GR. (2010) Temperature dependence of Henry's Law constant for hydrogen cyanide. Generation of trace standard gaseous hydrogen cyanide. Environ Sci Technol. 44(8): 3028-34.  Abstract 

Ma J, Dasgupta PK, Blackledge W, Boss GR. (2010) Cobinamide-based cyanide analysis by multi-wavelength spectrometry in a liquid core waveguide. Anal Chem. 82(14): 6244-50.  Abstract

Macrae CA. (2010) Cardiac Arrhythmia: In vivo screening in the zebrafish to overcome complexity in drug discovery. Expert Opin Drug Discov. 5(7): 619-32.  Abstract

Otsuka M, Marks SA, Winnica DE, Amoscato AA, Pearce LL, Peterson J. (2010) Covalent modifications of hemoglobin by nitrite anion: formation kinetics and properties of nitrihemoglobin. Chem Res Toxicol. 23(11): 1786-95.  Abstract

Petrikovics I, Baskin SI, Beigel KM, Schapiro BJ, Rockwood GA, Manage AB, Budai M, Szilasi M. (2010) Nano-intercalated rhodanese in cyanide antagonism. Nanotoxicology 4: 247-54.  Abstract

Youso SL, Rockwood GA, Lee JP, Logue BA. (2010) Determination of cyanide exposure by gas chromatography-mass spectrometry analysis of cyanide-exposed plasma proteins. Anal Chim Acta. 677(1): 24-8.  Abstract


Paralytic Neurotoxins

Catterall WA. (2010) Ion channel voltage sensors: structure, function, and pathophysiology. Neuron 67(6): 915-28.  Abstract

Karbat I, Ilan N, Zhang JZ, Cohen L, Kahn R, Benveniste M, Scheuer T, Catterall WA, Gordon D, Gurevitz M. (2010) Partial agonist and antagonist activities of a mutant scorpion β-toxin on sodium channels. J Biol Chem. 285(40): 30531-8. Abstract



Bharate SB, Guo L, Reeves TE, Cerasoli DM, Thompson CM. (2010) Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. Bioorg Med Chem Lett. 18(2): 787-94.  Abstract

Bharate SB, Prins JM, George KM, Thompson CM. (2010) Thionate versus oxon: comparison of stability, uptake, and cell toxicity of ((14)CH(3)O)(2)-labeled methyl parathion and methyl paraoxon with SH-SY5Y cells. J Agric Food Chem. 58(14): 8460-6.  Abstract

Du D, Chen W, Zhang W, Liu D, Li H, Lin Y. (2010) Covalent coupling of organophosphorus hydrolase loaded quantum dots to carbon nanotube/Au nanocomposite for enhanced detection of methyl parathion. Biosens Bioelectron 25(6): 1370-5.  Abstract

Etoga JG, Ahmed SK, Patel, S, Bridges RJ, Thompson CM. (2010) Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system x(c)(-) over the vesicular glutamate transporter. Bioorg Med Chem Lett. 20(8): 5101-4.  Abstract

Guo L, Suarez AI, Braden MR, Gerdes JM, Thompson CM (2010) Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonates. Bioorg Med Chem Lett. 20(3): 1194-7.  Abstract

Pinwattana K, Wang J, Lin CT, Wu H, Du D, Lin Y, Chailapakui O. (2010) CdSe/ZnS quantum dots-based electrochemical immunoassay for the detection of phosphorylated bovine serum albumin. Biosens Bioelectron 26(3): 1109-13. Abstract

Prins JM, George KM, Thompson CM. (2010) Paraoxon-induced protein expression changes to SH-SY5Y cells. Chem Res Toxicol. 23(11): 1656-62.  Abstract

Zou Z, Du D, Wang J, Smith JN, Timchalk C, Li Y, Lin Y. (2010) Quantum dot-based immunochromatographic fluorescent biosensor for biomonitoring trichloropyridinol, a biomarker of exposure to chlorpyrifos. Anal Chem 82(12): 5125-33.  Abstract


(112 Total 2010 Publications)


CounterACT Publications (2011)

Neurotoxic Agents

Alcolombri U, Elias M, Tawfik DS. (2011) Directed evolution of sulfotransferases and paraoxonases by ancestral libraries. J Mol Biol. 411(4): 837-53.  Abstract

Ashani Y, Goldsmith M, Leader H, Silman I, Sussman JL, Tawfik DS. (2011) In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases. Toxicol Lett. 206(1): 24-8.  Abstract

Boado RJ, Hui EK, Lu JZ, Pardridge WM. (2011) CHO cell expression, long term stability, and primate pharmacokinetics and brain uptake of an IgG-paraoxonase-1 fusion protein. Biotechnol Bioeng. 108(1): 186-96.  Abstract

Carletti E, Schopfer LM, Colletier JP, Froment MT, Nachon F, Weik M, Lockridge O, Masson P. (2011) Reaction of cresyl saligenin phosphate, the organophosphorus implicated in the aerotoxic syndrome, with human cholinesterases: Mechanistic studies employing kinetics, mass spectrometry and x-ray structure analysis. Chem Res Toxicol. 24(6): 797-808.  Abstract

Carter DS, Deshpande LS, Rafiq Q, Sombati S, Delorenzo RJ. (2011) Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals. Seizure 20(3): 218-24.  Abstract

Che MM, Chanda S, Song J, Doctor BP, Rezk PE, Sabnekar P, Perkins MW, Sciuto AM, Nambiar MP. (2011) Aerosolized scopolamine protects against microinstillation inhalation toxicity to sarin in guinea pigs. Toxicol Mech Methods. 21(6): 463-72.  Abstract

Cochran R, Kalisiak J, Kucukkilinc T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovaril Z, Fokin VV, Sharpless KB, Taylor P. (2011) Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. J. Biol Chem. 286(34): 29718-24.  Abstract

Deshpande LS, Blair RE, DeLorenzo RJ. (2011) Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neurons. Exp Neurol. 229(2): 264-73. Abstract

Deshpande LS, DeLorenzo RJ. (2011) Acetaminophen inhibits status epilepticus in cultured hippocampal neurons. Neuroreport. 22(1): 15-8.  Abstract

Duysen E, Koentgen F, Williams GR, Timperley C, Schopfer LM, Cerasoli DM, Lockridge O. (2011) Production of ES1 plasma carboxylesterase knockout mice for toxicity studies. Chem Res Toxicol. 24(11): 1891-8.  Abstract

Edwards JS, Kumbhar A, Roberts A, Hemmert AC, Edwards CC, Potter PM, Redinbo MR. (2011) Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles. Biotechnol Prog. 27(3): 863-9. Abstract

Ehrich M, Tassell RV, Li Y, Zhou Z, Kepley CL. (2011) Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitro. Toxicol In Vitro. 25(1): 301-7.  Abstract

Eterović VA, Pérez D, Martins AH, Cuadrado BL, Carrasco M, Ferchmin PA. (2012) A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity. Toxicol In Vitro. 25(7):1468-74.  Abstract

Figueiredo TH, Qashu F, Apland JP, Aroniadou-Anderjaska V, Souza AP, Braga MF. (2011) The GluK1 (GluR5) kainate/AMPA receptor antagonist LY293558 reduces soman-induced seizures and neuropathology. J Pharmacol Exp Ther. 226(2): 303-12.  Abstract

Geyer BC, Ben Ari S, Barbash S, Kilbourne J, Mor TS, Soreq H.(2011) Nicotinic stimulation induces Tristetraprolin over-production and attenuates inflammation in muscle. Biochim Biophys Acta. 1823(2):368-78.  Abstract

Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL, Tawfik DS. (2011) Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. Nat Chem Biol. 7(2):120-5.  Abstract

Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SL, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR. (2011) Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. PLoS One. 6(3):e17441.  Abstract

Khan FA, Campbell AJ, Hoyt B, Herdman C, Ku T, Thangavelu S, Gordon RK. (2011) Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride. Life Sci. 89(25-26): 911-7.  Abstract

Li Y, Lein PJ, Liu C, Bruun DA, Tewolde T, Ford G, Ford BD. (2011) Spatiotemporal pattern of neuronal injury induced by DFP in rats: A model for delayed neuronal cell death following acute OP intoxication. Toxicol Appl Pharmacol. 253(3): 261-9.  Abstract

Liyasova M, Schopfer LM, Nachon F, Masson P, Furlong CE, Lockridge O. (2011) Exposure to tri-o-cresyl phosphate detected in jet airplane passengers. Toxicol Appl Pharmacol. 256(3): 337-47. Abstract

Magliery TJ, Lavinder JJ, Sullivan BJ. (2011) Protein stability by number: high-throughput and statistical approaches to one of protein sciences's most difficult problems. Curr Opin Chem Biol. 15(3): 443-51.  Abstract

Marsillach J, Richter RJ, Kim JH, Stevens RC, Maccoss MJ, Tomazela D, Suzuki SM, Schopfer LM, Lockridge O, Furlong CE. (2011) Biomarkers of organophosphorus (OP) exposures in humans. Neurotoxicology 32(5): 656-60.  Abstract

Mamczarz J, Kulkarni GS, Pereira EF, Albuquerque EX. (2011) Galantamine counteracts development of learning impairment in guinea pigs exposed to the organophosphorus poison soman: Clinical significance. Neurotoxicology. 32(6): 785-98.  Abstract

Mumford H, Troyer JK.(2011) Post-exposure therapy with recombinant human BuChE following percutaneous VX challenge in guinea-pigs. Toxicol Lett. 206(1): 29-34.  Abstract

Ralph EC, Xiang L, Cashman JR, Zhang J. (2011) His-tag truncated butyrylcholinesterase as a useful construct for in vitro characterization of wildtype and variant butyrylcholinesterases. Protein Expr Purif. 80(1): 22-27.  Abstract

Rannals MD, Kapur J. (2011) Homeostatic strengthening of inhibitory synapses is mediated by the accumulation of GABAA receptors. J Neurosci. 31(48): 17701-12. Abstract

Rusin CG, Johnson SE, Kapur J, Hudson JL. (2011) Engineering the synchronization of neuron action potentials using global time-delayed feedback stimulation. Phys Rev E Stat Nonlin Soft Matter Phys. 84(6 Pt 2):066202.  Abstract

Sagi VN, Liu T, Lu X, Bartfai T, Roberts E. (2011) Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2. Bioorg Med Chem Lett. 21(23): 7210-5.  Abstract

Silbergleit R, Lowenstein D, Durkalski V, Conwit R; Neurological Emergency Treatment Trials (NETT) Investigators. (2011) RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. Epilepsia. 52 Suppl 8:45-7.  Abstract

Sit R, Radic Z, Gerardi V, Zhang L, Garcia E, Katalinic M, Amitai G, Kovarik Z, Fokin V, Sharpless KB, Taylor P. (2011) New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases. J Biol Chem. 286(22): 19422-30.  Abstract

Spradling KD, Lumley LA, Robison CL, Meyerhoff JL, Dillman JF 3rd. (2011) Transcriptional analysis of rat piriform cortex following exposure to the organophosphate anticholinesterase sarin and induction of seizures. J Neuroinflammation. 8(1): 83. Abstract

Spradling KD, Lumley LA, Robison CL, Meyerhoff JL, Dillman JF 3rd. (2011) Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin. J Neuroinflammation. 8(1): 84. Abstract 

Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih PA, Rao F, O'Connor DT, Taylor P. (2011) Naturally occurring variations in the human cholinesterase genes: Heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther. 338(1): 125-33.  Abstract

Wilfong EM, Kogiso Y, Muthukrishnan S, Kowatz T, Du Y, Bowie A, Naismith JH, Hadad CM, Toone EJ, Gustafson TL. (2011) A multidisciplinary approach to probing enthalpy-entrophy compensation and the interfacial mobility model. J Am Chem Soc. 133(30): 11515-23.  Abstract

Williams LR, Aroniadou-Anderjaska V, Qashu F, Finne H, Pidoplichko V, Bannon DI, Braga MF. (2011) RDX binds to the GABAA receptor-convulsant site and blocks GABAA receptor-mediated currents in the amygdala: A mechanism for RDX-induced seizures. Environ Health Perspect. 119(3): 357-63.  Abstract

Ziobro JM, Deshpande LS, Delorenzo RJ. (2011) An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. Brain Res. 1371: 110-20.  Abstract


Vesicating Agents 

Abel EL, Bubel JD, Simper MS, Powell L, McClellan SA, Andreeff M, Macleod MC, Digiovanni J. (2011) Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway. Toxicol Appl Pharmacol. 255(2): 176-83.  Abstract

Benson JM, Seagrave J, Weber WM, Santistevan CD, Grotendorst GR, Schultz GS, March TH. (2011) Time course of lesion development in the hairless guinea pig model of sulfur mustard-induced dermal injury. Wound Repair Regen. 19(3): 348-57.  Abstract

Benson JM, Tibbetts BM, Weber WM, Grotendorst GR. (2011) Uptake, tissue distribution, and excretion of (14)c-sulfur mustard vapor following inhalation in F344 rats and cutaneous exposure in hairless Guinea pigs. J Toxicol Environ Health A. 74(13): 875-85.  Abstract

Black AT, Gordon MK, Heck DE, Gallo MA, Laskin DL, Laskin JD. (2011) UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells. Biochem Pharmacol. 81(7): 873-80.  Abstract

Black AT, Hayden PJ, Casillas RP, Heck DE, Gerecke DR, Sinko PJ, Laskin DL, Laskin JD. (2011) Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol. 253(2): 112-20.  Abstract

Chao MW, Kozlosky J, Po IP, Strickland PO, Svoboda KK, Cooper K, Laumbach R, Gordon MK. (2011) Diesel exhaust particle exposure causes redistribution of endothelial tube VE-cadeherin. Toxicology. 279(1-3): 73-84.  Abstract

Dragomir AC, Laskin JD, Laskin DL. (2011) Macrophage activation by factors released from acetaminophen-injured hepatocytes: Potential role of HMGB1. Toxicol Appl Pharmacol. 253(3): 170-7.  Abstract

Gould NS, Day BJ. (2011) Targeting maladaptive glutathione responses in lung disease. Biochem Pharmacol. 81(2): 187-93.  Abstract

Fussell KC, Udasin RG, Gray JP, Mishin V, Smith PJ, Heck DE, Laskin JD. (2011) Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase. Free Radic Biol Med. 50(7): 874-82.  Abstract

Fussell KC, Udasin RG, Smith PJ, Gallo MA, Laskin JD. (2011) Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells. Carcinogenesis. 32(8): 1285-93. Abstract

Inturi S, Tewari-Singh N, Gu M, Shrotriya S, Gomez J, Agarwal C, White CW, Agarwal R. (2011) Mechanisms of sulfur mustard analog 2-chloroethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts. Free Radic Biol Med. 51(12): 2272-80.  Abstract

Jain AK, Tewari-Singh N, Gu M, Inturi S, White CW, Agarwal R. (2011) Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin. Toxicol Lett. 2011 Sep 10;205(3):293-301. Abstract

Jain AK, Tewari-Singh N, Orkicky DJ, White CW, Agarwal R. (2011) 2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin. Toxicology. 282(3): 129-38.  Abstract

Joseph LB, Gerecke DR, Heck DE, Black AT, Sinko PJ, Cervelli JA, Casillas RP, Babin MC, Laskin DL, Laskin JD. (2011) Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage. Exp Mol Pathol. 91(2): 515-527. Abstract

Kachadourian R, Pugazhenthi S, Velmurugan K, Backos DS, Franklin CC, McCord JM, Day BL. (2011) 2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways. Free Radic Biol Med. 51(6): 1146-54. Abstract

Laskin DL, Sunil VR, Gardner CR, Laskin JD. (2011) Macrophages and tissue injury: agents of defense of destruction? Annu Rev Pharmacol Toxicol. 51: 267-88.  Abstract

O'Neill HC, Orlicky DJ, Hendry-Hofer TB, Loader JE, Day BJ, White CW. (2011) Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analog CEES (2-chloroethyl etheyl sulfite). Am J Respir Cell Mol Bio. 45(2): 323-31.  Abstract

Price JA, Rogers JV, Wendling MQ, Plahovinsak JL, Perry MR, Reid FM, Kiser RC, Graham JS. (2011) Temporal effects in porcine skin following bromine vapor exposure. Cutan Ocul Toxicol. 303(3): 187-97.  Abstract

Rogers JV, Price JA, Wendling MQ, Perry MR, Reid FM, Kiser RC, Graham JS. (2011) An assessment of transcriptional changes in porcine skin exposed to bromine vapor. J Biochem Mol Toxicol. 25(4): 252-62.  Abstract

Sunil VR, Patel KJ, Shen J, Reimer D, Gow AJ, Laskin JD, Laskin DL. (2011) Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard. Toxicol Appl Pharmacol. 250(1): 10-8.  Abstract

Sunil VR, Patel-Vayas K, Shen J, Gow AJ, Laskin JD, Laskin DL. (2011) Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol. 250(3): 245-55. Abstract

Tewari-Singh N, Agarwal C, Huang J, Day BJ, White CW, Agarwal R. (2011) Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo. J Pharmacol Exp Ther. 336(2): 450-9. Abstract

Trabaris M, Laskin JD, Weisel CP. (2011) Percutaneous adsorption of haloacetronitriles and chloral hydrate and simulated human exposures. J Appl Toxicol. [Epub ahead of print]  Abstract

Weber WM, Kracko DA, Lehman MR, Cox CE, Cheng YS, Grotendorst GR, McDonald JD. (2011) Dermal and ocular exposure systems for the development of models of sulfur mustard-induced injury. Toxicol Mech Methods. 21(7): 547-53.  Abstract

Weinberger B, Laskin JD, Sunil V, Sinko PJ, Heck DE, Laskin DL. (2011) Sulfur mustard-induced pulmonary injury: Therapeutic approaches to mitigating toxicity. Pulm Pharmacol Ther. 24(1): 92-9.  Abstract 


Pulmonary Agents 

Bein K, Leikauf GD. (2011) Acrolein - a pulmonary hazard. Mol Nutr Food Res. 55(9): 1342-1360. Abstract

Bein K, Leight H, Leikauf GD. (2011) JUN-CCAAT/Enhancer binding protein (C/EBP) complexes inhibit surfactant associated protein B promoter activity. Am J Respir Cell Mol Biol. 45(2): 436-44. Abstract

Fabisiak JP, Medvedovic M, Alexander DC, McDunn JE, Concel VJ, Bein K, Jang AS, Berndt A, Vuga LJ, Brant KA, Pope-Varsalona H, Dopico RA Jr, Ganguly K, Upadhyay S, Li Q, Hu Z, Kaminiski N, Leikauf GD. (2011) Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury. Mol Nutr Food Res. 55(9): 1423-34.  Abstract 

Honavar J, Samal AA, Bradley KM, Brandon A, Balanay J, Squadrito GL, Mohankumar K, Masheshwari A, Postlethwait EM, Matalon S, Patel RP. (2010) Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting eNOS-dependent signaling. Am J Respir Cell Mol Biol. 45(2):419-25. Abstract

Jordt SE. (2011) Trigeminal TRPs and the scent of pain. Pain. 152(1):4-5.  Abstract

Lazrak A, Jurkuvenaite A, Chen L, Keeling KM, Collawn JF, Bedwell DM, Matalon S. (2011) Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung. Am J Physiol Lung Cell Mol Physiol. 301(4):L557-67.  Abstract

Leikauf GD, Concel VJ, Liu P, Bein K, Berndt A, Ganguly K, Jang AS, Brant KA, Dietsch M, Pope-Varsalona H, Dopico Jr RA, Di YP, Li Q, Vuga LJ, Medvedovic M, Kaminski N, You M, Prows DR. (2011) Haplotype association mapping of acute lung injury in mice implicates Activin A receptor, Type 1. Am J Respir Crit Care Med. 183(11): 1499-509.  Abstract

Lindsey JY, Ganguly K, Brass DM, Li Z, Potts EN, Degan S, Chen H, Brockway B, Abraham SN, Berndt A, Stripp BR, Foster WM, Leikauf GD, Schulz H, Hollingsworth JW. (2011) c-KIT is essential for alveolar maintenance and protection from emphysema-like disease in mice.  Am J Respir Crit Care Med. 183(12): 1644-52. Abstract

McGovern TK, Day BJ, White CW, Powell WS, Martin JG. (2011) AEOL10150: A novel therapeutic for rescue treatment following toxic gas lung injury. Free Radic Biol Med. 50(5): 602-8.  Abstract

Yadav AK, Doran SF, Samal AA, Sharma R, Vedagiri K, Postlethwait EM, Squadrito GL, Fanucchi MV, Roberts LJ 2nd, Patel RP, Matalon S. (2011) Mitigation of chlorine gas lung injury in rats by post exposure administration of sodium nitrite. Am J Physiol Lung Cell Mol Physiol.  300(3): L362-9.  Abstract

Zarogiannis SG, Jurkuvenaite A, Fernandez S, Doran SF, Yadav AK, Squadrito GL, Postlethwait EM, Bowen L, Matalon S. (2010) Ascorbate and deferoxamine administration post chlorine exposure decrease mortality and lung injury in mice. Am J Respir Cell Mol Biol. 45(2): 386-92.  Abstract

Zarogiannis SG, Matalon S. (2011) Constrictive bronchiolitis in soldiers. N Engl J Med. 365(18):1743; author reply 1744-5. Abstract


Metabolic/Cellular Poisons 

Cambal L. Swanson MR, Yuan Q, Weitz AC, Li HH, Pitt B, Peterson J, Pearce LL. (2011) Acute, sub-lethal cyanide poisoning in mice is ameliorated by nitrite alone: Complications arising from concomitant administration of nitrite and thiosulfate as an antidotal combination. Chem Res Toxicol. 24(7): 1104-12. Abstract

Chan A, Crankshaw DL, Monteil A, Patterson SE, Nagasawa HT, Briggs JE, Kozocas JA, Mahon SB, Brenner M, Pilz RB, Bigby TD, Boss GR. (2011) The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning. Clin Toxicol (Phila). 49(5): 366-73. Abstract

Lee SW, Heidary AE, Yoon D, Mukai D, Ramalingam T, Mahon S, Yin J, Jing J, Liu G, Chen Z, Brenner M. (2011) Quantification of airway thickness changes in smoke-inhalation injury using in vivo 3-D endscopic frequency-domain optical coherence tomography. Biomed Opt Express. 2(2): 243-54.  Abstract

Ma J, Ohira SI, Mishra SK, Puanngam M, Dasgupta PK, Mahon SB, Brenner M, Blackledge W, Boss GR. (2011) Rapid point of care analyzer for the measurement of cyanide in blood. Anal Chem. 83(11): 4319-24.  Abstract

Petrikovics I, Thompson DE, Rockwood GA, Logue BA, Martin S, Jayanna P, Yu JC. (2011) Organ-distribution of the metabolite 2-aminothiazoline-4-carboxylic acid in a rat model following cyanide exposure. Biomarkers. 16(8): 686-90. Abstract

Salnikov DS, Silaghi-Dumitrescu R, Makarov SV, van Eldik R, Boss GR. (2011) Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(ii) complex. Dalton Trans. 40(38): 9831-4.  Abstract


Paralytic Neurotoxins 

Gur M, Kahn R, Karbat I, Regev N, Wang J, Catterall WA, Gordon D, Gurevitz M. (2011) Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core-domain of scorpion alpha-toxins on sodium channels. J Biol Chem. 286(40): 35209-17.  Abstract

Payandeh J, Scheuer T, Zheng N, Catterall WA. (2011) The crystal structure of a voltage-gated sodium channel. Nature 475(7356): 353-8. Abstract

Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, Catterall WA. (2011) Mapping the receptor site for {alpha}-scorpion toxins on a Na+ channel voltage sensor. Proc Natl Acad Sci USA. 108(37): 15426-31.  Abstract

Zhang JZ, Karbat I, Cohen L, Yarov-Yarovoy V, Scheuer T, Gordon D, Gurevitz M, Catterall WA. (2011) Structure-function map of the receptor site for {beta}-scorpion toxins in domain II of voltage-gated sodium channels. J Biol Chem. 286(38): 33641-51.  Abstract



Du D, Chen A, Xie Y, Zhang A, Lin Y. (2011) Nanoparticle-based immunosensor with apoferritin templated metallic phosphate label for quantification of phosphorylated acetylcholinesterase. Biosens Bioelectron. [Epub ahead of print]  Abstract

Du D, Wang L, Shao Y, Wang J, Engelhard MH, Lin Y. (2011) Functionalized graphene oxide as a nanocarrier in a multienzyme labeling amplification strategy for ultrasensitive electrochemical immunoassay of phosphorylated p53 (S392). Anal Chem. 83(3): 746-52.  Abstract 

Du D, Wang J, Wang L, Lu D, Smith JN, Timchalk C, Lin Y. (2011) Magnetic electrochemical sensing platform for biomonitoring of exposure to organophosphorus pesticides and nerve agents based on simultaneous measurement of total enzyme amount and enzyme activity. Anal Chem. 83(10): 3770-7.  Abstract

Du D, Wang J, Lu D, Dohnalkova A, Lin Y. (2011) Multiplexed electrochemical immunoassay of phosphorylated proteins based on enzyme-functionalized gold nanorod labels and electric field-driven acceleration. Anal Chem. 83(17): 6580-5.  Abstract

Fu Z, Shao G, Wang J, Lu D, Wang W, Lin Y. (2011) Microfabricated renewable beads-trapping/releasing flow cell for rapid antigen-antibody reaction in chemiluminescent immunoassay. Anal Chem. 83(7): 2685-90.  Abstract

Lu D, Shao G, Du D, Wang J, Wang L, Wang W, Lin Y. (2011) Enzyme entrapped nanoporous scaffolds formed through flow-induced gelation in a microfluidic filter device for sensitive biosensing of organophosphorus compounds. Lab Chip. 11(3): 384-4.  Abstract

Wang L, Du D, Lu D, Lin CT, Smith JN, Timchalk C, Liu F, Wang J, Lin Y. (2011) Enzyme-linked immunosorbent assay for detection of organophosphorylated butyrylcholinesterase: A biomarker of exposure to organophosphorus agents. Anal Chim Acta. 5(1-2): 1-6.  Abstract

Wang L, Lu D, Wang J, Du D, Zou Z, Wang H, Smith JN, Timchalk C, Liu F, Lin Y. (2011) A novel immunochromatographic electrochemical biosensor for highly sensitive and selective detection of trichloropyridinol, a biomarker of exposure to chlorpyrifos. Biosens Bioelectron. 26(6): 2835-40.  Abstract

Wang Y, Li Z, Wang J, Li J, Lin Y. (2011) Graphene and graphene oxide: biofunctionalization and applications in biotechnology. Trends Biotechnol. 29(5): 205-12.  Abstract

Xie Y, Chen A, Du D, Lin Y. (2011) Graphene-based immunosensor for electrochemical quantification of phosphorylated p53 (S15). Anal Chim Acta. 699(1): 44-8.  Abstract


(92 Total 2011 Publications)

CounterACT Publications (2012)

Neurotoxic Agents 

Afriat-Jurnou L, Jackson CJ, Tawfik DS. (2012) Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling. Biochemistry. 51(31): 6047-55.  Abstract

Aroniadou-Anderjaska V, Pidoplichko VI, Figueiredo TH, Almeida-Suhett CP, Prager EM, Braga MF. (2012) Presynaptic facilitation of glutamate release in the basolateral amygdala: A mechanism for the anxiogenic and seizurogenic function of Gluk1 receptors. Neuroscience. 221: 157-69.  Abstract

Bajo M, Madamba SG, Lu X, Sharkey LM, Bartfai T, Siggins GR. (2011) Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. Addict Biol. 17(4): 694-705.  Abstract

Banks CN, Lein PJ. (2012) A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. Neurotoxicology. 33(3):575-84.  Abstract

Ben-David M, Elias M, Filippi JJ, Duñach E, Silman I, Sussman JL, Tawfik DS. (2012) Catalytic versatility and backups in enzyme active sites: The case of serum paraoxonase 1. J Mol Biol. 418(3-4): 181-96.  Abstract

Cao Z, Hammock BD, McCoy M, Rogawski M, Lein P, Pessah I. (2012) Tetramethylenedisulfotetramine Alters Ca2+ dynamics in cultured hippocampal neurons: Mitigation by NMDA blockade and GABAA receptor positive modulation. Toxicol Sci. 130(2): 362-72.  Abstract

Che MM, Song J, Oguntayo S, Doctor BP, Rezk P, Perkins MW, Sciuto AM, Nambiar MP. (2012) Treatment with endotracheal therapeutics after sarin microinstillation inhalation exposure increases blood cholinesterase levels in guinea pigs. Toxicol Mech Methods. 22(4): 250-9.  Abstract

Duysen EG, Cashman JR, Schopfer LM, Nachon F, Masson P, Lockridge O. (2012) Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran. Chem Biol Interact. 195(3):189-98.  Abstract

Falluel-Morel A, Lin L, Sokolowski K, McCandlish E, Buckley B, DiCicco-Bloom E. (2012) N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus. J Neurosci Res. 90(4): 743-50.  Abstract

Goldsmith M, Ashani Y, Simo Y, Ben-David M, Leader H, Silman I, Sussman JL, Tawfik DS. (2012) Evolved stereoselective hydrolases for broad-spectrum g-type nerve agent detoxification. Chem Biol. 19(4): 456-66. Abstract

Goldsmith M, Tawfik DS. (2012) Directed enzyme evolution: beyond the low-hanging fruit. Curr Opin Struct Biol. 22(4): 406-12.  Abstract

Hubbard KS, Gut IM, Lyman ME, Tuznik KM, Mesngon MT, McNutt PM. (2012) High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research. BMC Neurosci. 13:127.  Abstract

Kalisiak J, Ralph EC, Cashman JR. (2012) Nonquaternary reactivators for organophosphate-inhibited cholinesterases. J Med Chem. 55(1):465-74.  Abstract

Langston JL, Wright LK, Connis N, Lumley LA. (2012) Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: increased startle reactivity and perseverative behavior. Pharmacol Biochem Behav. 100(3): 382-91.  Abstract  

Li Y, Lein PJ, Liu C, Bruun DA, Giulivi C, Ford G, Tewolde T, Ross-Inta C, Ford BD. (2012) Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury. Toxicol Appl Pharmacol. 262(2):194-204.  Abstract

Martins AH, Alves JM, Perez D, Carrasco M, Torres-Rivera W, Eterović VA, Ferchmin PA, Ulrich H. (2012) Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of Kinin-B1 receptor agonists. PLoS One. 7(2):e30755. Abstract

Muthukrishnan S, Shete VS, Sanan TT, Vyas S, Oottikkal S, Porter LM, Magliery TJ, Hadad CM. (2012) Mechanistic insights into the hydrolysis of organophosphorus compounds by Paraoxonase-1: Exploring the limits of substrate tolerance in a promiscuous enzyme. J Phys Org Chem. 25(12):1247-1260. Abstract

Radic Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Fokin VV, Sharpless KB, Taylor P. (2012) Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. J Biol Chem. 287(15): 11798-809. Abstract

Rajasekaran K, Todorovic M, Kapur J. (2012) Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus. Ann Neurol. 72(1):91-102.  Abstract

Rodriguez-Mercado R, Ford GD, Xu Z, Kraiselburd EN, Martinez MI, Eterović VA, Colon E, Rodriguez IV, Portilla P, Ferchmin PA, Gierbolini L, Rodriguez-Carrasquillo M, Powell MD, Pulliam JV, McCraw CO, Gates A, Ford BD. (2012) Acute neuronal injury and blood genomic profiles in a nonhuman primate model for ischemic stroke. Comp Med. 62(5): 427-38.  Abstract

Sarkar M, Harsch CK, Matic GT, Hoffman K, Norris JR 3rd, Otto TC, Lenz DE, Cerasoli DM, Magliery TJ. (2012) Solubilization and humanization of paraoxonase-1. J Lipids. 2012:610937.  Abstract

Sayers KW, Nguyen PT, Blair RE, Sim-Selley LJ, Delorenzo RJ. (2012) Statistical parametric mapping reveals regional alterations in cannabinoid CB(1) receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain. Epilepsia. 53(5): 897-907.  Abstract

Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, Barsan W; NETT Investigators. (2012) Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 366(7):591-600.  Abstract

Skovira JW, Shih TM, McDonough JH. (2012) Neuropharmacological specificity of brain structures involved in soman-induced seizures. Neurotoxicology. 33(3): 463-8.  Abstract

Todorovic MS, Cowan ML, Balint CA, Sun C, Kapur J. (2012) Characterization of status epilepticus induced by two organophosphates in rats. Epilepsy Res. 101(3):268-76.  Abstract

White HS, Alex AB, Pollock A, Hen N, Shekh-Ahmad T, Wilcox KS, McDonough JH, Stables JP, Kaufmann D, Yagen B, Bialer M.(2012) A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia 53(1):134-46.  Abstract

Zhang J, Chen S, Ralph E, Dwyer M, Cashman J. (2012) Identification of human butyrylcholinesterase organophosphate-resistant variants through a novel mammalian enzyme functional screen. J Pharmacol Exp Ther. 343(3): 673-82.  Abstract

Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA.(2012) Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. J Pharmacol Exp Ther. 341(2): 435-46.  Abstract


Vesicating Agents 

Abel EL, Boulware S, Fields T, McIvor E, Powell KL, Digiovanni J, Vasquez KM, Macleod MC. (2012) Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog. Toxicol Appl Pharmacol. 266(3): 439-442.  Abstract

Boulware S, Fields T, McIvor E, Powell KL, Abel EL, Vasquez KM, Macleod MC. (2012) 2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog. Toxicol Appl Pharmacol. 263(2): 203-9.  Abstract

Brimfield AA, Soni SD, Trimmer KA, Zottola MA, Sweeney RE, Graham JS. (2012) Metabolic activation of sulfur mustard leads to oxygen free radical formation. Free Radic Biol Med. 52(4):811-7.  Abstract

Chao MW, Po I, Laumbach R, Koslosky J, Cooper K, Gordon MK. (2012) DEP induction of ROS in capillary-like endothelial tubes leads to VEGF-A expression. Toxicology. 297(1-3): 34-46.  Abstract

Deshmukh M, Kutscher HL, Gao D, Sunil VR, Malaviya R, Vayas K, Stein S, Laskin JD, Laskin DL, Sinko PJ. (2012) Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. J Control Release. 164(1): 65-73.  Abstract

Dragomir AC, Sun R, Mishin V, Hall LB, Laskin JD, Laskin DL. (2012) Role of Galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production. Toxicol Sci. 127(2):609-19.  Abstract

Dragomir AC, Sun R, Choi H, Laskin JD, Laskin DL. (2012) Role of Galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication. J Immunol. 189(12): 5934-41.  Abstract

Gardner CR, Hankey P, Mishin V, Francis M, Yu S, Laskin JD, Laskin DL. (2012) Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase. Toxicol Appl Pharmacol. 262(2):139-48.  Abstract

Gardner CR, Mishin V, Laskin JD, Laskin DL. (2012) Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole. Toxicol Sci. 125(2): 607-12.  Abstract 

Liu Y, Gardner CR, Laskin JD, Laskin DL. (2012) Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Exp Mol Pathol. 94(1): 160-7.  Abstract

Malaviya R, Venosa A, Hall L, Gow AJ, Sinko PJ, Laskin JD, Laskin DL. (2012) Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor. Toxicol Appl Pharmacol. 265(3): 279-91.  Abstract

Mishra NC, Rir-Sima-Ah J, Grotendorst GR, Langley RJ, Singh SP, Gundavarapu S, Weber WM, Pena-Philippides JC, Sopori ML. (2012) Inhalation of sulfur mustard causes long-term T cell-dependent inflammation: Possible role of Th17 cells in chronic lung pathology. Int Immunopharmacol. 13(1): 101-8.  Abstract  

Price JA, Rogers JV, Plahovinsak JL, Wendling MQ, Perry MR, Reid FM, Graham JS. (2012) Toxicogenomic analysis of chlorine vapor-induced porcine skin injury. Cutan Ocul Toxicol. 31(4): 323-31.  Abstract

Sunil VR, Patel-Vayas K, Shen J, Laskin JD, Laskin DL. (2012) Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress. Toxicol Appl Pharmacol. 263(2): 195-202.  Abstract

Sunil VR, Shen J, Patel-Vayas K, Gow AJ, Laskin JD, Laskin DL. (2012) Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning. Toxicol Appl Pharmacol. 261(1): 22-30.  Abstract

Tewari-Singh N, Jain AK, Inturi S, Agarwal C, White CW, Agarwal R. (2012) Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation. PLoS One. 7(9): e46149.  Abstract

Tewari-Singh N, Jain AK, Inturi S, Ammar DA, Agarwal C, Tyagi P, Kompella UB, Enzenauer RW, Petrash JM, Agarwal R. (2012) Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries. Toxicol Appl Pharmacol. 264(1): 23-31.  Abstract

Trabaris M, Laskin JD, Weisel CP. (2012) Percutaneous absorption of haloacetonitriles and chloral hydrate and simulated human exposures. J Appl Toxicol. 32(6): 387-94.  Abstract

Trabaris M, Laskin JD, Weisel CP. (2012) Effects of temperature, surfactants and skin location on the dermal penetration of haloacetonitriles and chloral hydrate. J Expo Sci Environ Epidemiol. 22(4): 393-7.  Abstract

Young SC, Fabio KM, Huang MT, Saxena J, Harman MP, Guillon CD, Vetrano AM, Heck DE, Flowers RA 2nd, Heindel ND, Laskin JD. (2012) Investigation of anticholinergic and non-steroidal anti-inflammatory prodrugs which reduce chemically induced skin inflammation. J Appl Toxicol. 32(2):135-41.  Abstract


Pulmonary Agents 

Bracher A, Doran SF, Squadrito GL, Postlethwait EM, Bowen L, Matalon S. (2012) Targeted aerosolized delivery of ascorbate in the lungs of chlorine-exposed rats. J Aerosol Med Pulm Drug Deliv. 25(6): 333-41.  Abstract

Chang W, Chen J, Schlueter CF, Rando RJ, Pathak YV, Hoyle GW. (2012) Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram. Toxicol Appl Pharmacol. 263(2): 251-8.  Abstract

Collawn JF, Lazrak A, Bebok Z, Matalon S. (2012) The CFTR and ENaC Debate - How Important is ENaC in CF lung disease? Am J Physiol Lung Cell Mol Physiol. 302(11): L1141-6. Abstract

Collawn JF, Matalon S. (2012) The role of CFTR in transepithelial liquid transport in pig alveolar epithelia. Am J Physiol Lung Cell Mol Physiol. 303(6):L489-91. Abstract

Connor AJ, Laskin JD, Laskin DL. (2012) Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4. Exp Mol Pathol. 92(2): 229-35.  Abstract

Fanucchi MV, Bracher A, Doran SF, Squadrito GL, Fernandez S, Postlethwait EM, Bowen L, Matalon S. (2012) Post-exposure antioxidant treatment decreases airway hyperplasia and hyperreactivity due to chlorine inhalation in rats. Am J Respir Cell Mol Biol. 46(5): 599-606.  Abstract

Filippidis AS, Zarogiannis SG, Randich A, Ness TJ, Matalon S. (2012) Assessment of locomotion in chlorine exposed mice by computer vision and neural networks. J Appl Physiol. 112(6): 1064-72.  Abstract

Groves AM, Gow AJ, Massa CB, Laskin JD, Laskin DL. (2012) Prolonged injury and altered lung function after ozone inhalation in mice with chronic lung inflammation. Am J Respir Cell Mol Biol. 47(6): 776-83.  Abstract

Lazrak A, Chen L, Jurkuvenaite A, Doran SF, Liu G, Li Q, Lancaster Jr JR, Matalon S. (2012) Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine breathing mice. Am J Respir Cell Mol Biol. 46(3): 342-54.  Abstract

Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico RA Jr, Upadhyay S, Di YP, Li Q, Hu Z, Vuga LJ, Medvedovic M, Kaminski N, You M, Alexander DC, McDunn JE, Prows DR, Knoell DL, Fabisiak JP. (2012) Integrative assessment of chlorine-induced acute lung injury in mice. Am J Respir Cell Mol Biol. 47(2): 234-44.  Abstract

Li HH, Li Q, Liu P, Liu Y, Li J, Wasserloos K, Chao W, You M, Oury TD, Chhinder S, Hackam DJ, Billiar TR, Leikauf GD, Pitt BR, Zhang LM. (2012) WNT1 inducible signaling pathway Protein 1 (WISP1) contributes to ventilator-induced lung injury. Am J Respir Cell Mol Biol. 47(4):528-35.  Abstract

Musah S, Chen J, Hoyle GW. (2012) Repair of tracheal epithelium by basal cells after chlorine-induced injury. Respir Res. 13(1): 107.  Abstract

Rancourt RC, Veress LA, Guo X, Jones TN, Hendry-Hofer TB, White CW. (2012) Airway tissue factor-dependent coagulation activity in response to sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES). Am J Physiol Lung Cell Mol Physiol. 302(1): L82-92.  Abstract

Samal AA, Honavar J, Brandon A, Bradley KM, Doran S, Liu Y, Dunaway C, Steele C, Postlethwait EM, Squadrito GL, Fanucchi MV, Matalon S, Patel RP. (2012) Administration of nitrite after chlorine gas exposure prevents lung injury: Effect of administration modality. Free Radic Biol Med. 53(7):1431-9.  Abstract

Yang S, Banerjee S, de Freitas A, Sanders YY, Ding Q, Matalon S, Thannickal VJ, Abraham E, Liu G. (2012) Participation of miR-200 in pulmonary fibrosis. Am J Pathol. 180(2): 484-93.  Abstract

Zarogiannis SG, Noah JW, Jurkuvenaite A, Steele C, Matalon S, Noah DL. (2012) Comparison of ribavirin and oseltamivir in reducing mortality and lung injury in mice infected with mouse adapted A/California/04/2009 (H1N1). Life Sci. 90(11-12): 440-5.   Abstract

Zhao RZ, Nie HG, Su XF, Han DY, Lee A, Huang Y, Chang Y, Matalon S, Ji HL. (2012) Characterization of a novel splice variant of δ ENaC subunit in human lungs. Am J Physiol Lung Cell Mol Physiol. 302(12): L12662-72.  Abstract


Metabolic/Cellular Poisons 

Belani KG, Singh H, Beebe DS, George P, Patterson SE, Nagasawa HT, Vince R. (2012) Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium. Anesth Analg. 114(5): 956-61.  Abstract

Benz OS, Yuan Q, Amoscato AA, Pearce LL, Peterson J. (2012) The metalloporphyrin Co(III)TMPyP ameliorates acute cyanide toxicity in mice. Chem Res Toxicol. 25(12): 2678-86.  Abstract

Bhandari RK, Oda RP, Youso SL, Petrikovics I, Bebarta VS, Rockwood GA, Logue BA. (2012) Simultaneous determination of cyanide and thiocyanate in plasma by chemical ionization gas chromatography mass-spectrometry (CI-GC-MS). Anal Bioanal Chem. 404(8):2287-94.  Abstract

Kim JG, Lee J, Mahon SB, Mukai D, Patterson SE, Boss GR, Tromberg BJ, Brenner M. (2012) Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism. J Biomed Opt. 17(10): 105005. Abstract

Ma J, Dasgupta PK, Zelder FH, Boss GR. (2012) Cobinamide chemistries for photometric cyanide determination. A merging zone liquid core waveguide cyanide analyzer using cyanoaquacobinamide. Anal Chim Acta. 736: 78-84.  Abstract

Sani S, Lee J, Patino R, Mukai D, Yoon D, Mahon S, Boss G, Patterson S, Brenner M. (2013) Development of a treatment agent for mass casualty smoke-cyanide exposure. Chest 142(4_MeetingAbstracts):746A.  Abstract

Vinnakota CV, Peetha NS, Perrizo MG, Ferris DG, Oda RP, Rockwood GA, Logue BA. (2012) Comparison of cyanide exposure markers in the biofluids of smokers and non-smokers. Biomarkers. 17(7):625-33.  Abstract

Youso SL, Rockwood GA, Logue BA. (2012) The analysis of protein-bound thiocyanate in plasma of smokers and non-smokers as a marker of cyanide exposure. J Anal Toxicol. 26(4): 265-9.  Abstract


Paralytic Neurotoxins 

Payandeh J, Gamal El-Din TM, Scheuer T, Zheng N, Catterall WA. (2012) Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. Nature. 486(7401): 135-9.  Abstract

Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA. (2012) Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated sodium channels. J Biol Chem. 287(36): 30719-28.  Abstract



Aryal UK, Lin CT, Kim JS, Heibeck TH, Wang J, Qian WJ, Lin Y. (2012) Identification of phosphorylated butyrylcholinesterase in human plasma using immunoaffinity purification and mass spectrometry. Anal Chim Acta. 723: 68-75.  Abstract

Chen A, Du D, Lin Y. (2012) Highly sensitive and selective immuno-capture/electrochemical assay of acetylcholinesterase activity in red blood cells: A biomarker of exposure to organophosphorus pesticides and nerve agents. Environ Sci Technol. 46(3): 1828-33.  Abstract

Du D, Wang J, Wang L, Lu D, Lin Y.(2012) Integrated lateral flow test strip with electrochemical sensor for quantification of phosphorylated cholinesterase: Biomarker of exposure to organophosphorus agents. Anal Chem. 84(3): 1380-5.  Abstract

Zou ZX, Wang J, Wang H, Li YQ, Lin Y. (2012) An integrated electrochemical device based on immunochromatographic test strip and enzyme labels for sensitive detection of disease-related biomarkers. Talanta. 94 58-64.  Abstract


(80 Total 2012 Publications)

CounterACT Publications (2013)

Neurotoxic Agents 

Ahmed SK, Belabassi Y, Sankaranarayanan L, Chao CK, Gerdes JM, Thompson CM. (2013) Synthesis and anti-acetylcholinesterase properties of novel β- and γ-substituted alkoxy organophosphonates. Bioorg Med Chem Lett. 23(7): 2048-51.  Abstract

Alkondon M, Albuquerque EX, Pereira EF. (2013) Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology. 36C: 72-81. Abstract

Andres D, Keyser BM, Petrali J, Benton B, Hubbard KS, McNutt PM, Ray R. (2013) Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid. BMC Neurosci. 14: 49.  Abstract

Apland JP, Aroniadou-Anderjaska V, Figueiredo TH, Green CE, Swezey RR, Yang C, Qashu F, Braga MF. (2013) Efficacy of the GluK1/AMPA receptor antagonist LY293558 against seizures and neuropathology in a soman-exposure model without pretreatment and its pharmacokinetics after intramuscular administration. J Pharmacol Exp Ther. 344(1): 133-40.  Abstract

Ben-David M, Wieczorek G, Elias M, Silman I, Sussman JL, Tawfik DS. (2013) Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. J Mol Biol. 425(6): 1028-38.  Abstract

Carver CM, Reddy DS. (2013) Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability. Psychopharmacology (Berl). 230(2): 151-88.  Abstract

Chen S, Zhang J, Lumley L, Cashman JR. (2013) Immunodetection of serum albumin adducts as biomarkers for organophosphorus exposure. J Pharmacol Exp Ther. 344(2):531-41. Abstract

Chen S, Ruan Y, Brown JD, Gallucci J, Maslak V, Hadad CM, Badjić JD. (2013) Assembly of amphiphilic baskets into stimuli-responsive vesicles. Developing a strategy for the detection of organophosphorus chemical nerve agents. J Am Chem Soc. 135(40): 14964-7. Abstract

Cherny I, Greisen P Jr, Ashani Y, Khare SD, Oberdorfer G, Leader H, Baker D, Tawfik DS. (2013) Engineering V-Type nerve agents detoxifying enzymes using computationally focused libraries. ACS Chem Biol. 8(11): 2394-403.  Abstract

Eterović VA, Del Valle-Rodriguez A, Pérez D, Carrasco M, Khanfar MA, El Sayed KA, Ferchmin PA. (2013) ective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: Preliminary structure-activity relationship and pharmacophore modeling. Bioorg Med Chem. 21(15): 4678-86.  Abstract

Ferchmin PA, Pérez D, Castro Alvarez W, Penzo MA, Maldonado HM, Eterovic VA. (2013) γ-Aminobutyric acid type a receptor inhibition triggers a nicotinic neuroprotective mechanism. J Neurosci Res. 91(3):416-25.  Abstract

Garrett TL, Joshi K, Rapp CM, Chapleau M, Cool DR, Schlager JJ, Lucot JB. (2013) The effects of 8-OH-DPAT on neuroinflammation after sarin exposure in mice. Toxicology 310:22-8.  Abstract

Gerdes JM, James S, Ahmed SA, Belabassi Y, Braden MR, VanBrocklin HF, Thompson CM (2013) A novel high affinity F-18 organophosphonate tracer for CNS acetylcholinesterase. J Nucl Med 54: 323.

Geyer BC, Larrimore KE, Kilbourne J, Kannan L, Mor TS. (2013) Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase. PLoS One. 8(3):e59159.  Abstract

Goldsmith M, Tawfik DS. (2013) Enzyme engineering by targeted libraries. Methods Enzymol. 523: 257-83.  Abstract

Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM. (2013) Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury. PLoS One. 8(5): e64423. Abstract

Hen N, Shekh-Ahmad T, Yagen B, McDonough JH, Finnell RH, Wlodarczyk B, Bialer M. (2013) Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butyl-propylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against Status EpilepticusJ Med Chem. 56(16): 6467-77.  Abstract

Hubbard KS, Gut IM, Lyman ME, McNutt PM. (2013) Longitudinal RNA sequencing of the deep transcriptome during neurogenesis of cortical glutamatergic neurons from murine ESCs. F1000Res. 2:35.  Abstract

Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD. (2013) Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. PLoS One. 8(12):e80922.  Abstract

Jiang W, Cashman JR, Nachon F, Masson P, Schopfer LM, Lockridge O. (2013) Mass spectrometry method to identify aging pathways of Sp- and Rp- tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond. Toxicol Sci. 132(2): 390-8.  Abstract

Jin S, Sarkar KS, Jin YN, Liu Y, Kokel D, Van Ham TJ, Roberts LD, Gerszten RE, Macrae CA, Peterson RT. (2013) An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action. J Biomol Screen. 18(1): 108-15.  Abstract

Kovarik Z, Maček N, Sit RK, Radić Z, Fokin VV, Barry Sharpless K, Taylor P. (2013) Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chem Biol Interact. 203(1): 77-80.  Abstract

Kozhemyakin M, Rajasekaran K, Todorovic MS, Kowalski SL, Balint C, Kapur J. (2013) Somatostatin type-2 receptor activation inhibits glutamate release and prevents status epilepticus. Neurobiol Dis. 54C: 94-104.  Abstract

Li B, Duysen EG, Froment MT, Masson P, Nachon F, Jiang W, Schopfer LM, Thiele GM, Klassen LW, Cashman JR, Williams GR, Lockridge O. (2013) Polyclonal antibody to soman-tyrosine. Chem Res Toxicol. 26(4): 584-92.  Abstract

Morris GM, Green LG, Radić Z, Taylor P, Sharpless KB, Olson AJ, Grynszpan F. (2013) Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase. J Chem Inf Model. 53(4): 898-906.  Abstract

Phillips KF, Deshpande LS, Delorenzo RJ. (2013) Hypothermia reduces calcium entry via the N-methyl-D-aspartate and ryanodine receptors in cultured hippocampal neurons. Eur J Pharmacol. 698(1-3): 186-92.  Abstract

Pidoplichko VI, Prager EM, Aroniadou-Anderjaska V, Braga MF. (2013) α7-containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability. J Neurophysiol. 110(10): 2358-69.  Abstract

Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D. (2013) Issues related to development of antiepileptogenic therapies. Epilepsia 54 Suppl 4:35-43.  Abstract 

Prager EM, Aroniadou-Anderjaska V, Almeida-Suhett CP, Figueiredo TH, Apland JP, Braga MF. (2013) Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure. Neurotoxicology. 38C: 84-90.  Abstract

Radic Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Duggan BM, Ajami D, Rebek Jr J, Taylor PW. (2013) Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes. Biochem J. 450(1): 231-42.  Abstract

Radić Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P. (2012) Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates. Chem Biol Interact. 203(1): 67-71.  Abstract

Reddy DS. (2013) Neuroendocrine aspects of catamenial epilepsy. Horm Behav. 63(2): 254-66.  Abstract

Reddy DS. (2013) Role of hormones and neurosteroids in epileptogenesis. Front Cell Neurosci. 7:115 (ecollection)  Abstract

Reddy DS, Kuruba R. (2013) Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions. Int J Mol Sci. 14(9):18284-318.  Abstract

Rosenberg YJ, Gearhart J, Mao L, Jiang X, Hernandez-Abanto S. (2013) Protection against paraoxon toxicity by an intravenous pretreatment with polyethylene-glycol-conjugated recombinant butyrylcholinesterase in macaques. Chem Biol Interact. 210: 20-5.  Abstract

Ryan K, Liang LP, Rivard C, Patel M. (2013) Temporal and spatial increase of reactive nitrogen species in the kainate model of temporal lobe epilepsy. Neurobiol Dis. 64: 8-15.  Abstract

Schneider JD, Castilho A, Neumann L, Altmann F, Loos A, Kannan L, Mor TS, Steinkellner H. (2013) Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue. Biotechnol J. [Epub ahead of Print]  Abstract

Shekh-Ahmad T, Hen N, McDonough JH, Yagen B, Bialer M. (2013) Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus. Epilepsia. 54 Suppl 6:99-102.  Abstract

Sokolowski K, Poku M, Robinson K, McCandlish E, Buckley B, Dicicco-Bloom E. (2013) Neural stem cell apoptosis after low methylmercury (MeHg) exposures in postnatal hippocampus produce persistent cell loss and adolescent memory deficits. Dev. Neurobiol. 73(12): 936-49.  Abstract

Topczewski JJ, Lodge AM, Yasapala SN, Payne MK, Keshavarzi PM, Quinn DM. (2013) Reversible inhibition of human acetylcholinesterase by methoxypyridinium species. Bioorg Med Chem Lett 23(21): 5786-9.  Abstract

Topczewski JJ, Quinn DM. (2013) Kinetic assessment of N-Methyl-2-methoxypyridinium species as phosphonate anion methylating agents. Org Lett. 15(5):1084-7. Abstract

Torres-Rivera W, Pérez D, Park KY, Carrasco M, Platt MO, Eterović VA, Ferchmin PA, Ulrich H, Martins AH. (2013) Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage. Neuroscience. 247C: 273-9.  Abstract

Vezzani A, Friedman A, Dingledine RJ. (2013) The role of inflammation in epileptogenesis. Neuropharmacology. 69: 16-24.  Abstract

Wasterlain CG, Naylor DE, Liu H, Niquet J, Baldwin R. (2013) Trafficking of NMDA receptors during status epilepticus: Therapeutic implications. Epilepsia. 54 Suppl 6:78-80.  Abstract


Vesicating Agents 

Chang YC, Wang JD, Svoboda KK, Casillas RP, Laskin JD, Gordon MK, Gerecke DR. (2013) Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model. Toxicol Appl Pharmacol. 268(2): 178-87.  Abstract

Connor AJ, Chen LC, Joseph LB, Laskin JD, Laskin DL. (2013) Distinct responses of lung and liver macrophages to acute endotoxemia: role of toll-like receptor 4. Exp Mol Pathol. 94(1): 216-27.  Abstract

D'Addio SM, Baldassano S, Shi L, Cheung L, Adamson DH, Bruzek M, Anthony JE, Laskin DL, Sinko PJ, Prud'homme RK. (2013) Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers. J. Control Release 168(1): 41-9.  Abstract

Inturi S, Tewari-Singh N, Jain AK, Roy S, White CW, Agarwal R. (2013) Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin. Toxicology. 311(3): 184-190.  Abstract

Liu Y, Gardner CR, Laskin JD, Laskin DL. (2013) Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Exp Mol Pathol. 94(1):160-7.  Abstract 

Ruff AL, Jarecke AJ, Hilber DJ, Rothwell CC, Beach SL, Dillman JF 3rd. (2013) Development of a mouse model for sulfur mustard-induced ocular injury and long-term clinical analysis of injury progression. Cutan Ocul Toxicol. 32(2): 140-9.  Abstract

Snider TH, Perry MR, Richter WR, Plahovinsak JL, Rogers J, Reid FM, Graham JS. (2013) A dynamic system for delivering controlled bromine and chlorine vapor exposures to weanling swine skin. Cutan Ocul Toxicol. [Epub ahead of Print]  Abstract

Srivastava RK, Li C, Chaudhary SC, Ballestas ME, Elmets CA, Robbins DJ, Matalon S, Deshane JS, Afaq F, Bickers DR, Athar M. (2013) Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption. Toxicol Appl Pharmacol. 272(3): 879-887.  Abstract

Sunil VR, Vayas KJ, Massa CB, Gow AJ, Laskin JD, Laskin DL. (2013) Ozone-induced injury and oxidative stress in bronchiolar epithelium is associated with altered pulmonary mechanics. Toxicol Sci. 133(2): 309-19.  Abstract

Tewari-Singh N, Jain AK, Inturi S, White CW, Agarwal R. (2013) Clinically-relevant cutaneous lesions by nitrogen mustard: useful biomarkers of vesicants skin injury in SKH-1 Hairless and C57BL/6 mice. PLoS One. 8(6): e67557.  Abstract

Yang S, Jan YH, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. (2013) Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. J. Biol Chem. 288(26): 19221-37.  Abstract

Yego EC, Dillman JF 3rd. (2013) Cytokine regulation by MAPK activated Kinase 2 in keratinocytes exposed to sulfur mustard. Toxicol In Vitro. 27(7): 2067-75. Abstract

Zheng R, Heck DE, Black AT, Gow A, Laskin DL, Laskin JD. (2013) Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med. 67: 1-9.  Abstract

Zheng R, Po I, Mishin V, Black AT, Heck DE, Laskin DL, Sinko PJ, R Gerecke D, Gordon MK, Laskin JD. (2013) The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicol Appl Pharmacol. 272(2): 345-55.  Abstract


Pulmonary Agents

Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW. (2013) Tissue factor signals airway epithelial basal cell survival via coagulation and PAR1/2. Am J Respir Cell Mol Biol. 48(1): 94-104.  Abstract

Ahmad A, Schaack JB, White CW, Ahmad S. (2013) Adenosine A2A receptor-dependent proliferation of pulmonary endothelial cells is mediated through calcium mobilization, PI3-kinase and ERK1/2 pathways. Biochem Biophys Res Commun. 434(3): 566-71.  Abstract

Ambalavanan N, Stanishevsky A, Bulger A, Halloran B, Steele C, Vohra Y, Matalon S. (2013) Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in mice. Am J Physiol Lung Cell Mol Physiol. 304(3):L152-61. Abstract

Bein K, Di Giuseppe M, Mischler SE, Ortiz LA, Leikauf GD. (2013) Lipopolysaccharide-treated macrophages cytokines repress surfactant protein B in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 49(2): 306-15.  Abstract

Chen J, Mo Y, Schlueter CF, Hoyle GW. (2013) Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol Appl Pharmacol. 272(2): 408-13.  Abstract

Day BJ. (2013) Antioxidant therapeutics: Pandora's box. Free Radic Biol Med. 66:58-64.  Abstract

Gessner MA, Doran SF, Yu Z, Dunaway CW, Matalon S, Steele C. (2013) Chlorine gas exposure increases susceptibility to invasive lung fungal infection. Am J Physiol Lung Cell Mol Physiol. 304(11): L765-73.  Abstract

Ghosh M, Ahmad S, Jian A, Li B, Smith RW, Helm KM, Seibold MA, Groshong SD, White CW, Reynolds SD. (2013) Human tracheobronchial basal cells: normal versus remodeling/repairing phenotypes in vivo and in vitro. Am J Respir Cell Mol Biol. 49(6): 1127-34.  Abstract

Groves AM, Gow AJ, Massa CB, Hall L, Laskin JD, Laskin DL. (2013) Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation. Am J Physiol Lung Cell Mol Physiol. 305(8): L555-68.  Abstract

Jugg B, Fairhall S, Smith A, Rutter S, Mann T, Perrott R, Jenner J, Salguero J, Shute J, Sciuto AM. (2013) N-acetyl-L-cysteine protects against inhaled sulfur mustard poisoning in the large swine. Clin Toxicol (Phila). 51(4): 216-24.  Abstract

Lazrak A, Fu L, Bali V, Bartoszewski R, Rab A, Havasi V, Keiles S, Kappes J, Kumar R, Lefkowitz E, Sorscher EJ, Matalon S, Collawn JF, Bebok Z. (2013) The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction. FASEB J. 27(11): 4630-45.  Abstract

Lazrak A, Jurkuvenaite A, Ness EC, Zhang S, Woodworth BA, Muhlebach MS, Stober VP, Lim YP, Garantziotis S, Matalon S. (2013) Inter-α-inhibitor blocks ENaC activation and decreases nasal potential differences in ΔF508 mice. Am J Respir Cell Mol Biol. [Epub ahead of Print]  Abstract

Leikauf GD, Concel VJ, Bein K, Liu P, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico Jr RA, Upadhyay S, Cario CL, Di YP, Vuga LJ, Kostem E, Eskin E, You M, Kaminski N, Prows DR, Knoell DL, Fabisiak JP. (2013) Functional genomic assessment of phosgene-induced acute lung injury in mice. Am J Respir Cell Mol Biol. 49(3): 368-83.  Abstract

Li C, Weng Z, Doran SF, Srivastava RK, Afaq F, Matalon S, Athar M. (2013) Chlorine induces the unfolded protein response in murine lungs and skin. Am J Respir Cell Mol Biol. 49(2): 197-203.  Abstract

Londino JD, Lazrak A, Jurkuvenaite A, Collawn JF, Noah JW, Matalon S. (2013) Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity. Am J Physiol Lung Cell Mol Physiol. 304(9):L582-92.  Abstract

Londino JD, Matalon S. (2013) Chloride secretion across adult alveolar epithelial cells contributes to cardiogenic edema. Proc Natl Acad Sci USA. 110(25): 10055-6.  Abstract

Mo Y, Chen J, Schlueter CF, Hoyle GW. (2013) Differential susceptibility of inbred mouse strains to chlorine-induced airway fibrosis. Am J Physiol Lung Cell Mol Physiol. 304(2):L92-L102.  Abstract

O'Koren EG, Hogan BL, Gunn MD. (2013) Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. Am J Respir Cell Mol Biol. 49(5): 788-97.  Abstract

Rancourt RC, Veress LA, Ahmad A, Hendry-Hofer TB, Rioux JS, Garlick RB, White CW. (2013) Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. Toxicol Appl Pharmacol. 272(1): 86-95.  Abstract

Veress LA, Hendry-Hofer TB, Loader JE, Rioux JS, Garlick RB, White CW. (2013) Tissue plasminogen activator prevents mortality from sulfur mustard analog-induced airway obstruction. Am J Respir Cell Mol Biol. 48(4): 439-47.  Abstract

Yang S, Jan YH, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. (2013) Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. J Biol Chem. 288(26):19221-37.  Abstract


Metabolic/Cellular Poisons

Benavides S, Brenner M, Mahoon S, Mukai D, Yoon D, Burney T, Alexander C, Boss G, Jaing J, Lee J. (2013) Cobinamide: A future treatment of hydrogen sulfide toxicity in mass casualty instances. Chest. 144(4-MeetingAbstracts): 369A.  Abstract 

Cambal LK, Weitz AC, Li HH, Zhang Y, Zheng X, Pearce LL, Peterson J. (2013) A comparison of the relative propensities of isoamyl nitrite and sodium nitrite to ameliorate acute cyanide poisoning in mice and a novel antidotal effect arising from anesthetics. Chem Res Toxicol.  26(5): 828-36.  Abstract

Dereven'kov IA, Salnikov DS, Makarov SV, Surducan M, Silaghi-Dumitrescu R, Boss GR. (2013) Comparative study of reaction of cobalamin and cobinamide with thiocyanate. J Inorg Biochem. 125C:32-39. Abstract

Dereven'kov IA, Salnikov DS, Makarov SV, Boss GR, Koifman OI. (2013) Kinetics and mechanism of oxidation of super-reduced cobalamin and cobinamide species by thiosulfate, sulfite and dithionite. Dalton Trans. 42(43): 15307-16.  Abstract

Fago A, Crumbliss AL, Hendrich MP, Pearce LL, Peterson J, Henkens R, Bonaventura C. (2013) Oxygen binding to partially nitrosylated hemoglobin. Biochim Biophys Acta. 1834(9): 1894-900.  Abstract

Haouzi P, Klingerman CM. (2013) Fate of intracellular H2S/HS- and metallo-proteins. Respir Physiol Neurobiol. 188(2): 229-30.  Abstract

Klingerman CM, Trushin N, Prokopczyk B, Haouzi P. (2013) H2S Concentrations in the arterial blood during H2S administration in relation to its toxicity and effects on breathing. Am J Physiol Regul Integr Comp Physiol. 305(6): R630-8.  Abstract

Kovacs K, Ancha M, Jane M, Lee S, Angalakurthi S, Negrito M, Rasheed S, Nwaneri A, Petrikovics I. (2013) Identification, solubility enhancement and in vivo testing of a cyanide antidote candidate. Eur J Pharm Sci. 49(3): 352-8.  Abstract

Mitchell BL, Bhandari RK, Bebarta VS, Rockwood GA, Boss GR, Logue BA. (2013) Toxicokinetic profiles of α-ketoglutarate cyanohydrin, a cyanide detoxification product, following exposure to potassium cyanide. Toxicol Lett. 222(1): 83-89.  Abstract

Mitchell BL, Rockwood GA, Logue BA. (2013) Quantification of α-ketoglutarate cyanohydrin in swine plasma by ultra-high performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 934: 60-5.  Abstract

Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, Macrae CA, Brenner M, Gerszten RE, Peterson RT. (2013) Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 27(5): 1928-38.  Abstract

Patterson SE, Monteil AR, Cohen JF, Crankshaw DL, Vince R, Nagasawa HT. (2013) Cyanide antidotes for mass casualties: Water-soluble salts of the dithiane (sulfanegen) from 3-Mercaptopyruvate for intramuscular administration. J Med Chem. 56(3):1346-9.  Abstract

Peterson RT, Macrae CA. (2013) Changing the scale and efficiency of chemical warfare countermeasure discovery using the zebrafish. Drug Discov Today Dis Models. 10(1): e37-42. Abstract

Satoh T, McKercher SR, Lipton SA. (2013) Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med. 65C: 645-57.  Abstract

Spitler R, Schwappacher R, Wu T, Kong X, Yokomori K, Pilz RB, Boss GR, Berns MW. (2013) Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase. Cell Signal. 25(12): 2374-2382.  Abstract



Chen S, Zhang J, Lumley L, Cashman JR. (2013) Immunodetection of serum albumin adducts as biomarkers for organophosphorus exposure. J Pharmacol Exp Ther. 344(2): 531-41.  Abstract

Jiang W, Cashman JR, Nachon F, Masson P, Schopfer LM, Lockridge O. (2013) Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond. Toxicol. Sci. 132(2): 390-8.  Abstract

Swezey R, Shinn W, Green C, Drover DR, Hammer GB, Schulman SR, Zajicek A, Jett DA, Boss GR. (2013) Comparison of a new cobinamide-based method to a standard laboratory method for measuring cyanide in human blood. J Anal Toxicol. 37(6): 382-5.  Abstract

Tian Y, Dasgupta PK, Mahon SB, Ma J, Brenner M, Wang JH, Boss GR. (2013) A disposable blood cyanide sensor. Anal Chim Acta. 768:129-35.  Abstract

Zhang W, Ge X, Tang Y, Du D, Liu D, Lin Y. (2013) Nanoparticle-based immunochromatographic test strip with fluorescent detector for quantification of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphorus agents. Analyst. 138(18): 5431-6.  Abstract

Zhang X, Wang H, Yang C, Du D, Lin Y. (2013) Preparation, characterization of Fe(3)O(4) at TiO(2) magnetic nanoparticles and their application for immunoassay of biomarker of exposure to organophosphorus pesticides. Biosens Bioelectron. 41: 669-74.  Abstract 

Zhao Y, Zhang W, Lin Y, Du D. (2013) The vital function of Fe(3)O(4)@Au nanocomposites for hydrolase biosensor design and its application in detection of methyl parathion. Nanoscale. 5(3):1121-6. Abstract 


(103 Total 2013 Publications)

CounterACT Publications (2014)

Neurotoxic Agents

James SL, Ahmed SK, Murphy ST, Braden MR, Belabassi Y, Vanbrocklin HF, Thompson CM, Gerdes JM. (2014) A novel fluorine-18 β-Fluoroethoxy organophosphate positron emission tomography imaging tracer targeted to central nervous system acetylcholinesterase. ACS Chem Neurosci. [Epub ahead of Print]  Abstract

Kaminski RM, Rogawski MA, Klitgaard H. (2014) The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments. Neurotherapeutics. [Epub ahead of Print]  Abstract

Prager EM, Aroniadou-Anderjaska V, Almeida-Suhett CP, Figueiredo TH, Apland JP, Rossetti F, Olsen CH, Braga MF. (2014) The recovery of acetylcholinesterase activity and the progression of neuropathological and pathophysiological alterations in the rat basolateral amygdala after soman-induced status epilepticus: Relation to anxiety-like behavior. Neuropharmacology. 81: 64-74. Abstract

Shekh-Ahmad T, Hen N, Yagen B, McDonough JH, Finnell RH, Wlodarczyk BJ, Bialer M. (2014) Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential. Epilepsia 55(2): 353-61.  Abstract

Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radić Z. (2014) Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification. J Med Chem. 57(4):1378-89.  Abstract

Zolkowska D, Dhir A, Krishnan K, Covey DF, Rogawski MA. (2014) Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms. Psychopharmacology (Berl). [Epub ahead of Print]  Abstract


Vesicating Agents

Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN. (2014) A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. Curr Biol. 24(5):473-83.  Abstract

Jain AK, Tewari-Singh N, Inturi S, Orlicky DJ, White CW, Agarwal R. (2014) Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice. Exp Toxicol Pathol. 66(2-3): 129-38.  Abstract

Jain AK, Tewari-Singh N, Inturi S, Orlicky DJ, White CW, Agarwal R. (2014) Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries. Toxicology 320C:25-33. Abstract

Jan YH, Heck DE, Dragomir AC, Gardner CR, Laskin DL, Laskin JD. (2014) Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol. [Epub ahead of Print]  Abstract

Joseph LB, Heck DE, Cervelli JA, Composto GM, Babin MC, Casillas RP, Sinko PJ, Gerecke DR, Laskin DL, Laskin JD. (2014) Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard. Exp Mol Pathol. [Epub ahead of Print]  Abstract

Tewari-Singh N, Jain AK, Orlicky DJ, White CW, Agarwal R. (2014) Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice. PLoS One. 9(1): e85402.  Abstract

Zheng R, Heck DE, Mishin V, Black AT, Shakarjian MP, Kong AN, Laskin DL, Laskin JD. (2014) Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product. Toxicol Appl Pharmacol. 275(2):113-21. Abstract


Pulmonary Agents

Fazzi F, Njah J, Di Giuseppe M, Winnica DE, Go K, Sala E, St Croix CM, Watkins SC, Tyurin VA, Phinney DG, Fattman CL, Leikauf GD, Kagan VE, Ortiz LA. (2014) TNFR1/Phox interaction and TNFR1 mitochondrial translocation thwart silica-induced pulmonary fibrosis. J Immunol. 192(*): 3837-46.  Abstract

Houin PR, Veress LA, Rancourt RC, Hendry-Hofer TB, Loader JE, Rioux JS, Garlick RB, White CW. (2014) Intratracheal heparin improves plastic bronchitis due to sulfur mustard analog. Pediatr Pulmonol. [Epub ahead of Print]  Abstract

Jan YH, Heck DE, Malaviya R, Casillas RP, Laskin DL, Laskin JD. (2014) Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not Redox cycling. Chem Res Toxicol. 27(1): 61-75.  Abstract

Malaviya R, Laskin JD, Laskin DL. (2014) Oxidative stress-induced autophagy: Role in pulmonary toxicity. Toxicol Appl Pharmacol. 275(2):145-151.  Abstract

Massa CB, Scott P, Abramova E, Gardner C, Laskin DL, Gow AJ. (2014) Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction. Toxicol Appl Pharmacol. [Epub ahead of Print]  Abstract


Metabolic/Cellular Poisons

Bhandari RK, Oda RP, Petrikovics I, Thompson DE, Brenner M, Mahon SB, Bebarta VS, Rockwood GA, Logue BA. (2014) Cyanide toxicokinetics: the behavior of cyanide, thiocyanate and 2-amino-2-thiazoline-4-carboxylic acid in multiple animal models. J Anal Toxicol. 38(4): 218-25.  Abstract

Brenner M, Benavides S, Mahon SB, Lee J, Yoon D, Mukai D, Viseroi M, Chan A, Jiang J, Narula N, Azer SM, Alexander C, Boss GR. (2014) The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model. Clin Toxicol (Phila). [Epub ahead of Print]  Abstract



Bhandari RK, Manandhar E, Oda RP, Rockwood GA, Logue BA. (2014) Simultaneous high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) analysis of cyanide and thiocyanate from swine plasma. Anal Bioanal Chem. 406(3): 727-34.  Abstract

Jackson RE, Oda RP, Bhandari RK, Mahon SB, Brenner M, Rockwood GA, Logue BA. (2014) The development of a fluorescence-based sensor for rapid diagnosis of cyanide exposure. Anal Chem. 86(3): 1845-52.  Abstract

Stutelberg MW, Vinnakota CV, Mitchell BL, Monteil AR, Patterson SE, Logue BA. (2014) Determination of 3-mercaptopyruvate in rabbit plasma by high performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 949-950C: 94-8.  Abstract


(23 Total 2014 Publications)

Last updated April 12, 2014