CounterACT Publications 2009

CounterACT Publications

Neurotoxic Organophosphorus Poisons (e.g. anti-convulsants, anti-seizures, neuroprotectants, cholinesterase reactivators, nerve agent bioscavengers)

Albuquerque EX, Pereira, EF, Alkondon M, Rogers SW. (2009) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol. Rev. 89(1): 73-120.  Abstract

Alkondon M, Aracava Y, Pereira ER, Albuquerque EX. (2009) A single in vivo application of cholinesterase inhibitors has neuron type-specific effects on nicotinic receptor activity in guinea pig hippocampus. J Pharmacol Exp Ther. 328(1): 69-82.  Abstract 

Aroniadou-Anderjaska V, Figueiredo TH, Apland JP, Qashu F, Braga MF. (2009) Primary brain targets of nerve agents: the role of the amygdala in comparison to the hippocampus. Neurotoxicology [Epub ahead of print]  Abstract

Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J. (2009) Chemical synthesis of two series of nerve agent model compounds and their stereoselective interactions with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. [Epub ahead of Print]  Abstract

Blair RE, Deshpande LS, Holbert WH, Churn SB, Delorenzo RJ. (2009) Age-dependent mortality in the pilocarpine model of status epilepticus. Neurosci Lett 453(3): 233-4.  Abstract

Budai M, Chapela P, Grof P, Zimmer A, Wales ME, Wild JR, Klebovich I, Petrikovics I, Szilasi M. (2009) Physiochemical characterization of stealth liposomes encapsulating an organophosphate hydrolyzing enzyme. J Lipsome Res. 23:1-6.  Abstract

Che MM, Conti M, Chanda S, Boylan M, Sabnekar P, Rezk P, Amari E, Sciuto AM, Gordon RK, Doctor BP, Nambiar MP. (2009) Post-exposure treatment with nasal atropine methyl bromide protects against micoinstillation inhalation exposure to sarin in guinea pigs. Toxicol Appl Pharmacol. 239(3): 251-7.  Abstract

Falenski KW, Carter DS, Harrison AJ, Martin BR, Blair RE, DeLorenzo RJ. (2009) Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. Brain Res. 1262:64-72.  Abstract 

Fawcett WP, Aracava Y, Adler M, Pereira EF, Albuquerque EX. (2009) Acute toxicity of organophosphorus compounds in guinea pigs is sex and age dependent and cannot be solely accounted by acetycholinesterase inhibition. J Pharmacol Exp Ther. 328(2): 516-24.  Abstract

Fritsch B, Qashu F, Figueriredo TH, Aroniadou-Anderjaska V, Rogawski MA, Braga MF. (2009) Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis. Neuroscience 163(1): 415-29.  Abstract

Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O. (2009) Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase. Chem Res Toxicol. [Epub ahead of print]  Abstract

Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM. (2009) Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 180(3): 492-8.  Abstract

Grigoryan H, Li B, Xue W, Grigoryan M, Schopfer LM, Lockridge O. (2009) Mass spectral characterization of organophosphate-labeled lysine in peptides. Anal Biochem 394(1): 92-100.  Abstract

Grigoryan H, Lockridge O. (2009) Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxons; implications for neurotoxicity. Toxiol Appl Pharmacol [Epub ahead of print]  Abstract

Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O. (2009) Mass spectrometry identifies multiple organophosphorylated sites on tublin. Toxicol Appl Pharmacol. 240(2): 149-58.  Abstract

Gullapalli R, Aracava Y, Zhuo J, Neto EH, Wang J, Makris G, Merchenthaler I, Pereira EF, Albuquerque EX. (2009) Magnetic resonance imaging reveals that galantamine prevents structural brain damage induced by an acute exposure of guinea pigs to soman. Neurotoxicology [Epub ahead of print]  Abstract

Joshi S, Kapur J. (2009) Slow intracellular accumulation of GABAA receptor delta subunit is modulated by BDNF. Neuroscience [Epub ahead of print]  Abstract

Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, Tawfik DS. (2009) Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization. Biochemistry 48(28): 6644-54.  Abstract

Li H, Ricordel I, Tong L, Schopfer LM, Baud F, Megarbane B, Maury E, Masson P, Lockridge O. (2009) Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum. J Appl Toxicol. 29(2): 149-55.  Abstract

Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O. (2009) Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine. Toxicol Sci 107(1): 144-55.  Abstract

Nagarkatti N, Deshpande LS, Delorenzo RJ. (2009) Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis. Expert Rev Neurother 9(6): 813-24.  Abstract

Otto TC, Harsch CK, Yeung DT, Magliery TJ, Cerasoli DM, Lenz DE. (2009) Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes. Biochemistry [Epub ahead of print]  Abstract

Pereira EF, Aracava Y, Alkondon M, Akkerman M, Merchenthaler I, Albuquerque EX. (2009) Molecular and cellular actions of galantamine: Clinical implications for treatment of organophosphorus poisoning. J Mol Neurosci [Epub ahead of print]  Abstract

Qashu F, Figueiredo TH, Aroniadou-Anderjaska V, Apland, JP, Braga MF. (2009) Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis. Amino Acids [Epub ahead of print]  Abstract

Reeves TE, Paliwal S, Wales ME, Wild JR, Simonian AL. (2009) Orientation specific positioning of organophosphorus hydrolase on on solid interfaces for biosensor applications. Langmuir 25(16): 9615-8.  Abstract

Ruiz CA, Rotundo RL. (2009) Dissociation of transcription, translation, and assembly of collagen tailed acetycholinesterase in skeletal muscle. J Biol Chem 284(32): 21488-95.  Abstract

Ruiz CA, Rotundo RL. (2009) Limiting role of protein disulfide isomerase in the expression of collagen-tailed acetylcholinesterase forms in muscle. J Biol Chem  [Epub ahead of print]  Abstract

Schopfer LM, Grigoryan H, Li B, Nachon F, Masson P, Lockridge O. (2009) Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: Characteristic mass fragments and a new binding motif for organophosphates. J Chromatogr B Analyt Technol Biomed Life Sci [Epub ahead of print]  Abstract

Tokuriki N, Tawfik DS. (2009) Chaperonin overexpression promotes genetic variation and enzyme evolution. Nature 459(7247): 668-73.  Abstract

Tomizawa M, Talley TT, Park JF, Maltby D, Medzihradszky KF, Durkin KA, Cornejo-Bravo JM, Burlingame AL, Casida JE, Taylor P. (2009) Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling. J Med Chem 52(12): 3735-41.  Abstract

Zaja-Milatovic S, Gupta RC, Aschner M, Milatovic D. (2009) Protection of DFP-Induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. Toxicol Appl Pharmacol. 240(2): 124-31.  Abstract

 

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Vesicating Agents (e.g. sulfur mustard)

Day BJ. (2009) Catalase and glutathione peroxidase mimics. Biochem Pharmacol. 77(3): 285-96. Abstract

Chang YC, Sabourin CL, Lu SE, Sasaki T, Svoboda KK, Gordon MK, Riley DJ, Casillas RP, Gerecke DR. (2009) Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model. J Biochem Mol Toxicol. 23(3): 172-184.  Abstract

Gerecke DR, Chen M, Isukapalli SS, Gordon MK, Chang YC, Tong W, Androulakis IP, Georgopoulos PG. (2009) Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect. Toxicol Appl Pharmacol. 234(2): 156-65.  Abstract

Gordon MK, Hahn RA. (2009) Collagens. Cell Tissue Res. [Epub ahead of print]  Abstract

Gould N, White CW, Day BJ. (2009) A role for mitochondrial oxidative stress in sulfur mustard analog CEES-induced lung cell injury and antioxidant protection.  J Pharmacol Exp Ther  328(3): 732-9.  Abstract

Laskin DL. (2009) Macrophages and inflammatory mediators in chemical toxicity: A battle of forces. Chem Res Toxicol. [Epub ahead of print]  Abstract

Pal A, Tewari-Singh N, Gu M, Agarwal C, Huang J, Day BJ, White CW, Agarwal R. (2009) Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. Free Radic Biol Med. [Epub ahead of print]  Abstract

Roberts RA, Laskin DL, Smith CV, Robertson FM, Allen EM, Doorn JA, Slikker W. (2009) Nitrative and oxidative stress in toxicology and disease. Toxicol Sci. [Epub ahead of print]  Abstract

Stabler SP, Sekhar J, Allen RH, O'Neill HC, White CW. (2009) Alpha-lipoic acid induced eleveated s-adenosylhomocysteine and depleted s-adenosylmethionine. Free Radic Biol Med 47(8): 1147-53.  Abstract

Sunil VR, Patel KJ, Mainelis G, Turpin BJ, Ridgely S, Laumbach RJ, Kipen HM, Nazarenko Y, Veleeparambil M, Gow AJ, Laskin JD, Laskin DL. (2009) Pulmonary effects of inhaled diesel exhaust in aged mice. Toxicol Appl Pharmacol [Epub ahead of print]  Abstract

Tewari-Singh N, Rana S, Gu M, Pal A, Orlicky DJ, White CW, Agarwal R. (2009) Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES)-induced skin injury in SKH-1 hairless mice. Toxicol Sci. 108(1): 194-206.  Abstract

 

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Pulmonary Agents (e.g. chlorine, bromine, etc.)

Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor M, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD. (2009) Surfactant associated protein B is critical to survival in nickel-induced injury in mice. Am J Respir Cell Mol Biol. 41(2): 226-36.  Abstract

Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE. (2009) Transient receptor potential ankyrin 1 antagonist block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 23(4):1102-14.  Abstract

Caceres AI, Brackmann M, Elie MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. (2009) A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Nat Acad Sci.106(22): 9099-104.  Abstract

Chang W, Chen J, Schlueter CF, Hoyle GW. (2009) Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung eputhelial and endothelial cells. Exp Lung Res 35(4):324-43.  Abstract

Chen L, Song W, Davis IC, Shrestha K, Schwiebert E, Sullender WM, Matalon S. (2009) Inhibition of Na+ transport in lung epithelial cells by respiratory syncytial virus infection. Am J Respir Cell Mol Biol. 40(5):588-600.  Abstract

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD. (2009) Matrix metalloproteinase (MMP) 14 mediates a phenotypic shift in airways to increase mucin production. Am J Respir Crit Care Med. [Epub ahead of print]  Abstract

Ganguly K, Depner M, Fattman C, Bein K, Oury TD, Wesselkamper SC, Borchers MT, Schreiber M, Gao F, Mutius EV, Kabesch M, Leikauf GD, Schulz H. (2009) Superoxide dismutase 3, extracellular (SOD3) variants and lung function. Physiol Genomics. 37(3):260-7.  Abstract

Ji HL, Song W, Gao Z, Su XF, Nie HG, Jiang Y, Peng JB, He YX, Liao Y, Zhou YJ, Tousson A, Matalon S. (2009) SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms. Am J Physiol Lung Cell Mol Physiol. 296(3): L372-83.  Abstract

Jurkuvenaite A, Chen L, Bartoszewski R, Goldstein R, Bebok Z, Matalon S, Collawn JF. (2009) Functional stability of rescued delta-F808 cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. Am J Respir Cell Mol Biol. [Epub ahead of print]  Abstract

Lazrak A, Iles KE, Liu G, Noah DL, Noah JW, Matalon S. (2009) Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species. FASEB J. [Epub ahead of Print]  Abstract

Lazrak A, Nita I, Subramaniyam D, Wei S, Song W, Ji H, Janciauskiene S, Matalon S. (2009) Alpha1-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo. Am J Respir Cell Mol Biol. 41(3): 261-70.  Abstract

Matalon S, Shrestha K, Kirk M, Waldheuser S, McDonald B, Smith K, Gao Z, Belaaouaj A, Crouch EC. (2009) Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo. FASEB J. 23(5):1415-30.  Abstract

Nemec AA, Leikauf GD, Pitt BR, Wasserloos KJ, Barchowsky A. (2009) Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. Am J Respir Cell Mol Biol. 41(1): 69-75.  Abstract

Sartor MA, Leikauf GD, Medvedovic M. (2009) LRpath: A logistic regression approach for identifying enriched biological groups in gene expression data. Bioinformatics 25(2):211-7.  Abstract

Song W, Liu G, Bosworth CA, Walker JR, Megaw GA, Lazrak A, Abraham E, Sullender WM, Matalon S. (2009) Respiratory syncytial virus inhibits lung ENaC by upregulating iNOS. J Biol Chem. 284(11): 7294-306.  Abstract

Vitturi DA, Teng X, Toledo JC, Matalon S, Lancaster Jr J, Patel, RP. (2009) Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation. Am J Physiol Heart Circ Physiol. 296(5):H1398-407.  Abstract

 

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Metabolic/Cellular Toxins (e.g. cyanide)

Lee J, Keuter KA, Kim J, Tran A, Uppal A, Mukai D, Mahon SB, Cancio LC, Batchinsky A, Tromberg BJ, Brenner M. (2009) Noninvasive in vivo monitoring of cyanide toxicity and treatment using diffuse optical spectroscopy in a rabbit model. Mil Med. 174(6): 615-21.  Abstract

Logue BA, Maserek WK, Rockwood GA, Keebaugh MW, Baskin SI (2009) The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers. Toxicology Mechanisms and Methods 19(3): 202-208.  Abstract

Petrikovics I, Budai M, Baskin SI, Rockwood GA, Childress J, Budai L, Grof P, Klebovich I, Szilasi M. (2009) Characterization of a liposomal vesicles encapsulating rhodanese for cyanide antagonism. Drug Deliv 16(6): 312-9.  Abstract 

Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. (2009) The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J Biol Chem. 284(6): 3521-8.  Abstract

Zottola MA. (2009) A partial exploration of the potential energy surfaces of SCN and HSCN: Implications for the enzyme-mediated detoxification of cyanide. J Mol Graph Model [Epub ahead of print]  Abstract

 

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Paralytic Neurotoxins (e.g. scorpion toxins)

Kahn R, Karbat I, Ilan N, Cohen L, Sokolov S, Catterall WA, Gordon D, Gurevitz M. (2009) Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins. J Biol Chem 284(31): 20684-91.  Abstract

 

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Diagnostics (e.g. EEG devices, OP detectors/biosensors)

Barry RC, Lin Y, Wang J, Liu G, Timchalk CA. (2009) Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures. J Expo Sci Environ Epidemiol. 19(1):1-18.  Abstract

Wang H, Wang J, Choi D, Tang Z, Wu H, Lin Y. (2009) EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation.  Biosens Bioelectron  24(8):2377-89.  Abstract

 

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(66 Total 2009 Publications)