The NINDS Stroke Trials Network is designed to maximize efficiencies to prioritize, harmonize and streamline the development of high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment, and recovery. Early phase 1-2 exploratory and confirmatory phase 3 clinical trials as well as biomarker-validation studies that are immediately preparatory to trials will be coordinated through Regional Coordinating Stroke Centers (RFA-NS-13-011), a National Clinical Coordinating Center (RFA-NS-13-012), and the National Data Management Center (RFA-NS-13-016). Additional efficiencies will be encouraged through the use of master trial agreements and a central IRB. Through aggressive data sharing and harmonization of protocol development, the network can ensure that data are collected in a way that facilitates sharing, maximizes comparisons between studies and builds knowledge with each ensuing trial independent of the trial outcome. The network will provide centralized infrastructure and support for data management, integration and opportunities for data sharing. Finally, strong multidisciplinary collaboration within and among sites will ensure successful trial completion. A steady pipeline of new trials developed outside as well as within the Network, and facilitated international and private-public partnerships will all serve to enhance the public health impact of the NINDS’s investment in stroke clinical trials.
NINDS has launched a large initiative by engaging the stroke research community to establish a new coordinated network to conduct clinical trials in stroke prevention, acute treatment, and recovery. For more see the NINDS Director's message on "Why the United States Needs a Network for Stroke Clinical Trials."
Scott Janis, PhD
NINDS Office of Clinical Research
Questions? Please email Stroke_Network@mail.nih.gov
Last updated June 11, 2013