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NINDS Stroke Trials Network

The NINDS Stroke Trials Network is designed to maximize efficiencies to prioritize, harmonize and streamline the development of high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment, and recovery.  Early phase 1-2 exploratory and confirmatory phase 3 clinical trials as well as biomarker-validation studies that are immediately preparatory to trials will be coordinated through Regional Coordinating Stroke Centers (RFA-NS-13-011), a National Clinical Coordinating Center (RFA-NS-13-012), and the National Data Management Center (RFA-NS-13-016).  Additional efficiencies will be encouraged through the use of master trial agreements and a central IRB.  Through aggressive data sharing and harmonization of protocol development, the network can ensure that data are collected in a way that facilitates sharing, maximizes comparisons between studies and builds knowledge with each ensuing trial independent of the trial outcome.  The network will provide centralized infrastructure and support for data management, integration and opportunities for data sharing.  Finally, strong multidisciplinary collaboration within and among sites will ensure successful trial completion.  A steady pipeline of new trials developed outside as well as within the Network, and facilitated international and private-public partnerships will all serve to enhance the public health impact of the NINDS’s investment in stroke clinical trials.

Network Initiation

NINDS has launched a large initiative by engaging the stroke research community to establish a new coordinated network to conduct clinical trials in stroke prevention, acute treatment, and recovery.  For more see the NINDS Director's message on "Why the United States Needs a Network for Stroke Clinical Trials."

Network Participants

The NIH Stroke Network or NIH StrokeNet is composed of 25 regional stroke centers working with nearby satellite facilities.  The University of Cincinnati will manage the national clinical coordinating center, which will oversee and coordinate the institutional review board and master trial agreements for all of the regional centers. NIH will announce the award of a national data management center in February. 

NIH StrokeNet National Clinical Coordinating Center

  • University of Cincinnati

NIH StrokeNet Regional Coordinating Stroke Centers

  • Case Western University
  • Emory University School of Medicine
  • Massachusetts General Hospital/Partners HealthCare
  • Medical University of South Carolina
  • MedStar Health Research Institute, MedStar NRH, Georgetown University
    MedStar Health Research Institute, MedStar Washington Hospital Center
  • The New York City Collaborative Regional Coordinating Center
  • New York – Presbyterian/Columbia University Medical CenterNew York - and Weill Cornell Medical College
  • Northwestern University at Chicago
  • The Ohio State University Wexner Medical Center
  • Stanford University
  • University of California, Los Angeles
  • University of California, San Diego
  • University of California, San Francisco
  • University of Cincinnati
  • University of Iowa
  • University of Miami Miller School of Medicine
  • University of Michigan Health System
  • University of Minnesota
  • University of Pennsylvania
  • University of Pittsburgh
  • The University of Texas Health Science Center at Houston
  • University of Utah
  • UW Medicine, University of Washington
  • University of Wisconsin Madison
  • Vanderbilt University Medical Center

Image of U.S. map displaying locations for Stroke Network Centers. (Western region - pink; Midwestern region - green; Southern region - yellow; Northeastern region - blue)


Scott Janis, PhD
Program Director
NINDS Office of Clinical Research
Telephone: 301-496-9135

Questions?  Please email

Last updated January 28, 2014