University of Pittsburgh (Pennsylvania)
Minhas P1,2, Gu XL1, Lu W1
1Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
2Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA.
Examining levels of neurogenesis and interneuron prevalence within the hippocampus is increasingly being used as a measure for mental and neurodegenerative diseases. AMPA- and NMDA- subtype ionotropic glutamate receptors mediate the majority of fast excitatory synaptic transmission in the brain and may serve as important modulators of adult neurogenesis and interneuron population diversification. Using a Cre-LoxP mouse model that contains brain region specific genetic deletion of these receptors, we found a decreased level of neurogenesis within the dentate gyrus as well as downstream effects on the somatostatin-positive interneuron population in the hippocampus. These findings provide novel insights into the role of glutamatergic input on neurogenesis and interneuron population specification as well as suggest a new therapeutic approach to regulate mental and neurodegenerative diseases.
Last updated November 27, 2013