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The Investigation of HHV6A Intranasal Infection in the Common Marmoset

2011 Exceptional Summer Student Award Winner Danielle Locust Danielle Locust

Human Herpesvirus 6 (HHV-6A) is associated with neurological diseases such as Multiple Sclerosis (MS). The virus’s association with the infection of MS is still being investigated. There are two strains of HHV-6 they are HHV- 6A and HHV-6B. HHV-6A is considered to be more neurotropic than HHV-6B, but pathogenesis and epidemiology of the virus are still unclear. Four common marmosets were inoculated intravenously and intranasally with HHV-6A. Viral DNA and mRNA can be located within the PBMCs, plasma, and saliva of infected marmosets. HHV-6A DNA can be amplified through Nested Polymerase Chain Reaction and Gel electrophoresis.

Last Modified December 23, 2013