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Identifying Retinal Ganglion Cells in the Zebrafish Transgenic Model


2011 Exceptional Summer Student Award Winner Bina Bansinath Bina Bansinath

Understanding the morphology of retinal ganglion cells it’s relation to the function of physiology of ganglion cells is an important topic in the study of image processing in the retina.

The functionality of retinal ganglion cells is well correlated with morphological classifications. The dendritic stratification of ganglion cells within the retinal inner plexiform layer determines the synaptic contacts with presynatpic bipolar cells. Bipolar cells in turn respond selectively to light onset or offset. Or may selectively contact cones containing different visual pigments. The stratification of ganglion cells maong the layers of bipolar-cell axon terminals within the inner plexiform layer determines the pattern of light responses seen in ganglion cells.

The use of transgenic animal models that selectively label ganglion cells is currently reshaping the way in which ganglion cells types are being identified.

In this study, microelectrode staining techniques were used to investigate the morphology of transgenically labeled ganglion cells in zebrafish (Dandio Reiro).

Last updated December 23, 2013