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NINDS is part of the
National Institutes of
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Miscellaneous scientific resources, such as antibodies, are available to the neuroscience community.

 

The UC Davis/NINDS/NIMH NeuroMab Facility

The mission of the UC Davis/NINDS/NIMH NeuroMab facility is to generate and distribute high quality, validated mouse monoclonal antibodies against molecular targets found in the nervous system (NeuroMabs). These antibodies are suitable for 1) immunocytochemical-based imaging studies of protein localization in adult, developing and pathological brain samples, for 2) biochemical analyses of subunit composition and post-translational modifications of native brain proteins, and for 3) proteomic analyses of native brain protein networks. The NeuroMab facility was recently funded for a five-year period with the goal of making monoclonal antibodies to 250-500 neuronal proteins. An initial emphasis is on selecting as targets membrane proteins (receptors/channels/transporters), synaptic proteins, other neuronal signaling molecules, and proteins with established links to disease states. These NeuroMabs will then be produced on a large scale and made available to the neuroscience research community at cost in the form of tissue culture supernatants and purified immunoglobulins.

Request for Information:
The NeuroMab facility is accepting suggestions as to potential targets. Requestors should supply NeuroMab with a scientific justification as to the biological importance of the target molecule, the importance of these reagents to the national neuroscience community, and the availability and suitability of existing polyclonal and/or monoclonal antibodies. Requestors should also include a list of reagents (synthetic peptides, fusion proteins, full-length cDNAs for transfection in mammalian cells, samples from knockout mice) that could be made available to the NeuroMab staff to facilitate the development and characterization of these NeuroMabs. Submit this information to NeuroMab at neuromab@ucdavis.edu. The NeuroMab advisory board, together with program officials from NINDS and NIMH, will then prioritize the request in the NeuroMab queue.

Related sites:
UC Davis/NINDS/NIMH NeuroMab Facility
NIH Neuroscience Blueprint

Contact:
Dr. Randall Stewart, Program Director, NINDS

Last updated April 29, 2008