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CounterACT Publications 2008

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CounterACT Publications

Neurotoxic Organophosphorus Poisons (e.g. anti-convulsants, anti-seizures, neuroprotectants, cholinesterase reactivators, nerve agent bioscavengers)

Aroniadou-Anderjaska V, Fritsch B, Qashu F, and Braga MF. (2008) Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy. Epilepsy Res. 78(2-3): 102-16. Abstract

Beck JM, Hadad CM. (2008) Hydrolysis of nerve agents by model nucleophiles: A computational study. Chem Biol Interact. [Epub ahead of print] Abstract

Carter DS, Harrison AJ, Falenski KW, Blair RE, DeLorenzo RJ. (2008) Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus. Epilepsy Res. 79(2-3): 213-23.   Abstract

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E, Delorenzo RJ. (2008) Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry. Eur J Pharmacol. 583(1): 77-83.  Abstract

Deshpande LS, Nagarkatti N, Sombati S, Delorenzo RJ. (2008) The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons. Epilepsy Res 79(2-3): 158-65.  Abstract

Deshpande LS, Sun DA, Sombati S, Baranova A, Wilson MS, Attkisson E, Hamm RJ, Delorenzo RJ. (2008) Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury. Neurosci Lett [Epub ahead of print] Abstract

Geyer BC, Woods RR, Mor TS. (2008) Increased organophosphate scavenging in a butryrlcholinesterase mutant. Chem Biol Interact [Epub ahead of print] Abstract

Goodkin HP, Joshi S, Mtchedlishvili Z, Brar J, and Kapur J. (2008) Subunit-specific trafficking of GABAa receptors during status epilepticus. J Neurosci. 28(10):2527-38.  Abstract  

Li H, Tong L, Schopfer LM, Masson P, Lockridge O. (2008) Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase. Chem Biol Interact [Epub ahead of print] Abstract

Lockridge O, Xue W, Gaydess A, Grigoryan H, Ding SJ, Schopfer LM, Hinrichs SH, Masson P. (2008) Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including residue 59 lysines. J Biol Chem [Epub ahead of print]. Abstract

Nagarkatti N, Deshpande LS, Delorenzo RJ. (2008) Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. Neurosci Lett. 436(3): 289-93. Abstract

Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. (2008) Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chem Biol Interact. [Epub ahead of print]. Abstract

Reeves TE, Wales ME, Grimsley JK, Li P, Cerasoli DM, Wild JR. (2008) Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities. Protein Engineering, Design & Selection 21(6): 405-412. Abstract

Sun DA, Despande LS, Sombati S, Baranova A, Wilson MS, Hamm RJ, Delorenzo RJ. (2008) Traumatic brain injury causes a long-lasting calcium (Ca(2+))-plateau of elevated intracellular Ca levels and altered Ca(2+) homeostatic mechanisms in hippocamplal neurons surviving brain injury. Eur J Neurosci 27(7): 1659-72. Abstract

Talley TT, Harel M, Hibbs Re, Radic Z, Tomizawa M, Casida JE, Taylor P. (2008) Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci USA 105(21): 7606-11. Abstract

Tomizawa M, Maltby D, Talley TT, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. (2008) Atypical nicotinic agonist bound conformations conferring subtype selectivity. Proc Natl Acad Sci USA 105(5): 1728-32. Abstract

Wang H, Cheng X, Taylor P, McCammon JA, Sine SM. (2008) Control of cation permeation through the nicotinic receptor channel. PLoS Comput. Biol. 4(2):e41. Abstract

Wetherington J, Serrano G, Dingledine R. (2008) Astrocytes in the epileptic brain. Neuron 58(2): 168-78. Abstract

Yeung DT, Smith JR, Sweeney, RE, Lenz DE, and Cerasoli DM. (2008). A gas chromatography-mass spectrometry approach to examine stereoselective interaction of human plasma proteins with soman. J. Anal. Toxicol. 32(1): 86-91. Abstract

 

Vesicating Agents (e.g. sulfur mustard)

Black AT, Gray JP, Shakarjian MP, Mishin V, Laskin DL, Heck DE, Laskin JD. (2008) UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicol Appl Pharmacol [Epub ahead of print] Abstract

Conlon P, Yang CJ, Wu Y, Chen Y, Martinez K, Kim Y, Stevens N, Marti AA, Jockusch S, Turro NJ, Tan W. (2008) Pyrene excimer signaling molecular beacons for probing nucleic acids. J Am Chem Soc 130(1): 336-42. Abstract

Day BJ. (2008) Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal. 10(2): 355-70. Abstract

Kim Y, Cao Z, Tan W. (2008) Molecular assembly for high-performance bivalent nucleic acid inhibitor. Proc Natl Acad Sci USA 105(15): 5664-9.  Abstract

Mallikaratchy P, Tang Z, Tan W. (2008) Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy. ChemMedChem 3(3): 425-8.  Abstract

O'Neill HC, Rancourt RC, White CW. (2008) Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH. Antioxidants & Redox Signaling 10(2): 277-85. Abstract

Shangguan D, Meng L, Cao ZC, Xiao Z, Fang X, Li Y, Cardonna D, Witek RP, Liu C, Tan W. (2008) Identification of liver cancer-specific aptamers using whole live cells. Anal Chem. 80(3): 721-8. Abstract

Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. (2008) Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med 44(6):1169-79. Abstract

Xiao Z, Shangguan D, Cao Z, Fang X, Tan W. (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14(6): 1769-75.  Abstract

 

Pulmonary Agents (e.g. chlorine)

Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. (2008) TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest. 118(5): 1899-910. Abstract

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. (2008) EGFR-tyrosine kinase inhibitors diminish transforming growth factor-alpha induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 294(6): L1217-25. Abstract

 

Metabolic/Cellular Toxins (e.g. cyanide)

Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. (2008) Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J. Infect. Dis. 197(3): 457-64. Abstract

 

Paralytic Neurotoxins (e.g. scorpion toxins)

Cohen L, Lipstein N, Karbat I, Ilan N, Gilles N, Kahn R, Gordon D, Gurevitz M. (2008) Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated Na-channels. J. Biol. Chem. 283(22):15169-76. Abstract

Schnur E, Turkov M, Kahn R, Gordon D, Gurevitz M, Anglister J. (2008) NMR analysis of interaction of Lqh-alphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel. Biochemistry 47(3): 911-21.  Abstract

Sokolov S, Kraus RL, Scheuer T, Catterall WA. (2008) Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II. Mol Pharmacol. 73(3):1020-8.  Abstract

 

Diagnostics (e.g. EEG devices, OP detectors/sensors)

Wang J, Liu G, Wu H, Lin Y. (2008) Quantum-dot-based electrochemical immunoassay for high-throughput screening of the prostate-specific antigen. Small 4(1): 82-6 Abstract

Wang J, Liu G, Timchalk C, Lin Y. (2008) Carbon nanotube-based electrochemical sensor for assay of salivary cholinesterase enzyme activity: an exposure biomarker of organophosphate pesticides and nerve agents. Environ. Sci. Technol. 42(7): 2688-2693. Abstract

 

Last updated July 07, 2008