Application Receipt Dates: February 16, June 16, October 16 (New, Type 1 applications)
The National Institute of Neurological Disorders and Stroke (NINDS) participates in the NIH Exploratory/Developmental Research Grant Award. Applicants must follow instructions in the parent program announcement when preparing an application. In addition, applicants to the NINDS Exploratory/Developmental Research Grant Award (R21) must be responsive to the "Guidelines for the NINDS R21 Program" (see below).
NIH Exploratory/Developmental Research Grant Award (R21): PA-11-261
The NINDS uses the Exploratory/Developmental (R21) Grant to provide research support for new research projects in areas of high relevance to the mission of the NINDS. Applicants may request a project period of up to two years with a combined budget for direct costs of up $275,000 for the two year period. For example, the applicant may request $100,000 in the first year and $175,000 in the second year. The request should be tailored to the needs of the project. Normally, no more than $200,000 may be requested in any single year (see also full program announcement).
As an Exploratory/Developmental mechanism, the R21 Grant is intended to support projects that meet one or more of the following criteria:
As stated in the parent announcement, to be eligible for consideration, proposals must be distinct from those traditionally submitted through the R01 mechanism. For example, projects designed to produce incremental advances in knowledge in a well-established area will not be considered.
NEW AND EARLY STAGE INVESTIGATORS
It is important to note that analyses of new investigator applications to NINDS indicate that the success rate for R21 applicants is lower than for R01 applicants (FY 2009 success rates for NINDS R21 New Investigators: 11% vs. NINDS R01 New Investigators: 19%). Given the current policy of the NIH to support New Investigator R01s at success rates equivalent to those of established investigators submitting new (Type 1) applications (http://grants.nih.gov/grants/guide/notice-files/not-od-09-013.html), the NINDS encourages New Investigators, and in particular Early Stage Investigators (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-08-121.html), to apply for R01 grants when seeking first-time funding from the NIH.
CLINICAL RESEARCH USING THE R21 MECHANISM
NINDS will not accept unsolicited R21 applications that include clinical trials or other clinical studies of potential therapies. NINDS places a high priority on the development and evaluation of such clinical interventions and has established specific mechanisms for supporting these types of proposals (see http://www.ninds.nih.gov/funding/funding_announcements/Funding-Bins-Clinical-Research.htm).
R21 applications that involve human subjects may be submitted to NINDS if the proposals do not include any clinical intervention AND if safety monitoring of study participants can be performed appropriately within the budgetary and time constraints of an R21. Any R21 proposal that does not meet the above criteria or does not provide adequate plans for the protection of the safety, privacy and confidentiality of study participants will not be funded.
TRANSLATIONAL RESEARCH USING THE R21 MECHANISM
NINDS also supports R21 Exploratory/Developmental Projects in Translational Research to support research projects intended to discover potential targets for therapeutic intervention, to identify candidate therapeutics, or to develop assays, animal models, devices, or technologies for screening or developing therapeutics. Such projects, if successful, should lead directly to a therapy development project for a particular neurological disorder. The three NINDS-specific R21 criteria discussed above do not apply to R21 applications in the NINDS Translational Research Program. A translational research R21 project includes a set of focused, practical goals that must be accomplished in order to launch a full-blown therapy development program. The NINDS policy on the use of the R21 mechanism for research on human subjects (stated in the previous paragraph) applies to translational research applications. For additional Information regarding the NINDS Translational Research Program, see: PAR-13-023.
Applicants are strongly encouraged to contact appropriate program staff within NINDS for advice about potential R21 proposals and to ensure that their proposals are consistent with the NINDS criteria. A complete listing of NINDS program director contacts can be found at: http://www.ninds.nih.gov/find_people/ninds/contact_people.htm.
General inquiries may be referred to:
Anna Taylor, Ph.D.
6001 Executive Boulevard , Room 3303
Bethesda , MD 20892
Phone: (301) 496-9248
Last updated March 1, 2013