The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Drug Abuse (NIDA), and the National Institute of Mental Health (NIMH) encourage applications to develop and use non-human lentiviral models of the neurological complications of AIDS.
Neurological dysfunction is a devastating complication of HIV/AIDS, affecting more than 25 percent of chronically infected individuals. Symptoms include cognitive deficits, motor impairment, and peripheral neuropathies. However, the strict host range of HIV-1 infection has blocked the widespread use of animal models in translational research toward the development of therapies for treating AIDS. The purpose of this announcement is to promote the development and use of non-human lentiviruses in animal models for research into the mechanisms underlying the neurological complications associated with HIV-1 infection in humans. The ultimate goal is to refine lentiviral model systems for use in discovering therapies for AIDS patients with and without a history of drug use.
For more information, potential applicants should contact Dr. Michael Nunn, Program Director, Neural Environment Cluster, NINDS; telephone: 301-496-1431; e-mail: email@example.com. For a more detailed description of this announcement, visit http://grants.nih.gov/grants/guide/pa-files/PAS-07-191.html.