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Funding News - Research Sought Targeting Diseases Caused by Protein Misfolding or Misprocessing

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  • The information on this page is for historical and research purposes only.
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The National Institute of Neurological Disorders and Stroke (NINDS) encourages grant applications for targeting diseases caused by protein misfolding or misprocessing. This announcement is made together with 2 other components of the National Institutes of Health (NIH).

The goal of this announcement is to support research to identify and optimize small molecule reagents of any kind that specifically ameliorate a protein folding or processing defect in inherited diseases. An NIH-sponsored scientific conference held in 2004 underscored the importance of protein folding and protein processing by cellular quality control systems in the manifestation of inherited human disease. While protein folding can occur either within the cytoplasm or within the secretory pathway, proteins that use the secretory pathway for folding and trafficking are responsible for a disproportionate share of inherited misfolding diseases.

Letters of Intent Receipt Date: December 12, 2006.
Application Receipt Date: January 12, 2007.

For more information, potential applicants should contact Dr. Danilo Tagle, Program Director, Neurogenetics Cluster, NINDS; telephone: 301-496-5745; e-mail: For a more detailed description of this announcement, visit