The National Institute of Neurological Disorders and Stroke (NINDS) invites grant applications for research on understanding and treating tuberous sclerosis complex (TSC). This announcement is made together with 4 other components of the National Institutes of Health (NIH) and is supported by 2 grant funding mechanisms: R03 and R21.*
The genes that cause TSC (TSC1 and TSC2) are known, understanding of the pathways in which they act is increasing, and animal models that mimic certain features of the disease now exist. As a result, there is a remarkable opportunity to increase knowledge about the mechanisms that cause TSC and translate that knowledge into therapies for this often devastating disorder.
Topics of research interest include, but are not limited to: studies of the role of hamartin and tuberin in basic cellular processes and development; development of more sophisticated animal models for TSC; development of cell culture models of TSC; identification of the downstream targets of tuberin and hamartin, with particular emphasis on potential molecular targets for drug therapy; elucidation of the molecular events that cause lesions to develop in specific tissues; and assessment and treatment of TSC-associated cognitive and behavioral problems, including both pharmacological and non-pharmacological interventions.
For more information, potential applicants should contact Dr. Jane Fountain, Program Director, Neural Environment Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2110, Bethesda, MD 20892; telephone: 301-496-1431; fax: 301-480-2424; e-mail: email@example.com.
*For a full list of supporting NIH components and a more detailed description of this announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PAS-06-205.html (R03), or http://grants.nih.gov/grants/guide/pa-files/PAS-06-206.html (R21).