The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Dental and Craniofacial Research (NIDCR), and the Office of Research on Women's Health (ORWH) invite grant applications for research on the etiological and pathophysiological mechanisms underlying a set of chronic, comorbid conditions associated with temporomandibular joint and muscle disorders (TMJMDs). This announcement is supported by 3 grant funding mechanisms: R03, R21, and R01.*
TMJMD, a complex heterogeneous disease, represents a collection of disorders with varying causes, affecting the tissues of the masticatory muscles and the temporomandibular joint. Due to this complexity and a lack of complete understanding of the underlying mechanisms of disease onset and progression, treatment for TMJMD currently is less than satisfactory.
Examples of research topics may include, but are not limited to: identification of molecular mechanisms in the central nervous system that modulate peripheral nociceptive neurotransmission; genomic studies that identify genes and gene polymorphisms that are causative or produce risk factors for comorbid conditions and TMJMD; effects of inflammatory pain and proinflammatory cytokines on hypersensitivity of central pain modulatory circuits; neuroimaging studies to identify brain regions and nerve tracts active in patients with TMJMD and comorbid conditions; use of animal models to examine the effects of chronic pain on affective behaviors; and clinical research approaches that help to discover behavioral changes influencing and influenced by TMJD and comorbid conditions.
For more information, potential applicants should contact Dr. Linda Porter, Program Director, Systems and Cognitive Neuroscience Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2113, Bethesda, MD 20892; telephone: 301-496-9964; fax: 301-402-2060; e-mail: firstname.lastname@example.org.
*For a more detailed description of this announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PA-06-267.html (R03), http://grants.nih.gov/grants/guide/pa-files/PA-06-268.html (R21), or http://grants.nih.gov/grants/guide/pa-files/PA-06-188.html (R01).