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Funding News - Research Sought on the Neurobiology of Persistent Pain

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  • The information on this page is for historical and research purposes only.
  • For the most current NINDS funding announcements, please see the NINDS list of Active Funding Initiatives or Follow Us on Twitter for the latest funding news.

The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Dental and Craniofacial Research (NIDCR) invite applications for research on the neurobiology of persistent pain mediated by the trigeminal nerve.*

A diverse group of disorders arises from trauma, pathology, structural or degenerative changes, and sometimes unknown causes that affect the deep tissues of the head and face and often lead to severe, chronic pain. Chronic pain is a debilitating condition that adversely affects the lives of millions of people. Pain disorders mediated by the trigeminal nerve are often associated with severe and persistent pain of deep tissues, which may be of neuronal, muscular, joint, or vascular origin.

Potential areas of research interest include, but are not limited to: development of model systems that appropriately mimic the clinical features of syndromes associated with deep tissue pain in the head and neck region to provide optimal tools for basic and clinical studies; discovery of mechanisms of plasticity at the neurochemical, molecular, and cellular levels, which contribute to abnormal pain responses (hyperalgesia, allodynia) and persistent pain associated with disorders of tissues innervated by the trigeminal nerve; neuroimaging of pain-signaling pathways to elucidate the roles of central and peripheral plasticity in mediating the onset, persistence, and management of chronic pain associated with migraine and other pain disorders of the head and neck; elucidation of the role of acid-sensitive ion channels in deep tissues of the head and neck in onset of pain and the development of abnormal pain responses and chronic pain; characterization of sensory, cognitive, affective, and other biobehavioral responses to noxious stimulation and pain perception in humans; determination of the usefulness of exercise in pain management through clinical trials; and development and testing of novel mechanism-based therapies for improved management of chronic pain associated with craniofacial disorders through appropriate clinical trials.

For more information, potential applicants should contact Dr. Linda Porter, Program Director, Systems and Cognitive Neuroscience Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2113, Bethesda, MD 20892; telephone: 301-496-9964; fax: 301-402-2060; e-mail:

*For a more detailed description of this announcement, please visit the NIH web site at: