The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the Muscular Dystrophy Association (MDA) invite applications for research on the nuclear structure-function defects in the pathogenesis of muscular dystrophy. This announcement is supported by 2 grant funding mechanisms: R21 and R01.*
TThe muscular dystrophies are hereditary, degenerative disorders affecting cardiac and skeletal muscle. Despite substantial research efforts, there are few therapies that are effective at slowing the course of muscular dystrophy.
Areas of research interest include, but are not limited to: basic cellular and molecular studies that link changes in nuclear structure and function to the specific pathologies that are associated with Emery-Dreifuss, facioscapulohumeral, limb girdle muscular dystrophy 1B, and oculopharyngeal muscular dystrophy; studies of disrupted chromatin organization, gene expression, RNA processing, DNA replication and repair, vulnerability to nuclear stress and apoptosis, anchorage of nuclear envelope proteins, and transport mechanisms between the nucleus and cytoplasm in this subset of muscular dystrophies; studies of altered gene transcription as a consequence of impaired mechanotransduction in this subset of muscular dystrophies; studies that determine the underlying mechanisms responsible for the tissue- and muscle group-specificity seen in this subset of muscular dystrophies; studies that address the role of nuclear dysfunction in the impaired myoblast activation, delayed differentiation kinetics, and impaired myogenic terminal differentiation programs seen during myogenesis and the impaired muscle regeneration capacity observed in the nucleus-based muscular dystrophies; and studies that develop appropriate cell- and model organism-based systems and use these to characterize nuclear events in the pathogenesis of this subset of muscular dystrophies.
Letters of Intent Receipt Date: August 21, 2006
Application Receipt Date: September 20, 2006
For more information, potential applicants should contact Dr. John Porter, Program Director, Channels, Synapses, and Circuits Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2142, Bethesda, MD 20892; telephone: 301-496-1917; fax: 301-402-1501; e-mail: email@example.com.
*For a more detailed description of this announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-07-002.html (R21), or http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-07-001.html (R01).