The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for research to discover genes for complex neurological and neurobehavioral disorders. This announcement is made together with 3 other components of the National Institutes of Health (NIH).*
Genetic factors contribute to a broad spectrum of neurological and neurobehavioral diseases. During the last decade, genes that cause many single-gene neurological disorders (e.g., Huntington's disease, neurofibromatosis, and Rett syndrome) have been identified. For these disorders, familial inheritance patterns follow the rules of Mendelian segregation. For many common disorders-such as stroke, Parkinson's disease, epilepsy, Alzheimer's disease, and attention deficit hyperactivity disorder-inheritance patterns are more complex, and progress in identifying genes that affect susceptibility and disease outcome has been slow. Such disorders appear to be caused by multiple genes or by a combination of genetic and environmental factors.
Applications responding to this announcement should focus on the identification of susceptibility genes that contribute to genetically complex disorders affecting the nervous system or to the phenotypes that underlie these disorders. Proposed studies can involve the initial collection of biomaterials and clinical information from a patient population or the subsequent application of genetic or molecular strategies for gene localization. Possible methodologies include, but are not limited to, traditional linkage analysis, sib-pair and affected-pedigree-member methods, case-control or family-based association studies, linkage disequilibrium mapping in genetically isolated populations, candidate gene analysis, cytogenetic studies to identify chromosomal abnormalities associated with a disorder, and positional cloning.
For more information, potential applicants should contact Dr. Robert Finkelstein, Director, Division of Extramural Research, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 3307, Bethesda, MD 20892; telephone: 301-496-4370; fax: 301-402-1501; e-mail: email@example.com.
*For a more detailed description of this announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PAS-06-204.html.