The National Institute of Neurological Disorders and Stroke (NINDS) invites grant applications for collaborative research in stem cell biology.*
Among the most important biomedical questions are how complex tissues and organs, such as the nervous system, develop from small founder populations of stem cells, how organs are maintained and sometimes regenerate during adult life, and how age and disease affect this capacity. Central to answering all these questions is a profound understanding of the biology and behavior of stem cells. No single investigator, laboratory, or institution has the resources to tackle these complex questions. The solution lies in developing synergy between the various scientific disciplines and investigators with very different expertise and resources.
Areas of research where synergy between different disciplines is of high interest include, but are not limited to: harnessing immune mechanisms to develop tolerance and overcome rejection for use of allogenic cells in the nervous system; defining the transcriptome and proteome of different stem cells and their microenvironment or niche within the host brain and spinal cord; defining co-regulated elements, so-called "hub genes," in stem cell differentiation toward neuronal or glial phenotypes; evaluating chemical libraries to identify small molecules for stem cell proliferation or neural differentiation; developing cell-based tools for drug discovery, or sensors for the detection and identification of chemical and biological agents that are important for clinical diagnostics for neurological disorders; developing non-invasive methods and agents with which to visualize or track stem cells in vivo; exploring the relationship between stem cells and brain tumors, and identifying factors influencing tumor risk in stem cell therapies; and investigating the use of stem cells as vehicles to deliver targeted therapeutics to sites in the nervous system.
For more information, potential applicants should contact Dr. David Owens, Program Director, Repair and Plasticity Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2204, Bethesda, MD 20892; telephone: 301-496-1447; fax: 301-480-1080; e-mail: firstname.lastname@example.org.
*For a more detailed description of this announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PAS-06-264.html.