The National Institute of Neurological Disorders and Stroke (NINDS) and the National Cancer Institute (NCI) encourage applications for research on understanding and preventing brain tumor dispersal.*
Many brain tumors are highly invasive and therefore extremely difficult to treat. Cells from the primary tumor often infiltrate surrounding brain tissues, so that removal of the main tumor mass is not sufficient to prevent recurrence. The goal of this announcement is to promote studies that identify the properties of brain tumor cells that cause them to migrate, determine how interaction of tumor cells with normal brain elements affects migration, and translate understanding of these parameters into interventions that target invading tumor cells.
Possible areas of research interest include, but are not limited to: analysis of candidate genes and signal transduction pathways that control brain tumor cell dispersal; genomic or proteomic expression profiling aimed at identifying novel genes or proteins that control brain tumor cell dispersal; determination of the cells of origin and specific properties of migrating brain tumor cells; studies of extracellular matrix properties that potentially control normal and aberrant migration of cells in the CNS; determination of what causes brain tumor cells to exit the cell cycle during migration and reenter it during subsequent cell proliferation; studies of neural progenitor cell biology that may shed light on brain tumor dispersal; investigation of why invading brain tumor cells are resistant to chemotherapy or radiation; and development of novel methodologies that permit more effective visualization of migrating brain tumor cells.
For more information, potential applicants should contact Dr. Jane Fountain, Program Director, Neural Environment Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2110, Bethesda, MD 20892; telephone: 301-496-1431; fax: 301-480-2424; e-mail: firstname.lastname@example.org.
*For a more detailed description of this announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PAS-06-201.html.