The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA) encourage grant applications for research on the neurovascular mechanisms of brain function and disease.*
Stroke is widely recognized as a major cause of premature mortality and disability, particularly cognitive and motor impairment. Significant progress has been made in dissecting the molecular pathways of excitotoxicity, oxidative stress, and apoptosis in ischemic neuronal cell death. However, translation of these laboratory results into clinically effective stroke treatments remains a major challenge for the stroke community. The purpose of this announcement is to achieve a better understanding of the integration of cerebrovascular and brain mechanisms in developing the healthy brain, in maintaining function in the aging brain, and in neurological disorders and stroke.
Research areas of interest include, but are not limited to, studies to: develop and characterize in vivo and in vitro models that reflect the unique features of neurovascular communication in the brain under normal, aging, and disease conditions; examination of the genes and proteins that are uniquely expressed by the neurovascular unit (NVU) and mechanisms by which brain cells regulate endothelial cell gene expression and vice versa; explore the genesis and regulation of the NVU, its stem cell origins, and the interactions of microvessel networks in the regions of the central nervous system with developing neurons and in areas of adult neurogenesis; identify signal transduction pathways of brain and capillary endothelial cells in the regulation of the extracellular matrix under normal and disease conditions; identify regional diversity of NVU properties within the brain and the microvasculature throughout the lifespan; identify changes in NVU integrative functions in vivo and/or in situ using imaging approaches; explore the cell-cell interactions among the cellular and matrix elements of the NVU; and examine cell-cell communication in tri-cultures with matrices of different composition.
For more information, potential applicants should contact Dr. Thomas Jacobs, Program Director, Neural Environment Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2112, Bethesda, MD 20892; telephone: 301-496-1431; fax: 301-480-2424; e-mail: email@example.com.
*For a more detailed description of this announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PAS-06-200.html.