The National Institute of Neurological Disorders and Stroke (NINDS) invites grant applications for research on the structural biology of membrane proteins. This announcement is made together with 9 other components of the National Institutes of Health (NIH).*
Membrane proteins and their complexes play crucial roles in many cellular and physiological processes. They are essential mediators of material, information, and energy transfer between cells and their environment, compartments within cells, and compartments comprising the organ systems. Functionally normal membrane proteins are vital to health, and specific defects are associated with many known diseases.
Areas of research interest include, but are not limited to: the development of new methods to approach the problem and the application of current methods to solve specific membrane protein structures; innovative methods for production of membrane proteins in sufficient quantities for characterization and structural studies of membrane proteins; novel approaches to cloning, expression, oligomeric assembly, solubilization, stabilization, and purification of membrane proteins to advance the production of structurally and functionally intact membrane proteins suitable for structural studies; and innovative methods for structure determination, including crystallization, phasing, isotopic labeling, and collecting x-ray crystallographic, nuclear magnetic resonance (NMR), and other relevant data.
For more information, potential applicants should contact Dr. Peter Preusch, Division of Pharmacology, Physiology, and Biological Chemistry, National Institute of General Medical Sciences (NIGMS), Building 45, Room 2AS.55E, 45 Center Drive, MSC 6200, Bethesda, MD 20892; telephone: 301-594-3827; e-mail: email@example.com; or Dr. Jean Chin, Division of Cell Biology and Biophysics, NIGMS, Building 45, Room 2AS.19A, 45 Center Drive, MSC 6200, Bethesda, MD 20892; telephone: 301-594-0828; e-mail: firstname.lastname@example.org.
*For a full list of supporting NIH components and a more detailed description of this announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PA-06-119.html.