The National Institutes of Health (NIH) requests applications for pilot-scale libraries for high-throughput screening.
This request for applications is an NIH Roadmap Initiative. The NIH Roadmap is an innovative approach to accelerate fundamental discovery and translate that knowledge into effective prevention strategies and new treatments. All NIH institutes and centers participate in Roadmap Initiatives.*
The last decade has witnessed major breakthroughs in the identification of genes, gene products, metabolic pathways, and signaling pathways, as well as progress in miniaturization and robotics, enabling the development of high-throughput, highly specific, mechanism-based biological assays. The new assays have, in turn, revolutionized the discovery of small molecules with powerful physiological effects. While high-throughput screening (HTS) of small-molecule libraries is widespread in the pharmaceutical industry, the goal of the Molecular Libraries Roadmap Initiative is to facilitate the use of HTS and chemical libraries within the academic and nonprofit community.
The goal of this initiative is to solicit applications to generate chemical libraries to increase the diversity and the uniqueness of the collection in the Molecular Libraries Small Molecule Repository (MLSMR). The pilot-scale libraries generated under this announcement will be submitted to the MLSMR and then to the Molecular Libraries Screening Center Network (MLSCN) for HTS evaluation.
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For more information, potential applicants should contact Dr. John Schwab, Division of Pharmacology, Physiology, and Biological Chemistry, National Institute of General Medical Sciences (NIGMS), 45 Center Drive, Room 2As.43A MSC 6200, Bethesda, MD 20892-6200; telephone: 301-594-3827; fax: 301-480-2802; e-mail: firstname.lastname@example.org.
*For a more detailed description of this RFA, please visit the NIH web site at: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-06-003.html.
For more information on the NIH Roadmap, please visit the web site at: http://nihroadmap.nih.gov/.