The National Institute of Neurological Disorders and Stroke (NINDS) requests small business innovation research (SBIR) applications to research and develop diagnostics for exposure to chemical threats. This announcement is made together with 5 other components of the National Institutes of Health (NIH).*
Chemical threat agents are toxic chemicals that could be used in a terrorist attack against civilians, or chemicals that could be released at toxic levels by accident or natural disaster. The purpose of this research program is to develop rapid and portable diagnostic tools suitable for use by emergency care providers in order to guide medical countermeasures and treatment.
Examples of research topics of interest include, but are not limited to, studies to develop: portable, inexpensive electroencephalogram (EEG) systems that can be rapidly deployed and configured for detection of seizures in civilian individuals under mass casualty conditions; arrays of a minimal, yet functional, number of adhesive surface electrodes suitable for a range of pediatric to adult civilian populations; EEG artifact suppression technologies that allow robust operation of monitors in field and clinical settings; a rapid field diagnostic test that distinguishes cyanide from nerve agent exposure; rapid, sensitive, and specific diagnostic assays utilizing blood, saliva, or urine to detect chemical agents and/or cyanide; rapid, sensitive, and specific diagnostic assays utilizing blood, saliva, or urine to detect markers or degradation products from chemical agent and/or cyanide exposure; portable and inexpensive mass spectroscopy instruments for detection in blood, saliva, or urine, of chemical threat exposure or corresponding degradation products; micro-total analytical system “lab-on-a-chip” technologies for detection of chemical threat exposure in biological samples; and simplified sample preparation methodologies that preserve key analytes to enable rapid field analysis or later validation in clinical settings.
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*For a full list of supporting NIH components and a more detailed description of this request for applications, please visit the NIH web site at: http://grants2.nih.gov/grants/guide/rfa-files/RFA-NS-06-007.html.