The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), and the National Institute of Nursing Research (NINR) invite grant applications for research on the cognitive sequelae of Parkinson’s disease (PD). This announcement is supported by 3 grant funding mechanisms: R01, R03, and R21.*
PD is commonly viewed as a movement disorder. However, it is more than a movement disease; it also affects thinking, reasoning, learning, processing speed, and other cognitive abilities. The cognitive changes seen in people with PD are less understood and studied than parkinsonian movement symptoms.
Areas of research interest include, but are not limited to: basic molecular or cellular studies of potential drugs or other treatments that could address cognitive impairments in PD; behavioral and physiological characterization of models based on the new molecular understanding of synuclein, parkin, and other proteins involved in the pathogenic processes of neurodegenerative disorders; the neurobiological basis of cognitive impairments in PD; the association between clinical disease onset, neuropathology in PD, and the development and severity of cognitive impairments; best outcome measures in PD patients with cognitive impairments, or co-morbid with dementia, depression, or other non-motor manifestations, including development and validation of specific assessment tools for PD patients with cognitive impairment; the relationship between age of onset of PD and PD-related cognitive changes; neuroanatomical circuits and neurochemical processes mediating cognitive states and cognition-based individual differences in PD; and the specific consequences of deep brain stimulation or other surgical interventions on the cognitive aspects of PD.
For more information, potential applicants should contact Dr. Debra Babcock, Program Director, Systems and Cognitive Neuroscience Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2108, Bethesda, MD 20892; telephone: 301-496-9964; fax: 301-402-2060; e-mail: firstname.lastname@example.org; or Dr. Diane Murphy, Program Director, Neurodegeneration Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2222, Bethesda, MD 20892; telephone: 301-496-5680; fax: 301-480-1080; e-mail: email@example.com.
*For a more detailed description of this announcement, please visit: http://grants.nih.gov/grants/guide/pa-files/PA-06-105.html (R01); http://grants.nih.gov/grants/guide/pa-files/PA-06-106.html (R03); or http://grants.nih.gov/grants/guide/pa-files/PA-06-107.html (R21).