The National Institute of Neurological Disorders and Stroke (NINDS) requests research grant applications for cell biological studies on Parkinson’s disease (PD).*
Studies to identify genes in PD are rapidly outpacing the cell biological studies which would reveal how these gene products are part of the disease process in PD. The purpose of this request for applications (RFA) is to stimulate studies devoted to understanding the functional role of these proteins in cells, or how these proteins may interact or share common pivotal molecular pathways. Dissemination of these cellular pathways may reveal points at which potential interventions for PD could be directed.
Areas of research interest include, but are not limited to: functional cellular studies of the proteins implicated in PD, including protein expression patterns, processing, folding, regulation, transport, protein-protein interactions or proteomics, protein degradation, etc.; studies of the involvement of these proteins in specific cellular pathways implicated in the pathogenesis of PD, such as proteasomal or lysosomal degradation pathways; studies of the potential interactions of these proteins in common cellular pathways, or cell-cell interactions; cellular studies of therapeutic approaches targeted to specific proteins implicated in PD; and exploratory studies on the development of potential biomarkers for PD based on these proteins.
LETTERS OF INTENT RECEIPT DATE: August 22, 2005.
APPLICATION RECEIPT DATE: September 21, 2005.
For more information, potential applicants should contact Dr. Diane Murphy, Program Director, Neurodegeneration Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2222, Bethesda, MD 20892; telephone: 301-496-5680; fax: 301-480-1080; e-mail: email@example.com.
*For a more detailed description of this RFA, please visit the NIH web site at: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-06-001.html.