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Funding News - NIH Announces New Transformative R01 Program

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  • The information on this page is for historical and research purposes only.
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NIH announces the Transformative R01 (T-R01), a new program designed to support highly creative, "out-of-the-box" projects. The program is part of the NIH Roadmap-an innovative approach to accelerate fundamental discovery and translate that knowledge into effective prevention strategies and new treatments.

Unlike the traditional R01 funding mechanism, the T-R01 provides a more flexible and engaging avenue of support for scientists who are testing exceptionally novel, high risk, original, or unconventional concepts, and proposing truly transformative ideas and approaches to major contemporary challenges. To be considered transformative, projects must have the potential to create or overturn fundamental scientific paradigms. Successful projects will have a major impact in a broad area of biomedical or behavioral research.

The program encourages projects in any area of research that falls within the NIH mission, especially those that fall in areas of highlighted need such as understanding and facilitating human behavior change, complex 3-dimensional tissue models, functional variation in mitochondria in disease, transitions from acute to chronic pain, formulation of novel protein capture reagents, and providing an evidence base for pharmacogenomics.

Letters of intent are due by December 26, 2008, and applications are due by January 29, 2009. For more information contact Dr. Kristin M. Abraham, Division of Strategic Coordination, OPASI, NIH at 301-594-8190 or, or visit