The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) request grant applications for basic and clinical research on hypoglycemia in patients with type 1 diabetes.*
Large clinical trials have demonstrated the effectiveness of intensified glucose control in preventing the long-term vascular complications of diabetes. However, episodes of severe hypoglycemia may complicate intensified treatment and are often a major obstacle to the achievement of euglycemia in many patients. This request for applications (RFA) seeks basic and clinical studies to enhance understanding of how the brain and other critical tissues sense and respond to hypoglycemia, delineate the effects of hypoglycemia on brain function, and develop improved methodologies to prevent hypoglycemia-based on an understanding of physiological glucose sensing and counterregulation.
Topics of potential research interest include studies to: understand the effect of diabetes and hypoglycemia on the metabolism of glucose by the brain; investigate the role of sleep in the development of hypoglycemia and elucidate the molecular mechanisms involved in the promotion of hypoglycemia by sleep; explore the role of sleep on counterregulatory responses, and determine the role of nighttime hypoglycemia in loss of awareness; understand the mechanisms underlying defective counterregulation after recurrent hypoglycemia and the development of hypoglycemia unawareness; describe and understand the long-term effects of recurrent hypoglycemia on brain function; assess the long-term adaptations of the central nervous system to recurrent episodes of hypoglycemia and the effects of hypoglycemia on synaptic plasticity; and apply existing imaging technologies, or develop new methods to image brain function, especially in the hypothalamus, in order to understand the neurological and cognitive effects of hypoglycemia and the neural substrates of hypoglycemia unawareness.
APPLICATION RECEIPT DATE: February 20, 2004.
For more information, potential applicants should contact the Neural Environment Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2114A, Bethesda, MD 20892; telephone: 301-496-1431; fax: 301-480-2424.
*For a more detailed description of this request for applications, please visit the NIH web site at: http://grants1.nih.gov/grants/guide/rfa-files/RFA-DK-03-017.html.